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Keywords: vascular smooth muscle
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Articles
Clin Sci (Lond) (2022) 136 (11): 803–817.
Published: 30 May 2022
...Miaomiao Song; Wei Hou; Atta Ul Mustafa; Pengpeng Li; Jianzhen Lei; Yingying Zhou; Li Ji; Yu Sun; Hongmei Zhou; Yinyan Xu; Juejin Wang Calcium influx from depolarized Ca V 1.2 calcium channels triggers the contraction of vascular smooth muscle cells (VSMCs), which is important for maintaining...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2021) 135 (9): 1189–1207.
Published: 14 May 2021
... implications for mechanical homeostasis in normal and diseased states. contractility focal adhesion mechanotransduction vascular smooth muscle Figure 2 FA signaling beyond calcium mechanisms Integrins are present at the cell membrane as inactive heterodimers. ECM binding (with the special...
Articles
Clin Sci (Lond) (2021) 135 (7): 887–905.
Published: 09 April 2021
...@charite.de ) 19 11 2020 23 03 2021 24 03 2021 25 03 2021 © 2021 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2021 atherosclerosis cytokines phenotypic switch PML nuclear bodies sumoylation vascular smooth muscle...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2021) 135 (6): 753–773.
Published: 17 March 2021
... underlying the peripheral vasculopathy mediated by CADASIL-causing Notch3 gain-of-function mutation. We studied: (i) small arteries and vascular smooth muscle cells (VSMCs) from TgNotch3 R169C mice (CADASIL model), (ii) VSMCs from peripheral arteries from CADASIL patients, and (iii) post-mortem brains from...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2021) 135 (2): 387–407.
Published: 29 January 2021
... vasodilation and attenuates Ang II-induced vasoconstriction. In endothelial cells activation of the ACE2/Ang-(1-7)/Mas1 axis increases production of the vasodilator’s nitric oxide and prostacyclin’s and in vascular smooth muscle cells it inhibits pro-contractile and pro-inflammatory signaling. Endothelial ACE2...
Articles
Clin Sci (Lond) (2020) 134 (15): 2019–2035.
Published: 04 August 2020
..., a dual-function ion channel/protein kinase, regulates vascular smooth muscle cell (VSMC) Mg 2+ homeostasis and mitogenic signaling. Mechanisms regulating vascular growth effects of TRPM7 are unclear, but epidermal growth factor (EGF) may be important because it is a magnesiotropic hormone involved...
Includes: Multimedia, Supplementary data
Articles
Clin Sci (Lond) (2018) 132 (18): 2045–2058.
Published: 19 September 2018
... on behalf of the Biochemical Society 2018 B type natriuretic peptide Ductus arteriosus vascular smooth muscle The ductus arteriosus (DA) is an essential artery in fetal circulation, connecting the pulmonary artery and the descending aorta. After birth, the DA usually closes spontaneously...
Articles
Clin Sci (Lond) (2017) 131 (15): 1801–1814.
Published: 05 July 2017
...Sarah K. Steinbach; Terrence M. Yau; Maral Ouzounian; Husam Abdel-Qadir; Mark Chandy; Thomas K. Waddell; Mansoor Husain Objective : Few methods enable molecular and cellular studies of vascular aging or Type 2 diabetes (T2D). Here, we report a new approach to studying human vascular smooth muscle...
Articles
Clin Sci (Lond) (2015) 128 (9): 579–592.
Published: 11 February 2015
..., in particular oxidized and chlorinated species, are altered within injured vessels and how they affect VSMC (vascular smooth muscle cell) remodelling processes. Vascular injury was induced in C57BL/6 mice and high fat-fed ApoE −/− (apolipoprotein E) mice by wire denudation and ligation of the left carotid...
Articles
Clin Sci (Lond) (2014) 126 (11): 785–800.
Published: 13 February 2014
.... Cav1 (caveolin 1)-enriched caveolae in vascular smooth muscle cells mediate ADAM17 (a disintegrin and metalloproteinase 17)-dependent EGFR (epidermal growth factor receptor) transactivation, which is linked to vascular remodelling induced by AngII. In the present study, we have tested our hypothesis...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2010) 119 (10): 437–442.
