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Keywords: skeletal muscle
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Clin Sci (Lond) (2022) 136 (14): 1081–1110.
Published: 27 July 2022
...Chantal A. Pileggi; Breana G. Hooks; Ruth McPherson; Robert R.M. Dent; Mary-Ellen Harper Metabolic demands of skeletal muscle are substantial and are characterized normally as highly flexible and with a large dynamic range. Skeletal muscle composition (e.g., fiber type and mitochondrial content...
Clin Sci (Lond) (2021) 135 (22): 2589–2605.
Published: 26 November 2021
...Alyson Deprez; Zakaria Orfi; Alexandra Radu; Ying He; Daniela Ravizzoni Dartora; Junio Dort; Nicolas A. Dumont; Anne Monique Nuyt Individuals born preterm show reduced exercise capacity and increased risk for pulmonary and cardiovascular diseases, but the impact of preterm birth on skeletal muscle...
Includes: Supplementary data
Clin Sci (Lond) (2021) 135 (7): 979–990.
Published: 16 April 2021
... regulators of myogenic factors to regulate muscle development. The present study aimed to investigate the physical exercise impact on insulin-like growth factor 2 (IGF2) and analyzed its functions on skeletal muscle cells in vitro . Using online databases, we stated that IGF2 was relatively highly expressed...
Includes: Supplementary data
Clin Sci (Lond) (2020) 134 (22): 3047–3062.
Published: 24 November 2020
...-7 (Ang 1-7), which is considered to exert cellular responses to counteract the activation of the RAS primarily through a receptor, Mas, in multiple organs including skeletal muscle. Previous studies have provided abundant evidence suggesting that Ang 1-7 modulates multiple signalling pathways...
Includes: Supplementary data
Clin Sci (Lond) (2020) 134 (21): 2835–2850.
Published: 04 November 2020
...Maarten M. Steinz; Estela Santos-Alves; Johanna T. Lanner Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by synovitis and the presence of serum autoantibodies. In addition, skeletal muscle weakness is a common comorbidity that contributes to inability to work and reduced...
Clin Sci (Lond) (2020) 134 (17): 2381–2398.
Published: 16 September 2020
...Miao Chen; Caoyu Ji; Qingchen Yang; Shuya Gao; Yue Peng; Zhe Li; Xingyu Gao; Yaoting Li; Nan Jiang; Yubin Zhang; Xiaohong Bian; Caiping Chen; Kaidi Zhang; Daniel Sanchis; Fangrong Yan; Junmei Ye Skeletal muscle is responsible for the majority of glucose disposal in the body. Insulin resistance...
Includes: Supplementary data
Clin Sci (Lond) (2020) 134 (16): 2177–2187.
Published: 26 August 2020
...Edmund Battey; Matthew J. Stroud; Julien Ochala Skeletal muscle weakness is an important determinant of age-related declines in independence and quality of life but its causes remain unclear. Accelerated ageing syndromes such as Hutchinson–Gilford Progerin Syndrome, caused by mutations in genes...
Clin Sci (Lond) (2018) 132 (14): 1487–1507.
Published: 23 July 2018
... 1 receptor (AT1R)) to the detriment of the protective arm (ACE2/Ang 1-7/Mas receptor (MasR)). The components of the RAS are present locally in white adipose tissue (WAT) and skeletal muscle, which act co-operatively, through specific mediators, in response to pathophysiological changes. In WAT, up...
Clin Sci (Lond) (2017) 131 (21): 2643–2653.
Published: 27 October 2017
... mechanistic target of rapamycin nutrition protein synthesis skeletal muscle The increase in plasma amino acid (AA) concentration that follows ingestion, digestion, and absorption of dietary protein is the major anabolic drive contributing to the reversal of the postabsorptive net efflux of amino...
Clin Sci (Lond) (2017) 131 (15): 1919–1922.
Published: 07 July 2017
... , Ventura-Clapier et al. highlights the role of sexual dimorphism in mitochondrial function in health and disease. However, we feel the authors have overlooked arguably one of the most mitochondria-rich organs in skeletal muscle. Many studies have demonstrated that mitochondria have a central role...
