Search Results | Clinical Science

1-40 of 40

Sort by

Sort Order Select

Articles

Diminished Rbfox1 increases vascular constriction by dynamically regulating alternative splicing of Ca V 1.2 calcium channel in hypertension

Miaomiao Song, Wei Hou, Atta Ul Mustafa, Pengpeng Li, Jianzhen Lei, Yingying Zhou, Li Ji, Yu Sun, Hongmei Zhou, Yinyan Xu, Juejin Wang

Clin Sci (Lond) (2022) 136 (11): 803–817.

DOI: https://doi.org/10.1042/CS20220226

Published: 30 May 2022

...Miaomiao Song; Wei Hou; Atta Ul Mustafa; Pengpeng Li; Jianzhen Lei; Yingying Zhou; Li Ji; Yu Sun; Hongmei Zhou; Yinyan Xu; Juejin Wang Calcium influx from depolarized Ca V 1.2 calcium channels triggers the contraction of vascular smooth muscle cells (VSMCs), which is important for maintaining...

View article titled, Diminished Rbfox1 increases vascular constriction by dynamically regulating alternative splicing of Ca V 1.2 calcium channel in hypertension

Includes: Supplementary data

Articles

Focal adhesion signaling: vascular smooth muscle cell contractility beyond calcium mechanisms

J.C. Ribeiro-Silva, A.A. Miyakawa, Jose E. Krieger

Clin Sci (Lond) (2021) 135 (9): 1189–1207.

DOI: https://doi.org/10.1042/CS20201528

Published: 14 May 2021

... that it is independent of cell- or tissue-specific mechanisms, but rather that it relies on mechanical homeostasis between cells and their environments. contractility focal adhesion mechanotransduction vascular smooth muscle The fundamental basis of the requirement for focal adhesion (FA) in proper...

View article titled, Focal adhesion signaling: vascular smooth muscle cell contractility beyond calcium mechanisms

Articles

Promyelocytic leukemia protein promotes the phenotypic switch of smooth muscle cells in atherosclerotic plaques of human coronary arteries

Weronika Karle, Samuel Becker, Philipp Stenzel, Christoph Knosalla, Günter Siegel, Oliver Baum, Andreas Zakrzewicz, Janine Berkholz

Clin Sci (Lond) (2021) 135 (7): 887–905.

DOI: https://doi.org/10.1042/CS20201399

Published: 09 April 2021

... with fluorescence mounting medium (Agilent Technologies, Santa Clara, CA, U.S.A.; Cat. No: S3023). atherosclerosis cytokines phenotypic switch PML nuclear bodies sumoylation vascular smooth muscle Atherosclerotic heart disease is one of the most frequent causes of death in humans worldwide [ 1...

View article titled, Promyelocytic leukemia protein promotes the phenotypic switch of smooth muscle cells in atherosclerotic plaques of human coronary arteries

Includes: Supplementary data

Articles

Peripheral arteriopathy caused by Notch3 gain-of-function mutation involves ER and oxidative stress and blunting of NO/sGC/cGMP pathway

Karla B. Neves, Hannah E. Morris, Rhéure Alves-Lopes, Keith W. Muir, Fiona Moreton, Christian Delles, Augusto C. Montezano, Rhian M. Touyz

Clin Sci (Lond) (2021) 135 (6): 753–773.

DOI: https://doi.org/10.1042/CS20201412

Published: 17 March 2021

... underlying the peripheral vasculopathy mediated by CADASIL-causing Notch3 gain-of-function mutation. We studied: (i) small arteries and vascular smooth muscle cells (VSMCs) from TgNotch3 R169C mice (CADASIL model), (ii) VSMCs from peripheral arteries from CADASIL patients, and (iii) post-mortem brains from...

View article titled, Peripheral arteriopathy caused by Notch3 gain-of-function mutation involves ER and oxidative stress and blunting of NO/sGC/cGMP pathway

Includes: Supplementary data

Articles

ACE2/Ang-(1-7)/Mas1 axis and the vascular system: vasoprotection to COVID-19-associated vascular disease

In Collection

ACE2, a multifunctional protein – from cardiovascular regulation to COVID-19

Jithin Kuriakose, Augusto C. Montezano, Rhian M. Touyz

Clin Sci (Lond) (2021) 135 (2): 387–407.

