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Keywords: uraemia
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Clin Sci (Lond) (2014) 126 (2): 175–181.
Published: 23 September 2013
...Sammy W. M. Shiu; Su-Mei Xiao; Ying Wong; Wing-Sun Chow; Karen S. L. Lam; Kathryn C.B. Tan LDL (low-density lipoprotein) is subjected to pro-atherogenic modifications in the circulation. A novel uraemia-independent mechanism of carbamylation of lipoproteins mediated by MPO (myeloperoxidase) has...
Clin Sci (Lond) (2006) 110 (1): 101–108.
Published: 12 December 2005
... may contribute to adverse cardiovascular morbidity in this population. However, there is little information utilizing newer non-invasive techniques in pre-dialysis patients with increasing degrees of uraemia. In the present study, 55 non-dialysis-dependent non-diabetic CKD patients with mean GFR...
Clin Sci (Lond) (2005) 109 (1): 75–82.
Published: 23 June 2005
... The Biochemical Society 2005 cardiovascular risk factor kidney disease natriuretic peptide N-terminal brain natriuretic peptide (N-BNP) mortality uraemia The risk of CV (cardiovascular) disease in patients with CKD (chronic kidney disease) is far in excess of that in the general population [ 1...
Clin Sci (Lond) (2002) 103 (1): 31–41.
Published: 06 June 2002
...Raj C. THURAISINGHAM; Norman B. ROBERTS; Mark WILKES; David I. NEW; A. Claudio MENDES-RIBEIRO; Susan M. DODD; Muhammad M. YAQOOB Results regarding the nitric oxide (NO) system in uraemia are contradictory. l -Arginine, the precursor of NO, is also metabolized by arginase to form ornithine and urea...
Clin Sci (Lond) (1999) 97 (3): 363–368.
Published: 06 August 1999
... © 1999 1999 acidosis adipocyte leptin rat uraemia 363Clinical Science (1999) 97, 363 368 (Printed in Great Britain) Effects of acidosis on leptin secretion from 3T3-L1 adipocytes and on serum leptin in the uraemic rat Daniel TETA, Alan BEVINGTON, Jeremy BROWN, David THROSSELL, Kevin P...
Clin Sci (Lond) (1999) 97 (2): 233–237.
Published: 29 June 1999
...Tessa SAVAGE; Aisling C. MCMAHON; Adrian MULLEN; Rachel M. TRIBE; Magdi M. YAQOOB Some aspects of vascular reactivity are altered in mild experimental uraemia, as shown by increased myogenic tone and a reduced lumen diameter in the femoral artery. This study was conducted to investigate...
Clin Sci (Lond) (1998) 95 (6): 681–686.
Published: 01 December 1998
... of atherosclerotic plaque. Uraemia is a proatherogenic process and is expected to be associated with impaired vascular reactivity. 2. To study this, 12 male Wistar rats were rendered uraemic by five-sixths nephrectomy and 12 control rats were sham operated simultaneously. After 8 weeks a tail-cuff systolic blood...
Clin Sci (Lond) (1998) 94 (4): 431–435.
Published: 01 April 1998
... haemodialysis leptins obesity uraemia Clinical Science (1998) 94,43 1-435 (Printed in Great Britain) 43 I Inappropriately high plasma leptin levels in obese haemodialysis patients can be reduced by high flux haemodialysis and haemodiafiltration Martin WIESHOLZER, Ferdinand HARM, Anna-Christine HAUSER...
Clin Sci (Lond) (1997) 93 (1): 57–64.
Published: 01 July 1997
... on haemodialysis. 2. Although K m values for total l-arginine influx were not significantly different in erythrocytes freshly isolated from controls or uraemic patients, uraemia was associated with an increase in the V max for transport (826 compared with 1176 μmol h −1 l −1 of cells) which was reduced to control...
Clin Sci (Lond) (1997) 92 (5): 497–503.
Published: 01 May 1997
...-trimethylammoniumphenyl)-6-phenyl-1,3,5-hexatriene anisotropy are important markers of cellular changes in essential hypertension, independent of renal disease. Uraemia, independently of hypertension, produces an alteration in the function of the sodium—lithium countertransporter which has previously been associated...
