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Articles

Revisiting blood pressure and body fluid status

Kento Kitada, Akira Nishiyama

Clin Sci (Lond) (2023) 137 (9): 755–767.

DOI: https://doi.org/10.1042/CS20220500

Published: 18 May 2023

...Kento Kitada; Akira Nishiyama Homeostasis of body fluid is a key component for maintaining health. An imbalance of body sodium and water causes various pathological states, such as dehydration, volume overload, hypertension, cardiovascular and renal diseases, and metabolic disorders. Conventional...

View article titled, Revisiting blood pressure and body fluid status

Articles

Skin-specific mechanisms of body fluid regulation in hypertension

Jun Yu Chen, Khai Syuen Chew, Sheon Mary, Philipp Boder, Domenico Bagordo, Gian Paolo Rossi, Rhian M. Touyz, Christian Delles, Giacomo Rossitto

Clin Sci (Lond) (2023) 137 (3): 239–250.

DOI: https://doi.org/10.1042/CS20220609

Published: 07 February 2023

... sweat sodium loss in hypertensive subjects compared with controls, suggesting an inverse relationship between blood pressure and sweat Na + concentration ([Na + ] sweat ) [ 10 ]. Additionally, generalizability of these data were questioned in relation to the unclear salt-status of the hypertensive...

View article titled, Skin-specific mechanisms of body fluid regulation in hypertension

Includes: Supplementary data

Articles

Mechanism-based strategies to prevent salt sensitivity and salt-induced hypertension

Theodore W. Kurtz, Michal Pravenec, Stephen E. DiCarlo

Clin Sci (Lond) (2022) 136 (8): 599–620.

DOI: https://doi.org/10.1042/CS20210566

Published: 22 April 2022

.... It is assumed that reducing the salt concentration of processed foods will substantially reduce mean salt intake in the general population. However, contrary to expectations, reducing the sodium density of nearly all foods consumed in England by 21% had little or no effect on salt intake in the general...

View article titled, Mechanism-based strategies to prevent salt sensitivity and salt-induced hypertension

Articles

Response to the letter regarding the hypothesis paper “Much ado about N…atrium: modelling tissue sodium as a highly sensitive marker of subclinical and localised oedema”

Giacomo Rossitto, Rhian M. Touyz, Mark C. Petrie, Christian Delles

Clin Sci (Lond) (2019) 133 (6): 761.

DOI: https://doi.org/10.1042/CS20190154

Published: 19 March 2019

... 2019 09 02 2019 28 02 2019 © 2019 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2019 oedema sodium salt We would like to thank Dr Bhave for the provocative discussion and for providing further details on his theoretical framework...

View article titled, Response to the letter regarding the hypothesis paper “Much ado about N…atrium: modelling tissue sodium as a highly sensitive marker of subclinical and localised oedema”

Articles

Quantitating excess tissue sodium

Gautam Bhave

Clin Sci (Lond) (2019) 133 (6): 739–740.

DOI: https://doi.org/10.1042/CS20190037

Published: 19 March 2019

... by Portland Press Limited on behalf of the Biochemical Society 2019 Extracellular Matrix Sodium Tonicity I read with great interest the hypothesis paper by Rossitto et al [ 1 ]. The authors should be commended for a thoughtful analysis of the interpretation of changes in tissue [Na...

View article titled, Quantitating excess tissue sodium

Articles

Much Ado about N…atrium: modelling tissue sodium as a highly sensitive marker of subclinical and localized oedema

Giacomo Rossitto, Rhian M. Touyz, Mark C. Petrie, Christian Delles

Clin Sci (Lond) (2018) 132 (24): 2609–2613.

DOI: https://doi.org/10.1042/CS20180575

Published: 13 December 2018

... of subclinical systemic and localized oedema. Classic physiology advocates the ultimate achievement of a constant balance between salt intake and excretion. At variance, over the last few years work by Titze and his collaborators has highlighted the phenomenon of hypertonic sodium (Na + ) accumulation...

View article titled, Much Ado about N…atrium: modelling tissue sodium as a highly sensitive marker of subclinical and localized oedema

Includes: Supplementary data

Articles

Short-term dietary salt supplementation blunts telmisartan induced increases in plasma renin activity in hypertensive patients with type 2 diabetes mellitus

Angela X. Chen, George Jerums, Sara Baqar, Elisabeth Lambert, Goji Somarajah, Georgina Thomas, Christopher O’Callaghan, Richard J. MacIsaac, Elif I. Ekinci

Clin Sci (Lond) (2015) 129 (5): 415–422.

DOI: https://doi.org/10.1042/CS20140536

Published: 11 June 2015

... has been associated with higher mortality rates in people with diabetes. Our aim is to examine the effect of angiotensin II receptor blocker (ARB), telmisartan, with and without dietary sodium chloride (NaCl) supplementation, on BP [mean arterial pressure (MAP)], plasma renin activity (PRA), serum...

