... Scaffolds Stem cells Vascular disease Vascular cells Vascular tissue engineering Vascular grafts The development of an intact and functional vascular endothelium is critical for successful vascular tissue engineering. When choosing an EC lineage for vascularization, it is important to know...

... are described below along with supporting data. targeted cancer therapy tyrosine kinase inhibitors vascular disease VEGF inhibitors Molecularly targeted cancer therapeutics have altered the treatment paradigm for many cancers, some of which were previously untreatable, resulting in improved...

... for Nox1 in the pathogenesis of cardiovascular diseases ranging from atherosclerosis to hypertension, restenosis and ischaemia/reperfusion injury. These data suggest that Nox1 is a potential therapeutic target for vascular disease, and drug development efforts are ongoing to identify a specific...

... Dehghan; Anton J.M. Roks Reduced nitric oxide (NO)/cGMP signalling is observed in age-related vascular disease. We hypothesize that this disturbed signalling involves effects of genomic instability, a primary causal factor in aging, on vascular smooth muscle cells (VSMCs) and that the underlying mechanism...

... to the ethical guidelines of Declaration of Helsinki. Patients provided written informed consent. Correspondence: Professor Jonathan Golledge (email jonathan.golledge@jcu.edu.au ) abdominal aortic aneurysm miRNA miR-155 transcript expression analysis vascular disease 20 9 2013 5...

... [ 21 ]. Therefore ligand-independent activation of Axl is more typical during pathophysiological conditions with increases in oxidative stress and excess receptor expression. Axl autoimmunity cancer receptor tyrosine kinase signal transduction vascular disease Axl, an RTK (receptor...

... associations, but which has important limitations: most critically, that effective treatment to reduce arterial damage is often delayed until the age at which cardiovascular events become common. This delay means that many of the early victims of vascular disease will not be identified in time. This delay also...

...Tim S. Schmidt; Eileen McNeill; Gillian Douglas; Mark J. Crabtree; Ashley B. Hale; Jeffrey Khoo; Charles A. O'Neill; Alphonsus Cheng; Keith M. Channon; Nicholas J. Alp BH 4 (tetrahydrobiopterin) supplementation improves endothelial function in models of vascular disease by maintaining eNOS...

... in the context of these structures. Various avenues of experimental investigation are explored which will be crucial in understanding the vascular consequences of dysfunctional HDL formation and the identification of novel mechanistic pathways in vascular disease. It is anticipated that further knowledge...

...Anastasia Z. Kalea; Ann Marie Schmidt; Barry I. Hudson RAGE [receptor for AGEs (advanced glycation end-products)] plays an important role in the development and progression of vascular disease. Studies in cultured cells and small animal models of disease have clearly demonstrated that RAGE...

... 3 2005 The Biochemical Society 2005 atherosclerosis culture-modified mononuclear cell (CMMC) endothelial cell endothelium restenosis vascular disease The endothelium plays a privileged role in cardiovascular biology. Previously conceived as a static barrier between...

...Qing LU; Ingemar BJÖRKHEM; Bengt WRETLIND; Ulf DICZFALUSY; Peter HENRIKSSON; Anna FREYSCHUSS Manifestations of vascular disease, including microvascular changes, constitute the major part of the morbidity and mortality in diabetic patients. Oxidative stress has been suggested to play an important...

...Joey M. KAYE; Kim G. STANTON; Vincent J. MCCANN; Samuel D. VASIKARAN; Valerie BURKE; Roger R. TAYLOR; Frank M. VAN BOCKXMEER In the present study, the determinants of fasting plasma homocysteine in diabetic subjects were examined; whether plasma homocysteine and vascular disease are related...

... 1996 The Biochemical Society and the Medical Research Society 1996 blood flow ultrasound vascular disease Clinical Science (1996) 91, 17-21 (Printed in Great Britain) Spiral laminar flow h vivo P. A. STONEBRIDGE, P. R. HOSKINS*, P.L. ALLANT and J. F. F. BELCH$ Department of Surgery...

...G. J. Kemp; L. J. Hands; G. Ramaswami; D. J. Taylor; A. Nicolaides; A. Amato; G. K. Radda 1. We set out to define abnormalities of oxidative ATP synthesis, cellular proton efflux and the efficiency of ATP usage in gastrocnemius muscle of patients with claudication due to peripheral vascular disease...

... Society and the Medical Research Society 1981 amino acids cysteine—homocysteine mixed disulphide cystine folic acid homocysteine homocystinuria pyridoxine renal failure vascular disease Clinical Science (1981) 61,743-749 743 Homocysteine in the plasma of renal transplant recipients...

... as creatinine. 2 1 1980 16 1 1980 © 1980 The Biochemical Society and the Medical Research Society 1980 amino acids β-aminoisobutyric acid cysteine-homocysteine mixed disulphide haemodialysis homocysteine homocystinuria methionine metabolism renal failure vascular disease...

... of the adrenals and kidneys or atrophy of the thymus. © 1976 The Biochemical Society and the Medical Research Society 1976 cardiac glycosides digitoxin heart hypertension kidney vascular disease Clinical Science and Molecular Medicine (1976) 51, 159s-162s. Delayed onset and reduced severity...