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Keywords: vascular smooth muscle
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Clin Sci (Lond) (2024) 138 (5): 251–268.
Published: 27 February 2024
... 2024 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2024 Epigenetics EZH2 inhibitor MMP2 vascular smooth muscle Vascular Stiffness American Heart Association (AHA) 100000968 903910 National Heart, Lung, and Blood Institute (NHLBI...
Includes: Supplementary data
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Clin Sci (Lond) (2023) 137 (19): 1533–1545.
Published: 03 October 2023
... the phenotypic switching of vascular smooth muscle cells from a contractile to synthetic state during AAA. In addition, it was demonstrated that colchicine was able to reduce vascular inflammation, oxidative stress, cell pyroptosis and immune cells infiltration to the aortic wall in the AAA mice model. Finally...
Includes: Supplementary data
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Clin Sci (Lond) (2021) 135 (7): 887–905.
Published: 09 April 2021
... sumoylation vascular smooth muscle Together with a wide variety of over 100 functionally diverse proteins, PML forms dynamic aggregates inside the nucleus known as ‘PML nuclear bodies’ (PML-NBs), which are potent modifiers of proteins and their functions [ 8 , 12 ]. Almost all PML-associated proteins...
Includes: Supplementary data
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Clin Sci (Lond) (2021) 135 (6): 753–773.
Published: 17 March 2021
... underlying the peripheral vasculopathy mediated by CADASIL-causing Notch3 gain-of-function mutation. We studied: (i) small arteries and vascular smooth muscle cells (VSMCs) from TgNotch3 R169C mice (CADASIL model), (ii) VSMCs from peripheral arteries from CADASIL patients, and (iii) post-mortem brains from...
Includes: Supplementary data
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Clin Sci (Lond) (2021) 135 (2): 387–407.
Published: 29 January 2021
... vasodilation and attenuates Ang II-induced vasoconstriction. In endothelial cells activation of the ACE2/Ang-(1-7)/Mas1 axis increases production of the vasodilator’s nitric oxide and prostacyclin’s and in vascular smooth muscle cells it inhibits pro-contractile and pro-inflammatory signaling. Endothelial ACE2...
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Clin Sci (Lond) (2018) 132 (18): 2045–2058.
Published: 19 September 2018
... by the fluorescence intensity (FL-1, 525 nm) of 10000 cells as previously described [ 19 ]. B type natriuretic peptide Ductus arteriosus vascular smooth muscle The ductus arteriosus (DA) is an essential artery in fetal circulation, connecting the pulmonary artery and the descending aorta. After...
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Clin Sci (Lond) (2015) 128 (9): 579–592.
Published: 11 February 2015
..., in particular oxidized and chlorinated species, are altered within injured vessels and how they affect VSMC (vascular smooth muscle cell) remodelling processes. Vascular injury was induced in C57BL/6 mice and high fat-fed ApoE −/− (apolipoprotein E) mice by wire denudation and ligation of the left carotid...
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Clin Sci (Lond) (2014) 126 (11): 785–800.
Published: 13 February 2014
.... Cav1 (caveolin 1)-enriched caveolae in vascular smooth muscle cells mediate ADAM17 (a disintegrin and metalloproteinase 17)-dependent EGFR (epidermal growth factor receptor) transactivation, which is linked to vascular remodelling induced by AngII. In the present study, we have tested our hypothesis...
Includes: Supplementary data
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Clin Sci (Lond) (2010) 119 (6): 225–238.
Published: 08 June 2010
.... The review concludes with suggestions for new and more sophisticated therapeutic approaches for the diabetic population. arteriogenesis collateral circulation diabetes mellitus endothelium peripheral arterial disease vascular smooth muscle Several studies have investigated the acute phase...
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Clin Sci (Lond) (2009) 116 (4): 273–282.
Published: 15 January 2009
...@htd.aphp.fr ). 4 3 2008 8 5 2008 3 6 2008 © The Authors Journal compilation © 2009 Biochemical Society 2009 antihypertensive medication cardiovascular risk central blood pressure hypertension peripheral blood pressure vascular smooth muscle Brachial artery BP (blood...
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Clin Sci (Lond) (2008) 115 (3): 79–89.
Published: 02 July 2008
... by these GPCRs is increased. Their signalling is tightly controlled by a class of proteins, the GRKs (GPCR kinases). Elevated levels of either GRK2 or GRK5 in both the lymphocytes and VSM (vascular smooth muscle) are associated with human hypertension and animal models of the disease. The focus of the present...
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Clin Sci (Lond) (2001) 100 (5): 473–479.