View article titled, Short-term dietary salt supplementation blunts telmisartan induced increases in plasma renin activity in hypertensive patients with type 2 diabetes mellitus

Articles

Salt and high blood pressure

Sailesh Mohan, Norm R. C. Campbell

Clin Sci (Lond) (2009) 117 (1): 1–11.

DOI: https://doi.org/10.1042/CS20080207

Published: 02 June 2009

... and human intervention studies demonstrate the association between salt intake and HBP. Furthermore, animal studies indicate that short-term interventions in humans may underestimate the health risks associated with high dietary sodium. Recent intervention studies have found decreases in cardiovascular...

View article titled, Salt and high blood pressure

Articles

The α-adducin Gly460Trp polymorphism and the antihypertensive effects of exercise among men with high blood pressure

Linda S. Pescatello, Bruce E. Blanchard, Gregory J. Tsongalis, Carl M. Maresh, Ann O'Connell, Paul D. Thompson

Clin Sci (Lond) (2007) 113 (5): 251–258.

DOI: https://doi.org/10.1042/CS20060345

Published: 01 August 2007

...Linda S. Pescatello; Bruce E. Blanchard; Gregory J. Tsongalis; Carl M. Maresh; Ann O'Connell; Paul D. Thompson The α-adducin Gly460Trp polymorphism alters renal sodium transport and is associated with hypertension. Despite the immediate sodium- and volume-depleting effects of aerobic exercise...

View article titled, The α-adducin Gly460Trp polymorphism and the antihypertensive effects of exercise among men with high blood pressure

Articles

Chronic effects of an endothelin-converting enzyme inhibitor on cardiorenal and hormonal function in heart failure

Atsuyuki WADA, Masato OHNISHI, Takayoshi TSUTAMOTO, Masanori FUJII, Takehiro MATSUMOTO, Takashi YAMAMOTO, Xinwen WANG, Masahiko KINOSHITA

Clin Sci (Lond) (2002) 103 (s2002): 254S–257S.

DOI: https://doi.org/10.1042/CS103S254S

Published: 01 September 2002

... prevented the reduction of urine flow rate and urinary sodium excretion in association with an increase in the glomerular filtration rate and renal plasma flow compared with the vehicle. FR901533 also suppressed significantly the elevation of plasma atrial natriuretic peptide and aldosterone levels which...

View article titled, Chronic effects of an endothelin-converting enzyme inhibitor on cardiorenal and hormonal function in heart failure

Articles

Importance of glycolytically derived ATP for Na+ loading via Na+/H+ exchange during metabolic inhibition in guinea pig ventricular myocytes

Hiroshi SATOH, Shiho SUGIYAMA, Noriyuki NOMURA, Hajime TERADA, Hideharu HAYASHI

Clin Sci (Lond) (2001) 101 (3): 243–251.

DOI: https://doi.org/10.1042/cs1010243

Published: 03 August 2001

... myocardial ischaemia. Correspondence: Dr Hiroshi Satoh (e-mail satoh36@hama-med.ac.jp ). 9 1 2001 27 3 2001 4 5 2001 The Biochemical Society and the Medical Research Society © 2001 2001 glycolysis metabolic inhibition myocytes Na+/H+ exchange sodium 243Clinical...

View article titled, Importance of glycolytically derived ATP for Na+ loading via Na+/H+ exchange during metabolic inhibition in guinea pig ventricular myocytes

Articles

Neurohormonal activation, the renal dopaminergic system and sodium handling in patients with severe heart failure under vasodilator therapy

António FERREIRA, Paulo BETTENCOURT, Paula DIAS, Manuel PESTANA, Paula SERRÃO, Patrício SOARES-DA-SILVA, Mário CERQUEIRA-GOMES

Clin Sci (Lond) (2001) 100 (5): 557–566.

DOI: https://doi.org/10.1042/cs1000557

Published: 09 April 2001

...António FERREIRA; Paulo BETTENCOURT; Paula DIAS; Manuel PESTANA; Paula SERRÃO; Patrício SOARES-DA-SILVA; Mário CERQUEIRA-GOMES The benefits of tailoring therapy with vasodilators in patients with severe heart failure are well documented, but this may lead to neurohormonal activation and sodium...

View article titled, Neurohormonal activation, the renal dopaminergic system and sodium handling in patients with severe heart failure under vasodilator therapy

Articles

Blood pressure and renal haemodynamic response to salt during the normal menstrual cycle

Antoinette PECHÈRE-BERTSCHI, Marc MAILLARD, Hans STALDER, Hans R. BRUNNER, Michel BURNIER

Clin Sci (Lond) (2000) 98 (6): 697–702.

DOI: https://doi.org/10.1042/cs0980697

Published: 10 May 2000

... not on oral contraceptives were enrolled; 17 were studied in the follicular phase and 18 in the luteal phase of the menstrual cycle. The women in each group were then randomly allocated to receive a low-sodium (40 mmol/day) or a high-sodium (250 mmol/day) diet for a 7-day period in two consecutive menstrual...

