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Keywords: sepsis
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Clin Sci (Lond) (2024) 138 (1): 65–85.
Published: 10 January 2024
...Kate Davies; James E. McLaren Sepsis is a heterogeneous condition defined as life-threatening organ dysfunction caused by a dysregulated host response to infection. For some, sepsis presents as a predominantly suppressive disorder, whilst others experience a pro-inflammatory condition which can...
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Clin Sci (Lond) (2023) 137 (18): 1499–1512.
Published: 26 September 2023
...Shuan Dong; Shasha Liu; Qiaoying Gao; Jia Shi; Kai Song; Ya Wu; Huayang Liu; Chenxu Guo; Yan Huang; Shihan Du; Xiangyun Li; Lixiu Ge; Jianbo Yu Background: Sepsis engenders an imbalance in the body’s inflammatory response, with cytokines assuming a pivotal role in its progression. A relatively...
Includes: Supplementary data
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Clin Sci (Lond) (2023) 137 (11): 881–893.
Published: 14 June 2023
...Jeroson C. Williams; Mandy L. Ford; Craig M. Coopersmith Sepsis is one of the leading causes of death worldwide. While mortality is high regardless of inciting infection or comorbidities, mortality in patients with cancer and sepsis is significantly higher than mortality in patients with sepsis...
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Clin Sci (Lond) (2023) 137 (8): 645–662.
Published: 21 April 2023
...Wiwat Chancharoenthana; Supitcha Kamolratanakul; Marcus J. Schultz; Asada Leelahavanichkul Both a leaky gut (a barrier defect of the intestinal surface) and gut dysbiosis (a change in the intestinal microbial population) are intrinsic to sepsis. While sepsis itself can cause dysbiosis, dysbiosis...
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Clin Sci (Lond) (2023) 137 (6): 401–414.
Published: 21 March 2023
...Tatiana Barichello; Vijayasree V Giridharan; Carlos Henrique R Catalão; Cristiane Ritter; Felipe Dal-Pizzol Sepsis is a life-threatening organ dysfunction triggered by a dysregulated host immune response to eliminate an infection. After the host immune response is activated, a complex, dynamic...
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Clin Sci (Lond) (2023) 137 (5): 333–351.
Published: 01 March 2023
...Clara Vigneron; Bénédicte F. Py; Guillaume Monneret; Fabienne Venet Sepsis is defined as a life-threatening organ dysfunction induced by a dysregulated host immune response to infection. Immune response induced by sepsis is complex and dynamic. It is schematically described as an early dysregulated...
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Clin Sci (Lond) (2022) 136 (24): 1877–1891.
Published: 22 December 2022
...Honglin Li; Zhiwen Liu; Ying Wang; Hui Wang; Juan Cai; Chengyuan Tang; Zheng Dong Sepsis is a leading cause of acute kidney injury (AKI), and the pathogenesis of septic AKI remains largely unclear. Parkinson disease protein 7 (PARK7) is a protein of multiple functions that was recently implicated...
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Clin Sci (Lond) (2022) 136 (13): 1045.
Published: 04 July 2022
... © 2022 The Author(s). 2022 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . Critical Illness Fasting Hypercortisolemia Ketogenesis Sepsis Tight...
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Clin Sci (Lond) (2022) 136 (11): 861–878.
Published: 01 June 2022
...Arno Téblick; Jan Gunst; Lies Langouche; Greet Van den Berghe Sepsis is defined as any life-threatening organ dysfunction caused by a dysregulated host response to infection. It remains an important cause of critical illness and has considerable short- and long-term morbidity and mortality...
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Clin Sci (Lond) (2021) 135 (20): 2341–2356.
Published: 18 October 2021
...Thiele Osvaldt Rosales; Verônica Vargas Horewicz; Marcella Amorim Ferreira; Geisson Marcos Nardi; Jamil Assreuy Renal vascular reactivity to vasoconstrictors is preserved in sepsis in opposition to what happens in the systemic circulation. We studied whether this distinct behavior was related to α1...
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Clin Sci (Lond) (2018) 132 (19): 2087–2101.
Published: 02 October 2018
... on behalf of the Biochemical Society 2018 acute kidney injury endothelin-1 fibroblast mTORC1 sepsis TSC1 Sepsis, a dysregulated host response to severe infection [ 1 ], has been shown to occur in 32.4–47.5% of critically ill patients with acute kidney injury (AKI). It is associated...
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Clin Sci (Lond) (2015) 129 (5): 423–437.
Published: 11 June 2015
.... This hypometabolic phenotype triggered by glucocorticoid-induced mitochondrial dysfunction activating the NLRP1 inflammasome prevents normal lymphocyte functionality and increases apoptosis. apoptosis inflammasome lymphocyte metabolism mitochondria sepsis • The mechanism underlying...
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Clin Sci (Lond) (2015) 128 (1): 57–67.