Clin Sci (Lond) (1996) 90 (1): 3–8.
Published: 01 January 1996
...Dalila B. Corry; Charma C. Ellis; Michael L. Tuck 1. We have reported a normal sodium (Na) pump, but decreased loop-diuretic-sensitive Na efflux in erythrocytes from patients with chronic renal failure on haemodialysis, suggesting a different mode of co-transport in uraemia. 2. The present work...
Clin Sci (Lond) (1995) 88 (4): 405–412.
Published: 01 April 1995
... hyperphosphataemia inorganic phosphate metabolic acidosis orthophosphate uraemia Clinical Science (1995) 88, 4 0 5 4 1 2 (Printed in Great Britain) 405 Metabolic acidosis is a potent stimulus for cellular inorganic phosphate generation in uraemia Alan BEVINGTON, Dennis BROUGH*, Frease E. BAKER, Jane...
Clin Sci (Lond) (1993) 84 (4): 441–447.
Published: 01 April 1993
... effects on exercise capacity that could be attributed to a spontaneous increase in physical activity after treatment of anaemia. 6 11 1992 9 12 1992 © 1993 The Biochemical Society and the Medical Research Society 1993 anaemia erythropoietin exercise haemodialysis uraemia...
Clin Sci (Lond) (1992) 82 (6): 659–665.
Published: 01 June 1992
... of the ultrafiltrate and laser desorption/ionization mass spectroscopy revealed that a fraction containing substances with a molecular mass of about 300 Da inhibited Ca 2+ −ATPase. 6. It is concluded that, in uraemia, a Ca 2+ −ATPase inhibitor accumulates in the plasma, and this could contribute to the toxicity...
Clin Sci (Lond) (1992) 82 (3): 255–258.
Published: 01 March 1992
... level of endothelin does not play a major role in the pathogenesis of renal hypertension. 4 9 1991 23 10 1991 © 1992 The Biochemical Society and the Medical Research Society 1992 cyclosporin A nephrotoxicity endothelin haemodialysis hypertension renal transplantation uraemia...
Clin Sci (Lond) (1992) 82 (1): 99–104.
Published: 01 January 1992
... erythrocyte fatty acids membrane transport sodium potassium adenosine triphosphatase uraemia Clinical Science (1992) 82,99-104 (Printed in Great Britain) Membrane incorporation of non-esterified fatty acids and effects on the sodium pump of human erythrocytes J. F. St. J. DWIGHT, A. C. MENDES RlBElRO...
Clin Sci (Lond) (1991) 81 (5): 645–653.
Published: 01 November 1991
..., uraemia. Abbreviations: ASP, alkali-soluble protein; GDH, gluta- mate dehydrogenase (EC; a-KG, a-ketogluta- rate; PCM, palmitoyl-L-carnitine plus L-malate; PM, pyruvate plus L-malate; PPKM, pyruvate plus palmitoyl-L- carnitine plus a-ketoglutarate plus L-malate; PTH, para- thyroid hormone; Succ...
Clin Sci (Lond) (1991) 81 (1): 113–121.
Published: 01 July 1991
... erythropoietin. 11 2 1991 26 2 1991 © 1991 The Biochemical Society and the Medical Research Society 1991 desferrioxamine erythropoietin haemodialysis haemosiderosis iron overload uraemia Clinical Science (1991) 81,113-121 113 Hepatic computed tomography for monitoring the iron...
Clin Sci (Lond) (1991) 80 (2): 137–141.
Published: 01 February 1991
... 19.4 (SD 2.4) pmol/l in patients on haemo- dialysis and 7.4 (SD 1.4) pmol/l in control subjects. These differences were significant (P < 0.001). Key words: choline, dialysis, erythrocyte, membrane transport, uraemia. (P< 0.001). Correspondence: Dr B. M. Hendry, Nuffield Department of Clinical Medicine...
Clin Sci (Lond) (1990) 79 (6): 663–668.
Published: 01 December 1990
... is a response to the increased water intake associated with this, and presumably other, rat models of uraemia. The increased enzyme activity against tyrosyl-glycine found in the mid and distal regions of the small intestine of uraemic rats may be caused by an increased small-intestinal transit rate, but could...