DOI: https://doi.org/10.1042/CS20200480

Published: 29 January 2021

... vasodilation and attenuates Ang II-induced vasoconstriction. In endothelial cells activation of the ACE2/Ang-(1-7)/Mas1 axis increases production of the vasodilator’s nitric oxide and prostacyclin’s and in vascular smooth muscle cells it inhibits pro-contractile and pro-inflammatory signaling. Endothelial ACE2...

View article titled, ACE2/Ang-(1-7)/Mas1 axis and the vascular system: vasoprotection to COVID-19-associated vascular disease

Articles

Epidermal growth factor signaling through transient receptor potential melastatin 7 cation channel regulates vascular smooth muscle cell function

Zhi-Guo Zou, Francisco J. Rios, Karla B. Neves, Rheure Alves-Lopes, Jiayue Ling, George S. Baillie, Xing Gao, William Fuller, Livia L. Camargo, Thomas Gudermann, Vladimir Chubanov, Augusto C. Montezano, Rhian M. Touyz

Clin Sci (Lond) (2020) 134 (15): 2019–2035.

DOI: https://doi.org/10.1042/CS20200827

Published: 04 August 2020

..., a dual-function ion channel/protein kinase, regulates vascular smooth muscle cell (VSMC) Mg 2+ homeostasis and mitogenic signaling. Mechanisms regulating vascular growth effects of TRPM7 are unclear, but epidermal growth factor (EGF) may be important because it is a magnesiotropic hormone involved...

View article titled, Epidermal growth factor signaling through transient receptor potential melastatin 7 cation channel regulates vascular smooth muscle cell function

Includes: Multimedia, Supplementary data

Articles

B-type natriuretic peptide prevents postnatal closure of ductus arteriosus by both vasodilation and anti-remodeling in neonatal rats

Jwu-Lai Yeh, Jiunn-Ren Wu, Bin-Nan Wu, Sheau-Fang Yang, Zen-Kong Dai, Shu-Fen Liou, Jong-Hau Hsu

Clin Sci (Lond) (2018) 132 (18): 2045–2058.

DOI: https://doi.org/10.1042/CS20180201

Published: 19 September 2018

... peptide Ductus arteriosus vascular smooth muscle B-type natriuretic peptide (BNP) is a 32-amino acid polypeptide hormone mainly produced by the myocardium and has been widely used as a clinical biomarker in heart failure and intensive care of CHD and PDA [ 5 , 9 , 10 ]. Physiologically...

View article titled, B-type natriuretic peptide prevents postnatal closure of ductus arteriosus by both vasodilation and anti-remodeling in neonatal rats

Articles

Skin-derived precursors from human subjects with Type 2 diabetes yield dysfunctional vascular smooth muscle cells

Sarah K. Steinbach, Terrence M. Yau, Maral Ouzounian, Husam Abdel-Qadir, Mark Chandy, Thomas K. Waddell, Mansoor Husain

Clin Sci (Lond) (2017) 131 (15): 1801–1814.

DOI: https://doi.org/10.1042/CS20170239

Published: 05 July 2017

...Sarah K. Steinbach; Terrence M. Yau; Maral Ouzounian; Husam Abdel-Qadir; Mark Chandy; Thomas K. Waddell; Mansoor Husain Objective : Few methods enable molecular and cellular studies of vascular aging or Type 2 diabetes (T2D). Here, we report a new approach to studying human vascular smooth muscle...

View article titled, Skin-derived precursors from human subjects with Type 2 diabetes yield dysfunctional vascular smooth muscle cells

Articles

Differential effects of chlorinated and oxidized phospholipids in vascular tissue: implications for neointima formation

Fiona H. Greig, Lisa Hutchison, Corinne M. Spickett, Simon Kennedy

Clin Sci (Lond) (2015) 128 (9): 579–592.