View article titled, Blood pressure and renal haemodynamic response to salt during the normal menstrual cycle

Articles

Renal effects of brain natriuretic peptide in patients with congestive heart failure

Kaare T. JENSEN, Hans EISKJÆR, Jan CARSTENS, Erling B. PEDERSEN

Clin Sci (Lond) (1998) 96 (1): 5–15.

DOI: https://doi.org/10.1042/cs0960005

Published: 01 January 1999

... increased from 1.6 to 101 ;pmol/l in control subjects and from 25 to 173 ;pmol/l in congestive heart failure during infusion. Urinary sodium excretion increased significantly in both congestive heart failure (60%) and control subjects (71%), but the absolute increase was significantly lower in congestive...

View article titled, Renal effects of brain natriuretic peptide in patients with congestive heart failure

Articles

Increased Na+ and decreased Mg2+ intracellular concentrations in vascular smooth muscle cells from spontaneously hypertensive rats

Klaus KISTERS, Ernst-Rudolf KREFTING, Claus SPIEKER, Walter ZIDEK, Karl Heinz DIETL, Michael BARENBROCK, Karl Heinz RAHN

Clin Sci (Lond) (1998) 95 (5): 583–587.

DOI: https://doi.org/10.1042/cs0950583

Published: 01 November 1998

...Klaus KISTERS; Ernst-Rudolf KREFTING; Claus SPIEKER; Walter ZIDEK; Karl Heinz DIETL; Michael BARENBROCK; Karl Heinz RAHN 1. Although in blood cells decreased magnesium concentrations and increased sodium concentrations in essential hypertension have often been described, only sparse data exist...

View article titled, Increased Na+ and decreased Mg2+ intracellular concentrations in vascular smooth muscle cells from spontaneously hypertensive rats

Articles

Clinical and therapeutic significance of the Na+,K+ pump

Torben CLAUSEN

Clin Sci (Lond) (1998) 95 (1): 3–17.

DOI: https://doi.org/10.1042/cs0950003

Published: 01 July 1998

... catecholamines digitalis heart insulin muscle potassium sodium thyroid hormones training 3Clinical Science (1998) 95, 3 17 (Printed in Great Britain) + R E V I E W Clinical and therapeutic significance of the Na+,K+ pump* Torben CLAUSEN Department of Physiology, University of Aarhus, DK-8000 AI rhus C...

View article titled, Clinical and therapeutic significance of the Na+,K+ pump

Articles

Elevated Plasma and Urinary Endothelin-I Levels in Human Salt-Sensitive Hypertension

Claudio Ferri, Cesare Bellini, Giovambattista Desideri, Clarita Mazzocchi, Luca De Siati, Anna Santucci

Clin Sci (Lond) (1997) 93 (1): 35–41.

DOI: https://doi.org/10.1042/cs0930035

Published: 01 July 1997

... renal and cardiovascular damage. 7 2 1997 25 3 1997 © 1997 The Biochemical Society and the Medical Research Society 1997 cardiovascular system endothelins endothelium hypertension sodium Clinical Science ( I 997) 93, 35-41 (Printed in Great Britain) 35 Elevated plasma...

View article titled, Elevated Plasma and Urinary Endothelin-I Levels in Human Salt-Sensitive Hypertension

Articles

Effect of Urodilatin Infusion on Renal Haemodynamics, Tubular Function and Vasoactive Hormones

JAN Carstens, Kaare T. Jensen, Erling B. Pedersen

Clin Sci (Lond) (1997) 92 (4): 397–407.

DOI: https://doi.org/10.1042/cs0920397

Published: 01 April 1997

...JAN Carstens; Kaare T. Jensen; Erling B. Pedersen 1. The renal efficacy of urodilatin in humans has only been partly investigated. It is unknown whether intravenously infused urodilatin has an effect on sodium reabsorption in both the proximal and distal part of the nephron. 2. Twelve healthy...

View article titled, Effect of Urodilatin Infusion on Renal Haemodynamics, Tubular Function and Vasoactive Hormones

Articles

Mechanism of the Impaired Natriuretic Response to Frusemide during Sodium Depletion: A Micropuncture Study in Rats

D. G. Shirley, S. J. Walter, R. J. Unwin

Clin Sci (Lond) (1996) 91 (3): 299–305.

DOI: https://doi.org/10.1042/cs0910299

Published: 01 September 1996

...D. G. Shirley; S. J. Walter; R. J. Unwin 1. The nephron sites involved in the blunted natriuretic response to frusemide during sodium depletion were investigated using micropuncture techniques in anaesthetized rats. 2. Glomerular filtration rate was lower, and fractional sodium reabsorption...