Clin Sci (Lond) (1990) 79 (5): 537–542.
Published: 01 November 1990
...S. B. Ireland; P. M. Stewart 1. The effect of uraemia on the rates of protein synthesis and protein degradation in liver, heart and vastus lateralis muscle were examined in the rat. Uraemia was induced by a five-sixths nephrectomy and the rates of protein turnover were compared with pair-fed sham...
Clin Sci (Lond) (1990) 79 (5): 477–482.
Published: 01 November 1990
... conclude that this mediator might be involved in the genesis of uraemic pruritus. chronic renal failure haemodialysis histamine pruritus uraemia Clinical Science (1990) 79,477-482 477 Increased plasma histamine levels in uraemic pruritus FELIX STOCKENHUBER, ROBERT W. KURZ*, KASPAR SERTL, GEORG...
Clin Sci (Lond) (1990) 78 (3): 295–302.
Published: 01 March 1990
... 9 1989 7 11 1989 © 1990 The Biochemical Society and the Medical Research Society 1990 acetazolamide acid-base balance acidosis calcium metabolism haemodialysis uraemia vitamin D Clinical Science (1990) 78,295-302 295 Severe metabolic acidosis and disturbances of calcium...
Clin Sci (Lond) (1990) 78 (1): 67–73.
Published: 01 January 1990
... © 1990 The Biochemical Society and the Medical Research Society 1990 atrial natriuretic peptide blood pressure blood volume guanosine 3′:5′-cyclic monophosphate uraemia Clinical Science (1990) 78,67-73 67 Effect of atrial natriuretic peptide on blood pressure, guanosine 3 : 5 -cyclic...
Clin Sci (Lond) (1989) 76 (5): 559–563.
Published: 01 May 1989
... 1989 The Biochemical Society and the Medical Research Society 1989 erythrocytes sodium transport uraemia Clinical Science (1989) 76, 559-563 559 Stimulation by uraemic plasma of frusemide-sensitive sodium efflux in erythrocytes from normal women DALILA B. CORRY, MICHAEL L. TUCK AND DAVID B...
Clin Sci (Lond) (1989) 76 (4): 419–422.
Published: 01 April 1989
...). A similar increase in V max. in uraemic cells compared with controls was seen in erythrocytes which were studied in zero-trans conditions after depletion of intracellular amino acids. The mean values of K m and K D were not significantly different in uraemia. The origins of this increased membrane transport...
Clin Sci (Lond) (1988) 74 (2): 155–163.
Published: 01 February 1988
...Anders Alvestrand; Ralph A. Defronzo; Douglas Smith; John Wahren 1. To examine whether insulin resistance in uraemia extends to amino acid metabolism, the effect of physiological hyperinsulinaemia on plasma amino acid concentrations was studied in 17 chronically uraemic and 28 healthy subjects...
Clin Sci (Lond) (1987) 73 (3): 247–252.
Published: 01 September 1987
... sensitive to changes in plasma K+ concentration. Correspondence: Dr G. I. Sandie, Department of Medicine, Clinical Sciences Building, Hope Hospital, Eccles Old Road, Salford M6 8HD, UK Key words: dialysis, large intestine, potassium transport, uraemia. Abbreviations: CAPD, chronic ambulatory peritoneal...
Clin Sci (Lond) (1987) 72 (1): 103–112.
Published: 01 January 1987
... 4 8 1986 © 1970 The Biochemical Society and the Medical Research Society 1970 δ-aminolaevulinic acid cerebrospinal fluid erythrocytes haematin plasma porphyria pregnancy saliva uraemia ClinicalScience (1987) 72,103-1 12 103 d-Aminolaevulinic acid in plasma, cerebrospinal...
Clin Sci (Lond) (1986) 71 (6): 657–663.
Published: 01 December 1986
...C. Aalkjær; E. B. Pedersen; H. Danielsen; O. Fjeldborg; B. Jespersen; T. kjær; S. S. Sørensen; M. J. Mulvany 1. In order to obtain direct information on the properties of the resistance vasculature of patients with advanced uraemia, a technique was developed to dissect out small arteries (internal...