Published: 29 March 2001
... μ M), supporting the role of NO in maintenance of basal relaxation and vascular tone in females. We have examined the relative activity of the specific PKG subtypes 1α and 1β in vascular smooth muscle, based on relaxation of rat aortas by two cGMP analogues with different selectivity, β-phenyl-l- N...
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Clin Sci (Lond) (1995) 88 (2): 149–157.
Published: 01 February 1995
... observed during endotoxic shock. 5 9 1994 16 9 1994 © 1995 The Biochemical Society and the Medical Research Society 1995 disseminated intravascular coagulation endotoxic shock heparin hirudin nitric oxide thrombin vascular smooth muscle Clinical Science (1995) 88, 149-157...
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Clin Sci (Lond) (1993) 84 (3): 287–295.
Published: 01 March 1993
.... 6. N -Acetylcysteine causes an endothelium-independent relaxation of resistance arteries which is probably unrelated to the putative ability of this compound to scavenge superoxide radicals and may reflect a direct action on vascular smooth muscle. © 1993 The Biochemical Society and the Medical...
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Clin Sci (Lond) (1991) 81 (s25): 525–529.
Published: 01 October 1991
... or less) were shown not to alter vascular smooth muscle contractility or sensitivity to noradrenaline. 3. In contrast, higher concentrations of ouabain (100 nmol/l or more) were found to depress vascular smooth muscle contractility and to reduce the sensitivity of the noradrenaline concentration-response...
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Clin Sci (Lond) (1988) 74 (2): 207–211.
Published: 01 February 1988
... in vivo. © 1970 The Biochemical Society and the Medical Research Society 1970 atrial natriuretic peptide vascular smooth muscle vasodilatation Clinical Science (1988) 74, 207-21 1 207 Direct effect of a-human atrial natriuretic peptide on human vasculature in vivo and in vitro A. HUGHES, S...
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Clin Sci (Lond) (1985) 68 (s10): 141s–146s.
Published: 01 January 1985
... vascular smooth muscle contraction, which most likely is sensitized by the elevated intracellular calcium concentration. © 1985 The Biochemical Society and the Medical Research Society 1985 adrenaline essential hypertension forearm blood flow platelets vascular smooth muscle clinical Science...
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Clin Sci (Lond) (1985) 68 (s10): 1s–7s.
Published: 01 January 1985
.... Key words: activation processes, a-adrenoceptors, agonists, antagonists, excitation-contraction coupling, vascular smooth muscle. Abbreviations: EDRF, endothelium-derived re- laxant factor; ejp, excitatory junction potential; PI, phosphatidylinositol. Introduction The object of the Workshop...
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Clin Sci (Lond) (1985) 68 (s10): 117s–120s.
Published: 01 January 1985
...James R. Docherty; Lisa Hyland 1. It is now established that α 2 -adrenoceptors can be present on vascular smooth muscle as targets for exogenous agonists, but some controversy exists as to whether these vascular α 2 -receptors may also be the target for neurally released noradrenaline. 2. In human...
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Clin Sci (Lond) (1985) 68 (s10): 51s–53s.
Published: 01 January 1985
...G. Haeusler; J. E. De Peyer 1. Strips of rabbit main pulmonary artery (RMPA) were used to study the effects of several agonists on tension development and membrane potential of the vascular smooth muscle cells. 2. The following α-adrenoceptor agonists were employed: methoxamine and St 587 (α 1...
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Clin Sci (Lond) (1982) 63 (s8): 73s–75s.
Published: 01 October 1982
... in the vascular smooth muscle of different arteries in hypertension. Furthermore, in addition to the general increase in vascular sensitivity that occurs in hyper- tension, there is a specific increase in its mem- brane receptors through which methysergide has an agonistic action. Thus it is not surprising...
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Clin Sci (Lond) (1981) 61 (3): 273–279.
Published: 01 September 1981
.... 13 3 1981 26 3 1981 © 1981 The Biochemical Society and the Medical Research Society 1981 aortic diameter aortic elastic modulus aortic stress clonidine vascular smooth muscle Clinical Science (1981) 61,273-279 273 Effects of clonidine on aortic pressure-diameter and elastic...
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Clin Sci Mol Med (1974) 47 (5): 471–479.
Published: 01 November 1974
... to that involved in contraction and relaxation. This would accord with the common derivation of the renin-producing and vascular smooth muscle cells Clinical Science and Molecular Medicine (1974) 47,471479. THE INHIBITION O F RENIN SECRETION BY ALPHA-ADRENERGIC STIMULATION I N THE ISOLATED RAT KIDNEY R. VANDONGEN...