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Keywords: statins
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Clin Sci (Lond) (2018) 132 (12): 1243–1252.
Published: 21 June 2018
... 2018 atherosclerosis atherogenesis inflammation lipids macrophages statins Numerous data support the key role of the inflammatory mechanisms to atheroma formation [ 1–4 ]. Leukocyte recruitment and proinflammatory cytokines participate pivotally in the early phase of atherogenesis [ 1...
Clin Sci (Lond) (2017) 131 (15): 2007–2017.
Published: 13 July 2017
... ( satohm@iwate-med.ac.jp ) 24 03 2017 07 06 2017 23 06 2017 23 06 2017 © 2017 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2017 Atherosclerosis cardiovascular events microRNA peripheral blood mononuclear cell statins telomere...
Clin Sci (Lond) (2017) 131 (14): 1561–1578.
Published: 30 June 2017
... hypercholesterolaemia statins vascular dementia Dementia is a progressive and largely irreversible clinical syndrome comprising global impairment of mental function, which manifests as difficulties in memory, language, activities of daily living, and psychosocial and psychiatric disturbance [ 1 , 2...
Clin Sci (Lond) (2017) 131 (8): 747–758.
Published: 06 April 2017
...Jerome Morel; Iain Hargreaves; David Brealey; Viruna Neergheen; Janne T. Backman; Sandro Lindig; Marcus Bläss; Michael Bauer; Daniel F. McAuley; Mervyn Singer Statins may offer protective effects in sepsis through anti-inflammatory, mitochondrial protection and other actions. We thus evaluated...
Includes: Supplementary data
Clin Sci (Lond) (2017) 131 (4): 261–268.
Published: 20 January 2017
... whereas others found no significant role for the LDLR in that process. This elusive pathway appears clearly distinct from that of the widely prescribed statins that also enhance LDLR function but do not lower circulating Lp (a) levels in humans. So how does PCSK9 inhibition with mAbs reduce Lp...
Clin Sci (Lond) (2015) 129 (12): 1195–1206.
Published: 11 November 2015
... is observed during dementia and hypercholesterolaemia. We investigated the hypothesis that statin intervention in mid-life mitigates the inflammatory effects of oxLDL on the microvasculature. Human microvascular endothelial cells (HMVECs) were maintained in transwells to mimic the microvasculature and exposed...
Includes: Supplementary data
Clin Sci (Lond) (2003) 105 (3): 251–266.
Published: 01 September 2003
...Justin C. MASON The statins reduce cholesterol synthesis through inhibition of HMG-CoA (3-hydroxy-3-methylglutaryl-CoA) reductase and are widely prescribed for hyperlipidaemia to reduce the risk of atherosclerotic complications. The beneficial effect of lipid lowering by statins in the treatment...