Clin Sci (Lond) (1986) 70 (6): 627–634.
Published: 01 June 1986
...Rita A. Klim; Marta Albajar; Reginald Hems; Dermot H. Williamson 1. The effects of chronic uraemia on glucose production and nitrogen release (urea plus ammonia formation) from alanine, glutamine or serine in isolated rat hepatocytes were studied. 2. Uraemia increased the rate of formation of urea...
Clin Sci (Lond) (1985) 69 (5): 637–640.
Published: 01 November 1985
...Alan J. Watson; Donald Di Pette 1. Baroreflex sensitivity and pressor responsiveness to exogenous noradrenaline, angiotensin II and arginine vasopressin were determined in a rat model of uraemia. 2. The slope of the regression line relating Δheart rate to Δblood pressure after phenylephrine...
Clin Sci (Lond) (1985) 69 (4): 449–457.
Published: 01 October 1985
... peritoneal glucose absorption. Insulin levels were raised in uraemic patients but were unchanged by CAPD. 3. Uraemia was associated with raised levels of the gluconeogenic precursors lactate and alanine and a further rise in fasting and 24 h mean alanine concentrations occurred with CAPD. Fasting total...
Clin Sci (Lond) (1985) 69 (1): 81–86.
Published: 01 July 1985
... control of heart rate in uraemic patients. Key words: autonomic dysfunction, baroreflexes, dialysis, endogenous opioids, met-enkephalin, uraemia. Introduction Evidence is emerging that endogenous opioids play an important role in reflex cardiovascular control. In rats, intraventricular injection...
Clin Sci (Lond) (1985) 68 (3): 255–261.
Published: 01 March 1985
..., uraemia. Abbreviations: ECF, extracellular fluid; GFR, glomerular filtration rate. Correspondence: Dr Antonio Dal Canton, Cattedra di Nefrologia Medica, Seconda Facoltl di Medicina e Chirurgia, Via S. Pansini 5, 80131 Napoli, Italy. Introduction In patients with chronic renal failure, plasma urea levels...
Clin Sci (Lond) (1984) 67 (3): 365–368.
Published: 01 September 1984
... hypothesis that there is a deficiency of a renin inhibitor in uraemic plasma. 15 2 1984 19 3 1984 © 1984 The Biochemical Society and the Medical Research Society 1984 angiotensin renin uraemia Clinical Science (1984) 67,365-368 365 Enzymatic activity of renin in plasma of normal...
Clin Sci (Lond) (1984) 67 (2): 161–166.
Published: 01 August 1984
.... ainical Science (1984) 67, 161-166 161 Vascular hypersensitivity to noradrenaline: a possible mechanism of hypertension in rats with chronic uraemia R. R. ZIMLICHMAN, C. CHAIMOVITZ, Y. CHAICHENCO, M . GOLIGORSKY, J . RAPOPORT A N D J . KAPLANSKI Departments of Mephrology and Internal Medicine, Soroka...
Clin Sci (Lond) (1982) 63 (6): 539–548.
Published: 01 December 1982
... and the Medical Research Society 1994 calcium nutrition phosphorus renal function uraemia Clinical Science (1982) 63,539-548 539 Beneficial effect of low phosphorus diet in uraemic rats: a reappraisal D E N I S E L A O U A R I , C L A I R E K L E I N K N E C H T , G I U L I A C O U R N O T - W I T M...
Clin Sci (Lond) (1982) 63 (3): 285–292.
Published: 01 September 1982
... Society and the Medical Research Society 1982 uraemia dialysis autonomic dysfunction Clinical Science (1982) 63,285-292 285 Defective reflex control of heart rate in dialysis patients: evidence for an afferent autonomic lesion c. Z O C C A L I , M. C I C C A R E L L I A N D Q. M A G G I O R E...
Clin Sci (Lond) (1982) 62 (4): 427–429.
Published: 01 April 1982
... and the Medical Research Society 1982 1,25-dihydroxycholecalciferol kidney radioimmunoassay uraemia Clinical Science (1982) 6 5 421429 427 SHORT COMMUNICA TION The effect of renal function on changes in circulating concentrations of 1,25-dihydroxycholecalciferol after an oral dose S. E. PAPAPOULOS, T...
