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Tom Macleod, Charles Bridgewood, Isabel Hyde, Megan Heague, Philip Helliwell, Martin Stacey, Miriam Wittmann
Clin Sci (Lond) (2022) 136 (12): 935–952.
Published: 22 June 2022
... for this chronic disease. We consider both the skin and the musculoskeletal compartment and how different manifestations of psoriatic inflammation are linked. This review brings a focus to the importance of inflammatory feedback loops that exist in the initiation and chronic stages of the condition, and how close...
Clin Sci (Lond) (2022) 136 (8): 579–597.
Published: 21 April 2022
..., and disruption of the normal circadian rhythms has been linked to elevation of multiple health risks. The skin serves as a protective barrier to prevent microbial infection and maintain homoeostasis of the underlying tissue and the whole organism. However, in chronic non-healing wounds such as diabetic foot...
Steven Horsburgh, Nicola Fullard, Mathilde Roger, Abbie Degnan, Stephen Todryk, Stefan Przyborski, Steven O’Reilly
Clin Sci (Lond) (2017) 131 (15): 1923–1940.
Published: 13 July 2017
...Steven Horsburgh; Nicola Fullard; Mathilde Roger; Abbie Degnan; Stephen Todryk; Stefan Przyborski; Steven O’Reilly The skin is the largest organ of the integumentary system and possesses a vast number of functions. Due to the distinct layers of the skin and the variety of cells which populate each...
Sarah K. Steinbach, Terrence M. Yau, Maral Ouzounian, Husam Abdel-Qadir, Mark Chandy, Thomas K. Waddell, Mansoor Husain
Clin Sci (Lond) (2017) 131 (15): 1801–1814.
Published: 05 July 2017
... cell (VSMC) pathophysiology by examining VSMCs differentiated from progenitors found in skin. Approach and results : Skin-derived precursors (SKPs) were cultured from biopsies ( N =164, ∼1 cm 2 ) taken from the edges of surgical incisions of older adults ( N =158; males 72%; mean age 62.7 ± 13 years...
Clin Sci (Lond) (2011) 120 (3): 99–120.
Published: 20 October 2010
... biological processes, and this situation has been documented in active vitiligo skin. Tyrosinase activity is impaired by excess H 2 O 2 through oxidation of methionine residues in this key melanogenic enzyme. Mechanisms for repairing this oxidant damage are also damaged by H 2 O 2 , compounding the effect...
Patricia Sansilvestri-Morel, Florence Fioretti, Alain Rupin, Karim Senni, Jean Noël Fabiani, Gaston Godeau, Tony J. Verbeuren
Clin Sci (Lond) (2007) 112 (4): 229–239.
Published: 17 January 2007
... described and could be at the origin of its weakness and altered elasticity. We have described previously a dysregulation of collagen synthesis in cultured smooth muscle cells from saphenous veins and in dermal fibroblasts from the skin of patients with varicose veins, suggesting a systemic defect...
Clin Sci (Lond) (2003) 105 (5): 533–535.
Published: 01 November 2003
...Richard WELLER Nitric oxide (NO) is involved in several processes in the skin, including wound healing, pigmentation and regulation of apoptosis. Pharmacological intervention with NO donors appears to be a promising treatment for conditions such as diabetic ulceration. In this issue of Clinical...
Clin Sci (Lond) (2003) 105 (5): 577–584.
Published: 01 November 2003
... in decomposition rate between 19 and 37 °C. In the forearm of eight normal male subjects, we found that D -SNAG produced a significant dose-dependent vasodilator effect ( P =0.001) with good reproducibility (19%) on repeated testing. We propose that delivery of NO from D -SNAG to the forearm skin microvessels most...
Clin Sci (Lond) (2001) 101 (6): 567–572.
Published: 22 October 2001
..., methacholine, bradykinin and substance P were administered iontophoretically to the forearm skin of healthy volunteers on two to three occasions. Dose-dependent increases in skin microvascular blood flow in response to these drugs were measured with laser Doppler imaging. Vascular responses to acetylcholine...
Clin Sci (Lond) (2001) 100 (4): 395–400.
Published: 26 February 2001
... significant amounts of NO. The originally described system was messy and impractical, and the high acidity may cause pain and further tissue damage in ulcerated skin. To overcome this, a selectively permeable, hydrophilic polyester co-polymer membrane system (Sympatex™) has been identified that can be placed...