DOI: https://doi.org/10.1042/CS20140578

Published: 11 February 2015

..., in particular oxidized and chlorinated species, are altered within injured vessels and how they affect VSMC (vascular smooth muscle cell) remodelling processes. Vascular injury was induced in C57BL/6 mice and high fat-fed ApoE −/− (apolipoprotein E) mice by wire denudation and ligation of the left carotid...

View article titled, Differential effects of chlorinated and oxidized phospholipids in vascular tissue: implications for neointima formation

Articles

Caveolin 1 is critical for abdominal aortic aneurysm formation induced by angiotensin II and inhibition of lysyl oxidase

Takehiko Takayanagi, Kevin J. Crawford, Tomonori Kobayashi, Takashi Obama, Toshiyuki Tsuji, Katherine J. Elliott, Tomoki Hashimoto, Victor Rizzo, Satoru Eguchi

Clin Sci (Lond) (2014) 126 (11): 785–800.

DOI: https://doi.org/10.1042/CS20130660

Published: 13 February 2014

.... Cav1 (caveolin 1)-enriched caveolae in vascular smooth muscle cells mediate ADAM17 (a disintegrin and metalloproteinase 17)-dependent EGFR (epidermal growth factor receptor) transactivation, which is linked to vascular remodelling induced by AngII. In the present study, we have tested our hypothesis...

View article titled, Caveolin 1 is critical for abdominal aortic aneurysm formation induced by angiotensin II and inhibition of lysyl oxidase

Includes: Supplementary data

Articles

Glycyrrhetinic acid attenuates vascular smooth muscle vasodilatory function in healthy humans

Piotr Sobieszczyk, Barry A. Borlaug, Heather L. Gornik, Wesley D. Knauft, Joshua A. Beckman

Clin Sci (Lond) (2010) 119 (10): 437–442.

DOI: https://doi.org/10.1042/CS20100087

Published: 05 August 2010

... administration of methacholine (0.3–10 μg/min) and vascular smooth muscle function with incremental verapamil (10–300 μg/min). GA increased the 24-h urinary cortisol/cortisone ratio compared with placebo ( P =0.008). GA tended to reduce the FBF (forearm blood flow) response to methacholine ( P =0.09...

View article titled, Glycyrrhetinic acid attenuates vascular smooth muscle vasodilatory function in healthy humans

Articles

Diabetes impairs arteriogenesis in the peripheral circulation: review of molecular mechanisms

Matthijs S. Ruiter, Jolanda M. van Golde, Nicolaas C. Schaper, Coen D. Stehouwer, Maya S. Huijberts

Clin Sci (Lond) (2010) 119 (6): 225–238.

DOI: https://doi.org/10.1042/CS20100082

Published: 08 June 2010

... Society 2010 arteriogenesis collateral circulation diabetes mellitus endothelium peripheral arterial disease vascular smooth muscle DM is recognized as a major cardiovascular risk factor. PAD is a common vascular complication in the diabetic population, as diabetes increases the risk...

View article titled, Diabetes impairs arteriogenesis in the peripheral circulation: review of molecular mechanisms

Articles

Programming of growth, insulin resistance and vascular dysfunction in offspring of late gestation diabetic rats

Emily M. Segar, Andrew W. Norris, Jian-Rong Yao, Shanming Hu, Stacia L. Koppenhafer, Robert D. Roghair, Jeffrey L. Segar, Thomas D. Scholz

Clin Sci (Lond) (2009) 117 (3): 129–138.

DOI: https://doi.org/10.1042/CS20080550

Published: 02 July 2009

... 2009 Biochemical Society 2009 cardiovascular disease fetal programming endothelium gestational diabetes glucose vascular smooth muscle There is increasing evidence that adverse factors in the perinatal environment predispose an individual to disease later in life. This concept...

View article titled, Programming of growth, insulin resistance and vascular dysfunction in offspring of late gestation diabetic rats

Articles

Central blood pressure and hypertension: role in cardiovascular risk assessment

Michel E. Safar, Piotr Jankowski

Clin Sci (Lond) (2009) 116 (4): 273–282.

