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Clin Sci (Lond) (2017) 131 (1): 3–12.
Published: 21 November 2016
...Wei Ling Lau; Nosratola D. Vaziri Blood levels of urea rise with progressive decline in kidney function. Older studies examining acute urea infusion suggested that urea was well-tolerated at levels 8–10× above normal values. More recent in vitro and in vivo work argue the opposite and demonstrate...
Satish C. Kalhan, John Edmison, Susan Marczewski, Srinivasan Dasarathy, Lourdes L. Gruca, Carole Bennett, Clarita Duenas, Rocio Lopez
Clin Sci (Lond) (2011) 121 (4): 179–189.
Published: 04 May 2011
... with estimates of whole body rate of protein turnover and urea synthesis in clinically stable biopsy-confirmed subjects with NASH (non-alcoholic steatohepatitis). Subjects with NASH were more insulin-resistant and had significantly higher plasma concentrations of usCRP (ultrasensitive C-reactive protein), TNFα...
Clin Sci (Lond) (2002) 103 (6): 633–639.
Published: 19 November 2002
... containing 18% (w/w) casein (CON), a low-protein diet containing 9% casein (MLP), or the low-protein diet supplemented with 3% glycine (MLPG), alanine (MLPA) or urea (MLPU). The offspring were weaned on to standard laboratory chow, and blood pressure was measured at 4 weeks of age. Blood pressure...
Clin Sci (Lond) (2001) 101 (4): 339–344.
Published: 04 September 2001
...Per IVARSEN; Jacob GREISEN; Hendrik VILSTRUP Intracellular hydration may play a role in the regulation of protein and nitrogen metabolism. The hepatic removal of nitrogen by urea synthesis has a key regulatory role in nitrogen balance. The purpose of the present study was to establish the acute...
Clin Sci (Lond) (1999) 97 (5): 547–555.
Published: 28 September 1999
... as lactose-[ 13 C]ureide was recovered on the breath, and about 80% of label given as lactose-[ 15 N, 15 N]ureide was not recovered in stool, indicating that 80% of the dose was completely fermented. At least 5% of the labelled urea was absorbed and excreted as the intact molecule. Of the 15 N derived from...
Clin Sci (Lond) (1998) 95 (4): 397–407.
Published: 01 October 1998
... reduce the concentration of intermediates of the urea cycle. It is possible that a glutamine-utilizing pathway exists in mononuclear phagocytes that may connect with the urea cycle. 2. In this paper we report that mouse peritoneal resident and Bacillus Calmette–Guerin (BCG)-activated macrophages...
Clin Sci (Lond) (1996) 90 (1): 73–75.
Published: 01 January 1996
... turnover (25%), synthesis (26%) and breakdown (25%), but short-term urinary nitrogen excretion remained unchanged. 9 10 1995 16 10 1995 © 1996 The Biochemical Society and the Medical Research Society 1996 ammonia bed rest exercise glycine post-absorptive protein turnover urea...
Clin Sci (Lond) (1993) 84 (5): 543–548.
Published: 01 May 1993
... groups. Apparent urea balance was significantly increased and became positive in the group receiving the formula with the higher proportion of non-protein nitrogen and urea nitrogen. Nitrogen retention, however, was significantly depressed in this group, indicating decreased efficiency of nitrogen...
Clin Sci (Lond) (1992) 83 (5): 607–614.
Published: 01 November 1992
... <0.001), but these normalized at the end of the observation period. In the same period, liver glutamine uptake increased ( P <0.01), concomitantly with increased HCO - 3 , glucose and urea production, which also normalized. Portal drained viscera ammonia production decreased, concomitant...
Clin Sci (Lond) (1992) 82 (6): 709–716.
Published: 01 June 1992
...M. Salleh; M. Ardawi 1. The hepatic metabolism of glutamine, alanine, ammonia, urea, glutathione and glucose was studied in rats made septic by caecal ligation and puncture and was compared with that in rats that had undergone sham operation (laparotomy). 2. Sepsis resulted in increases...
Clin Sci (Lond) (1991) 80 (1): 77–84.
Published: 01 January 1991
...Alain Soupart; Alain Stenuit; Olivier Perier; Guy Decaux 1. At present there is no consensus about the optimal management of hyponatraemia to prevent demyelinating brain lesions. We have evaluated in a large series of rats ( n = 136) the protective role of urea for the brain in the treatment...
Clin Sci (Lond) (1990) 79 (4): 299–305.
Published: 01 October 1990
... filtration rate and a higher serum concentration of urea were seen in 50-day-old essential fatty acid-deficient rats compared with age-matched controls. Later, the glomerular filtration rate progressively deteriorated in parallel with a decline in effective renal plasma flow and with a concomittant rise...
Clin Sci (Lond) (1990) 78 (3): 273–281.
Published: 01 March 1990
...) dextrose (D-glucose) infusion and at the end of days 7 and 8 of each diet, were analysed for urea, glucose, lactate, triacylglycerols, fatty acids, glycerol, 3-hydroxybutyrate, insulin and glucagon. 3. The effect of increasing glucose intake was to increase nitrogen balance by 0.60 ± 0.25 ( sem ) mg/kJ...
Clin Sci (Lond) (1989) 77 (3): 351–355.