Clin Sci (Lond) (2017) 131 (13): 1437–1447.
Published: 23 June 2017
... on skeletal muscle protein maintenance and carbohydrate metabolism during lipopolysaccharide (LPS)-induced endotoxaemia. Sprague-Dawley rats were fed either standard chow (control) or standard chow containing Rosi (8.5 ± 0.1 mg·kg −1 ·day −1 ) for 2 weeks before and during 24 h continuous intravenous infusion...
Clin Sci (Lond) (2016) 130 (24): 2245–2256.
Published: 04 November 2016
...). published by Portland Press Limited on behalf of the Biochemical Society 2016 large intervening non-coding RNA myocardium non-coding RNA skeletal muscle therapeutics It has been predicted that >75% of the entire human genome is transcribed into RNA, however only approximately 2–3% codes...
Clin Sci (Lond) (2016) 130 (11): 843–852.
Published: 22 April 2016
... the recent findings concerning the dysregulation of these processes in skeletal muscle in obesogenic conditions. 1 These authors contributed equally to this work. Correspondence: Dr Joris Hoeks (email j.hoeks@maastrichtuniversity.nl ). 5 11 2015 25 1 2016 12 2 2016 ©...
Clin Sci (Lond) (2016) 130 (1): 35–44.
Published: 30 November 2015
... involves activation of ATP-sensitive K + channels and phosphodiesterase inhibition. As both mechanisms are potentially involved in malignant hyperthermia (MH), in the present study we addressed the involvement of the L -cysteine/hydrogen sulfide pathway in MH. Skeletal muscle biopsies obtained from 25 MH...
Includes: Supplementary data
Clin Sci (Lond) (2015) 129 (7): 589–599.
Published: 14 July 2015
...Joaquin Perez-Schindler; Andrew Philp Skeletal muscle metabolism is highly dependent on mitochondrial function, with impaired mitochondrial biogenesis associated with the development of metabolic diseases such as insulin resistance and type 2 diabetes. Mitochondria display substantial plasticity...
Clin Sci (Lond) (2015) 128 (6): 357–365.
Published: 28 November 2014
...Marlou L. Dirks; Dominique Hansen; Aimé Van Assche; Paul Dendale; Luc J. C. Van Loon Fully sedated patients, being treated in the intensive care unit (ICU), experience substantial skeletal muscle loss. Consequently, survival rate is reduced and full recovery after awakening is compromised...
Includes: Supplementary data
Clin Sci (Lond) (2015) 128 (5): 307–319.
Published: 05 November 2014
...Franco Cisternas; María Gabriela Morales; Carla Meneses; Felipe Simon; Enrique Brandan; Johanna Abrigo; Yaneisi Vazquez; Claudio Cabello-Verrugio Skeletal muscle atrophy is a pathological condition characterized by the loss of strength and muscle mass, an increase in myosin heavy chain (MHC...
Includes: Supplementary data
Clin Sci (Lond) (2015) 128 (2): 143–151.
Published: 19 September 2014
... in skeletal muscle of obese subjects are elevated and inversely relate to insulin sensitivity. The present study aimed to investigate whether short-term high-fat high-calorie (HFHC) diet already increases macrophage markers and affects glucose metabolism in skeletal muscle of healthy lean subjects. Muscle...
Includes: Supplementary data
Clin Sci (Lond) (2014) 127 (12): 655–663.
Published: 08 August 2014
... by lipid deposition within the liver [intrahepatocellular lipid (IHCL)], is associated with insulin resistance and the metabolic syndrome (MS). It has been suggested that impaired skeletal muscle mitochondrial function may contribute to ectopic lipid deposition, and the associated MS, by altering post...
Clin Sci (Lond) (2014) 127 (5): 315–322.
Published: 07 May 2014
...Francis B. Stephens; Buddhike Mendis; Chris E. Shannon; Scott Cooper; Catharine A. Ortori; David A. Barrett; Peter Mansell; Kostas Tsintzas Acylcarnitine accumulation in skeletal muscle and plasma has been observed in numerous models of mitochondrial lipid overload and insulin resistance. Fish oil...
