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Keywords: vascular smooth muscle
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Articles

Colchicine protects against the development of experimental abdominal aortic aneurysm

Yi Zhao, Qi-Rui Shen, Yu-Xin Chen, Yu Shi, Wen-Bing Wu, Qiao Li, Dong-Jie Li, Fu-Ming Shen, Hui Fu
Journal: Clinical Science
Clin Sci (Lond) (2023) 137 (19): 1533–1545.
https://doi.org/10.1042/CS20230499
Published: 03 October 2023
... the phenotypic switching of vascular smooth muscle cells from a contractile to synthetic state during AAA. In addition, it was demonstrated that colchicine was able to reduce vascular inflammation, oxidative stress, cell pyroptosis and immune cells infiltration to the aortic wall in the AAA mice model. Finally...
View article titled, Colchicine protects against the development of experimental abdominal aortic aneurysm
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Includes: Supplementary data
Articles

Diminished Rbfox1 increases vascular constriction by dynamically regulating alternative splicing of Ca V 1.2 calcium channel in hypertension

Miaomiao Song, Wei Hou, Atta Ul Mustafa, Pengpeng Li, Jianzhen Lei, Yingying Zhou, Li Ji, Yu Sun, Hongmei Zhou, Yinyan Xu, Juejin Wang
Journal: Clinical Science
Clin Sci (Lond) (2022) 136 (11): 803–817.
https://doi.org/10.1042/CS20220226
Published: 30 May 2022
...Miaomiao Song; Wei Hou; Atta Ul Mustafa; Pengpeng Li; Jianzhen Lei; Yingying Zhou; Li Ji; Yu Sun; Hongmei Zhou; Yinyan Xu; Juejin Wang Calcium influx from depolarized Ca V 1.2 calcium channels triggers the contraction of vascular smooth muscle cells (VSMCs), which is important for maintaining...
View article titled, Diminished Rbfox1 increases vascular constriction by dynamically regulating alternative splicing of Ca V 1.2 calcium channel in hypertension
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Includes: Supplementary data
Articles

Focal adhesion signaling: vascular smooth muscle cell contractility beyond calcium mechanisms

J.C. Ribeiro-Silva, A.A. Miyakawa, Jose E. Krieger
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (9): 1189–1207.
https://doi.org/10.1042/CS20201528
Published: 14 May 2021
... showed a sustained contractile response on a timescale that extends beyond the activation of PKC, implying the involvement of additional mechanisms [ 59 , 62 , 63 ]. contractility focal adhesion mechanotransduction vascular smooth muscle The fundamental basis of the requirement for focal...
View article titled, Focal adhesion signaling: <span class="search-highlight">vascular</span> <span class="search-highlight">smooth</span> <span class="search-highlight">muscle</span> cell contractility beyond calcium mechanisms
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Articles

Promyelocytic leukemia protein promotes the phenotypic switch of smooth muscle cells in atherosclerotic plaques of human coronary arteries

Weronika Karle, Samuel Becker, Philipp Stenzel, Christoph Knosalla, Günter Siegel, Oliver Baum, Andreas Zakrzewicz, Janine Berkholz
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (7): 887–905.
https://doi.org/10.1042/CS20201399
Published: 09 April 2021
... 2021 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2021 atherosclerosis cytokines phenotypic switch PML nuclear bodies sumoylation vascular smooth muscle Atherosclerotic heart disease is one of the most frequent causes of death in humans...
View article titled, Promyelocytic leukemia protein promotes the phenotypic switch of smooth muscle cells in atherosclerotic plaques of human coronary arteries
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Includes: Supplementary data
Articles

Peripheral arteriopathy caused by Notch3 gain-of-function mutation involves ER and oxidative stress and blunting of NO/sGC/cGMP pathway

Karla B. Neves, Hannah E. Morris, Rhéure Alves-Lopes, Keith W. Muir, Fiona Moreton, Christian Delles, Augusto C. Montezano, Rhian M. Touyz
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (6): 753–773.
https://doi.org/10.1042/CS20201412
Published: 17 March 2021
... underlying the peripheral vasculopathy mediated by CADASIL-causing Notch3 gain-of-function mutation. We studied: (i) small arteries and vascular smooth muscle cells (VSMCs) from TgNotch3 R169C mice (CADASIL model), (ii) VSMCs from peripheral arteries from CADASIL patients, and (iii) post-mortem brains from...
View article titled, Peripheral arteriopathy caused by Notch3 gain-of-function mutation involves ER and oxidative stress and blunting of NO/sGC/cGMP pathway
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Includes: Supplementary data
Articles