Published: 29 August 2014
...Yvette C. Luiking; Martijn Poeze; Nicolaas E. Deutz Arginine deficiency in sepsis may impair nitric oxide (NO) production for local perfusion and add to the catabolic state. In contrast, excessive NO production has been related to global haemodynamic instability. Therefore, the aim of the present...
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Clin Sci (Lond) (2013) 124 (6): 389–390.
Published: 27 November 2012
... cycling in cardiac tissue of rats with early sepsis could discriminate survivors from non-survivors. These findings underscore the great potential of systems biology in translational medicine. However, further investigations should be done to make the benchside results more feasible for routine clinical...
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Clin Sci (Lond) (2012) 123 (3): 173–192.
Published: 12 April 2012
... of antioxidant processes that reside in every cell. In the present review, we provide an overview of the mitochondrial generation of ROS and discuss the role of ROS in the regulation of endothelial and adipocyte function. Moreover, we also discuss recent findings on the role of ROS in sepsis, cerebral ataxia...
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Clin Sci (Lond) (2012) 122 (3): 133–142.
Published: 11 October 2011
..., we investigated whether muscle protein degradation is increased in critically ill patients with sepsis and which proteolytic enzyme systems are involved in this degradation. Eight patients and seven healthy volunteers were studied. In vivo muscle protein kinetics was measured using arteriovenous...
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Clin Sci (Lond) (2010) 118 (6): 421–427.
Published: 14 December 2009
...Rokhsareh F. Vesali; Norbert Cibicek; Towe Jakobsson; Maria Klaude; Jan Wernerman; Olav Rooyackers The human endotoxin model has been used to study the early phase of sepsis. The aim of the present study was to assess leg muscle protein kinetics after an endotoxin challenge given to healthy human...
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Clin Sci (Lond) (2009) 117 (9): 313–319.
Published: 01 September 2009
... of glutathione status and glutathione kinetics in healthy volunteers during the initial phase of sepsis using a human endotoxin model. The present study was a descriptive pilot study in healthy male volunteers ( n =8) before and after an endotoxin challenge. The glutathione status was determined in plasma...
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Clin Sci (Lond) (2009) 116 (9): 721–730.
Published: 02 April 2009
...Visith Thongboonkerd; Wararat Chiangjong; Jan Mares; Jiri Moravec; Zdenek Tuma; Thomas Karvunidis; Supachok Sinchaikul; Shui-Tein Chen; Karel Opatrný, Jr; Martin Matejovic Sepsis is a systemic response to infection commonly found in critically ill patients and is associated with multi-organ failure...
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Clin Sci (Lond) (2007) 112 (9): 499–506.
Published: 02 April 2007
...Maria Klaude; Katarina Fredriksson; Inga Tjäder; Folke Hammarqvist; Bo Ahlman; Olav Rooyackers; Jan Wernerman Patients with sepsis in the ICU (intensive care unit) are characterized by skeletal muscle wasting. This leads to muscle dysfunction that also influences the respiratory capacity, resulting...
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Clin Sci (Lond) (2000) 99 (6): 489–496.
Published: 07 November 2000
...Quan WANG; Xiaoyan SUN; Timothy A. PRITTS; Hector R. WONG; Per-Olof HASSELGREN Previous studies suggest that production of interleukin-6 (IL-6) is increased in the intestinal mucosa during sepsis and endotoxaemia. We tested the hypothesis that mucosal IL-6 production during endotoxaemia...
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Clin Sci (Lond) (2000) 99 (4): 321–328.
Published: 05 September 2000
...Cécile CHAMBRIER; Martine LAVILLE; Khalid RHZIOUAL BERRADA; Michelle ODEON; Paul BOULÉTREAU; Michel BEYLOT In order to quantify the changes in insulin sensitivity, particularly of endogenous glucose production and fat metabolism, in patients with severe sepsis, a prospective study was conducted...
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Clin Sci (Lond) (2000) 98 (2): 193–200.
Published: 11 January 2000
... increase in blood pressure as observed in matched sheep of the l -NMMA group (non-septic phase). Treatment was discontinued after 3 h. Sepsis was initiated and maintained by a continuous infusion of live Pseudomonas aeruginosa . After 24 h of sepsis, the sheep were again challenged over a treatment period...
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Clin Sci (Lond) (1999) 97 (5): 529–538.
Published: 15 September 1999
... and monocytes, and higher concentrations of IL-6, IL-8 and sIL-2R. C-reactive protein and soluble E-selectin concentrations did not differ between groups. No parameter alone identified all patients that subsequently developed OF. However, a sepsis-related inflammation severity score (SISS), developed...
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Clin Sci (Lond) (1998) 95 (4): 467–478.
Published: 01 October 1998
... injury normally found during sepsis in our porcine model. 8. These findings suggest that during sepsis a protective endogenous β 2 adrenergic receptor-mediated anti-inflammatory response is activated via cell membrane transduction to stimulate the trimeric G-protein complex Gs and activate the second...
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