DOI: https://doi.org/10.1042/CS20080072

Published: 15 January 2009

.... Safar (email michel.safar@htd.aphp.fr ). 4 3 2008 8 5 2008 3 6 2008 © The Authors Journal compilation © 2009 Biochemical Society 2009 antihypertensive medication cardiovascular risk central blood pressure hypertension peripheral blood pressure vascular smooth muscle...

View article titled, Central blood pressure and hypertension: role in cardiovascular risk assessment

Articles

GPCR signalling in hypertension: role of GRKs

David M. Harris, Heather I. Cohn, Stéphanie Pesant, Andrea D. Eckhart

Clin Sci (Lond) (2008) 115 (3): 79–89.

DOI: https://doi.org/10.1042/CS20070442

Published: 02 July 2008

... by these GPCRs is increased. Their signalling is tightly controlled by a class of proteins, the GRKs (GPCR kinases). Elevated levels of either GRK2 or GRK5 in both the lymphocytes and VSM (vascular smooth muscle) are associated with human hypertension and animal models of the disease. The focus of the present...

View article titled, GPCR signalling in hypertension: role of GRKs

Articles

Gender differences in protein kinase G-mediated vasorelaxation of rat aorta

Helena TEEDE, Andrea VAN DER ZYPP, Henryk MAJEWSKI

Clin Sci (Lond) (2001) 100 (5): 473–479.

DOI: https://doi.org/10.1042/cs1000473

Published: 29 March 2001

... μ M), supporting the role of NO in maintenance of basal relaxation and vascular tone in females. We have examined the relative activity of the specific PKG subtypes 1α and 1β in vascular smooth muscle, based on relaxation of rat aortas by two cGMP analogues with different selectivity, β-phenyl-l- N...

View article titled, Gender differences in protein kinase G-mediated vasorelaxation of rat aorta

Articles

Co-expression of prepro-adrenomedullin with a putative adrenomedullin receptor gene in vascular smooth muscle

Dominic J. AUTELITANO, F. TANG

Clin Sci (Lond) (1999) 96 (5): 493–498.

DOI: https://doi.org/10.1042/cs0960493

Published: 14 April 1999

...Dominic J. AUTELITANO; F. TANG The prepro-adrenomedullin (prepro-AM) gene encodes several biologically active peptides, including the potent vasodilator AM. At least part of the vasodilator action of AM appears to be mediated via interactions with receptors on vascular smooth muscle cells (VSMC...

View article titled, Co-expression of prepro-adrenomedullin with a putative adrenomedullin receptor gene in vascular smooth muscle

Articles

Activation of Two Inward Chloride Transport Systems in Rat Femoral Arterial Smooth Muscle in Deoxycorticosterone Acetate/Salt Hypertension

Alexander A. Harper, Julian P. L. Davis, Alan R. Chipperfield

Clin Sci (Lond) (1997) 93 (4): 295–298.

DOI: https://doi.org/10.1042/cs0930295

Published: 01 October 1997

... chloride deoxycorticosterone acetate/salt hypertension sodium—potassium—chloride co-transport vascular smooth muscle Clinical Science (1997) 93,295-298 (Printed in Great Britain) 295 Activation of two inward chloride transport systems in rat femoral arterial smooth muscle in deoxycorticosterone...

View article titled, Activation of Two Inward Chloride Transport Systems in Rat Femoral Arterial Smooth Muscle in Deoxycorticosterone Acetate/Salt Hypertension

Articles

Low Concentrations of Ouabain Increase Cytosolic Free Calcium Concentration in Rat Vascular Smooth Muscle Cells

Zhiming Zhu, Martin Tepel, Marcus Neusser, Walter Zidek

Clin Sci (Lond) (1996) 90 (1): 9–12.

DOI: https://doi.org/10.1042/cs0900009

Published: 01 January 1996

... ouabain concentrations affect intracellular cytosolic free calcium concentration homoeostasis. 7 9 1995 28 9 1995 © 1996 The Biochemical Society and the Medical Research Society 1996 calcium ouabain vascular smooth muscle Clinical Science (1996) 9-12 (Printed in Great Britain...