ACE2/Ang-(1-7)/Mas1 axis and the vascular system: vasoprotection to COVID-19-associated vascular disease

In Collection
ACE2, a multifunctional protein – from cardiovascular regulation to COVID-19
Jithin Kuriakose, Augusto C. Montezano, Rhian M. Touyz
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (2): 387–407.
https://doi.org/10.1042/CS20200480
Published: 29 January 2021
... vasodilation and attenuates Ang II-induced vasoconstriction. In endothelial cells activation of the ACE2/Ang-(1-7)/Mas1 axis increases production of the vasodilator’s nitric oxide and prostacyclin’s and in vascular smooth muscle cells it inhibits pro-contractile and pro-inflammatory signaling. Endothelial ACE2...
View article titled, ACE2/Ang-(1-7)/Mas1 axis and the vascular system: vasoprotection to COVID-19-associated vascular disease
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Articles

Epidermal growth factor signaling through transient receptor potential melastatin 7 cation channel regulates vascular smooth muscle cell function

Zhi-Guo Zou, Francisco J. Rios, Karla B. Neves, Rheure Alves-Lopes, Jiayue Ling, George S. Baillie, Xing Gao, William Fuller, Livia L. Camargo, Thomas Gudermann, Vladimir Chubanov, Augusto C. Montezano, Rhian M. Touyz
Journal: Clinical Science
Clin Sci (Lond) (2020) 134 (15): 2019–2035.
https://doi.org/10.1042/CS20200827
Published: 04 August 2020
..., a dual-function ion channel/protein kinase, regulates vascular smooth muscle cell (VSMC) Mg 2+ homeostasis and mitogenic signaling. Mechanisms regulating vascular growth effects of TRPM7 are unclear, but epidermal growth factor (EGF) may be important because it is a magnesiotropic hormone involved...
View article titled, Epidermal growth factor signaling through transient receptor potential melastatin 7 cation channel regulates <span class="search-highlight">vascular</span> <span class="search-highlight">smooth</span> <span class="search-highlight">muscle</span> cell function
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Includes: Multimedia, Supplementary data
Articles

B-type natriuretic peptide prevents postnatal closure of ductus arteriosus by both vasodilation and anti-remodeling in neonatal rats

Jwu-Lai Yeh, Jiunn-Ren Wu, Bin-Nan Wu, Sheau-Fang Yang, Zen-Kong Dai, Shu-Fen Liou, Jong-Hau Hsu
Journal: Clinical Science
Clin Sci (Lond) (2018) 132 (18): 2045–2058.
https://doi.org/10.1042/CS20180201
Published: 19 September 2018
... by the fluorescence intensity (FL-1, 525 nm) of 10000 cells as previously described [ 19 ]. B type natriuretic peptide Ductus arteriosus vascular smooth muscle The ductus arteriosus (DA) is an essential artery in fetal circulation, connecting the pulmonary artery and the descending aorta. After...
View article titled, B-type natriuretic peptide prevents postnatal closure of ductus arteriosus by both vasodilation and anti-remodeling in neonatal rats
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Articles

Skin-derived precursors from human subjects with Type 2 diabetes yield dysfunctional vascular smooth muscle cells

Sarah K. Steinbach, Terrence M. Yau, Maral Ouzounian, Husam Abdel-Qadir, Mark Chandy, Thomas K. Waddell, Mansoor Husain
Journal: Clinical Science
Clin Sci (Lond) (2017) 131 (15): 1801–1814.
https://doi.org/10.1042/CS20170239
Published: 05 July 2017
...Sarah K. Steinbach; Terrence M. Yau; Maral Ouzounian; Husam Abdel-Qadir; Mark Chandy; Thomas K. Waddell; Mansoor Husain Objective : Few methods enable molecular and cellular studies of vascular aging or Type 2 diabetes (T2D). Here, we report a new approach to studying human vascular smooth muscle...
View article titled, Skin-derived precursors from human subjects with Type 2 diabetes yield dysfunctional <span class="search-highlight">vascular</span> <span class="search-highlight">smooth</span> <span class="search-highlight">muscle</span> cells
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Articles

Differential effects of chlorinated and oxidized phospholipids in vascular tissue: implications for neointima formation

