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Keywords: uric acid
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Clin Sci (Lond) (2016) 130 (23): 2167–2180.
Published: 26 October 2016
...Richard O. Day; Bishoy Kamel; Diluk R.W. Kannangara; Kenneth M. Williams; Garry G. Graham Xanthine oxidoreductase (XOR) is the rate-limiting enzyme in purine catabolism and converts hypoxanthine to xanthine, and xanthine into uric acid. When concentrations of uric acid exceed its biochemical...
Clin Sci (Lond) (2003) 105 (4): 425–430.
Published: 01 October 2003
...W. S. WARING; A. CONVERY; V. MISHRA; A. SHENKIN; D. J. WEBB; S. R. J. MAXWELL Uric acid (UA) possesses free-radical-scavenging properties, and systemic administration is known to increase serum antioxidant capacity. However, it is not known whether this protects against oxidative stress...
Clin Sci (Lond) (1999) 96 (4): 381–385.
Published: 01 April 1999
...% higher in sportsmen than in controls ( P < 0.005). Accordingly, plasma hydrosoluble antioxidant levels (ascorbic acid and uric acid) were found to be significantly elevated in the soccer players ( P < 0.005). In addition, these subjects showed high concentrations of α-tocopherol in plasma compared...
Clin Sci (Lond) (1994) 86 (5): 511–516.
Published: 01 May 1994
...Marguerite Hatch; N. D. Vaziri 1. The potential contribution of enteric pathways to the extra-renal excretion of uric acid in chronic renal failure was evaluated by measuring [ 14 C]-urate and 36 Cl − transport in isolated, short-circuited segments of jejunum, ileum and distal colon from normal...
Clin Sci (Lond) (1987) 73 (1): 109–116.
Published: 01 July 1987
... transport. Our data suggest a decreased Na + /K + -ATPase activity in IGT, which may be of pathophysiological significance in relation to hypertension. 13 1 1987 17 2 1987 blood pressure glucose tolerance Na + /K + -ATPase platelet sodium uric acid © 1970 The Biochemical Society...
Clin Sci (Lond) (1984) 67 (2): 249–258.
Published: 01 August 1984
... tubular net excretion of urate. Key words: familial hyperuricaemic nephropathy, gout, Lesch-Nyhan syndrome, lymphocytes, mono- nuclear cells, purine synthesis de novo, purines, renal failure, urate, uric acid. Abbreviations: APRT, adenine phosphoribosyltrans- ferase; HPRT, hypoxanthine phosphoribosyltrans...
Clin Sci (Lond) (1980) 59 (s6): 409s–410s.
Published: 01 December 1980
...F. H. Messerli; E. D. Frohlich; G. R. Dreslinski; D. H. Suarez; G. G. Aristimuno 1. Glomerular filtration rate, renal and systemic haemodynamics and intravascular volume were measured in 20 established essential hypertensive patients classified according to serum uric acid level into two groups...
Clin Sci (Lond) (1979) 57 (s5): 367s–369s.
Published: 01 December 1979
... or serum electrolytes, urea, creatinine, glucose, cholesterol and triglycerides, and in creatinine clearance, did not differ in the two groups of patients. 3. In patients taking tienilic acid a significant decrease in serum uric acid and an increase in urate clearance was observed, whereas in patients...
Clin Sci Mol Med (1978) 54 (6): 595–601.
Published: 01 June 1978
.... These results are in agreement with the inconstant acceleration of purine biosynthesis de novo in gouty patients as seen by others with measurement of [ 14 C]glycine incorporation into urinary uric acid. Clinical Science and Molecular Medicine (1978) 54, 595-601 Purine biosynthesis de novo by lymphocytes...
Clin Sci Mol Med (1978) 54 (5): 509–516.
Published: 01 May 1978
... phosphate and an increase in the urinary excretion of oxalic acid and uric acid, but these changes were all fully reversible when EHDP was stopped. 4. The average rate of stone formation per patient per year decreased from 2·4 to 0·2 during treatment with EHDP and remained low during the following 24 months...
Clin Sci Mol Med (1977) 53 (4): 379–386.
Published: 01 October 1977
...-quantitative estimates of the various components of urate transport in man. 24 11 1976 4 6 1977 © 1977 The Biochemical Society and the Medical Research Society 1977 diuretic hypouricaemia pyrazinamide renal transport tienilic acid uric acid Clinical Science and Molecular Medicine...
Clin Sci (1972) 43 (3): 331–341.
Published: 01 September 1972
...G. M. Danovitch; J. Weinberger; G. M. Berlyne 1. The results of studies of renal uric acid excretion in eleven patients with advanced chronic renal failure are presented. 2. The pyrazinamide suppression test was used to separate secretion from reabsorption of uric acid in the renal tubule. 3...