View article titled, Mechanism of the Impaired Natriuretic Response to Frusemide during Sodium Depletion: A Micropuncture Study in Rats

Articles

Effect of the Transmembrane Gradient of Magnesium and Sodium on the Regulation of Cytosolic Free Magnesium Concentration in Human Platelets

Mitsuisa Yoshimura, Tetsuya Oshima, Hideo Matsuura, Mitsuaki Watanabe, Yukihito Higashi, Norihisa Ono, Hiroyuki Hiraga, Masayuki Kambe, Goro Kajiyama

Clin Sci (Lond) (1995) 89 (3): 293–298.

DOI: https://doi.org/10.1042/cs0890293

Published: 01 September 1995

... gradients, and a Na + -Mg 2+ exchanger may be involved in the regulation of [Mg 2+ ] i in human platelets. 14 3 1995 24 4 1995 © 1995 The Biochemical Society and the Medical Research Society 1995 cytosolic magnesium mag-fura-2 ouabain sodium Clinical Science (1995) 89, 293-298...

View article titled, Effect of the Transmembrane Gradient of Magnesium and Sodium on the Regulation of Cytosolic Free Magnesium Concentration in Human Platelets

Articles

Insulin Unresponsiveness of Tubular Monovalent Cation Transport during Fructose-Induced Hypertension in Rats

Eric Féraille, Sophie Marsy, Catherine Barlet-Bas, Martine Rousselot, Lydie Cheval, Herve Favre, Alain Doucet

Clin Sci (Lond) (1995) 88 (3): 293–299.

DOI: https://doi.org/10.1042/cs0880293

Published: 01 March 1995

...Eric Féraille; Sophie Marsy; Catherine Barlet-Bas; Martine Rousselot; Lydie Cheval; Herve Favre; Alain Doucet 1. Hyperinsulinaemia is considered to be a pathogenic factor for human and experimental hypertension. Thus, the contribution of the known insulin-stimulated tubular sodium reabsorption...

View article titled, Insulin Unresponsiveness of Tubular Monovalent Cation Transport during Fructose-Induced Hypertension in Rats

Articles

Plasma Endogenous Digoxin-Like Substance Levels are Dependent on Blood O 2 in Man

Claudio Ferri, Cesare Bellini, Simonetta Coassin, Claudio De Angelis, Alessandro Perrone, Anna Santucci

Clin Sci (Lond) (1994) 87 (4): 447–451.

DOI: https://doi.org/10.1042/cs0870447

Published: 01 October 1994

... Research Society 1994 digoxin-like substances oxygen respiratory disease sodium Clinical Science (1994) 87, 447451 (Printed in Great Britain) 447 Plasma endogenous digoxiwlike substance levels are dependent on blood 0, in man Claudio FERRI, Cesare BELLINI, Simonetta COASSIN, Claudio DE ANGELIS...

View article titled, Plasma Endogenous Digoxin-Like Substance Levels are Dependent on Blood O 2 in Man

Articles

Impaired Renin Stimulation in Pre-Eclampsia

Mark A. Brown, Loretta Reiter, Alison Rodger, Judith A. Whitworth

Clin Sci (Lond) (1994) 86 (5): 575–581.

DOI: https://doi.org/10.1042/cs0860575

Published: 01 May 1994

... with pre-eclampsia by intravenous frusemide, which stimulates renin acutely through a prostacyclin-mediated mechanism. 2. Plasma active renin concentration, plasma aldosterone concentration, haematocrit and urinary sodium, creatinine and 6-keto-prostaglandin F 1α were measured before (0) and 15, 30 and 60...

View article titled, Impaired Renin Stimulation in Pre-Eclampsia

Articles

Acute Sodium Loading in Patients with Uncomplicated Diabetes Mellitus: Renal and Hormonal Effects

Carlo Beretta-Piccoli, Francesca Elshater-Zanetti, Sidney Shaw, Daniele Cusi, Peter Weidmann

Clin Sci (Lond) (1994) 86 (4): 383–390.

DOI: https://doi.org/10.1042/cs0860383

Published: 01 April 1994

...Carlo Beretta-Piccoli; Francesca Elshater-Zanetti; Sidney Shaw; Daniele Cusi; Peter Weidmann 1. Diabetes mellitus is associated with high body sodium, but the pathogenetic mechanism is still unknown. The possibility that an abnormal renal handling of sodium, an abnormal responsiveness of sodium...

View article titled, Acute Sodium Loading in Patients with Uncomplicated Diabetes Mellitus: Renal and Hormonal Effects

Articles

Do Thiazides Reduce Intestinal Oxalate Absorption?: A Study In Vitro Using Rabbit Colon

M. Hatch, N. D. Vaziri

Clin Sci (Lond) (1994) 86 (3): 353–357.

DOI: https://doi.org/10.1042/cs0860353

Published: 01 March 1994

... Research Society 1994 absorption chloride diuretics oxalate secretion sodium Clinical Science (1994) 86, 353-357 (Printed in Great Britain) Do thiazides reduce intestinal oxalate absorption?: a study in vitro using rabbit colon M. HATCH and N. D. VAZlRl Division of Nephrology, Department...

