...Yen-Yu Lu; Yung-Kuo Lin; Zhi-Hong Wen; Yao-Chang Chen; Shih-Ann Chen; Yi-Jen Chen AF (atrial fibrillation) is the most common sustained arrhythmia, and the PVs (pulmonary veins) play a critical role in triggering AF. Stretch causes structural remodelling, including cytoskeleton rearrangement, which...

...Bao-Wei Wang; Hang Chang; Kou-Gi Shyu Resistin has a potential role in atherosclerosis; however, the molecular mechanism underlying the increase in resistin expression in atherosclerosis remains unclear. As mechanical stretch plays an important role in atherosclerosis, in the present study we...

... stretch can up-regulate the expression of hypoxia-inducible factor-1α and vascular endothelial growth factor, which is a key regulator of blood vessel remodelling, provides us with further insight into the mechanisms underlying remodelling at sites of occlusive disease within the cardiovascular system...

... not been reported previously, and therefore we sought to investigate the regulation of HIF-1α by cyclical mechanical stretch in cultured rat VSMCs. Rat VSMCs grown on a flexible membrane base were stretched by vacuum to 20% of the maximum elongation at 60 cycles/min. The levels of HIF-1α protein began...

... - channels) and (iii) osmoregulated Cl - channels. In this study, we examined comparatively the effects of cyclic stretch and endothelin-1 (ET-1) on Cl - channel activity in primary cultures of neonatal rat ventricular myocytes using an 125 I-efflux assay. About 4min after the start of the 125 I-efflux (mean...

...M. Pagani; M. Bergamaschi; A. Malliani 1. The effects of mechanical activation of aortic sympathetic sensory fibres have been studied in conscious dogs. 2. A cannula covered by an inflatable rubber balloon, previously implanted in the descending thoracic aorta, was used to stretch the aortic walls...