Includes: Supplementary data
Clin Sci (Lond) (2014) 127 (4): 251–264.
Published: 16 April 2014
...María Gabriela Morales; Johanna Ábrigo; Carla Meneses; Felipe Simon; Franco Cisternas; Juan Carlos Rivera; Yaneisi Vazquez; Claudio Cabello-Verrugio AngII (angiotensin II) induces pathological conditions such as fibrosis in skeletal muscle. In this process, AngII increases ROS (reactive oxygen...
Includes: Supplementary data
Clin Sci (Lond) (2013) 125 (8): 383–389.
Published: 14 June 2013
... (skeletal muscle) structure/function. We have demonstrated recently that (−)-ERC (epicatechin-rich cocoa) improves SkM mitochondrial structure [Taub, Ramirez-Sanchez, Ciaraldi, Perkins, Murphy, Naviaux, Hogan, Ceballos, Maisel, Henry et al. (2012) Clin. Trans. Sci. 5 , 43–47]. We hypothesized...
Clin Sci (Lond) (2013) 124 (11): 675–686.
Published: 15 February 2013
... and energy metabolism. The aim of the present study was to examine whether acute in vivo exposure of healthy humans to hyperinsulinaemia and hyperglycaemia have independent or additive effects on expression of key metabolic genes in skeletal muscle. On three randomized occasions, seven young subjects...
Includes: Supplementary data
Clin Sci (Lond) (2012) 123 (11): 611–625.
Published: 01 August 2012
... miRNAs are also essential for muscle function. In the present review, we outline the miRNAs involved in embryonic muscle development and those that have been found to be dysregulated in diseases associated with skeletal muscle or are changed during muscle adaptation. miRNAs are promising biomarkers...
Clin Sci (Lond) (2012) 122 (3): 133–142.
Published: 11 October 2011
... The Authors Journal compilation © 2012 Biochemical Society 2012 calpain caspase critical illness multiple organ dysfunction muscle wasting protein degradation sepsis skeletal muscle Skeletal muscle wasting is a common feature in different diseased states, e.g. cancer, sepsis, burns...
Clin Sci (Lond) (2010) 118 (8): 507–518.
Published: 26 January 2010
...Sean L. McGee; Mark Hargreaves Skeletal muscle phenotype plays a critical role in human performance and health, and skeletal muscle oxidative capacity is a key determinant of exercise tolerance. More recently, defective muscle oxidative metabolism has been implicated in a number of conditions...
Clin Sci (Lond) (2010) 118 (6): 421–427.
Published: 14 December 2009
... phenylalanine from skeletal muscle, whereas protein balance was unaffected. Both protein synthesis and breakdown were decreased to a similar extent. Correspondence: Dr Olav Rooyackers (email olav.rooyackers@ki.se ). 17 6 2009 9 9 2009 14 9 2009 14 9 2009 © The Authors Journal...
Clin Sci (Lond) (2009) 117 (9): 313–319.
Published: 01 September 2009
... and whole blood at baseline and hourly for 4 h after intravenous endotoxin injection and in skeletal muscle at baseline and at 2 and 4 h after endotoxin injection. In plasma, the concentration of total glutathione decreased 24% ( P <0.05) at 3 h after endotoxin injection and 32% ( P <0.001) at 4 h...
Clin Sci (Lond) (2009) 117 (8): 281–291.
Published: 24 August 2009
...William D.-C. Man; Paul Kemp; John Moxham; Michael I. Polkey Skeletal muscle dysfunction in COPD (chronic obstructive pulmonary disease) patients, particularly of the quadriceps, is of clinical interest because it not only influences the symptoms that limit exercise, but may also contribute...
Clin Sci (Lond) (2009) 117 (7): 251–264.
Published: 17 August 2009
...William D.-C. Man; Paul Kemp; John Moxham; Michael I. Polkey COPD (chronic obstructive pulmonary disease), although primarily a disease of the lungs, exhibits secondary systemic manifestations. The skeletal muscles are of particular interest because their function (or dysfunction) not only...
Clin Sci (Lond) (2007) 113 (7): 313–318.