Fiona H. Greig, Lisa Hutchison, Corinne M. Spickett, Simon Kennedy
Journal: Clinical Science
Clin Sci (Lond) (2015) 128 (9): 579–592.
https://doi.org/10.1042/CS20140578
Published: 11 February 2015
..., in particular oxidized and chlorinated species, are altered within injured vessels and how they affect VSMC (vascular smooth muscle cell) remodelling processes. Vascular injury was induced in C57BL/6 mice and high fat-fed ApoE −/− (apolipoprotein E) mice by wire denudation and ligation of the left carotid...
View article titled, Differential effects of chlorinated and oxidized phospholipids in vascular tissue: implications for neointima formation
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Articles

Caveolin 1 is critical for abdominal aortic aneurysm formation induced by angiotensin II and inhibition of lysyl oxidase

Takehiko Takayanagi, Kevin J. Crawford, Tomonori Kobayashi, Takashi Obama, Toshiyuki Tsuji, Katherine J. Elliott, Tomoki Hashimoto, Victor Rizzo, Satoru Eguchi
Journal: Clinical Science
Clin Sci (Lond) (2014) 126 (11): 785–800.
https://doi.org/10.1042/CS20130660
Published: 13 February 2014
.... Cav1 (caveolin 1)-enriched caveolae in vascular smooth muscle cells mediate ADAM17 (a disintegrin and metalloproteinase 17)-dependent EGFR (epidermal growth factor receptor) transactivation, which is linked to vascular remodelling induced by AngII. In the present study, we have tested our hypothesis...
View article titled, Caveolin 1 is critical for abdominal aortic aneurysm formation induced by angiotensin II and inhibition of lysyl oxidase
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Includes: Supplementary data
Articles

Glycyrrhetinic acid attenuates vascular smooth muscle vasodilatory function in healthy humans

Piotr Sobieszczyk, Barry A. Borlaug, Heather L. Gornik, Wesley D. Knauft, Joshua A. Beckman
Journal: Clinical Science
Clin Sci (Lond) (2010) 119 (10): 437–442.
https://doi.org/10.1042/CS20100087
Published: 05 August 2010
... administration of methacholine (0.3–10 μg/min) and vascular smooth muscle function with incremental verapamil (10–300 μg/min). GA increased the 24-h urinary cortisol/cortisone ratio compared with placebo ( P =0.008). GA tended to reduce the FBF (forearm blood flow) response to methacholine ( P =0.09...
View article titled, Glycyrrhetinic acid attenuates <span class="search-highlight">vascular</span> <span class="search-highlight">smooth</span> <span class="search-highlight">muscle</span> vasodilatory function in healthy humans
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Articles

Diabetes impairs arteriogenesis in the peripheral circulation: review of molecular mechanisms

Matthijs S. Ruiter, Jolanda M. van Golde, Nicolaas C. Schaper, Coen D. Stehouwer, Maya S. Huijberts
Journal: Clinical Science
Clin Sci (Lond) (2010) 119 (6): 225–238.
https://doi.org/10.1042/CS20100082
Published: 08 June 2010
.... The review concludes with suggestions for new and more sophisticated therapeutic approaches for the diabetic population. arteriogenesis collateral circulation diabetes mellitus endothelium peripheral arterial disease vascular smooth muscle Several studies have investigated the acute phase...
View article titled, Diabetes impairs arteriogenesis in the peripheral circulation: review of molecular mechanisms
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Articles

Programming of growth, insulin resistance and vascular dysfunction in offspring of late gestation diabetic rats

Emily M. Segar, Andrew W. Norris, Jian-Rong Yao, Shanming Hu, Stacia L. Koppenhafer, Robert D. Roghair, Jeffrey L. Segar, Thomas D. Scholz
Journal: Clinical Science
Clin Sci (Lond) (2009) 117 (3): 129–138.
https://doi.org/10.1042/CS20080550
Published: 02 July 2009
... 2009 Biochemical Society 2009 cardiovascular disease fetal programming endothelium gestational diabetes glucose vascular smooth muscle There is increasing evidence that adverse factors in the perinatal environment predispose an individual to disease later in life. This concept...
View article titled, Programming of growth, insulin resistance and vascular dysfunction in offspring of late gestation diabetic rats
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Articles

