...Cali B. Corbett; Amanda K. St. Paul; Michael V. Autieri As many as 70% of cells in atherosclerotic plaque are vascular smooth muscle cell (VSMC) in origin, and pathways and proteins which regulate VSMC migration, proliferation, and phenotype modulation represent novel targets for rational drug...

... above) corresponding to various in vitro experiments. Atherosclerosis is narrowing of the arteries caused by a buildup of intimal plaques containing lipid-laden macrophage foam cells, vascular smooth muscle cells (VSMCs), and extracellular matrix (ECM) [ 1 ]. Atherosclerosis is triggered...

...@toyaku.ac.jp ) 29 05 2018 11 10 2018 05 11 2018 06 11 2018 © 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2018 atherosclerosis endothelial cell macrophage vasostatin-1 vascular smooth muscle cell Atherosclerosis...

...)-stimulated vascular smooth muscle cells (VSMCs) and wire injury-stimulated vascular tissue. Using a gain-of-function approach, overexpression of mindin in VSMCs exhibited strong anti-proliferative and anti-migratory effects on VSMCs, whereas significant suppression of intimal hyperplasia was observed...

... in vascular biology. Correspondence: Dr Augusto C. Montezano (email amonteza@uottawa.ca ). 20 7 2010 1 9 2010 14 9 2010 In heterologously expressing cells [ 23 ], endothelial cells [ 18 ] and vascular smooth muscle cells [ 33 ], Nox4 has a strong immunofluorescence...

... in thrombosis, TF has pro-atherogenic properties, as it is involved in neointima formation by inducing vascular smooth muscle cell migration. As inhibition of TF action appears to be an attractive target for the treatment of cardiovascular disease, therapeutic strategies are under investigation to specifically...

... © The Authors Journal compilation © 2009 Biochemical Society 2009 blood pressure cardiac myocyte G-protein-coupled receptor heterotrimeric GTP-binding protein regulator of G-protein signalling (RGS) vascular smooth muscle cell Hypertension is a prevalent condition within...

... migration neointima remodelling restenosis vascular smooth muscle cell Atherosclerotic stenosis and its ischaemic complications necessitate arterial reconstruction. Current therapeutic strategies to restore blood flow in stenotic coronary arteries include percutaneous transluminal angioplasty...

.... aldosterone collagen deposition epidermal growth factor receptor (EGFR) ischaemia mineralocorticoid receptor (MR) stroke vascular smooth muscle cell Correspondence: Dr Anne M. Dorrance, at the present address: Department of Pharmacology/Toxicology, Michigan State University, East Lansing, MI...

... type-1 receptor), a G-protein-coupled receptor, mediates most of the physiological and pathophysiological actions of AngII, and this receptor is predominantly expressed in cardiovascular cells, such as VSMCs (vascular smooth muscle cells). AngII activates various signalling molecules, including G...

... have been shown to influence activation of the nuclear transcription factor NF-κB (nuclear factor κB), which is involved in the regulation of adhesion molecule expression in ECs [ 45 ]. cardiovascular disease endothelial cell gender-associated protection oestrogen vascular smooth muscle cell...

...Laura Molero; Antonio García-Méndez; Sergio Alonso-Orgaz; Carolina Carrasco; Carlos Macaya; Antonio J. López Farré The aim of the present study was to use proteomics to analyse modifications in the level of expression of different proteins in BVSMCs (bovine vascular smooth muscle cells) incubated...

... Jones (email R.D.Jones@sheffield.ac.uk ). 24 11 2003 24 2 2004 1 3 2004 1 3 2004 The Biochemical Society 2004 androgen receptor testosterone vascular smooth muscle cell vasodilatation voltage-gated calcium channel Following equilibration...

... The Biochemical Society and the Medical Research Society 2002 endothelin-1 mitogen-activated protein kinase vascular smooth muscle cell ...

... induces apoptosis in cultured vascular smooth muscle cells (VSMC), but only when 100% confluency is reached. These results suggested that cell–cell contact inhibition (cell growth arrest) may be a critical factor for induction of VSMC apoptosis by PDGF-BB. In the present study, we explored the role...

.... In this lesion we identified apoptosis of vascular smooth muscle cells (VSMCs) by in situ DNA labelling and electron microscopy in the neointima on the 14th day after injury. mRNA expression levels of bcl-2 , bax , bcl-x , p53 and caspase-1 were determined by the reverse transcriptase–polymerase chain reaction...

...KO Yon; Willy Nettekoven; Roger Christian; Andreas J. Wieczorek; Rainer Düsing; Hans Vetter; Agapios Sachinidis 1. in the present study the effects of acute and chronic insulin treatment on growth factor-induced cell growth were investigated in vascular smooth muscle cells. Cell growth...