View article titled, Do Thiazides Reduce Intestinal Oxalate Absorption?: A Study In Vitro Using Rabbit Colon

Articles

Hormonal and other Mechanisms Involved in the Pathogenesis of Cyclosporin-Induced Nephrotoxicity and Hypertension in Man

Nigel D.C. Sturrock, A.D. Struthers

Clin Sci (Lond) (1994) 86 (1): 1–9.

DOI: https://doi.org/10.1042/cs0860001

Published: 01 January 1994

...Nigel D.C. Sturrock; A.D. Struthers © 1994 The Biochemical Society and the Medical Research Society 1994 calcium cyclosporin hypertension nephrotoxicity prostaglandins renin-angiotensin system sodium Clinical Science (1994) 86, 1-9 (Printed in Great Britain) I Editorial Review...

View article titled, Hormonal and other Mechanisms Involved in the Pathogenesis of Cyclosporin-Induced Nephrotoxicity and Hypertension in Man

Articles

Atrial Natriuretic Peptide-Cyclic Gmp Relationships in Normal Humans: Effects of Dietary Sodium Intake

G. A. Sagnella, N. D. Markandu, M. G. Buckley, D. R. J. Singer, G. A. MacGregor

Clin Sci (Lond) (1993) 85 (1): 13–17.

DOI: https://doi.org/10.1042/cs0850013

Published: 01 July 1993

...G. A. Sagnella; N. D. Markandu; M. G. Buckley; D. R. J. Singer; G. A. MacGregor 1. The present study was designed to investigate the relationships between circulating atrial natriuretic peptide, plasma and urinary cyclic GMP and sodium excretion under basal conditions and in response to changes...

View article titled, Atrial Natriuretic Peptide-Cyclic Gmp Relationships in Normal Humans: Effects of Dietary Sodium Intake

Articles

Dopamine and the Kidney: Ten Years on

M. R. Lee

Clin Sci (Lond) (1993) 84 (4): 357–375.

DOI: https://doi.org/10.1042/cs0840357

Published: 01 April 1993

... dopaminergic agonists of therapeutic utility. 7. Final conclusions and unanswered questions. © 1993 The Biochemical Society and the Medical Research Society 1993 dopamine hypertension kidney sodium Clinical Science (1993) 81, 357-375 (Printed in Great Britain) 357 Editorial Review Dopamine...

View article titled, Dopamine and the Kidney: Ten Years on

Articles

Changes in Sodium Transport during the Human Menstrual Cycle and Pregnancy

G. D. Webb, G. G. Ashmead, S. Al-Mahdi, F. J. Auletta, M. K. McLaughlin

Clin Sci (Lond) (1993) 84 (4): 401–405.

DOI: https://doi.org/10.1042/cs0840401

Published: 01 April 1993

... + -K + pump rate constant during the menstrual cycle. 23 10 1992 25 11 1992 © 1993 The Biochemical Society and the Medical Research Society 1993 adenosine triphosphatase erythrocytes menstrual cycle potassium pregnancy sodium sodium-potassium pump Clinical Science (1993...

View article titled, Changes in Sodium Transport during the Human Menstrual Cycle and Pregnancy

Articles

Lithium clearance method and the renal response to low-dose dopamine in man: a randomized, controlled study

Niels Vidiendal Olsen, Michael Hecht Olsen, Niels Fogh-Andersen, Bo Feldt-Rasmussen, Annelise Kamper, Inger Plum, Svend Strandgaard, Paul Peter Leyssac

Clin Sci (Lond) (1993) 84 (2): 237–242.

DOI: https://doi.org/10.1042/cs0840237

Published: 01 February 1993

... baseline period and three 1 h periods during dopamine infusion. 2. Baseline sodium clearance with placebo was 0.65 ± 0.35 ml/min, but with lithium it increased to 1.25 ± 0.44 ( P < 0.001) and 1.17 ± 0.46 ml/min ( P < 0.01) after 450 and 600 mg, respectively. Urine flow rates were unchanged compared...

View article titled, Lithium clearance method and the renal response to low-dose dopamine in man: a randomized, controlled study

Articles

Altered prostaglandin synthesis and impaired sodium conservation in the kidneys of old rats

M. Rathaus, Z. Greenfeld, E. Podjarny, M. Brezis, J. Green, J. Bernheim

Clin Sci (Lond) (1992) 83 (3): 301–306.

DOI: https://doi.org/10.1042/cs0830301

Published: 01 September 1992

... of prostacyclin synthesis during Na + deprivation could impair Na + conservation. 23 3 1992 8 6 1992 © 1992 The Biochemical Society and the Medical Research Society 1992 ageing prostacyclin prostaglandin E 2. renal papilla sodium thromboxane Clinical Science (1992) 63, 301-306...

View article titled, Altered prostaglandin synthesis and impaired sodium conservation in the kidneys of old rats

Articles

Erythrocyte sodium-lithium countertransport: clinically useful, pathophysiologically instructive or just phenomenology?