Central blood pressure and hypertension: role in cardiovascular risk assessment

Michel E. Safar, Piotr Jankowski
Journal: Clinical Science
Clin Sci (Lond) (2009) 116 (4): 273–282.
https://doi.org/10.1042/CS20080072
Published: 15 January 2009
...@htd.aphp.fr ). 4 3 2008 8 5 2008 3 6 2008 © The Authors Journal compilation © 2009 Biochemical Society 2009 antihypertensive medication cardiovascular risk central blood pressure hypertension peripheral blood pressure vascular smooth muscle Brachial artery BP (blood...
View article titled, Central blood pressure and hypertension: role in cardiovascular risk assessment
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Articles

GPCR signalling in hypertension: role of GRKs

David M. Harris, Heather I. Cohn, Stéphanie Pesant, Andrea D. Eckhart
Journal: Clinical Science
Clin Sci (Lond) (2008) 115 (3): 79–89.
https://doi.org/10.1042/CS20070442
Published: 02 July 2008
... by these GPCRs is increased. Their signalling is tightly controlled by a class of proteins, the GRKs (GPCR kinases). Elevated levels of either GRK2 or GRK5 in both the lymphocytes and VSM (vascular smooth muscle) are associated with human hypertension and animal models of the disease. The focus of the present...
View article titled, GPCR signalling in hypertension: role of GRKs
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Articles

Gender differences in protein kinase G-mediated vasorelaxation of rat aorta

Helena TEEDE, Andrea VAN DER ZYPP, Henryk MAJEWSKI
Journal: Clinical Science
Clin Sci (Lond) (2001) 100 (5): 473–479.
https://doi.org/10.1042/cs1000473
Published: 29 March 2001
... μ M), supporting the role of NO in maintenance of basal relaxation and vascular tone in females. We have examined the relative activity of the specific PKG subtypes 1α and 1β in vascular smooth muscle, based on relaxation of rat aortas by two cGMP analogues with different selectivity, β-phenyl-l- N...
View article titled, Gender differences in protein kinase G-mediated vasorelaxation of rat aorta
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Articles

Co-expression of prepro-adrenomedullin with a putative adrenomedullin receptor gene in vascular smooth muscle

Dominic J. AUTELITANO, F. TANG
Journal: Clinical Science
Clin Sci (Lond) (1999) 96 (5): 493–498.
https://doi.org/10.1042/cs0960493
Published: 14 April 1999
...Dominic J. AUTELITANO; F. TANG The prepro-adrenomedullin (prepro-AM) gene encodes several biologically active peptides, including the potent vasodilator AM. At least part of the vasodilator action of AM appears to be mediated via interactions with receptors on vascular smooth muscle cells (VSMC...
View article titled, Co-expression of prepro-adrenomedullin with a putative adrenomedullin receptor gene in <span class="search-highlight">vascular</span> <span class="search-highlight">smooth</span> <span class="search-highlight">muscle</span>
Open the PDF for Co-expression of prepro-adrenomedullin with a putative adrenomedullin receptor gene in <span class="search-highlight">vascular</span> <span class="search-highlight">smooth</span> <span class="search-highlight">muscle</span> in another window
Articles

Activation of Two Inward Chloride Transport Systems in Rat Femoral Arterial Smooth Muscle in Deoxycorticosterone Acetate/Salt Hypertension

Alexander A. Harper, Julian P. L. Davis, Alan R. Chipperfield
Journal: Clinical Science
Clin Sci (Lond) (1997) 93 (4): 295–298.
https://doi.org/10.1042/cs0930295
Published: 01 October 1997
... chloride deoxycorticosterone acetate/salt hypertension sodium—potassium—chloride co-transport vascular smooth muscle Clinical Science (1997) 93,295-298 (Printed in Great Britain) 295 Activation of two inward chloride transport systems in rat femoral arterial smooth muscle in deoxycorticosterone...
View article titled, Activation of Two Inward Chloride Transport Systems in Rat Femoral Arterial Smooth Muscle in Deoxycorticosterone Acetate/Salt Hypertension
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Articles

Low Concentrations of Ouabain Increase Cytosolic Free Calcium Concentration in Rat Vascular Smooth Muscle Cells

