... platelet aggregation in response to collagen (from 55.83±20.63 to 67.67±14.44%; P <0.05). At baseline, all urinary AA metabolites, including PGE 2 , 6-keto-PGF 1α , 8-epi-PGF 2α and 11-dehydro-thromboxane B 2 , were elevated in cirrhotic patients when compared with a group of normal subjects. After...

..., MN 55905, U.S.A. © 2002 The Biochemical Society and the Medical Research Society 2002 aorta carotid artery endothelium high-fat diet prostanoid risk factors thromboxane vascular vasoconstriction 13SClinical Science (2002) 103 (Suppl. 48), 13S 15S (Printed in Great Britain...

...Sidath D. KATUGAMPOLA; Rhoda E. KUC; Janet J. MAGUIRE; Anthony P. DAVENPORT Endothelin (ET)-1 and thromboxane (Tx) levels are increased in human atherosclerosis. One of the aims of this study was to understand how receptors for a peptide mediator (ET-1) with a long physiological half life, would...

...Hsiu-Ching Hsu; Ming-Fong Chen; Chii-Ming Lee; Yuan-Teh Lee 1. Myocardial thromboxane A 2 production increases in patients with pacing-induced ischaemia and correlates with a decrease in myocardial lactate extraction. The release of myocardial thromboxane A 2 before any lactate production...

...Å. Wennmalm; G. Benthin; E.F. Granström; L. Persson; S. Winell 1. Urinary levels of the 2,3-dinor metabolites of thromboxane A 2 (2,3-dinor-thromboxane A 2 , Tx-M) and prostacyclin (2,3-dinor-6-keto-prostaglandin F 1α , PGI-M) are frequently analysed as indices of platelet and endothelial activity...

...M. Rathaus; Z. Greenfeld; E. Podjarny; M. Brezis; J. Green; J. Bernheim 1. The aim of this investigation was to study the role of prostaglandins in the impaired Na + conservation of the ageing kidney. 2. We measured the urinary excretion of thromboxane B 2 , 6-keto-prostaglandin F 1α...

...K. P. G. Harris; H. Yanagisawa; G. F. Schreiner; S. Klahr 1. After bilateral ureteral obstruction there is an enhanced production of thromboxane A 2 by the kidney which contributes to a decline in renal function. An acute interstitial macrophage infiltrate also occurs. 2. The relative contribution...

... of parameters related to free-radical production, blood levels of thromboxane B 2 and peripheral resistance during reperfusion were determined. 3. Compared with controls (groups 1 and 3) which had flap survival rates (expressed as percentage surface area surviving) of 27.1% and 31.6%, respectively, N...

... wall interaction in men. The aim of the present study was to test the hypothesis that cigarette smoking is linked to an increased platelet activity in women also. 2. In 26 healthy smoking and non-smoking women (age 21–49 years) the urinary excretion of the thromboxane A 2 metabolite 2,3-dinor...

...) and/or the thromboxane synthetase inhibitor UK-38,485. 2. After 30 min of reperfusion, superoxide dismutase treatment significantly reduced blood thromboxane levels, elevated during ischaemia. Superoxide dismutase also reduced tissue levels of malonyldialdehyde and xanthine oxidase, indicators of free-radical damage...

... of platelet aggregation in response to collagen, adenosine 5′-pyrophosphate and arachidonate. Thromboxane generation after stimulated platelet aggregation and whole-blood coagulation was also measured. 4. At each aspirin concentration, both platelet aggregation and thromboxane generation in response...

...R. K. McCulloch; J. Summers; R. Vandongen; I. L. Rouse 1. At present it is unclear whether platelet-activating-factor (PAF)-induced aggregation is mediated by thromboxane. To obtain further information about this event we have compared the affects of aspirin on platelet aggregation and secretion...

...M. Rathaus; E. Podjarny; A. Pomeranz; J. Shapira; N. Kariv; J. Bernheim 1. The synthesis of prostaglandin (PG) E 2 , PGF 2α , 6-keto-PGF 1α and thromboxane (TX) B 2 by isolated glomeruli, cortical tubules, inner medullary slices and outer medullary slices was measured in salt-depleted (LNa) rats...

... with buffer or various aspirin concentrations at 37°C for up to 4.5 h. Platelet aggregation and thromboxane generation were measured in response to collagen (0.4–6.3 μg/ml) and adenosine 5′-pyrophosphate (0.5–4 μmol/l). 3. The concentration of aspirin needed to inhibit platelet aggregation in response...

...Allan D. Cumming; Robert M. Lindsay; J. W. D. McDonald; Adam L. Linton 1. Eleven healthy, unanaesthetized sheep were given either a single intravenous bolus infusion of U63,577A (Upjohn), a selective thromboxane synthetase inhibitor, at a dose of 30 mg/kg (group 1, n = 6), or vehicle alone (group 2...

... in eicosapentaenoic acid (EPA) for 4 weeks. The supplement was equivalent to 1.8 g of EPA daily. Thromboxane synthesis and platelet aggregation responses to sodium arachidonate, thrombin and the ionophore A23187 were also investigated. 2. A marked increase in the relative EPA content of phosphatidylcholine (PC...

...Colin Johnston; Frank Carey; Robert A. Forder; Duncan Haworth 1. Levels of immunoreactive 6-oxo-prostaglandin F 1α (6-oxo-PGF 1α ) and thromboxane B 2 (TXB 2 ) were measured in peripheral venous plasma in a group of volunteers and non-insulin dependent diabetic patients (NIDDS). Levels...