Published: 05 August 2010
... administration of methacholine (0.3–10 μg/min) and vascular smooth muscle function with incremental verapamil (10–300 μg/min). GA increased the 24-h urinary cortisol/cortisone ratio compared with placebo ( P =0.008). GA tended to reduce the FBF (forearm blood flow) response to methacholine ( P =0.09...
Articles
Clin Sci (Lond) (2010) 119 (6): 225–238.
Published: 08 June 2010
... Society 2010 arteriogenesis collateral circulation diabetes mellitus endothelium peripheral arterial disease vascular smooth muscle DM is recognized as a major cardiovascular risk factor. PAD is a common vascular complication in the diabetic population, as diabetes increases the risk...
Articles
Clin Sci (Lond) (2009) 117 (3): 129–138.
Published: 02 July 2009
... 362±5 660±8 638±18 650±18 767±16  ODM 358±5 642±10 636±21 712±37 719±29 © The Authors Journal compilation © 2009 Biochemical Society 2009 cardiovascular disease fetal programming endothelium gestational diabetes glucose vascular smooth muscle Offspring used...
Articles
Clin Sci (Lond) (2009) 116 (4): 273–282.
Published: 15 January 2009
... 2008 8 5 2008 3 6 2008 © The Authors Journal compilation © 2009 Biochemical Society 2009 antihypertensive medication cardiovascular risk central blood pressure hypertension peripheral blood pressure vascular smooth muscle The primary role of arteries as cushions...
Articles
Clin Sci (Lond) (2008) 115 (3): 79–89.
Published: 02 July 2008
... by these GPCRs is increased. Their signalling is tightly controlled by a class of proteins, the GRKs (GPCR kinases). Elevated levels of either GRK2 or GRK5 in both the lymphocytes and VSM (vascular smooth muscle) are associated with human hypertension and animal models of the disease. The focus of the present...
Articles
Clin Sci (Lond) (2001) 100 (5): 473–479.
Published: 29 March 2001
... μ M), supporting the role of NO in maintenance of basal relaxation and vascular tone in females. We have examined the relative activity of the specific PKG subtypes 1α and 1β in vascular smooth muscle, based on relaxation of rat aortas by two cGMP analogues with different selectivity, β-phenyl-l- N...
Articles
Clin Sci (Lond) (1999) 96 (5): 493–498.
Published: 14 April 1999
...Dominic J. AUTELITANO; F. TANG The prepro-adrenomedullin (prepro-AM) gene encodes several biologically active peptides, including the potent vasodilator AM. At least part of the vasodilator action of AM appears to be mediated via interactions with receptors on vascular smooth muscle cells (VSMC...
Articles
Clin Sci (Lond) (1997) 93 (4): 295–298.
Published: 01 October 1997
... chloride deoxycorticosterone acetate/salt hypertension sodium—potassium—chloride co-transport vascular smooth muscle Clinical Science (1997) 93,295-298 (Printed in Great Britain) 295 Activation of two inward chloride transport systems in rat femoral arterial smooth muscle in deoxycorticosterone...
Articles
Clin Sci (Lond) (1996) 90 (1): 9–12.
Published: 01 January 1996
... ouabain concentrations affect intracellular cytosolic free calcium concentration homoeostasis. 7 9 1995 28 9 1995 © 1996 The Biochemical Society and the Medical Research Society 1996 calcium ouabain vascular smooth muscle Clinical Science (1996) 9-12 (Printed in Great Britain...
Articles
Clin Sci (Lond) (1995) 88 (2): 149–157.
Published: 01 February 1995
... observed during endotoxic shock. 5 9 1994 16 9 1994 © 1995 The Biochemical Society and the Medical Research Society 1995 disseminated intravascular coagulation endotoxic shock heparin hirudin nitric oxide thrombin vascular smooth muscle Clinical Science (1995) 88, 149-157...