View article titled, Low Concentrations of Ouabain Increase Cytosolic Free Calcium Concentration in Rat Vascular Smooth Muscle Cells

Articles

Thrombin Does Not Alter Vascular Hyporeactivity in Models of Endotoxin-Induced Septic Shock in Rats

Viviane Martin, Marie-Louise Wiesel, Anne Albert, Alain Beretz

Clin Sci (Lond) (1995) 88 (2): 149–157.

DOI: https://doi.org/10.1042/cs0880149

Published: 01 February 1995

... observed during endotoxic shock. 5 9 1994 16 9 1994 © 1995 The Biochemical Society and the Medical Research Society 1995 disseminated intravascular coagulation endotoxic shock heparin hirudin nitric oxide thrombin vascular smooth muscle Clinical Science (1995) 88, 149-157...

View article titled, Thrombin Does Not Alter Vascular Hyporeactivity in Models of Endotoxin-Induced Septic Shock in Rats

Articles

Serum and Platelet-Derived Growth Factor-Induced Expression of Vascular Permeability Factor Mrna by Human Vascular Smooth Muscle Cells In Vitro

Bryan Williams, Anne Quinn-Baker, Barbara Gallacher

Clin Sci (Lond) (1995) 88 (2): 141–147.

DOI: https://doi.org/10.1042/cs0880141

Published: 01 February 1995

...Bryan Williams; Anne Quinn-Baker; Barbara Gallacher 1. Endothelial dysfunction and vascular smooth muscle cell (VSMC) proliferation are key events in the pathogenesis of atherosclerosis. Vascular permeability factor (VPF), an endothelial-cell-specific multifunctional cytokine, was recently...

View article titled, Serum and Platelet-Derived Growth Factor-Induced Expression of Vascular Permeability Factor Mrna by Human Vascular Smooth Muscle Cells In Vitro

Articles

Atrial Natriuretic Peptide Inhibits Cyclosporin A-Induced Endothelin Production and Calcium Accumulation in Rat Vascular Smooth Muscle Cells

Dirk Bokemeyer, Ursula Friedrichs, Angela Bäcker, Sabine Drechsler, Herbert J. Kramer, Harald Meyer-Lehnert

Clin Sci (Lond) (1994) 87 (4): 383–387.

DOI: https://doi.org/10.1042/cs0870383

Published: 01 October 1994

...Dirk Bokemeyer; Ursula Friedrichs; Angela Bäcker; Sabine Drechsler; Herbert J. Kramer; Harald Meyer-Lehnert 1. As we have previously shown, cyclosporin A enhances the vasoconstrictor-induced rise in intracellular free calcium in vascular smooth muscle cells. This effect may contribute to important...

View article titled, Atrial Natriuretic Peptide Inhibits Cyclosporin A-Induced Endothelin Production and Calcium Accumulation in Rat Vascular Smooth Muscle Cells

Articles

Reduced Cytosolic Free Sodium Concentration in Vascular Smooth Muscle Cells from Spontaneously Hypertensive Rats

Martin Tepel, JAN Holthues, Marcus Neusser, Petra Golinski, Zhiming Zhu, Norbert Mehring, Walter Zidek

Clin Sci (Lond) (1994) 86 (6): 741–747.

DOI: https://doi.org/10.1042/cs0860741

Published: 01 June 1994

...Martin Tepel; JAN Holthues; Marcus Neusser; Petra Golinski; Zhiming Zhu; Norbert Mehring; Walter Zidek 1. Cytosolic free sodium concentration and sodium transport systems were measured in intact cultured vascular smooth muscle cells from spontaneously hypertensive rats of the Münster strain...

View article titled, Reduced Cytosolic Free Sodium Concentration in Vascular Smooth Muscle Cells from Spontaneously Hypertensive Rats

Articles

Culture Techniques and Their Applications to Studies of Vascular Smooth Muscle

Julie H. Campbell, Gordon R. Campbell

Clin Sci (Lond) (1993) 85 (5): 501–513.

DOI: https://doi.org/10.1042/cs0850501

Published: 01 November 1993

...Julie H. Campbell; Gordon R. Campbell © 1993 The Biochemical Society and the Medical Research Society 1993 cell culture cell dispersion culture techniques vascular smooth muscle Clinical Science (1993) 85, 501-513 (Printed in Great Britain) Techniques in Clinical Research Culture...

