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Keywords: thrombosis
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Clin Sci (Lond) (2020) 134 (16): 2189–2201.
Published: 26 August 2020
... biologic mechanisms link together hemostasis and fibrosis: focal parenchymal extinction and direct stellate cell activation by thrombin and Factor Xa. Available translational research further supports the role of thrombosis in fibrosis. In this review, we will summarize what is known about the convergence...
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Clin Sci (Lond) (2017) 131 (12): 1245–1260.
Published: 07 June 2017
... inadequately to standard antiplatelet therapy. Furthermore, they often experience recurrent events as well as side effects that include excess bleeding. This highlights the need for identification of novel regulators of diabetes-associated thrombosis to target for therapeutic intervention. It is well...
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Clin Sci (Lond) (2013) 124 (3): 123–137.
Published: 02 October 2012
... in thrombosis and wound healing with a particular focus on: (i) the influence of plasma FXIIIa on the formation of stable fibrin clots able to withstand mechanical and enzymatic breakdown through fibrin–fibrin cross-linking and cross-linking of fibrinolysis inhibitors, in particular α 2 -antiplasmin; (ii...
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Clin Sci (Lond) (2012) 122 (9): 397–407.
Published: 21 December 2011
... (potassium) and accumulation of Ca (calcium) and Na [ 41 ]. These alterations might, in part, mediate low Mg effects on endothelial cells. atherosclerosis endothelial cell inflammation magnesium oxidative stress thrombosis Despite considerable advances over the last decades...
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Clin Sci (Lond) (2009) 116 (11): 791–804.
Published: 01 May 2009
.... These plaques are prone to rupture leading to thrombosis, followed by either occlusion or episodic plaque expansion. Moreover, during plaque development, remodelling of the artery takes place and consists of reactive changes in the underlying vessel wall to preserve a normal lumen and prevent flow occlusion...
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Clin Sci (Lond) (2008) 115 (4): 129–131.
Published: 15 July 2008
... thrombosis Toll-like receptor (TLR) An interesting observation reported in the paper by Ishikawa et al. [ 1 ] was the finding that, in a retrospective study, TLR expression was associated with disease manifestation and that also prospectively expression levels were related with cardiovascular end...
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Clin Sci (Lond) (2008) 115 (4): 133–140.
Published: 15 July 2008
...Yuh Ishikawa; Mamoru Satoh; Tomonori Itoh; Yoshitaka Minami; Yuji Takahashi; Motoyuki Akamura Several reports suggest that a chronic inflammatory process plays a key role in coronary artery plaque instability and subsequent occlusive thrombosis. In a previous study, we found that TLR4 (Toll-like...
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Clin Sci (Lond) (2005) 108 (3): 255–263.
Published: 18 February 2005
... as binding and activation of FVII (factor VII) can result in thrombosis. Although PAR2 (protease-activated receptor-2) is expressed on vascular endothelium, its precise physiological significance and mechanism of activation have yet to be defined. In the present study, we investigated whether PAR2 can...
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Clin Sci (Lond) (2003) 105 (6): 699–707.
Published: 01 December 2003
... 2003 The Biochemical Society 2003 aging circulatory physiology endothelial function heart failure inflammation thrombosis vasculature Clinical Science (2003) 105, 699 707 (Printed in Great Britain) 699 Cutaneous vascular reactivity is reduced in aging and in heart failure: association...
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Clin Sci (Lond) (2003) 104 (4): 349–356.
Published: 06 March 2003
... . In conclusion, high-dose heparin did not prevent lung dysfunction in this model, in which acute lung injury was induced by combined smoke and septic challenge. anticoagulant haemodynamics infection/inflammation Pseudomonas aeruginosa septic shock thrombosis Correspondence: Professor Daniel L...
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Clin Sci (Lond) (1995) 89 (3): 205–214.
Published: 01 September 1995
...Gregory Y. H. Lip; Gordon D. O. Lowe © 1995 The Biochemical Society and the Medical Research Society 1995 d-dimer fibrin thrombosis Clinical Science (1995) 89, 205-2214 (Printed in Great Britain) 205 Editorial Review Fibrin IHJimer: a useful clinical marker of thrombogenesis! Gregory...
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