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Keywords: spontaneously hypertensive rat
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Clin Sci (Lond) (2019) 133 (8): 939–951.
Published: 29 April 2019
...) and their synthetic analogs have cardiovascular protective effects. Here, we investigated the action of a novel EET analog EET-B on the progression of post-myocardial infarction (MI) heart failure in spontaneously hypertensive rats (SHR). Adult male SHR were divided into vehicle- and EET-B (10 mg/kg/day; p.o., 9...
Clin Sci (Lond) (2008) 114 (10): 651–659.
Published: 14 April 2008
...José M. González; Beatriz Somoza; M. Victoria Conde; Maria S. Fernández-Alfonso; M. Carmen González; Silvia M. Arribas The present study explores the contribution of alterations in resting tone to cerebral artery narrowing in SHRs (spontaneously hypertensive rats) and the role of hypertension...
Clin Sci (Lond) (2004) 106 (5): 541–546.
Published: 01 May 2004
...-related BP (blood pressure) development in MSHR (male spontaneously hypertensive rats). Whether this decrease is due to an effect on the endothelium or smooth muscle is unknown. To determine this effect, we examined the role of E 2 on vascular endothelium and smooth muscle separately. We treated MSHR...
Clin Sci (Lond) (2004) 106 (3): 251–259.
Published: 01 March 2004
... hypertrophy and renal injury in spontaneously hypertensive rats (SHRs), and explores how these effects are modified when spontaneous hypertension is transformed in a low-renin model by the administration of deoxycorticosterone acetate (DOCA). The following groups were used: SHR-control, SHR+DOCA, SHR+losartan...
Clin Sci (Lond) (2004) 106 (2): 163–171.
Published: 01 February 2004
...Jennifer M. HUGHES; Stuart J. BUND In the present study, myogenic properties of femoral arteries from control hindlimbs and those distal to external iliac artery partial ligation of spontaneously hypertensive rats (SHRs) and normotensive Wistar–Kyoto (WKY) rats were assessed. Arterial pressure...
Clin Sci (Lond) (2001) 101 (4): 385–393.
Published: 14 September 2001
...Stuart J. BUND This investigation related arterial structure to myogenic (pressure-dependent) contractile responses in resistance arteries from spontaneously hypertensive rats (SHRs) and Wistar-Kyoto (WKY) normotensive control rats under pressurized conditions in vitro . Femoral and mesenteric...
Clin Sci (Lond) (2000) 99 (4): 277–283.
Published: 01 September 2000
... Balfagón (e-mail gloria.balfagon@uam.es ). 4 1 2000 29 3 2000 2 6 2000 The Biochemical Society and the Medical Research Society © 2000 2000 electrical field stimulation nitrergic innervation protein kinase C rat mesenteric artery spontaneously hypertensive rat...
Clin Sci (Lond) (2000) 98 (3): 277–282.
Published: 09 February 2000
... in anaesthetized spontaneously hypertensive rats (SHR). Miconazole, a non-selective inhibitor of CYP-450 that inhibits both hydroxylation and epoxidation, substantially suppressed mesenteric vasoconstrictor responses to angiotensin II in SHR, but had no effect on responses to noradrenaline or sympathetic nerve...
Clin Sci (Lond) (1999) 97 (2): 239–246.
Published: 29 June 1999
...-old male spontaneously hypertensive rats (SHR 12 and SHR 20 respectively) and age-matched Wistar–Kyoto rats (WKY 12 and WKY 20 respectively). These rats were killed after measurement of haemodynamic parameters by transthoracic echocardiography and use of a tipmanometer via the right carotid artery...
Clin Sci (Lond) (1998) 95 (3): 303–309.
Published: 01 September 1998
... accordingly. 303Clinical Science (1998) 95, 303 309 (Printed in Great Britain) Influences of carvedilol treatment on the effects of acetylcholine on regional haemodynamics in the spontaneously hypertensive rat Sven-Olof GRANSTAM, Bengt FELLSTRO> M and Lars LIND Department of Medicine, University Hospital...
Clin Sci (Lond) (1998) 94 (3): 231–238.
Published: 01 March 1998
...Stuart J. Bund 1. Endothelium-dependent acetylcholine-mediated relaxations of small coronary arteries (∼200 μm internal diameter) from 20 weeks old spontaneously hypertensive rats (SHR) and normotensive Wistar—Kyoto (WKY) controls were compared under pressurized no-flow conditions after...
Clin Sci (Lond) (1998) 94 (3): 225–229.
Published: 01 March 1998
...Susana R. Garcia; Stuart J. Bund 1. The endothelium contributes substantially to the modulation of myogenic tone in coronary arteries from spontaneously hypertensive rats (SHR) and Wistar—Kyoto rats (WKY). This study has addressed the contributions of endothelium-derived nitric oxide and cyclo...
Clin Sci (Lond) (1995) 88 (6): 719–725.
Published: 01 June 1995
... in hypertensive strains are scarce. 2. We studied the effects of 27 weeks of a fructose-versus a corn-starch-enriched (69.5% w/w) diet in the spontaneously hypertensive rat. 3. In both dietary groups, blood pressure increased with ageing, with no apparent difference between the diets. The fructose-fed rats gained...
Clin Sci (Lond) (1994) 87 (1): 1–4.
Published: 01 July 1994
...Michael A. Kaiser; David Lodwick; Nilesh J. Samani 1. S A is a recently identified gene implicated in blood pressure regulation in rodent models of genetic hypertension. In this study we have examined, by Northern blotting, its expression in tissues of the spontaneously hypertensive rat, the Wistar...
Clin Sci (Lond) (1993) 85 (5): 585–591.
