...-A binds to and activates two tyrosine kinase receptors, VEGFR (VEGF receptor)-1 and VEGFR-2. VEGFR-2 mediates most of the endothelial growth and survival signals, but VEGFR-1-mediated signalling plays important roles in pathological conditions such as cancer, ischaemia and inflammation. In solid tumours...

... the basic features of proteomic technologies, including the basics of MS, and we consider the main current applications and challenges of proteomics in cancer research, including (i) protein expression profiling of tumours, tumour fluids and tumour cells; (ii) protein microarrays; (iii) mapping of cancer...

...Kazuhiro TAKAHASHI; Kazuhito TOTSUNE; Tomomi KITAMURO; Masahiko SONE; Osamu MURAKAMI; Shigeki SHIBAHARA Evidence has accumulated showing that vasoactive peptides, such as endothelin-1, adrenomedullin and urotensin-II, are expressed in various kinds of tumour cells. In the present study...

... that of the extranuclear bile acid pool. Moreover, they indicate that, during hepatocarcinogenesis, the composition of the nuclear pool undergoes important alterations. The Biochemical Society and the Medical Research Society © 2002 2002 allo-cholic acid cancer hepatocyte neoplasia tumour ursodeoxycholic acid...

... cirrhosis, but not in viral hepatitis. Flat-BAs were better detected in urine than in serum. Urinary Δ 4 -unsaturated-BA output was significantly lower in patients with small tumours (< 3 cm) compared with those with higher size tumours. No correlation between flat-BA output into urine and serum alpha...

... not have cyclo-oxygenase nor RNA for synthesis of such enzymes are affected by sulindac. Therefore the presumptive effect is probably not correct. 2. It has also been found that sulindac stimulates apoptosis. It is herein postulated that in tumour cells such effects may be due to interaction of the anionic...

...M. A. McNurlan; S. D. Heys; K. G. M. Park; J. Broom; D. S. Brown; O. Eremin; P. J. Garlick 1 Rates of protein synthesis have been measured from the incorporation of 57 mg of l-[1- 13 C]leucine/kg for 90 min into muscle tissue and colorectal tumours removed at surgery from cancer patients. 2...

... dialysis. This neutral activation was completely abolished by a serine proteinase inhibitor. 3. A large fraction of the renin in this tumour is inactive. In comparison with other pro-hormones produced in tumours the findings support strongly the proposition that renin passes through a proenzyme step...

... culture tissue iso-renin tumour © 1976 The Biochemical Society and the Medical Research Society 1976 Clinical Science and Molecular Medicine (1976) 51, 117s-120s. REVIEW Tissue iso-renins D. GANTEN, J. S. HUTCHINSON, H. HAEBARA, P. SCHELLING, Department of Pharmacology, University of Heidelberg...