... sitting evokes vascular dysfunction and that this dysfunction is caused by reduced shear stress. This commentary highlights this series of investigations and culminates with an overview of how prior exercise and standing are effective strategies to circumvent vascular dysfunction that is caused...

... Society 2017 aerobic exercise blood flow endothelial function shear stress sitting Peripheral artery disease preferentially develops in the vasculature of the lower extremities [ 1 – 4 ]; however, factors contributing to the increased predisposition of the leg vasculature...

...Yu-Wen Chen; Yi-Ching Chen; Jong-Shyan Wang HS (high shear) stress associated with artery stenosis facilitates TG (thrombin generation) by increasing the release of procoagulant PDMPs (platelet-derived microparticles). Physical exercise and hypoxia may paradoxically modulate vascular thrombotic...

...Kou-Gi Shyu Cells in the cardiovascular system are permanently subjected to mechanical forces due to the pulsatile nature of blood flow and shear stress, created by the beating heart. These haemodynamic forces play an important role in the regulation of vascular development, remodelling, wound...

... shear stress vasoconstriction vascular tone Adequate blood supply to tissues is an absolute requirement for survival from the time that embryos reach a body length of approx. 2 mm; furthermore, perfusion demands change throughout development and with many physiological adaptations in adults...

... function handgrip exercise hyperaemia occlusion shear stress vasodilation Blood flow exerts a frictional force on the endothelial surface of the vessel lumen known as haemodynamic shear stress [ 1 ]. This mechanical stimulus triggers the release of nitric oxide from the endothelium, which...

... Society 2002 coronary flow coronary vasoconstriction nitric oxide shear stress 376S Clinical Science (2002) 103 (Suppl. 48), 376S 379S (Printed in Great Britain) Coronary effects of endothelin-1 during acute hypertension in anaesthetized goats Nuria FERNA; NDEZ, Mar !a ANGELES MARTI;NEZ, Angel...

... The Biochemical Society and the Medical Research Society 2002 endothelial nitric oxide synthase pulmonary vascular remodelling endothelin-1 shear stress 289SClinical Science (2002) 103 (Suppl. 48), 289S 293S (Printed in Great Britain) Effects of increased pulmonary flow on the expression...

... decreased after infusion of either saline or alcohol, but was unchanged after oral ethanol administration. Both oral and intravenous ethanol administration were associated with significant decreases in baroreflex sensitivity, carotid shear stress and blood velocity, compared with resting values, while...

... that this particular aspect of endothelial function is not impaired in this setting. 24 10 1997 31 10 1997 © 1998 The Biochemical Society and the Medical Research Society 1998 body cooling flow-mediated dilatation nitric oxide Raynaud's disease shear stress Clinical Science (1998) 94,239...

...Jaime Levenson; Marie-Aude Devynck; Isabelle Pithois-Merli; Kim Hanh Le Quan Sang; Vincenzo Filitti; Alain Simon 1. Blood cells and vascular endothelial cells are subjected to a wide range of haemodynamically generated shear stress forces. In vitro , membrane stretching or shear stress have been...

... raised pressure, suggesting altered arterial wall mechanics in essential hypertension. 3. These abnormalities will influence the wall shear stress, a major determinant of arterial function. The abnormal arterial wall mechanics and abnormal blood flow pattern may contribute to the increased risk...