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Keywords: vascular disease
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Clin Sci (Lond) (2019) 133 (9): 1115–1135.
Published: 14 May 2019
... Tissue engineering Scaffolds Stem cells Vascular disease Vascular cells Vascular tissue engineering Vascular grafts Vascularization is vital during development and wound healing, where formation of hierarchical networks enables efficient transfer of oxygen, nutrients, immune cells and other...
Clin Sci (Lond) (2016) 130 (20): 1763–1779.
Published: 09 September 2016
... Limited on behalf of the Biochemical Society 2016 targeted cancer therapy tyrosine kinase inhibitors vascular disease VEGF inhibitors Molecularly targeted cancer therapeutics have altered the treatment paradigm for many cancers, some of which were previously untreatable, resulting...
Clin Sci (Lond) (2016) 130 (3): 151–165.
Published: 17 December 2015
... for Nox1 in the pathogenesis of cardiovascular diseases ranging from atherosclerosis to hypertension, restenosis and ischaemia/reperfusion injury. These data suggest that Nox1 is a potential therapeutic target for vascular disease, and drug development efforts are ongoing to identify a specific...
Clin Sci (Lond) (2015) 129 (12): 1061–1075.
Published: 13 October 2015
... Dehghan; Anton J.M. Roks Reduced nitric oxide (NO)/cGMP signalling is observed in age-related vascular disease. We hypothesize that this disturbed signalling involves effects of genomic instability, a primary causal factor in aging, on vascular smooth muscle cells (VSMCs) and that the underlying mechanism...
Includes: Supplementary data
Clin Sci (Lond) (2014) 126 (11): 795–803.
Published: 21 February 2014
... of this vascular disease. abdominal aortic aneurysm miRNA miR-155 transcript expression analysis vascular disease • miRNAs, the negative regulators of gene expression, have been shown previously to be associated with a broad range of human pathologies. • In the present study, we screened...
Includes: Supplementary data
Clin Sci (Lond) (2012) 122 (8): 369–373.
Published: 14 December 2011
... associations, but which has important limitations: most critically, that effective treatment to reduce arterial damage is often delayed until the age at which cardiovascular events become common. This delay means that many of the early victims of vascular disease will not be identified in time. This delay also...
Clin Sci (Lond) (2012) 122 (8): 361–368.
Published: 14 December 2011
... tyrosine kinase signal transduction vascular disease Axl, an RTK (receptor tyrosine kinase), derives its name from the Greek word anexelekto which means uncontrolled. Axl was initially discovered in cancer cells over two decades ago [ 1 ]. Axl is a founder of a unique TAM (Tyro3, Axl and Mertk...
Clin Sci (Lond) (2010) 119 (3): 131–142.
Published: 06 May 2010
...Tim S. Schmidt; Eileen McNeill; Gillian Douglas; Mark J. Crabtree; Ashley B. Hale; Jeffrey Khoo; Charles A. O'Neill; Alphonsus Cheng; Keith M. Channon; Nicholas J. Alp BH 4 (tetrahydrobiopterin) supplementation improves endothelial function in models of vascular disease by maintaining eNOS...
Includes: Supplementary data
Clin Sci (Lond) (2009) 116 (9): 681–695.
Published: 02 April 2009
... in the context of these structures. Various avenues of experimental investigation are explored which will be crucial in understanding the vascular consequences of dysfunctional HDL formation and the identification of novel mechanistic pathways in vascular disease. It is anticipated that further knowledge...
Clin Sci (Lond) (2009) 116 (8): 621–637.
Published: 16 March 2009
...Anastasia Z. Kalea; Ann Marie Schmidt; Barry I. Hudson RAGE [receptor for AGEs (advanced glycation end-products)] plays an important role in the development and progression of vascular disease. Studies in cultured cells and small animal models of disease have clearly demonstrated that RAGE...
Clin Sci (Lond) (2005) 109 (1): 27–37.
Published: 23 June 2005
... 8 3 2005 The Biochemical Society 2005 atherosclerosis culture-modified mononuclear cell (CMMC) endothelial cell endothelium restenosis vascular disease The endothelium plays a privileged role in cardiovascular biology. Previously conceived as a static barrier between...
Clin Sci (Lond) (2005) 108 (6): 507–513.
Published: 24 May 2005
...Qing LU; Ingemar BJÖRKHEM; Bengt WRETLIND; Ulf DICZFALUSY; Peter HENRIKSSON; Anna FREYSCHUSS Manifestations of vascular disease, including microvascular changes, constitute the major part of the morbidity and mortality in diabetic patients. Oxidative stress has been suggested to play an important...
Clin Sci (Lond) (2002) 102 (6): 631–637.
Published: 17 May 2002
...Joey M. KAYE; Kim G. STANTON; Vincent J. MCCANN; Samuel D. VASIKARAN; Valerie BURKE; Roger R. TAYLOR; Frank M. VAN BOCKXMEER In the present study, the determinants of fasting plasma homocysteine in diabetic subjects were examined; whether plasma homocysteine and vascular disease are related...
Clin Sci (Lond) (1996) 91 (1): 17–21.
Published: 01 July 1996
..., vascular disease. Correspondence: Mr P. A. Stonebridge, Department of Surgery, Ninewells Hospital, Dundee DDI 9SY, U.K 18 P. A. Stonebridge Flow Flow towards away from probe probe v Plane of probe Fig. 1. Diagram of the anticipated effect of rotational flow sampled in a true transverse plane on a colour...
Clin Sci (Lond) (1995) 89 (6): 581–590.
Published: 01 December 1995
...G. J. Kemp; L. J. Hands; G. Ramaswami; D. J. Taylor; A. Nicolaides; A. Amato; G. K. Radda 1. We set out to define abnormalities of oxidative ATP synthesis, cellular proton efflux and the efficiency of ATP usage in gastrocnemius muscle of patients with claudication due to peripheral vascular disease...
Clin Sci (Lond) (1981) 61 (6): 743–749.
Published: 01 December 1981
... cystine folic acid homocysteine homocystinuria pyridoxine renal failure vascular disease © 1981 The Biochemical Society and the Medical Research Society 1981 16 3 1981 11 6 1981 Clinical Science (1981) 61,743-749 743 Homocysteine in the plasma of renal transplant recipients...
Clin Sci (Lond) (1980) 58 (5): 427–430.
Published: 01 May 1980
... as creatinine. 2 1 1980 16 1 1980 © 1980 The Biochemical Society and the Medical Research Society 1980 amino acids β-aminoisobutyric acid cysteine-homocysteine mixed disulphide haemodialysis homocysteine homocystinuria methionine metabolism renal failure vascular disease...
Clin Sci Mol Med (1976) 51 (s3): 159s–162s.
Published: 01 December 1976
... of the adrenals and kidneys or atrophy of the thymus. © 1976 The Biochemical Society and the Medical Research Society 1976 cardiac glycosides digitoxin heart hypertension kidney vascular disease Clinical Science and Molecular Medicine (1976) 51, 159s-162s. Delayed onset and reduced severity...