Articles
Clin Sci (Lond) (1995) 88 (2): 141–147.
Published: 01 February 1995
...Bryan Williams; Anne Quinn-Baker; Barbara Gallacher 1. Endothelial dysfunction and vascular smooth muscle cell (VSMC) proliferation are key events in the pathogenesis of atherosclerosis. Vascular permeability factor (VPF), an endothelial-cell-specific multifunctional cytokine, was recently...
Articles
Clin Sci (Lond) (1994) 87 (4): 383–387.
Published: 01 October 1994
...Dirk Bokemeyer; Ursula Friedrichs; Angela Bäcker; Sabine Drechsler; Herbert J. Kramer; Harald Meyer-Lehnert 1. As we have previously shown, cyclosporin A enhances the vasoconstrictor-induced rise in intracellular free calcium in vascular smooth muscle cells. This effect may contribute to important...
Articles
Clin Sci (Lond) (1994) 86 (6): 741–747.
Published: 01 June 1994
...Martin Tepel; JAN Holthues; Marcus Neusser; Petra Golinski; Zhiming Zhu; Norbert Mehring; Walter Zidek 1. Cytosolic free sodium concentration and sodium transport systems were measured in intact cultured vascular smooth muscle cells from spontaneously hypertensive rats of the Münster strain...
Articles
Clin Sci (Lond) (1993) 85 (5): 501–513.
Published: 01 November 1993
...Julie H. Campbell; Gordon R. Campbell cell culture cell dispersion culture techniques vascular smooth muscle © 1993 The Biochemical Society and the Medical Research Society 1993 Clinical Science (1993) 85, 501-513 (Printed in Great Britain) Techniques in Clinical Research Culture...
Articles
Clin Sci (Lond) (1993) 84 (3): 287–295.
Published: 01 March 1993
.... 6. N -Acetylcysteine causes an endothelium-independent relaxation of resistance arteries which is probably unrelated to the putative ability of this compound to scavenge superoxide radicals and may reflect a direct action on vascular smooth muscle. 11 11 1992 17 11 1992 © 1993...
Articles
Clin Sci (Lond) (1991) 81 (s25): 525–529.
Published: 01 October 1991
... or less) were shown not to alter vascular smooth muscle contractility or sensitivity to noradrenaline. 3. In contrast, higher concentrations of ouabain (100 nmol/l or more) were found to depress vascular smooth muscle contractility and to reduce the sensitivity of the noradrenaline concentration-response...
Articles
Clin Sci (Lond) (1991) 81 (1): 73–78.
Published: 01 July 1991
..., mean ± sd , n = 17) compared with age-matched, unoperated control animals (134.0 ± 4.2 mmHg, n = 8, P < 0.001). 2. The membrane potential of femoral artery vascular smooth muscle measured in vitro was −55.1 ± 6.3 mV (mean ± sd , n = 154) for normotensive and −50.8 ± 5.7 mV ( n = 82) for hypertensive...
Articles
Clin Sci (Lond) (1988) 74 (2): 207–211.
Published: 01 February 1988
... in vivo. 10 8 1987 17 8 1987 © 1970 The Biochemical Society and the Medical Research Society 1970 atrial natriuretic peptide vascular smooth muscle vasodilatation Clinical Science (1988) 74, 207-21 1 207 Direct effect of a-human atrial natriuretic peptide on human vasculature...
Articles
Clin Sci (Lond) (1987) 73 (5): 547–552.
Published: 01 November 1987
... vascular smooth muscle ...
Articles
Clin Sci (Lond) (1985) 68 (s10): 141s–146s.
Published: 01 January 1985
... vascular smooth muscle contraction, which most likely is sensitized by the elevated intracellular calcium concentration. © 1985 The Biochemical Society and the Medical Research Society 1985 adrenaline essential hypertension forearm blood flow platelets vascular smooth muscle clinical Science...
Articles
Clin Sci (Lond) (1985) 68 (s10): 99s–104s.