Zhiming Zhu, Martin Tepel, Marcus Neusser, Walter Zidek
Journal: Clinical Science
Clin Sci (Lond) (1996) 90 (1): 9–12.
https://doi.org/10.1042/cs0900009
Published: 01 January 1996
... ouabain concentrations affect intracellular cytosolic free calcium concentration homoeostasis. 7 9 1995 28 9 1995 © 1996 The Biochemical Society and the Medical Research Society 1996 calcium ouabain vascular smooth muscle Clinical Science (1996) 9-12 (Printed in Great Britain...
View article titled, Low Concentrations of Ouabain Increase Cytosolic Free Calcium Concentration in Rat <span class="search-highlight">Vascular</span> <span class="search-highlight">Smooth</span> <span class="search-highlight">Muscle</span> Cells
Open the PDF for Low Concentrations of Ouabain Increase Cytosolic Free Calcium Concentration in Rat <span class="search-highlight">Vascular</span> <span class="search-highlight">Smooth</span> <span class="search-highlight">Muscle</span> Cells in another window
Articles

Thrombin Does Not Alter Vascular Hyporeactivity in Models of Endotoxin-Induced Septic Shock in Rats

Viviane Martin, Marie-Louise Wiesel, Anne Albert, Alain Beretz
Journal: Clinical Science
Clin Sci (Lond) (1995) 88 (2): 149–157.
https://doi.org/10.1042/cs0880149
Published: 01 February 1995
... observed during endotoxic shock. 5 9 1994 16 9 1994 © 1995 The Biochemical Society and the Medical Research Society 1995 disseminated intravascular coagulation endotoxic shock heparin hirudin nitric oxide thrombin vascular smooth muscle Clinical Science (1995) 88, 149-157...
View article titled, Thrombin Does Not Alter Vascular Hyporeactivity in Models of Endotoxin-Induced Septic Shock in Rats
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Articles

Serum and Platelet-Derived Growth Factor-Induced Expression of Vascular Permeability Factor Mrna by Human Vascular Smooth Muscle Cells In Vitro

Bryan Williams, Anne Quinn-Baker, Barbara Gallacher
Journal: Clinical Science
Clin Sci (Lond) (1995) 88 (2): 141–147.
https://doi.org/10.1042/cs0880141
Published: 01 February 1995
...Bryan Williams; Anne Quinn-Baker; Barbara Gallacher 1. Endothelial dysfunction and vascular smooth muscle cell (VSMC) proliferation are key events in the pathogenesis of atherosclerosis. Vascular permeability factor (VPF), an endothelial-cell-specific multifunctional cytokine, was recently...
View article titled, Serum and Platelet-Derived Growth Factor-Induced Expression of Vascular Permeability Factor Mrna by Human <span class="search-highlight">Vascular</span> <span class="search-highlight">Smooth</span> <span class="search-highlight">Muscle</span> Cells In Vitro
Open the PDF for Serum and Platelet-Derived Growth Factor-Induced Expression of Vascular Permeability Factor Mrna by Human <span class="search-highlight">Vascular</span> <span class="search-highlight">Smooth</span> <span class="search-highlight">Muscle</span> Cells In Vitro in another window
Articles

Atrial Natriuretic Peptide Inhibits Cyclosporin A-Induced Endothelin Production and Calcium Accumulation in Rat Vascular Smooth Muscle Cells

Dirk Bokemeyer, Ursula Friedrichs, Angela Bäcker, Sabine Drechsler, Herbert J. Kramer, Harald Meyer-Lehnert
Journal: Clinical Science
Clin Sci (Lond) (1994) 87 (4): 383–387.
https://doi.org/10.1042/cs0870383
Published: 01 October 1994
...Dirk Bokemeyer; Ursula Friedrichs; Angela Bäcker; Sabine Drechsler; Herbert J. Kramer; Harald Meyer-Lehnert 1. As we have previously shown, cyclosporin A enhances the vasoconstrictor-induced rise in intracellular free calcium in vascular smooth muscle cells. This effect may contribute to important...
View article titled, Atrial Natriuretic Peptide Inhibits Cyclosporin A-Induced Endothelin Production and Calcium Accumulation in Rat <span class="search-highlight">Vascular</span> <span class="search-highlight">Smooth</span> <span class="search-highlight">Muscle</span> Cells
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Articles

Reduced Cytosolic Free Sodium Concentration in Vascular Smooth Muscle Cells from Spontaneously Hypertensive Rats