View article titled, Culture Techniques and Their Applications to Studies of Vascular Smooth Muscle

Articles

Free-radical scavengers, thiol-containing reagents and endothelium-dependent relaxation in isolated rat and human resistance arteries

W. Sunman, A.D. Hughes, P.S. Sever

Clin Sci (Lond) (1993) 84 (3): 287–295.

DOI: https://doi.org/10.1042/cs0840287

Published: 01 March 1993

.... 6. N -Acetylcysteine causes an endothelium-independent relaxation of resistance arteries which is probably unrelated to the putative ability of this compound to scavenge superoxide radicals and may reflect a direct action on vascular smooth muscle. 11 11 1992 17 11 1992 © 1993...

View article titled, Free-radical scavengers, thiol-containing reagents and endothelium-dependent relaxation in isolated rat and human resistance arteries

Articles

Low-concentration ouabain does not inhibit noradrenaline-induced contraction of human resistance arteries

Robin G. Woolfson, Nicholas T. Richards, Lucilla Poston

Clin Sci (Lond) (1991) 81 (s25): 525–529.

DOI: https://doi.org/10.1042/cs0810525

Published: 01 October 1991

... or less) were shown not to alter vascular smooth muscle contractility or sensitivity to noradrenaline. 3. In contrast, higher concentrations of ouabain (100 nmol/l or more) were found to depress vascular smooth muscle contractility and to reduce the sensitivity of the noradrenaline concentration-response...

View article titled, Low-concentration ouabain does not inhibit noradrenaline-induced contraction of human resistance arteries

Articles

Comparison of the electrical properties of arterial smooth muscle in normotensive rats and rats with deoxycorticosterone acetate-salt-induced hypertension: Possible involvement of (Na + -K + -Cl − ) co-transport

J. P. L. Davis, A. R. Chipperfield, A. A. Harper

Clin Sci (Lond) (1991) 81 (1): 73–78.

DOI: https://doi.org/10.1042/cs0810073

Published: 01 July 1991

..., mean ± sd , n = 17) compared with age-matched, unoperated control animals (134.0 ± 4.2 mmHg, n = 8, P < 0.001). 2. The membrane potential of femoral artery vascular smooth muscle measured in vitro was −55.1 ± 6.3 mV (mean ± sd , n = 154) for normotensive and −50.8 ± 5.7 mV ( n = 82) for hypertensive...

View article titled, Comparison of the electrical properties of arterial smooth muscle in normotensive rats and rats with deoxycorticosterone acetate-salt-induced hypertension: Possible involvement of (Na + -K + -Cl − ) co-transport

Articles

Direct effect of α -human atrial natriuretic peptide on human vasculature in vivo and in vitro

A. Hughes, S. Thom, P. Goldberg, G. Martin, P. Sever

Clin Sci (Lond) (1988) 74 (2): 207–211.

DOI: https://doi.org/10.1042/cs0740207

Published: 01 February 1988

... in vivo. © 1970 The Biochemical Society and the Medical Research Society 1970 atrial natriuretic peptide vascular smooth muscle vasodilatation Clinical Science (1988) 74, 207-21 1 207 Direct effect of a-human atrial natriuretic peptide on human vasculature in vivo and in vitro A. HUGHES, S...

View article titled, Direct effect of α -human atrial natriuretic peptide on human vasculature in vivo and in vitro

Articles

Endothelium-dependent relaxation in isolated human arteries and veins

S. Thom, A. Hughes, G. Martin, P. S. Sever

Clin Sci (Lond) (1987) 73 (5): 547–552.

DOI: https://doi.org/10.1042/cs0730547

Published: 01 November 1987

... vascular smooth muscle ...

View article titled, Endothelium-dependent relaxation in isolated human arteries and veins

Articles

The adrenaline -α 2 -adrenoceptor-mediated vasoconstrictor axis

Peter Bolli, Paul Erne, Wolfgang Kiowski, Franz W. Amman, Fritz R. Bühler

Clin Sci (Lond) (1985) 68 (s10): 141s–146s.