Published: 03 September 2007
... and IV were not affected by ischaemia and reperfusion. Figure 1 Concentrations of energy-rich compounds and activities of mitochondrial enzymes in skeletal muscle preoperatively (pre), at maximal ischaemia (max) and after 24 h of reperfusion (reperf) in patients ( n =15) undergoing knee...
Includes: Supplementary data
Clin Sci (Lond) (2007) 112 (9): 499–506.
Published: 02 April 2007
...Maria Klaude; Katarina Fredriksson; Inga Tjäder; Folke Hammarqvist; Bo Ahlman; Olav Rooyackers; Jan Wernerman Patients with sepsis in the ICU (intensive care unit) are characterized by skeletal muscle wasting. This leads to muscle dysfunction that also influences the respiratory capacity, resulting...
Clin Sci (Lond) (2007) 112 (8): 457–466.
Published: 13 March 2007
..., and before any change in Akt phosphorylation or glucose uptake in muscle [ 7 ]. blood flow capillary glucose uptake insulin muscle oxygen uptake restricted nutritive capacity skeletal muscle The Biochemical Society 2007 6 11 2006 6 12 2006 6 12 2006 Figure 2...
Clin Sci (Lond) (2005) 108 (2): 159–165.
Published: 21 January 2005
..., skeletal muscle oxygenation was measured using a new Clark-type TC P O 2 [transcutaneous P O 2 (partial pressure of O 2 )]/ P CO 2 (partial pressure of CO 2 ) monitoring system and optical NIRS (near-infrared spectroscopy) at graded levels of hypoxaemia using a rabbit model ( n =6). The TC P O 2 / P CO 2...
Clin Sci (Lond) (2004) 107 (6): 601–607.
Published: 24 November 2004
...). The other 20 patients were subjected to major abdominal surgery and were therefore scheduled to stay overnight in the recovery room during the first postoperative night (defined as major surgery). Protein FSRs (fractional synthesis rates) in skeletal muscle were determined during a measurement period of 90...
Clin Sci (Lond) (2004) 106 (3): 241–249.
Published: 01 March 2004
... dehydrogenase complex (PDCa) in skeletal muscle. Ten patients with IC and peripheral arterial disease [ankle/brachial index (ABI)=0.73±0.13] and eight healthy controls (ABI=1.17±0.13) completed three maximal walking tests. From these tests, averaged estimates of walking time, peak V O 2 and the time constant...
Clin Sci (Lond) (2003) 104 (3): 287–294.
Published: 18 February 2003
...Michael KOLL; Julie A. BEESO; Frank J. KELLY; Ulrich A. SIMANOWSKI; Helmut K. SEITZ; Timothy J. PETERS; Victor R. PREEDY Chronic alcohol muscle disease is characterized by reduced skeletal muscle mass precipitated by acute reduction in protein synthesis. The pathogenic mechanisms remain obscure...
Clin Sci (Lond) (2003) 104 (3): 275–282.
Published: 14 February 2003
...U.B. FLÄRING; O.E. ROOYACKERS; J. WERNERMAN; F. HAMMARQVIST Glutathione is quantitatively the most important endogenous scavenger system. Glutathione depletion in skeletal muscle is pronounced following major trauma and sepsis in intensive care unit patients. Also, following elective surgery...
Clin Sci (Lond) (2003) 104 (2): 153–162.
Published: 17 January 2003
... L.vanLoon@HB.Unimaas.nl ). 18 6 2002 13 9 2002 14 11 2002 The Biochemical Society and the Medical Research Society © 2003 2003 creatine phosphate ergogenic aids functional foods metabolism oxidative capacity skeletal muscle substrate utilization 153Clinical Science...
Clin Sci (Lond) (2002) 102 (5): 531–539.
Published: 18 April 2002
... 22 11 2001 31 1 2001 The Biochemical Society and the Medical Research Society © 2002 2002 electrical stimulation fatigue MAD deficiency skeletal muscle 531Clinical Science (2002) 102, 531 539 (Printed in Great Britain) Muscle function during repetitive moderate- intensity...
Clin Sci (Lond) (2001) 101 (6): 551–558.
