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Keywords: tumour-induced bone disease
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Clin Sci (Lond) (2006) 110 (3): 279–291.
Published: 10 February 2006
... as a potential therapeutic for the treatment of both osteoporosis and tumour-induced bone disease. Indeed, in murine models of cancer-induced bone disease, inhibition of osteoclastic activity by OPG was also associated with a reduction in tumour burden. The discovery that OPG can bind to and inhibit the activity...