P. A. Rutherford, T. H. Thomas, R. Wilkinson

Clin Sci (Lond) (1992) 82 (4): 341–352.

DOI: https://doi.org/10.1042/cs0820341

Published: 01 April 1992

...P. A. Rutherford; T. H. Thomas; R. Wilkinson © 1992 The Biochemical Society and the Medical Research Society 1992 diabetes mellitus erythrocyte hyperlipidaemia hypertension lithium pregnancy sodium Clinical Science (1992) 82, 341-352 (Printed in Great Britain) Editorial Review 34...

View article titled, Erythrocyte sodium-lithium countertransport: clinically useful, pathophysiologically instructive or just phenomenology?

Articles

Kinetics of sodium-lithium countertransport activity in patients with uncomplicated type I diabetes

Peter A. Rutherford, Trevor H. Thomas, Susan J. Carr, Roy Taylor, Robert Wllklnson

Clin Sci (Lond) (1992) 82 (3): 291–299.

DOI: https://doi.org/10.1042/cs0820291

Published: 01 March 1992

...Peter A. Rutherford; Trevor H. Thomas; Susan J. Carr; Roy Taylor; Robert Wllklnson 1. Increased erythrocyte sodium-lithium countertransport activity has been reported to be associated with nephropathy in type 1 diabetes and linked to a family history of essential hypertension. 2. This study aimed...

View article titled, Kinetics of sodium-lithium countertransport activity in patients with uncomplicated type I diabetes

Articles

Membrane incorporation of non-esterified fatty acids and effects on the sodium pump of human erythrocytes

J. F. St. J. Dwight, A. C. Mendes Ribeiro, B. M. Hendry

Clin Sci (Lond) (1992) 82 (1): 99–104.

DOI: https://doi.org/10.1042/cs0820099

Published: 01 January 1992

...J. F. St. J. Dwight; A. C. Mendes Ribeiro; B. M. Hendry 1. Sodium pump function has been assessed by measurement of ouabain-sensitive 86 Rb uptake in human erythrocytes after incorporation of palmitic, stearic, oleic and linoleic acids into the erythrocyte membrane. 14 C-labelled fatty acids were...

View article titled, Membrane incorporation of non-esterified fatty acids and effects on the sodium pump of human erythrocytes

Articles

Na + ,K + -ATPase activity and hormones in single nephron segments from nephrotic rats

B. Vogt, H. Favre

Clin Sci (Lond) (1991) 80 (6): 599–604.

DOI: https://doi.org/10.1042/cs0800599

Published: 01 June 1991

...B. Vogt; H. Favre 1. In the nephrotic syndrome the kidneys retain salt and water, which leads to oedema formation. The site of this sodium retention has been localized in the cortical collecting tubule by micropuncture studies. Whether or not this phenomenon is an intrinsic renal problem...

View article titled, Na + ,K + -ATPase activity and hormones in single nephron segments from nephrotic rats

Articles

Na + /H + antiport and buffering capacity in human polymorphonuclear and mononuclear leucocytes

V. Frighi, L. L. Ng, A. Lewis, H. Dhar

Clin Sci (Lond) (1991) 80 (2): 95–99.

DOI: https://doi.org/10.1042/cs0800095

Published: 01 February 1991

..., although in vivo the presence of HCO − 3 /Cl − exchangers may also contribute to intracellular pH homoeostasis. 7 8 1990 16 8 1990 © 1991 The Biochemical Society and the Medical Research Society 1991 amiloride leucocytes pH sodium Clinical Science ( 199 1 ) 80, 95-99 95 Na+/H...

View article titled, Na + /H + antiport and buffering capacity in human polymorphonuclear and mononuclear leucocytes

Articles

A Serial Study of Erythrocyte Sodium Content and Sodium Pump Kinetics in Pregnancy

S. MacPhail, T. H. Thomas, R. Wilkinson, J. M. Davison, W. Dunlop

Clin Sci (Lond) (1990) 79 (6): 631–638.

DOI: https://doi.org/10.1042/cs0790631

Published: 01 December 1990

...S. MacPhail; T. H. Thomas; R. Wilkinson; J. M. Davison; W. Dunlop 1. Normotensive primigravid pregnant women were studied longitudinally during pregnancy and 20 weeks after delivery. 2. Erythrocyte sodium content, ouabain-sensitive sodium flux and sodium pump rate constant were measured in whole...

View article titled, A Serial Study of Erythrocyte Sodium Content and Sodium Pump Kinetics in Pregnancy

Articles

Stimulation of Active Renin Release in Normal and Hypertensive Pregnancy

Mark A. Brown, Vivienne C. Zammit, Delma Adsett

Clin Sci (Lond) (1990) 79 (5): 505–511.