Published: 26 October 2001
...Daniel LARBAUD; Michèle BALAGE; Daniel TAILLANDIER; Lydie COMBARET; Jean GRIZARD; Didier ATTAIX In order to characterize the poorly defined mechanisms that account for the anti-proteolytic effects of insulin in skeletal muscle, we investigated in rats the effects of a 3h systemic euglycaemic...
Clin Sci (Lond) (2001) 100 (3): 283–290.
Published: 30 January 2001
...Andrew D. H. CLARK; Eugene J. BARRETT; Stephen RATTIGAN; Michelle G. WALLIS; Michael G. CLARK Insulin-mediated increases in limb blood flow are thought to enhance glucose uptake by skeletal muscle. Using the perfused rat hindlimb, we report that macro laser Doppler flowmetry (LDF) probes positioned...
Clin Sci (Lond) (2000) 98 (5): 579–585.
Published: 05 April 2000
...C. J. DE RUITER; B. G. M. VAN ENGELEN; R. A. WEVERS; A. DE HAAN Myoadenylate deaminase (MAD) is an enzyme active in skeletal muscle, probably during exercise of moderate intensity but certainly during vigorous exercise, when the deamination of AMP leads to increased levels of IMP and ammonia...
Clin Sci (Lond) (2000) 98 (3): 329–337.
Published: 10 February 2000
...F. CAQUELARD; H. BURNET; F. TAGLIARINI; E. CAUCHY; J. P. RICHALET; Y. JAMMES This study tested the hypothesis that a prolonged decrease in arterial oxygen pressure in resting or contracting skeletal muscles alters their ability to develop force through an impairment of energy-dependent metabolic...
Clin Sci (Lond) (2000) 98 (3): 339–347.
Published: 09 February 2000
...@physiology.unimelb.edu.au ). 17 2 1999 15 9 1999 25 10 1999 The Biochemical Society and the Medical Research Society © 2000 2000 2-adrenoceptor agonists cardiac muscle exercise skeletal muscle sprint training swimming 339Clinical Science (2000) 98, 339 347 (Printed in Great Britain...
Clin Sci (Lond) (1999) 97 (4): 449–455.
Published: 24 August 1999
...-operative insulin resistance single fibres skeletal muscle specific tension 449Clinical Science (1999) 97, 449 455 (Printed in Great Britain) Post-operative effects on insulin resistance and specific tension of single human skeletal muscle fibres Hans DEGENS Mattias SOOPŒ, Peter HO$ O$ K Olle...
Clin Sci (Lond) (1997) 93 (2): 159–165.
Published: 01 August 1997
... 9 4 1997 © 1997 The Biochemical Society and the Medical Research Society 1997 l-arginine cyclic GMP nitric oxide positron emission tomography skeletal muscle Clinical Science (I 997) 93, 159- 165 (Printed in Great Britain) I59 Dose-related effect of intravenous L-arginine...
Clin Sci (Lond) (1997) 93 (2): 167–174.
Published: 01 August 1997
... on skeletal muscle survival following 2 h of tourniquet ischaemia and 24 h of reperfusion were compared with those of the antiinflammatory steroid, dexamethasone. 2. Administration of each of the NOS inhibitors or dexamethasone 30 min before reperfusion reduced the degree of skeletal muscle necrosis 24 h...
Clin Sci (Lond) (1995) 89 (6): 581–590.
Published: 01 December 1995
... P magnetic resonance spectroscopy skeletal muscle vascular disease Clinical Science (1995) 89, 581-590 (Printed in Great Britain) 581 Calf muscle mitochondria1 and glycogenolytic ATP synthesis in patients with claudication due to peripheral vascular disease analysed using 31P magnetic resonance...
Clin Sci (Lond) (1995) 88 (5): 543–550.
Published: 01 May 1995
... intake ( P < 0.01). The integrated increase in leg oxygen uptake was 305.1 ± 394.3 μmol 240 min −1 100 g −1 . Assuming leg oxygen uptake mainly represents average skeletal muscle, the skeletal muscle mass can explain around 45% of the whole-body glucose-induced thermogenesis. 3. It is concluded...