DOI: https://doi.org/10.1042/cs068s141

Published: 01 January 1985

... vascular smooth muscle contraction, which most likely is sensitized by the elevated intracellular calcium concentration. © 1985 The Biochemical Society and the Medical Research Society 1985 adrenaline essential hypertension forearm blood flow platelets vascular smooth muscle clinical Science...

View article titled, The adrenaline -α 2 -adrenoceptor-mediated vasoconstrictor axis

Articles

Influence of blood gases, Ca 2+ -entry blockade and angiotensin converting enzyme inhibition on pressor responses to α-adrenoceptor agonists: evidence in vivo for subtypes of response independent of receptor subtype?

J. W. O'Brien, N. A. Flavahan, T. L. Grant, J. C. McGrath, R. J. Marshall

Clin Sci (Lond) (1985) 68 (s10): 99s–104s.

DOI: https://doi.org/10.1042/cs068s099

Published: 01 January 1985

... them. © 1985 The Biochemical Society and the Medical Research Society 1985 α-adrenoceptor agonists angiotensin blood pressure Ca 2+ -entry blockade carbon dioxide nifedipine oxygen vascular smooth muscle Clinical Science (1985) 68 (Suppl. lo), 99s-104s 99s Influence of blood gases...

View article titled, Influence of blood gases, Ca 2+ -entry blockade and angiotensin converting enzyme inhibition on pressor responses to α-adrenoceptor agonists: evidence in vivo for subtypes of response independent of receptor subtype?

Articles

Commentary on Workshop on α-Adrenoceptors

J. C. McGrath, J. L. Reid

Clin Sci (Lond) (1985) 68 (s10): 1s–7s.

DOI: https://doi.org/10.1042/cs068s001

Published: 01 January 1985

... and is intended as a guide to the papers in this Supplement. © 1985 The Biochemical Society and the Medical Research Society 1985 activation processes α-adrenoceptors agonists antagonists excitation-contraction coupling vascular smooth muscle Clinical Science (1985) 68 (Suppl. lo), 1s-7s 1s...

View article titled, Commentary on Workshop on α-Adrenoceptors

Articles

Vascular α 2 -adrenoceptors can mediate nerve stimulation-evoked contractions

James R. Docherty, Lisa Hyland

Clin Sci (Lond) (1985) 68 (s10): 117s–120s.

DOI: https://doi.org/10.1042/cs068s117

Published: 01 January 1985

...James R. Docherty; Lisa Hyland 1. It is now established that α 2 -adrenoceptors can be present on vascular smooth muscle as targets for exogenous agonists, but some controversy exists as to whether these vascular α 2 -receptors may also be the target for neurally released noradrenaline. 2. In human...

View article titled, Vascular α 2 -adrenoceptors can mediate nerve stimulation-evoked contractions

Articles

Human vascular smooth muscle responses mediated by α 2 mechanisms in vivo and in vitro

S. Thom, J. Calvete, R. Hayes, G. Martin, P. Sever

Clin Sci (Lond) (1985) 68 (s10): 147s–150s.

DOI: https://doi.org/10.1042/cs068s147

Published: 01 January 1985

... of the endothelium, and provides evidence that α 2 -receptors may mediate release of the endothelium-derived relaxing factor. α 2 -adrenoceptors forearm blood flow vascular smooth muscle Clinical Science (1985) 68 (Suppl. lo), 147s-150s 147s Human vascular smooth muscle responses mediated by a2 mechanisms...

View article titled, Human vascular smooth muscle responses mediated by α 2 mechanisms in vivo and in vitro

Articles

Electrical membrane events in response to α-adrenoceptor stimulation

G. Haeusler, J. E. De Peyer

Clin Sci (Lond) (1985) 68 (s10): 51s–53s.

DOI: https://doi.org/10.1042/cs068s051

Published: 01 January 1985

...G. Haeusler; J. E. De Peyer 1. Strips of rabbit main pulmonary artery (RMPA) were used to study the effects of several agonists on tension development and membrane potential of the vascular smooth muscle cells. 2. The following α-adrenoceptor agonists were employed: methoxamine and St 587 (α 1...