Martin Tepel, JAN Holthues, Marcus Neusser, Petra Golinski, Zhiming Zhu, Norbert Mehring, Walter Zidek
Journal: Clinical Science
Clin Sci (Lond) (1994) 86 (6): 741–747.
https://doi.org/10.1042/cs0860741
Published: 01 June 1994
...Martin Tepel; JAN Holthues; Marcus Neusser; Petra Golinski; Zhiming Zhu; Norbert Mehring; Walter Zidek 1. Cytosolic free sodium concentration and sodium transport systems were measured in intact cultured vascular smooth muscle cells from spontaneously hypertensive rats of the Münster strain...
View article titled, Reduced Cytosolic Free Sodium Concentration in <span class="search-highlight">Vascular</span> <span class="search-highlight">Smooth</span> <span class="search-highlight">Muscle</span> Cells from Spontaneously Hypertensive Rats
Open the PDF for Reduced Cytosolic Free Sodium Concentration in <span class="search-highlight">Vascular</span> <span class="search-highlight">Smooth</span> <span class="search-highlight">Muscle</span> Cells from Spontaneously Hypertensive Rats in another window
Articles

Culture Techniques and Their Applications to Studies of Vascular Smooth Muscle

Julie H. Campbell, Gordon R. Campbell
Journal: Clinical Science
Clin Sci (Lond) (1993) 85 (5): 501–513.
https://doi.org/10.1042/cs0850501
Published: 01 November 1993
...Julie H. Campbell; Gordon R. Campbell Clinical Science (1993) 85, 501-513 (Printed in Great Britain) Techniques in Clinical Research Culture techniques and their applications to studies of vascular smooth muscle Julie H. CAMPBELL and Gordon R. CAMPBELL Centre for Research in Vascular Biology...
View article titled, Culture Techniques and Their Applications to Studies of <span class="search-highlight">Vascular</span> <span class="search-highlight">Smooth</span> <span class="search-highlight">Muscle</span>
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Articles

Free-radical scavengers, thiol-containing reagents and endothelium-dependent relaxation in isolated rat and human resistance arteries

W. Sunman, A.D. Hughes, P.S. Sever
Journal: Clinical Science
Clin Sci (Lond) (1993) 84 (3): 287–295.
https://doi.org/10.1042/cs0840287
Published: 01 March 1993
.... 6. N -Acetylcysteine causes an endothelium-independent relaxation of resistance arteries which is probably unrelated to the putative ability of this compound to scavenge superoxide radicals and may reflect a direct action on vascular smooth muscle. © 1993 The Biochemical Society and the Medical...
View article titled, Free-radical scavengers, thiol-containing reagents and endothelium-dependent relaxation in isolated rat and human resistance arteries
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Articles

Low-concentration ouabain does not inhibit noradrenaline-induced contraction of human resistance arteries

Robin G. Woolfson, Nicholas T. Richards, Lucilla Poston
Journal: Clinical Science
Clin Sci (Lond) (1991) 81 (s25): 525–529.
https://doi.org/10.1042/cs0810525
Published: 01 October 1991
... or less) were shown not to alter vascular smooth muscle contractility or sensitivity to noradrenaline. 3. In contrast, higher concentrations of ouabain (100 nmol/l or more) were found to depress vascular smooth muscle contractility and to reduce the sensitivity of the noradrenaline concentration-response...
View article titled, Low-concentration ouabain does not inhibit noradrenaline-induced contraction of human resistance arteries
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Articles

Comparison of the electrical properties of arterial smooth muscle in normotensive rats and rats with deoxycorticosterone acetate-salt-induced hypertension: Possible involvement of (Na + -K + -Cl − ) co-transport

J. P. L. Davis, A. R. Chipperfield, A. A. Harper
Journal: Clinical Science
Clin Sci (Lond) (1991) 81 (1): 73–78.
https://doi.org/10.1042/cs0810073
Published: 01 July 1991
..., mean ± sd , n = 17) compared with age-matched, unoperated control animals (134.0 ± 4.2 mmHg, n = 8, P < 0.001). 2. The membrane potential of femoral artery vascular smooth muscle measured in vitro was −55.1 ± 6.3 mV (mean ± sd , n = 154) for normotensive and −50.8 ± 5.7 mV ( n = 82) for hypertensive...
View article titled, Comparison of the electrical properties of arterial smooth muscle in normotensive rats and rats with deoxycorticosterone acetate-salt-induced hypertension: Possible involvement of (Na + -K + -Cl − ) co-transport
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Articles

Direct effect of α -human atrial natriuretic peptide on human vasculature in vivo and in vitro