Published: 01 November 1993
...Robert I Norman; Navtej Achall 1. The relationships between systolic blood pressure and altered erythrocyte Ca 2+ -Mg 2+ -ATPase activity and membrane microviscosity were assessed in membranes prepared from 20-week-old female Wistar-Kyoto normotensive and spontaneously hypertensive rats obtained...
Clin Sci (Lond) (1991) 81 (s25): 491–497.
Published: 01 October 1991
.... The production of prostaglandin E 2 , 6-keto-prostaglandin F 1α and thromboxane B 2 was greater by glomeruli from untreated spontaneous hypertensive rats (prostaglandin E 2 2.24 ± 0.41, 6-keto-prostaglandin F 1α 1.20 ± 0.13 and thromboxane B 2 2.75 ± 0.43 ng 10 min −1 mg −1 of protein) than by those from Wistar...
Clin Sci (Lond) (1987) 72 (3): 321–327.
Published: 01 March 1987
...A. Louise Sugden; Barbara L. Bean; James A. Straw 1. These studies were designed to investigate the effects of high dietary K + on electrolyte and water balance in young spontaneously hypertensive rats (SHR) and to relate these effects to changes in blood pressure. 2. The high K + diet reduced...
Clin Sci (Lond) (1987) 72 (3): 271–275.
Published: 01 March 1987
...Jaroslav Kunes; Stephen C. Pang; Marc Cantin; Jacques Genest; P. Hamet 1. Cardiac hyperplasia in newborn spontaneously hypertensive rats (SHR) has been noted by our group as well as by other investigators. The present study was designed to establish whether early (neonatal) hyperplasia is confined...
Clin Sci (Lond) (1987) 72 (3): 313–319.
Published: 01 March 1987
...A. Louise Sugden; James A. Straw; Barbara L. Bean 1. Blood pressure was measured after treatment with a high K + , a low Na + and a combined high K + /low Na + diet in young spontaneously hypertensive rats (SHR). 2. A high K + diet reduced blood pressure by approximately 10 mmHg during...
Clin Sci (Lond) (1985) 68 (4): 407–410.
Published: 01 April 1985
...J. Higaki; T. Ogihara; Y. Kumahara; E. L. Bravo 1. Intracellular calmodulin levels were measured by direct radioimmunoassay in spontaneously hypertensive rats (SHR) and Wistar—Kyoto rats (WKY). 2. Decreased calmodulin levels were demonstrated in the brain, heart, aorta and kidney of spontaneously...
Clin Sci (Lond) (1982) 63 (s8): 49s–52s.
Published: 01 October 1982
..., to diffuse alterations of cell membrane structure, which seem to be similar to those caused by high salt intake. Key words: diphenylhexatriene, fluorescence polarization, high salt intake, plasma membrane, spontaneously hypertensive rat. Abbreviation: DPH, diphenylhexatriene. Correspondence: M. A. Devynck...
Clin Sci (Lond) (1981) 61 (6): 685–691.
Published: 01 December 1981
...M. Bianchi; G. Bellini; H. Hessan; K. E. Kim; C. Swartz; M. Fernandes 1. Plasma volume, packed cell volume (PCV), blood volume, extracellular fluid volume (ECFV) and Evans blue disappearance rate were measured in conscious spontaneously hypertensive rats and in weight-matched Wistar normotensive...
Clin Sci (Lond) (1981) 61 (2): 249–251.
Published: 01 August 1981
...Kenji Mizuno; Shunichi Hata; Soitsu Fukuchi 1. The effect of sodium intake on angiotensin-converting enzyme activity in subcellular fractions of aorta (homogenate, mitochondria, microsomes and supernatant) was studied in normotensive and spontaneously hypertensive rats. 2. Angiotensin-converting...
Clin Sci (Lond) (1981) 60 (3): 267–272.
Published: 01 March 1981
...I. Tikkanen; A. Miettinen; F. Fyhrquist; T. Törnroth 1. To explore the effect of nephritis on development of genetic hypertension we immunized 10-week-old spontaneously hypertensive rats with purified rat kidney brush-border antigen. This induces Heymann nephritis (autologous immune complex...
Clin Sci (Lond) (1981) 60 (2): 229–232.
Published: 01 February 1981
...G. Berglund; L. Sigström; S. Lundin; B. E. Karlberg; H. Herlitz 1. Intra-erythrocyte sodium, potassium, ATP and (Na + ,K + -activated)-ATPase concentrations and urinary aldosterone excretion were compared in 3-month-old spontaneously hypertensive rats ( n = 11) and normotensive Wistar-Kyoto control...
Clin Sci (Lond) (1979) 57 (s5): 27s–29s.
Published: 01 December 1979
... arteries but only in the smallest cerebral arteries. © 1979 The Biochemical Society and the Medical Research Society 1979 cerebral renal and mesenteric arteries morphometry spontaneously hypertensive rat Clinical Science (1979) 51,279-29s The ratio between thickness of media and internal...
Clin Sci (Lond) (1979) 56 (2): 163–167.
Published: 01 February 1979
... © 1979 The Biochemical Society and the Medical Research Society 1979 baroreceptor reflex propranolol spontaneously hypertensive rat Clinical Science (1979) 56,163-167 The role of the baroreceptor reflex in the cardiovascular effects of propranolol in the conscious spontaneously...
Clin Sci Mol Med (1978) 55 (3): 261–270.
Published: 01 September 1978
...J. D. Barrett; P. Eggena; M. P. Sambhi 1. A renin-like enzyme in aortic tissue of the spontaneously hypertensive rat was found to be a freely dissociable enzyme (saline homogenization) with an affinity for the renin inhibitor pepstatin. At neutral pH values, the enzyme was active in homologous...