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Keywords: thrombin
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Clin Sci (Lond) (2021) 135 (3): 447–463.
Published: 01 February 2021
... of serpina3c in atherosclerosis after HFD for 12 weeks. Compared with Apoe −/− mice, the Apoe −/− /serpina3c −/− mice developed more severe atherosclerosis, and the number of VSMCs and macrophages in aortic plaques was significantly increased. The present study revealed serpina3c as a novel thrombin inhibitor...
Includes: Supplementary data
Clin Sci (Lond) (2015) 129 (4): 363–374.
Published: 27 May 2015
... the manner in which normoxic and hypoxic exercise regimens affect procoagulant monocyte-derived microparticle (MDMP) formation and monocyte-promoted thrombin generation (TG). Forty sedentary healthy males were randomized to perform either normoxic (NET; 21% O 2 , n =20) or hypoxic (HET; 15% O 2 , n =20...
Clin Sci (Lond) (2007) 112 (3): 167–174.
Published: 03 January 2007
..., both in the absence and presence of extracellular Ca 2+ . Platelet stimulation with thrombin in the absence and presence of extracellular Ca 2+ induced a rapid rise in [Ca 2+ ] i that was of greater magnitude in platelets from BDL rats than in controls. Ca 2+ storage was significantly elevated...
Clin Sci (Lond) (1998) 94 (4): 437–445.
Published: 01 April 1998
...Marcus K. Ilton; Marcia L. Taylor; Neil L. A. Misso; Philip J. Thompson; Joseph Hung 1. Close contact between platelets and neutrophils modulates their cellular interactions in thrombotic and inflammatory states, with stimulation of P-selectin expression on platelets by agonists such as thrombin...
Clin Sci (Lond) (1997) 93 (3): 249–255.
Published: 01 September 1997
... the efflux of 86 Rb + (a marker for K + ) from 86 Rb + -loaded cells, and have defined their responses to stimulation by the platelet agonist thrombin and the calcium ionophore ionomycin. 3. Thrombin (0.1–0.6 i.u./ml) stimulated an increase in 86 Rb + efflux from the platelets in a concentration-dependent...
Clin Sci (Lond) (1995) 88 (3): 277–283.
Published: 01 March 1995
...R. M. Touyz; E. L. Schiffrin 1. Endothelin-1 has anti-aggregatory properties, but the mechanism underlying this inhibitory action is unknown. This in vitro study investigates effects of endothelin-1 on thrombin-stimulated aggregation and intracellular free calcium concentration in human platelets...
Clin Sci (Lond) (1995) 88 (2): 149–157.
Published: 01 February 1995
... feature of septicaemia. We hypothesized that thrombin generated during disseminated intravascular coagulation might modulate the changes in vascular tone induced by endotoxin. 2. Incubation of rat aortic rings for 4 h with α-thrombin (0.003–3.0 NIH units/ml) did not change their reactivity...
Clin Sci (Lond) (1992) 82 (4): 383–388.
Published: 01 April 1992
... h of incubation with added thrombin (stimulated production) or media (basal production). Supernatants were then collected for measurement of 6-keto-prostaglandin F 1α by radioimmunoassay. 3. Basal production of 6-keto-prostaglandin F 1α was greater in response to serum from non-pregnant women than...
Clin Sci (Lond) (1991) 80 (3): 205–211.
Published: 01 March 1991
.... These results suggest that structural membrane modifications may participate in the various functional abnormalities observed in platelets from hypertensive patients. Key words: cytosolic Ca2+, essential hypertension, fluor- escence depolarization, membrane fluidity, platelets, thrombin. Abbreviations: DPH, 1,6...
Clin Sci (Lond) (1986) 70 (5): 495–500.
Published: 01 May 1986
...C. C. T. Smith; A. P. Wilson; B. N. C. Prichard; D. J. Betteridge 1. Using high-performance liquid chromatography with electrochemical detection, we have studied the release of endogenous catecholamines from washed platelets induced to aggregate by ADP and thrombin. 2. Washed platelets exhibit...