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Keywords: signalling
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Articles
Clin Sci (Lond) (2022) 136 (12): 911–934.
Published: 20 June 2022
... clinical target for regenerative therapies that can preserve contractile function and thus prevent the development of heart failure. Our review focuses on recent progress in understanding the tight regulation of signaling pathways and their downstream molecular mechanisms that underly the inability of CM...
Articles
Clin Sci (Lond) (2020) 134 (13): 1637–1658.
Published: 01 July 2020
...Gianluca Baldanzi; Beatrice Ragnoli; Mario Malerba The mechanism promoting exacerbated immune responses in allergy and autoimmunity as well as those blunting the immune control of cancer cells are of primary interest in medicine. Diacylglycerol kinases (DGKs) are key modulators of signal...
Articles
Clin Sci (Lond) (2017) 131 (18): 2319–2345.
Published: 25 August 2017
...-cardiomyocyte interactions, oxidative stress, endoplasmic reticulum (ER) stress, autophagy alterations, impairment of metabolism and signalling pathways), leading to HF. This review describes the key molecular and cellular responses involved in pathological cardiac remodelling. Correspondence : Qi-zhu Tang...
Articles
Clin Sci (Lond) (2017) 131 (1): 13–23.
Published: 01 December 2016
... challenge is to explain how neurotrophins are able to induce plasticity, improve learning and memory and prevent age-dependent cognitive decline through receptor signalling. This article will review the mechanism of action of neurotrophins and how BDNF/tropomyosin receptor kinase B (TrkB) receptor signaling...
Articles
Clin Sci (Lond) (2015) 129 (12): 1237–1249.
Published: 11 November 2015
... signalling pathways via co-ordinated repression of mothers against decapentaplegic homolog 7 (SMAD7) and phosphatase and tensin homologue (PTEN) respectively. This represents a previously uncharacterized interaction axis between miR-21 and PTEN–SMAD7. Targeting of these proteins by miR-21 resulted in de...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2014) 127 (4): 217–231.
Published: 10 April 2014
...Stacey J. Coleman; Charo Bruce; Athina-Myrto Chioni; Hemant M. Kocher; Richard P. Grose FGFR (fibroblast growth factor receptor) signalling plays critical roles in embryogensis, adult physiology, tissue repair and many pathologies. Of particular interest over recent years, it has been implicated...
Articles
Clin Sci (Lond) (2014) 126 (4): 275–288.
Published: 14 October 2013
... in mice attenuated TGF-β signalling, protected mice against progressive ventricular dysfunction, and significantly reduced the mortality after experimental MI (myocardial infarction). In the present study, we investigated the role of fibulin-2 in AngII-induced TGF-β signalling and subsequent cardiac...