A. Hughes, S. Thom, P. Goldberg, G. Martin, P. Sever
Journal: Clinical Science
Clin Sci (Lond) (1988) 74 (2): 207–211.
https://doi.org/10.1042/cs0740207
Published: 01 February 1988
... in vivo. © 1970 The Biochemical Society and the Medical Research Society 1970 atrial natriuretic peptide vascular smooth muscle vasodilatation Clinical Science (1988) 74, 207-21 1 207 Direct effect of a-human atrial natriuretic peptide on human vasculature in vivo and in vitro A. HUGHES, S...
View article titled, Direct effect of α -human atrial natriuretic peptide on human vasculature in vivo and in vitro
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Articles

Endothelium-dependent relaxation in isolated human arteries and veins

S. Thom, A. Hughes, G. Martin, P. S. Sever
Journal: Clinical Science
Clin Sci (Lond) (1987) 73 (5): 547–552.
https://doi.org/10.1042/cs0730547
Published: 01 November 1987
... vascular smooth muscle ...
View article titled, Endothelium-dependent relaxation in isolated human arteries and veins
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Articles

The adrenaline -α 2 -adrenoceptor-mediated vasoconstrictor axis

Peter Bolli, Paul Erne, Wolfgang Kiowski, Franz W. Amman, Fritz R. Bühler
Journal: Clinical Science
Clin Sci (Lond) (1985) 68 (s10): 141s–146s.
https://doi.org/10.1042/cs068s141
Published: 01 January 1985
... vascular smooth muscle contraction, which most likely is sensitized by the elevated intracellular calcium concentration. © 1985 The Biochemical Society and the Medical Research Society 1985 adrenaline essential hypertension forearm blood flow platelets vascular smooth muscle clinical Science...
View article titled, The adrenaline -α 2 -adrenoceptor-mediated vasoconstrictor axis
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Articles

Influence of blood gases, Ca 2+ -entry blockade and angiotensin converting enzyme inhibition on pressor responses to α-adrenoceptor agonists: evidence in vivo for subtypes of response independent of receptor subtype?

J. W. O'Brien, N. A. Flavahan, T. L. Grant, J. C. McGrath, R. J. Marshall
Journal: Clinical Science
Clin Sci (Lond) (1985) 68 (s10): 99s–104s.
https://doi.org/10.1042/cs068s099
Published: 01 January 1985
... them. © 1985 The Biochemical Society and the Medical Research Society 1985 α-adrenoceptor agonists angiotensin blood pressure Ca 2+ -entry blockade carbon dioxide nifedipine oxygen vascular smooth muscle Clinical Science (1985) 68 (Suppl. lo), 99s-104s 99s Influence of blood gases...
View article titled, Influence of blood gases, Ca 2+ -entry blockade and angiotensin converting enzyme inhibition on pressor responses to α-adrenoceptor agonists: evidence in vivo for subtypes of response independent of receptor subtype?
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Articles

Commentary on Workshop on α-Adrenoceptors

J. C. McGrath, J. L. Reid
Journal: Clinical Science
Clin Sci (Lond) (1985) 68 (s10): 1s–7s.
https://doi.org/10.1042/cs068s001
Published: 01 January 1985
.... Key words: activation processes, a-adrenoceptors, agonists, antagonists, excitation-contraction coupling, vascular smooth muscle. Abbreviations: EDRF, endothelium-derived re- laxant factor; ejp, excitatory junction potential; PI, phosphatidylinositol. Introduction The object of the Workshop...
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Articles

Vascular α 2 -adrenoceptors can mediate nerve stimulation-evoked contractions

James R. Docherty, Lisa Hyland
Journal: Clinical Science
Clin Sci (Lond) (1985) 68 (s10): 117s–120s.
https://doi.org/10.1042/cs068s117
Published: 01 January 1985
...James R. Docherty; Lisa Hyland 1. It is now established that α 2 -adrenoceptors can be present on vascular smooth muscle as targets for exogenous agonists, but some controversy exists as to whether these vascular α 2 -receptors may also be the target for neurally released noradrenaline. 2. In human...
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Articles

Human vascular smooth muscle responses mediated by α 2 mechanisms in vivo and in vitro