Published: 01 January 1985
... them. © 1985 The Biochemical Society and the Medical Research Society 1985 α-adrenoceptor agonists angiotensin blood pressure Ca 2+ -entry blockade carbon dioxide nifedipine oxygen vascular smooth muscle Clinical Science (1985) 68 (Suppl. lo), 99s-104s 99s Influence of blood gases...
Articles
Clin Sci (Lond) (1985) 68 (s10): 1s–7s.
Published: 01 January 1985
... and is intended as a guide to the papers in this Supplement. © 1985 The Biochemical Society and the Medical Research Society 1985 activation processes α-adrenoceptors agonists antagonists excitation-contraction coupling vascular smooth muscle Clinical Science (1985) 68 (Suppl. lo), 1s-7s 1s...
Articles
Clin Sci (Lond) (1985) 68 (s10): 117s–120s.
Published: 01 January 1985
...James R. Docherty; Lisa Hyland 1. It is now established that α 2 -adrenoceptors can be present on vascular smooth muscle as targets for exogenous agonists, but some controversy exists as to whether these vascular α 2 -receptors may also be the target for neurally released noradrenaline. 2. In human...
Articles
Clin Sci (Lond) (1985) 68 (s10): 147s–150s.
Published: 01 January 1985
... of the endothelium, and provides evidence that α 2 -receptors may mediate release of the endothelium-derived relaxing factor. © 1985 The Biochemical Society and the Medical Research Society 1985 α 2 -adrenoceptors forearm blood flow vascular smooth muscle Clinical Science (1985) 68 (Suppl. lo), 147s...
Articles
Clin Sci (Lond) (1985) 68 (s10): 51s–53s.
Published: 01 January 1985
...G. Haeusler; J. E. De Peyer 1. Strips of rabbit main pulmonary artery (RMPA) were used to study the effects of several agonists on tension development and membrane potential of the vascular smooth muscle cells. 2. The following α-adrenoceptor agonists were employed: methoxamine and St 587 (α 1...
Articles
Clin Sci (Lond) (1982) 63 (s8): 73s–75s.
Published: 01 October 1982
... in the vascular smooth muscle of different arteries in hypertension. Furthermore, in addition to the general increase in vascular sensitivity that occurs in hyper- tension, there is a specific increase in its mem- brane receptors through which methysergide has an agonistic action. Thus it is not surprising...
Articles
Clin Sci (Lond) (1981) 61 (3): 273–279.
Published: 01 September 1981
.... 13 3 1981 26 3 1981 © 1981 The Biochemical Society and the Medical Research Society 1981 aortic diameter aortic elastic modulus aortic stress clonidine vascular smooth muscle Clinical Science (1981) 61,273-279 273 Effects of clonidine on aortic pressure-diameter and elastic...
Articles
Clin Sci (Lond) (1980) 59 (s6): 225s–228s.
Published: 01 December 1980
... as an antihypertensive agent. © 1980 The Biochemical Society and the Medical Research Society 1980 α 1 - and α 2 -adrenoreceptors autoperfused dog hind limb neuronally released and exogenous noradrenaline prazosin rauwolscine vascular smooth muscle Clinical Science (1980) 5 9 , 2 2 5 ~ 2 2 8 s 225s...
Articles
Clin Sci (Lond) (1979) 56 (5): 445–453.
Published: 01 May 1979
... and to electrolyte homeostasis. 19 6 1978 1 1 1979 © 1979 The Biochemical Society and the Medical Research Society 1979 angiotensin Auto-analyzer methods carotid artery hydrostatic pressure ouabain potassium sodium vascular smooth muscle Clinical Science (1979), 56,445453 Influence...
Articles
Clin Sci Mol Med (1974) 47 (5): 471–479.
Published: 01 November 1974
... to that involved in contraction and relaxation. This would accord with the common derivation of the renin-producing and vascular smooth muscle cells 12 6 1974 © 1974 The Biochemical Society and the Medical Research Society 1974 adrenergic receptors renin secretion vascular smooth muscle...