... biologic mechanisms link together hemostasis and fibrosis: focal parenchymal extinction and direct stellate cell activation by thrombin and Factor Xa. Available translational research further supports the role of thrombosis in fibrosis. In this review, we will summarize what is known about the convergence...

... inadequately to standard antiplatelet therapy. Furthermore, they often experience recurrent events as well as side effects that include excess bleeding. This highlights the need for identification of novel regulators of diabetes-associated thrombosis to target for therapeutic intervention. It is well...

...Yi-Ching Chen; Ching-Wen Ho; Hsing-Hua Tsai; Jong-Shyan Wang Acute hypoxic exposure increases vascular thrombotic risk. The release of procoagulant-rich microparticles from neutrophils accelerates the pathogenesis of inflammatory thrombosis. The present study explicates the manner in which interval...

... the non-personalized treatment (ischemic and bleedings events: 8.2% versus 18.7% respectively; HR=0.46; 95%CI: 0.29–0.70; P <0.001). Further analysis indicated that patients with aggregation values within the therapeutic window (21–49 units) experienced the lowest event rates (stent thrombosis...

... the risk of thrombosis associated with stenotic arteries. Correspondence : Professor Jong-Shyan Wang (email s5492@mail.cgu.edu.tw ). 4 10 2012 5 12 2012 20 12 2012 20 12 2012 © The Authors Journal compilation © 2013 Biochemical Society 2013 hypoxia microparticle...

... in thrombosis and wound healing with a particular focus on: (i) the influence of plasma FXIIIa on the formation of stable fibrin clots able to withstand mechanical and enzymatic breakdown through fibrin–fibrin cross-linking and cross-linking of fibrinolysis inhibitors, in particular α 2 -antiplasmin; (ii...

... infarction matrix metalloproteinase-9 (MMP-9) pigment epithelial-derived factor (PEDF) plaque rupture proteomics thrombosis Thrombotic occlusion of an epicardial coronary artery upon atherosclerotic plaque rupture is considered the ultimate and key step in AMI (acute myocardial infarction) [ 1...

... factors [ 29 ]. Under normal circumstances, endothelial cells actively prevent thrombosis by synthesizing molecules that block platelet adhesion and aggregation, inhibit coagulation and lyse the clots [ 29 ]. Healthy endothelium produces prostacyclin and NO, which are co-released and form a particular...

... and they rarely rupture. By contrast, the fibrous cap in unstable plaques is thin, especially at the shoulder lesion and contains few SMCs, but numerous inflammatory cells. These plaques are prone to rupture leading to thrombosis, followed by either occlusion or episodic plaque expansion. Moreover, during plaque...

... ruptured plaque thrombosis Toll-like receptor (TLR) Correspondence: Dr Gerard Pasterkamp (email g.pasterkamp@umcutrecht.nl ). 14 3 2008 3 4 2008 3 4 2008 © The Authors Journal compilation © 2008 Biochemical Society 2008 First, association studies have shown...

...Yuh Ishikawa; Mamoru Satoh; Tomonori Itoh; Yoshitaka Minami; Yuji Takahashi; Motoyuki Akamura Several reports suggest that a chronic inflammatory process plays a key role in coronary artery plaque instability and subsequent occlusive thrombosis. In a previous study, we found that TLR4 (Toll-like...

... ligand (sCD40L) thrombosis CD40L (CD40 ligand) is a transmembrane protein, structurally related to TNF-α (tumour necrosis factor-α), that was first identified on CD4+ T-cells [ 1 , 2 ]. Subsequently, CD40L has been found on the surface membrane of activated platelets [ 3 ] from where sCD40L...

... as binding and activation of FVII (factor VII) can result in thrombosis. Although PAR2 (protease-activated receptor-2) is expressed on vascular endothelium, its precise physiological significance and mechanism of activation have yet to be defined. In the present study, we investigated whether PAR2 can...

... 2003 The Biochemical Society 2003 aging circulatory physiology endothelial function heart failure inflammation thrombosis vasculature Clinical Science (2003) 105, 699 707 (Printed in Great Britain) 699 Cutaneous vascular reactivity is reduced in aging and in heart failure: association...

... 77555-0833, U.S.A. (e-mail dltraber@utmb.edu ). 26 9 2002 25 10 2002 3 1 2003 The Biochemical Society and the Medical Research Society © 2003 2003 anticoagulant haemodynamics infection/inflammation Pseudomonas aeruginosa septic shock thrombosis 349Clinical Science...

...Gregory Y. H. Lip; Gordon D. O. Lowe © 1995 The Biochemical Society and the Medical Research Society 1995 d-dimer fibrin thrombosis Clinical Science (1995) 89, 205-2214 (Printed in Great Britain) 205 Editorial Review Fibrin IHJimer: a useful clinical marker of thrombogenesis! Gregory...

... arterial thrombosis among elderly people in cold weather. Compared with thermoneutral control experiments, skin temperature (trunk) fell from 35.5 to 29.5°C, with little change in core temperature. 2. Erythrocyte count rose in the cold from 4.29 to 4.69 × 10 12 /l, without a change in mean corpuscular...