... Visser; A.H. Jan Danser; Jorie Versmissen Vascular endothelial growth factor antagonism with angiogenesis inhibitors in cancer patients induces a ‘preeclampsia-like’ syndrome including hypertension, proteinuria and elevated endothelin (ET)-1. Cyclo-oxygenase (COX) inhibition with aspirin is known...

... ( cferrari@wakehealth.edu ) 28 01 2021 12 02 2021 16 02 2021 © 2021 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2021 adipocytes angiotensin converting enzyme 2 heart failure vascular endothelial growth factor Obesity...

.... However, these drugs are associated with cardiovascular toxicities which can impact optimal cancer treatment in the short-term and may lead to increased morbidity and mortality in the longer term. Vascular endothelial growth factor inhibitors (VEGFIs) are associated with hypertension, left ventricular...

... antibodies that target angiogenesis by inhibiting vascular endothelial growth factor (VEGF) signaling pathways. Despite their anti-angiogenic and anti-cancer benefits, the use of VEGF inhibitors (VEGFi) and other tyrosine kinase inhibitors (TKIs) has been hampered by potent vascular toxicities especially...

... a single granuloma. Figure 1 The ‘bacterial tumour’: similarities between the TB granuloma and solid tumours (Top left) Both lesions are hypoxic and drive the formation of a leaky and haemostatic vasculature through the production of vascular endothelial growth factor (VEGF) and angiopoietin...

...Vincent Pang; David O. Bates; Lopa Leach The human placenta nourishes and protects the developing foetus whilst influencing maternal physiology for fetal advantage. It expresses several members of the vascular endothelial growth factor (VEGF) family including the pro-angiogenic/pro-permeability...

... of both the inner and outer retinal barriers of the retinal vasculature and retinal pigmented epithelial (RPE)–choroid respectively. Vascular endothelial growth factor (VEGF-A), a key regulator of angiogenesis and permeability, is the target of most pharmacological interventions of DR. VEGF-A can...

... compared with S group, after ischaemic injury. In addition, immunostaining and Western blot analyses revealed that impaired angiogenic response in V mice occurred in association with reduced VEGF (vascular endothelial growth factor) production and decreased eNOS (endothelial nitric oxide synthase) and Akt...

... of angiogenesis, that is vascular endothelial growth factor (VEGF) and its soluble receptor sFlt-1. We studied 234 patients (145 males; mean age 68.6±10 years) with proven PAD (ankle brachial pressure index <0.8) and compared them with 50 healthy controls. Levels of VEGF ( P = 0.001) and TF ( P = 0.043) were...

...Masumi AKIMOTO; Hiroshi HASHIMOTO; Atsushi MAEDA; Mutsuo SHIGEMOTO; Katsuko YAMASHITA Endothelins (ETs) participate directly and indirectly in angiogenesis via ET receptors. During early fetal angiogenesis, vascular endothelial growth factor (VEGF) and its receptors kinase insert domain-containing...

... to determine the effect of diabetes mellitus on endothelin (ET)-1, ET-3, vascular endothelial growth factor (VEGF) and interleukin-8 (IL-8)-mediated angiogenesis. In an initial group of experiments, streptozotocin-induced diabetes resulted in impairment of ET-1-mediated angiogenesis from 69% to 32...

... claudication. However, the mechanisms by which exercise tolerance is improved remain unclear. Vascular endothelial growth factor (VEGF) is a potent endothelial mitogen that results in angiogenesis when overexpressed in human subjects. To assess the potential role of VEGF in the improvement in exercise...

...Funmi M. BELGORE; Andrew D. BLANN; Gregory Y. LIP Vascular endothelial growth factor (VEGF) mediates endothelial cell mitogenesis and enhances vascular permeability. VEGF interacts with the endothelium via two membrane-spanning receptors, fms-like tyrosine kinase (Flt)-1 and kinase domain receptor...

...Giovambattista DESIDERI; Claudio FERRI Correspondence : Dr G Desideri (e-mail gbdesi@freemail.it ). 13 12 1999 The Biochemical Society and the Medical Research Society © 2000 2000 chronic hepatitis cirrhosis vascular endothelial growth factor 159Clinical Science (2000...

...Nicholas J. A. Webb; Martyn J. Bottomley; Carolyn J. Watson; Paul E. C. Brenchley 1. Dysregulated vascular endothelial growth factor (VEGF) expression has been reported in several pathological states based upon evidence of elevated serum VEGF levels. Using two immunoassays for VEGF, this study...

...Yoshinori Seko; Yasushi Imai; Shin Suzuki; Shuichi Kamijukkoku; Kazuya Hayasaki; Yasuinari Sakomura; Kazuyuki Tobe; Takashi Kadowaki; Hiromitsu Maekawa; Naoyuki Takahashi; Yoshio Yazaki 1. Vascular endothelial growth factor, a potent angiogenic mitogen, is known to be induced in response...