Clin Sci (Lond) (1995) 89 (1): 69–73.
Published: 01 July 1995
...Andrew E. Pocock; Martin J. O. Francis; Roger Smith 1. Skin fibroblast lines were cultured from nine patients who had the features of idiopathic juvenile osteoporosis, six relatives, five unrelated control subjects and three unrelated patients with osteogenesis imperfecta type I. Some patients...
Yves Cherel, Didier Attaix, Danuta Rosolowska-Huszcz, Rajae Belkhou, Jean-Patrice Robin, Maurice Arnal, Yvon Le Maho
Clin Sci (Lond) (1991) 81 (5): 611–619.
Published: 01 November 1991
... in the whole body. k s was selectively depressed in skeletal muscles, mainly owing to a reduced k RNA , and was not modified in heart, liver and skin. The contribution of skin to whole-body protein synthesis increased by 39%. 3. During the phase of protein sparing (5 days of fasting), k d in the whole body...
Clin Sci (Lond) (1986) 70 (3): 249–255.
Published: 01 March 1986
...Henry J. Duncan; Irwin B. Faris 1. A simplified isotope washout technique has been devised to calculate the skin perfusion pressure (SPP) and skin vascular resistance (SVR). This test is simple, requires inexpensive equipment and is well tolerated by patients. 2. SPP and SVR were calculated in 20...
Clin Sci (Lond) (1982) 63 (5): 461–472.
Published: 01 November 1982
... reached a steady state after 5–6 weeks of u.v. irradiation or of oral intake within the usual intake range. 6. Cholecalciferol synthesis in skin calculated from the steady-state equation was 0·0015 ± 0·0008 nmol/mJ. 7. Cholecalciferol synthesis in skin was also calculated from the oral dosage required...
Clin Sci (Lond) (1982) 62 (6): 605–609.
Published: 01 June 1982
... 1981 14 12 1981 © 1982 The Biochemical Society and the Medical Research Society 1982 blood flow head-up tilt nervous blockade skin spinal reflex tetraplegia vasoconstrictor response veno-arteriolar reflex Clinical Science (1982) 62,605-609 605 Sympathetic reflex control...
Clin Sci (Lond) (1982) 62 (2): 243–245.
Published: 01 February 1982
.... The underlying mechanism may be neuronal inhibition, probably antidromic, in sympathetic fibres. 21 9 1981 5 10 1981 © 1982 The Biochemical Society and the Medical Research Society 1982 Acute myocardial infarction local suction skin subatmospheric pressure subcutaneous blood flow veno...
Clin Sci (Lond) (1981) 60 (5): 499–506.
Published: 01 May 1981
... 1980 © 1981 The Biochemical Society and the Medical Research Society 1981 blood circulation blood pressure oxygen skin vascular diseases venous pressure Clinical Science (198 I) 60, 499-506 Dependence of transcutaneous oxygen tension on local arteriovenous pressure gradient...
Clin Sci (Lond) (1980) 58 (3): 235–242.
Published: 01 March 1980
...M. Davie; D. E. M. Lawson 1. The response of 25-hydroxyvitamin D [25-(OH)D] to artificial ultraviolet irradiation applied to a known area of dorsal skin was investigated in 18 subjects, small quantities of ultraviolet energy being used. Ultraviolet irradiation was administered on days, 1, 3, 5, 8...
Clin Sci Mol Med (1976) 51 (5): 467–474.
Published: 01 November 1976
...M. J. O. Francis; M. C. Sanderson; R. Smith 1. Skin collagen from fifteen patients with idiopathic adolescent scoliosis, three with congenital scoliosis, and fourteen patients with various degrees of Marfan's syndrome has been examined. 2. The stability of a polymeric collagen fraction, extracted...
Clin Sci Mol Med (1976) 50 (4): 307–310.
Published: 01 April 1976
...C. D. Moutafis; N. B. Myant 1. The specific radioactivity of [ 14 C]cholesterol in plasma and in serial biopsies of muscle and skin was measured in Rhesus monkeys for 156 days after a single intravenous injection of [ 14 C]cholesterol. 2. Analysis of the specific radioactivity—time curves in terms...