... ROS reactive oxygen species RT-PCR reverse-transcriptase polymerase chain reaction SO Sham operation TCF-21 transcription factor 21 UCP-1 uncoupling protein-1 heart failure perivascular adipose tissue renin-angiotensin system vascular function...

... to interact with the angiotensin II type 1 receptor (AT-1). We hypothesized that, in pregnant mice, STBEVs would impair vascular function via LOX-1 and would specifically affect angiotensin II responses. Uterine arteries from pregnant control (C57BL/6) and LOX-1 knockout (LOX-1KO) mice were isolated...

... (IP) receptor, while inhibition of the thromboxane (TP) receptor significantly ameliorated vascular dysfunction in the SHRSP, suggesting this is the downstream target responsible for constrictor prostanoid activity. Importantly, Y chromosome lineage was shown to modulate vascular function in the SHRSP...

... of the surrounding perivascular adipose tissue (PVAT) on the regulation of vascular function and arterial stiffening in obesity. In particular, we focus on the highly plastic nature of the vasculature in response to altered oxidant and inflammatory signaling and highlight how weight management can be an effective...

... with poor vascular function. However, maternal vascular function is enhanced in pregnancy. It is not understood how this is achieved in the face of the adverse metabolic and inflammatory environment. Research into cardiovascular disease demonstrates that plasma HDL (high-density lipoprotein), by merit...

... 2015 Our data identify putative molecular mechanisms involving Rac1/2-sensitive, NADPH oxidase (Nox)-dependent pathways, whereby statins may protect against vascular dysfunction in diabetes. inflammation NADPH oxidase (Nox) oxidative stress statin Type 2 diabetes vascular function...

...-5 BN rat, having chromosome 5 from the salt-resistant Brown Norway rat (carrying all CYP4A genes) introgressed on to the SS genetic background. Our laboratory has demonstrated restoration of normal vascular function in the SS rat with inhibition of the CYP4A/20-HETE pathway, suggesting a direct role...

... review and analysis highlights the pivotal role of long-term changes in vascular function and identifies areas of growing interest, specifically, response to hypoxia, immune modification, epigenetics and the anti-angiogenic in utero milieu. Correspondence: Dr Paul Leeson (email paul.leeson...

..., Houston, TX, U.S.A., and four at the University of Pennsylvania School of Medicine, Philadelphia, PA, U.S.A. angiotensin II clinical trial hypertension insulin signalling obesity vascular function Epidemic obesity threatens to reverse progress made in reducing the burden...

... of 11β-HSD (11-β hydroxysteroid dehydrogenase), namely 11β-HSD2 and 11β-HSD1 (type 2 and type 1 11β-HSD respectively). We hypothesized that inhibition of 11β-HSD would attenuate vascular function in healthy humans. A total of 15 healthy subjects were treated with the selective 11β-HSD inhibitor GA...

... to vasomotor control mechanisms in most vascular beds. Vascular TRP channels are activated by various stimuli, such as mechanical perturbation, receptor activation and dietary molecules. Some of the specific roles of these channels in normal and impaired vascular function have emerged in recent years...

... improvements of vascular function and, in this issue of Clinical Science , Hägg and co-authors propose a coronary artery effect. The use of a Doppler technique for non-invasive assessment of coronary flow reserve in a small animal model is an exciting aspect of this study. If feasible in the hands of other...

... and anti-atherogenic, and these are likely to be impaired under conditions of insulin resistance. 1 7 2004 19 8 2004 24 8 2004 24 8 2004 The Biochemical Society 2004 adipocytokine diabetes endothelium insulin obesity vascular function Endothelium...

...-mail paul.nicholls@royalhospitals.n-i.nhs.uk ). 21 11 2003 6 1 2004 6 1 2004 © 2004 The Biochemical Society 2004 homocysteine methionine loading nitric oxide pulmonary circulation vascular function Clinical Science (2004) 106, 413 419 (Printed in Great Britain) 413 Changes...