Clin Sci (Lond) (1981) 61 (1): 43–46.
Published: 01 July 1981
...M. A. Mansell; A. J. Grimes; N. F. Jones 1. We have measured adenosine 5′-triphosphate (ATP) levels in isolated leucocyte suspensions from patients with renal failure. 2. Leucocyte ATP is reduced in these patients, unlike erythrocyte ATP which is known to be elevated in uraemia. 3. The relevance...
Clin Sci (Lond) (1981) 60 (3): 273–282.
Published: 01 March 1981
... hormone phosphate adaptation phosphate transport proximal tubule uraemia volume expansion Clinical Science (1981) 60, 273-282 Renal phosphate adaptation in uraemic dogs with a remnant kidney S.-F. WEN AND R. W. STOLL Department ofMedicine, University ofWisconsin Center for Health Sciences, Madison...
Clin Sci (Lond) (1981) 60 (1): 73–80.
Published: 01 January 1981
... and the Medical Research Society 1981 apolipoproteins lipoprotein lipase renal transplantation triacylglycerols uraemia Clinical Science (1981) 60, 73-80 Impaired lipoprotein lipase activation by uraemic and post- transplant sera G. A. CRAWFORD, J. F. MAHONY AND J. H. STEWART Medical Research...
Clin Sci (Lond) (1980) 59 (2): 143–145.
Published: 01 August 1980
... haemodialysis, on the contrary, is more beneficial for oxygenation of tissue and post-dialysis symptoms may be reduced. 28 8 1979 4 3 1980 © 1980 The Biochemical Society and the Medical Research Society 1980 2,3-diphosphoglycerate haemodialysis ultrafiltration uraemia Clinical...
Clin Sci (Lond) (1979) 56 (5): 509–512.
Published: 01 May 1979
... faeces methylamine uraemia Clinical Science (1979), 56,509-512 SHORT COMMUNICATION Faecal methylamine in normal and uraemic subjects C. W. I . OWENS AND W. PADOVAN Department of Medicine, Rayne Institute, University College Hospital Medical School, London (Received 29 November 1978; accepted 29...
Clin Sci (Lond) (1979) 56 (1): 9–14.
Published: 01 January 1979
... -aminobenzoic acid and its glycine conjugate. 29 3 1978 28 7 1978 © 1979 The Biochemical Society and the Medical Research Society 1979 p -aminobenzoic acid p -aminobenzoylglycine p -aminohippuric acid liver uraemia Clinical Science (1979) 56,9-I4 Metabolism ofp-aminobenzoic acid...
Clin Sci Mol Med (1978) 55 (3): 271–275.
Published: 01 September 1978
... 1978 The Biochemical Society and the Medical Research Society 1978 adrenergic agents brain adenosine 3′: 5′-cyclic monophosphate phenol uraemia Clinical Science and Molecular Medicine (1978), 55,211-275 Effect of unconjugated and conjugated phenol and uraemia on the synthesis of adenosine 3...
Clin Sci Mol Med (1978) 54 (1): 51–60.
Published: 01 January 1978
...J. Bergström; P. Fürst; L.-O. Norée; E. Vinnars 1. Free amino acids were determined in the plasma and in the muscle tissue of 14 patients with chronic uraemia; eight were not on dialysis and six were having regular peritoneal dialysis. The concentration of each amino acid in muscle water...
Clin Sci Mol Med (1977) 53 (4): 307–316.
Published: 01 October 1977
...E. D. Pellegrino; R. M. Biltz; J. M. Letteri 1. Chemical and morphological features of uraemic bone disease were studied by comparison of bone composition in 44 patients with uraemia (12 dialysed and 32 non-dialysed) and 36 control subjects. The significant changes included decreased bone mineral...
Clin Sci Mol Med (1977) 52 (2): 125–135.
Published: 01 February 1977
... buffer capacity, pH 1 becomes a function of extracellular pH. 4. Cells seem more protected from acute acidosis than from acute alkalosis. 22 7 1975 9 8 1976 © 1977 The Biochemical Society and the Medical Research Society 1977 acidosis alkalosis DMO intracellular pH uraemia...