DOI: https://doi.org/10.1042/cs0790505

Published: 01 November 1990

... of active renin is prematurely reset to that in the non-pregnant state but that secretion of active renin responds normally to posture. 14 5 1990 6 6 1990 © 1990 The Biochemical Society and the Medical Research Society 1990 angiotensin pregnancy-induced hypertension renin sodium...

View article titled, Stimulation of Active Renin Release in Normal and Hypertensive Pregnancy

Articles

Evidence for Abnormal Na + /H + Antiport Activity Detected by Phosphorus Nuclear Magnetic Resonance Spectroscopy in Exercising Skeletal Muscle of Patients with Essential Hypertension

C. R. K. Dudley, D. J. Taylor, L. L. Ng, G. J. Kemp, P. J. Ratcliffe, G. K. Radda, J. G. G. Ledingham

Clin Sci (Lond) (1990) 79 (5): 491–497.

DOI: https://doi.org/10.1042/cs0790491

Published: 01 November 1990

... 6 1990 © 1990 The Biochemical Society and the Medical Research Society 1990 hypertension leucocyte muscle nuclear magnetic resonance protons sodium Clinical Science ( 1 990) 79,491-497 49 1 Evidence for abnormal Na+ /H + antiport activity detected by phosphorus nuclear magnetic...

View article titled, Evidence for Abnormal Na + /H + Antiport Activity Detected by Phosphorus Nuclear Magnetic Resonance Spectroscopy in Exercising Skeletal Muscle of Patients with Essential Hypertension

Articles

Effect of Sodium-Transport Inhibitors on Airway Smooth Muscle Contractility in Vitro

Alan J. Knox, Paul Ajao, John R. Britton, Anne E. Tattersfield

Clin Sci (Lond) (1990) 79 (4): 315–323.

DOI: https://doi.org/10.1042/cs0790315

Published: 01 October 1990

...Alan J. Knox; Paul Ajao; John R. Britton; Anne E. Tattersfield 1. To determine whether alterations in membrane sodium transport in airway smooth muscle can alter its contractility, we studied the effect of ouabain (a Na + /K + -adenosine triphosphatase inhibitor) and amiloride on contractile...

View article titled, Effect of Sodium-Transport Inhibitors on Airway Smooth Muscle Contractility in Vitro

Articles

Time-course and relationship of the early changes in renal sodium excretion and aldosterone secretion during dietary sodium restriction in normal man

D. J. S. Carmichael, M. S. Sutters, R. J. Unwin, D. Gordon, J. Few, V. H. T. James, J. Wadsworth, W. S. Peart

Clin Sci (Lond) (1990) 78 (6): 605–612.

DOI: https://doi.org/10.1042/cs0780605

Published: 01 June 1990

...D. J. S. Carmichael; M. S. Sutters; R. J. Unwin; D. Gordon; J. Few; V. H. T. James; J. Wadsworth; W. S. Peart 1. The fall in renal sodium excretion after dietary sodium restriction is prompt and reproducible. The importance of increased aldosterone secretion during the early phase (within 48 h...

View article titled, Time-course and relationship of the early changes in renal sodium excretion and aldosterone secretion during dietary sodium restriction in normal man

Articles

Renal tubular reabsorption of sodium and water during infusion of low-dose dopamine in normal man

N. V. Olsen, J. M. Hansen, S. D. Ladefoged, N. Fogh-Andersen, P. P. Leyssac

Clin Sci (Lond) (1990) 78 (5): 503–507.

DOI: https://doi.org/10.1042/cs0780503

Published: 01 May 1990

...N. V. Olsen; J. M. Hansen; S. D. Ladefoged; N. Fogh-Andersen; P. P. Leyssac 1. Using the renal clearance of lithium ( C Li ) as an index of proximal tubular outflow of sodium and water, together with simultaneous measurements of effective renal plasma flow, glomerular filtration rate (GFR...

View article titled, Renal tubular reabsorption of sodium and water during infusion of low-dose dopamine in normal man

Articles

Overall renal and tubular function during infusion of amino acids in normal man

N. V. Olsen, J. M. Hansen, S. D. Ladefoged, N. Fogh-Andersen, S. Levin Nielsen, P. P. Leyssac

Clin Sci (Lond) (1990) 78 (5): 497–501.

DOI: https://doi.org/10.1042/cs0780497

Published: 01 May 1990

... and tubuloglomerular feedback activity. 2. Glomerular function and the renal tubular handling of sodium during infusion of amino acids was studied in 12 normal volunteers. 3. Clearance of sodium ( C Na ) was unchanged. Effective renal plasma flow increased slightly, but significantly, by 9% ( P <0.05). GFR...

View article titled, Overall renal and tubular function during infusion of amino acids in normal man

Articles

Increased spillover of dopa into arterial blood during dietary salt loading

Ehud Grossman, Aaron Hoffman, Peter C. Chang, Harry R. Keiser, David S. Goldstein

Clin Sci (Lond) (1990) 78 (4): 423–429.