S. Thom, J. Calvete, R. Hayes, G. Martin, P. Sever
Journal: Clinical Science
Clin Sci (Lond) (1985) 68 (s10): 147s–150s.
https://doi.org/10.1042/cs068s147
Published: 01 January 1985
... of the endothelium, and provides evidence that α 2 -receptors may mediate release of the endothelium-derived relaxing factor. Clinical Science (1985) 68 (Suppl. lo), 147s-150s 147s Human vascular smooth muscle responses mediated by a2 mechanisms in vivo and in vitro S. T H O M , J . C A L V E T E , R . H A Y E S , G...
View article titled, Human <span class="search-highlight">vascular</span> <span class="search-highlight">smooth</span> <span class="search-highlight">muscle</span> responses mediated by α 2 mechanisms in vivo and in vitro
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Articles

Electrical membrane events in response to α-adrenoceptor stimulation

G. Haeusler, J. E. De Peyer
Journal: Clinical Science
Clin Sci (Lond) (1985) 68 (s10): 51s–53s.
https://doi.org/10.1042/cs068s051
Published: 01 January 1985
...G. Haeusler; J. E. De Peyer 1. Strips of rabbit main pulmonary artery (RMPA) were used to study the effects of several agonists on tension development and membrane potential of the vascular smooth muscle cells. 2. The following α-adrenoceptor agonists were employed: methoxamine and St 587 (α 1...
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Articles

Increased Vascular Sensitivity to Serotonin and Methysergide in Hypertension in Rats

R. Clinton Webb
Journal: Clinical Science
Clin Sci (Lond) (1982) 63 (s8): 73s–75s.
https://doi.org/10.1042/cs063073s
Published: 01 October 1982
... in the vascular smooth muscle of different arteries in hypertension. Furthermore, in addition to the general increase in vascular sensitivity that occurs in hyper- tension, there is a specific increase in its mem- brane receptors through which methysergide has an agonistic action. Thus it is not surprising...
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Articles

Effects of Clonidine on Aortic Pressure-Diameter and Elastic Stiffness-Stress Relations in Anaesthetized Rabbits

A. Friggi, H. Bodard
Journal: Clinical Science
Clin Sci (Lond) (1981) 61 (3): 273–279.
https://doi.org/10.1042/cs0610273
Published: 01 September 1981
.... 13 3 1981 26 3 1981 © 1981 The Biochemical Society and the Medical Research Society 1981 aortic diameter aortic elastic modulus aortic stress clonidine vascular smooth muscle Clinical Science (1981) 61,273-279 273 Effects of clonidine on aortic pressure-diameter and elastic...
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Articles

Presence of Postsynaptic α 2 -Adrenoreceptors of Predominantly Extrasynaptic Location in the Vascular Smooth Muscle of the Dog Hind Limb

S. Z. Langer, R. Massingham, N. B. Shepperson
Journal: Clinical Science
Clin Sci (Lond) (1980) 59 (s6): 225s–228s.
https://doi.org/10.1042/cs059225s
Published: 01 December 1980
... as an antihypertensive agent. © 1980 The Biochemical Society and the Medical Research Society 1980 α 1 - and α 2 -adrenoreceptors autoperfused dog hind limb neuronally released and exogenous noradrenaline prazosin rauwolscine vascular smooth muscle Clinical Science (1980) 5 9 , 2 2 5 ~ 2 2 8 s 225s...
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Articles

Influence of Angiotensin II, Ouabain and Hydrostatic Pressure on Inulin and Electrolyte Concentration of Fluid Perfusing Pig Carotid Arteries in Vitro

J. K. Healy, A. J. Elliott, I. J. Oweczkin
Journal: Clinical Science
Clin Sci (Lond) (1979) 56 (5): 445–453.
https://doi.org/10.1042/cs0560445
Published: 01 May 1979
... and to electrolyte homeostasis. 19 6 1978 1 1 1979 © 1979 The Biochemical Society and the Medical Research Society 1979 angiotensin Auto-analyzer methods carotid artery hydrostatic pressure ouabain potassium sodium vascular smooth muscle Clinical Science (1979), 56,445453 Influence...
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Articles

The Inhibition of Renin Secretion by Alpha-Adrenergic Stimulation in the Isolated Rat Kidney

R. Vandongen, W. S. Peart
Journal: Clinical Science
Clin Sci Mol Med (1974) 47 (5): 471–479.
https://doi.org/10.1042/cs0470471
Published: 01 November 1974
... to that involved in contraction and relaxation. This would accord with the common derivation of the renin-producing and vascular smooth muscle cells Clinical Science and Molecular Medicine (1974) 47,471479. THE INHIBITION O F RENIN SECRETION BY ALPHA-ADRENERGIC STIMULATION I N THE ISOLATED RAT KIDNEY R. VANDONGEN...
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