Published: 01 September 1989
... by using urea, without observing clinical CPM. This led us to analyse the brain damage induced by hypertonic saline and by urea when used for the correction of hyponatraemia in a rat model of SIADH. 2. Severe hyponatraemia (serum Na + < 115 mmol/l) was produced in 28 rats. Seven rats were excluded from...
Clin Sci (Lond) (1986) 70 (6): 627–634.
Published: 01 June 1986
...Rita A. Klim; Marta Albajar; Reginald Hems; Dermot H. Williamson 1. The effects of chronic uraemia on glucose production and nitrogen release (urea plus ammonia formation) from alanine, glutamine or serine in isolated rat hepatocytes were studied. 2. Uraemia increased the rate of formation of urea...
Clin Sci (Lond) (1985) 68 (2): 193–199.
Published: 01 February 1985
...O. M. Wrong; A. J. Vince; J. C. Waterlow 1. To establish the role of endogenous urea as a source of faecal ammonia, the plasma urea of two healthy men was labelled with 15 N at a constant level for several days and its 15 N enrichment was compared with that of faecal ammonia and total nitrogen. 2...
Clin Sci (Lond) (1983) 64 (1): 101–108.
Published: 01 January 1983
... of 15 N in ammonia and in urea over a 9 h period after an oral dose of [ 15 N]glycine. 2. The food intake during the 2 study days was identical for individual patients. The amount each received was determined from measurement of their intake of food ad libitum on the day preceding the pre-operative...
Clin Sci (Lond) (1982) 62 (5): 553–556.
Published: 01 May 1982
...G. T. Royle; J. A. Molnar; Marta H. Wolfe; R. R. Wolfe; J. F. Burke 1. The simultaneous effects of an intravenous glucose infusion on plasma urea, glucose and alanine kinetics were investigated in normal post-absorptive man. 2. The primed constant intravenous infusion of compounds labelled...
Clin Sci (Lond) (1981) 61 (2): 217–228.
Published: 01 August 1981
...E. B. Fern; P. J. Garlick; Margaret A. McNurlan; J. C. Waterlow 1. Four normal adults were given [ 15 N]-glycine in a single dose either orally or intravenously. Rates of whole-body protein turnover were estimated from the excretion of 15 N in ammonia and in urea during the following 9 h. The rate...
Clin Sci (Lond) (1979) 57 (4): 305–312.
Published: 01 October 1979
... of the urine-faeces in the colon some reabsorption of bicarbonate occurs, probably in part by ionic diffusion since chloride concentration in the lumen increases. 4. Evidence suggestive of non-ionic diffusion of ammonia was found in only one patient. It seems probable that higher rates of urea breakdown...
Clin Sci Mol Med (1978) 54 (5): 503–508.
Published: 01 May 1978
... urea fell when acidosis was induced with hydrochloric acid. 4. The renal production of ammonia per ml of renal blood flow was increased in acidosis, but this was independent of the amount of glutamine delivered to the kidney. 5. The results indicate that acute acidosis affects production of urea...
Clin Sci Mol Med (1977) 52 (6): 577–583.
Published: 01 June 1977
... and the Medical Research Society 1977 calcitonin calcium creatinine parathyroid hormone renal failure thyrocalcitonin urea Clinical Science and Molecular Medicine (1 977) 52, 571-583. Plasma calcitonin in chronic renal failure: relation to other factors of importance in bivalent ion metabolism R...
Clin Sci Mol Med (1977) 52 (1): 9–17.
Published: 01 January 1977
...J. Kopstein; O. M. Wrong 1. Saliva obtained from the parotid duct of normal and uraemic subjects had an average urea concentration of 86% of the plasma concentration whereas in mixed saliva obtained from the mouth the urea concentration was only 31% of the plasma concentration. Ammonia...
Clin Sci Mol Med (1976) 51 (3): 313–322.
Published: 01 September 1976
... of ammonia, particularly those in which bacterial counts fell during incubation. As normal faeces contain negligible amounts of urea this ammonia must have been generated from sources other than urea. 3. Ammonia was also generated by faeces delivered by sodium chloride enema, and by ileostomy fluid...
Clin Sci Mol Med (1975) 48 (4): 269–278.
Published: 01 April 1975
... to vasopressin the urine was not significantly less concentrated than after fluid deprivation. 3. Oral urea-loading also enhanced the urine-concentrating power of vasopressin but its effect was less marked than that of fludrocortisone. Oral urea did not increase further the urine concentration achieved...
Clin Sci (1972) 43 (6): 759–769.
Published: 01 December 1972
...J. F. Cade; M. C. F. Pain 1. Lung function was studied in fifty-six symptom-free asthmatic subjects after the inhalation of urea, an agent not previously used for asthma provocation. The effects of urea were compared with those produced by the inhalation of methacholine and of isoprenaline. 2...
Clin Sci (1972) 42 (4): 395–404.
Published: 01 April 1972
...P. L. Balestri; P. Rindi; M. Biagini; S. Giovannetti 1. Uptake of glucose by the rat diaphragm in vitro and utilization of glucose by human erythrocytes were inhibited by urea, creatinine and, to an even greater extent, by urea plus creatinine. Guanidine, methylguanidine and guanidinoacetic acid...