DOI: https://doi.org/10.1042/cs0780423

Published: 01 April 1990

... Society 1990 denervation dopa dopamine natriuresis salt sodium Clinical Science (1990) 78,423-429 423 Increased spillover of dopa into arterial blood during dietary salt loading EHUD GROSSMAN', AARON HOFFMAN', PETER C. CHANG', HARRY R. KEISER' AND DAVID S. GOLDSTEIN' 'Hypertension-Endocrine...

View article titled, Increased spillover of dopa into arterial blood during dietary salt loading

Articles

myo -Inositol influx into human leucocytes: methods of measurement and the effect of glucose

D. Simmons, J. Bomford, L. L. Ng

Clin Sci (Lond) (1990) 78 (3): 335–341.

DOI: https://doi.org/10.1042/cs0780335

Published: 01 March 1990

... min −1 and a saturable component with a K m of 61 ± 23 μmol/l and a V max. of 11.3 ± 4.5 × 10 −4 mmol min −1 l −1 . Ouabain and low extracellular concentrations of sodium partly inhibited influx. Uptake was predominantly into the cytosolic fraction of the cell with 12% entering the membrane-associated...

View article titled, myo -Inositol influx into human leucocytes: methods of measurement and the effect of glucose

Articles

Ethanol predominantly alters sodium influx in human leucocytes

J. Main, T. Thomas

Clin Sci (Lond) (1990) 78 (2): 235–238.

DOI: https://doi.org/10.1042/cs0780235

Published: 01 February 1990

...J. Main; T. Thomas 1. Although ethanol appears to alter cellular sodium transport, the exact nature of its effects has not been clearly defined. We have studied the effects of different concentrations of ethanol on human leucocyte sodium content, and on the rise in leucocyte sodium content which...

View article titled, Ethanol predominantly alters sodium influx in human leucocytes

Articles

Intracellular pH Clamping of Human Leucocytes: A Technique for Determination of Cellular Buffering Power and Na + /H + Antiport Characteristics

L. L. Ng, C. Dudley

Clin Sci (Lond) (1989) 77 (4): 417–423.

DOI: https://doi.org/10.1042/cs0770417

Published: 01 October 1989

... and the Medical Research Society 1989 amiloride leucocytes sodium Clinical Science ( 1989) 77, 41 7-423 417 Intracellular pH clamping of human leucocytes: a technique for determination of cellular buffering power and Na+/H+ antiport characteristics L. L. NG AND C . DUDLEY Sheikh Rashid Diabetes Unit...

View article titled, Intracellular pH Clamping of Human Leucocytes: A Technique for Determination of Cellular Buffering Power and Na + /H + Antiport Characteristics

Articles

Problems in Measuring Human Leucocyte Cation Content: Effects of Cell Preparation and Handling

J. Main, T. H. Thomas, R. Wilkinson

Clin Sci (Lond) (1989) 77 (2): 157–160.

DOI: https://doi.org/10.1042/cs0770157

Published: 01 August 1989

...J. Main; T. H. Thomas; R. Wilkinson 1. Previous published measurements of leucocyte cation content are inconsistent, with sodium concentrations having particularly high coefficients of variation. We have measured the effects of recovery time after isolation, different types of handling...

View article titled, Problems in Measuring Human Leucocyte Cation Content: Effects of Cell Preparation and Handling

Articles

Effects of sodium depletion on renal prostanoid synthesis in rats: influence of the converting enzyme inhibitor captopril

M. Rathaus, E. Podjarny, A. Pomeranz, J. Shapira, N. Kariv, J. Bernheim

Clin Sci (Lond) (1989) 76 (5): 469–474.

DOI: https://doi.org/10.1042/cs0760469

Published: 01 May 1989

... angiotensin II prostaglandin E 2 prostaglandin F 2α prostaglandin I 2 sodium thromboxane Clinical Science (1989) 76,469-474 469 Effects of sodium depletion on renal prostanoid synthesis in rats: influence of the converting enzyme inhibitor captopril M. RATHAUS, E. PODJARNY, A. POMERANZ, J. SHAPIRA...

View article titled, Effects of sodium depletion on renal prostanoid synthesis in rats: influence of the converting enzyme inhibitor captopril

Articles

Endogenous digoxin-like immunoreactivity and erythrocyte sodium transport in uraemic patients undergoing dialysis

Ricardo J. Bosch, Natividad Hernando, Santos Casado, José M. Lopez-Novoa

Clin Sci (Lond) (1989) 76 (2): 157–163.

DOI: https://doi.org/10.1042/cs0760157

Published: 01 February 1989

... to be markers of secondary hypertension in these patients. 15 6 1988 22 6 1988 © 1989 The Biochemical Society and the Medical Research Society 1989 chronic renal failure co-transport countertransport endogenous digoxin-like immunoreactivity natriuretic hormone sodium sodium pump...

View article titled, Endogenous digoxin-like immunoreactivity and erythrocyte sodium transport in uraemic patients undergoing dialysis

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