View article titled, Electrical membrane events in response to α-adrenoceptor stimulation

Articles

Increased Vascular Sensitivity to Serotonin and Methysergide in Hypertension in Rats

R. Clinton Webb

Clin Sci (Lond) (1982) 63 (s8): 73s–75s.

DOI: https://doi.org/10.1042/cs063073s

Published: 01 October 1982

... in the vascular smooth muscle of different arteries in hypertension. Furthermore, in addition to the general increase in vascular sensitivity that occurs in hyper- tension, there is a specific increase in its mem- brane receptors through which methysergide has an agonistic action. Thus it is not surprising...

View article titled, Increased Vascular Sensitivity to Serotonin and Methysergide in Hypertension in Rats

Articles

Effects of Clonidine on Aortic Pressure-Diameter and Elastic Stiffness-Stress Relations in Anaesthetized Rabbits

A. Friggi, H. Bodard

Clin Sci (Lond) (1981) 61 (3): 273–279.

DOI: https://doi.org/10.1042/cs0610273

Published: 01 September 1981

.... 13 3 1981 26 3 1981 © 1981 The Biochemical Society and the Medical Research Society 1981 aortic diameter aortic elastic modulus aortic stress clonidine vascular smooth muscle Clinical Science (1981) 61,273-279 273 Effects of clonidine on aortic pressure-diameter and elastic...

View article titled, Effects of Clonidine on Aortic Pressure-Diameter and Elastic Stiffness-Stress Relations in Anaesthetized Rabbits

Articles

Presence of Postsynaptic α 2 -Adrenoreceptors of Predominantly Extrasynaptic Location in the Vascular Smooth Muscle of the Dog Hind Limb

S. Z. Langer, R. Massingham, N. B. Shepperson

Clin Sci (Lond) (1980) 59 (s6): 225s–228s.

DOI: https://doi.org/10.1042/cs059225s

Published: 01 December 1980

... as an antihypertensive agent. © 1980 The Biochemical Society and the Medical Research Society 1980 α 1 - and α 2 -adrenoreceptors autoperfused dog hind limb neuronally released and exogenous noradrenaline prazosin rauwolscine vascular smooth muscle Clinical Science (1980) 5 9 , 2 2 5 ~ 2 2 8 s 225s...

View article titled, Presence of Postsynaptic α 2 -Adrenoreceptors of Predominantly Extrasynaptic Location in the Vascular Smooth Muscle of the Dog Hind Limb

Articles

Influence of Angiotensin II, Ouabain and Hydrostatic Pressure on Inulin and Electrolyte Concentration of Fluid Perfusing Pig Carotid Arteries in Vitro

J. K. Healy, A. J. Elliott, I. J. Oweczkin

Clin Sci (Lond) (1979) 56 (5): 445–453.

DOI: https://doi.org/10.1042/cs0560445

Published: 01 May 1979

... and to electrolyte homeostasis. 19 6 1978 1 1 1979 © 1979 The Biochemical Society and the Medical Research Society 1979 angiotensin Auto-analyzer methods carotid artery hydrostatic pressure ouabain potassium sodium vascular smooth muscle Clinical Science (1979), 56,445453 Influence...

View article titled, Influence of Angiotensin II, Ouabain and Hydrostatic Pressure on Inulin and Electrolyte Concentration of Fluid Perfusing Pig Carotid Arteries in Vitro

Articles

The Inhibition of Renin Secretion by Alpha-Adrenergic Stimulation in the Isolated Rat Kidney

R. Vandongen, W. S. Peart

Clin Sci Mol Med (1974) 47 (5): 471–479.

DOI: https://doi.org/10.1042/cs0470471

Published: 01 November 1974

... to that involved in contraction and relaxation. This would accord with the common derivation of the renin-producing and vascular smooth muscle cells 12 6 1974 © 1974 The Biochemical Society and the Medical Research Society 1974 adrenergic receptors renin secretion vascular smooth muscle...

View article titled, The Inhibition of Renin Secretion by Alpha-Adrenergic Stimulation in the Isolated Rat Kidney

Email alerts

CONNECT

EXPLORE

This Feature Is Available To Subscribers Only