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Keywords: sepsis
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Clin Sci (Lond) (2022) 136 (24): 1877–1891.
Published: 22 December 2022
...Honglin Li; Zhiwen Liu; Ying Wang; Hui Wang; Juan Cai; Chengyuan Tang; Zheng Dong Sepsis is a leading cause of acute kidney injury (AKI), and the pathogenesis of septic AKI remains largely unclear. Parkinson disease protein 7 (PARK7) is a protein of multiple functions that was recently implicated...
Clin Sci (Lond) (2022) 136 (13): 1045.
Published: 04 July 2022
... Critical Illness Fasting Hypercortisolemia Ketogenesis Sepsis Tight glucose control © 2022 The Author(s). 2022 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License...
Clin Sci (Lond) (2022) 136 (11): 861–878.
Published: 01 June 2022
...Arno Téblick; Jan Gunst; Lies Langouche; Greet Van den Berghe Sepsis is defined as any life-threatening organ dysfunction caused by a dysregulated host response to infection. It remains an important cause of critical illness and has considerable short- and long-term morbidity and mortality...
Clin Sci (Lond) (2021) 135 (20): 2341–2356.
Published: 18 October 2021
...Thiele Osvaldt Rosales; Verônica Vargas Horewicz; Marcella Amorim Ferreira; Geisson Marcos Nardi; Jamil Assreuy Renal vascular reactivity to vasoconstrictors is preserved in sepsis in opposition to what happens in the systemic circulation. We studied whether this distinct behavior was related to α1...
Clin Sci (Lond) (2020) 134 (13): 1715–1734.
Published: 10 July 2020
...Manasi Nandi; Simon K. Jackson; Duncan Macrae; Manu Shankar-Hari; Jordi L. Tremoleda; Elliot Lilley Sepsis is a major worldwide healthcare issue with unmet clinical need. Despite extensive animal research in this area, successful clinical translation has been largely unsuccessful. We propose one...
Clin Sci (Lond) (2020) 134 (13): 1677.
Published: 07 July 2020
... Figure 3 Effect of IL-4 and GdCl 3 treatment on microglia activation after sepsis Sepsis was induced by cecal ligation and perforation (CLP), and immediately following surgery animals were treated with IL-4 or GdCl 3 . Animals were killed at 24 h, 3 or 10 days after surgery and IBA-1...
Clin Sci (Lond) (2020) 134 (7): 765–776.
Published: 07 April 2020
... of gadolinium chloride and the expression of M2 microglia was induced by IL-4 administration in an animal model of sepsis to better characterize the role of microglial phenotypes in sepsis-induced brain dysfunction. Methods: Wistar rats were submitted to sham or cecal ligation and perforation (CLP) and treated...
Clin Sci (Lond) (2019) 133 (18): 1993–2004.
Published: 24 September 2019
... Ritter; Felipe Dal-Pizzol Background: Several different mechanisms have been proposed to explain long-term cognitive impairment in sepsis survivors. The role of persisting mitochondrial dysfunction is not known. We thus sought to determine whether stimulation of mitochondrial dynamics improves...
Includes: Supplementary data
Clin Sci (Lond) (2018) 132 (19): 2087–2101.
Published: 02 October 2018
... on behalf of the Biochemical Society 2018 acute kidney injury endothelin-1 fibroblast mTORC1 sepsis TSC1 Sepsis, a dysregulated host response to severe infection [ 1 ], has been shown to occur in 32.4–47.5% of critically ill patients with acute kidney injury (AKI). It is associated...
Includes: Supplementary data
Clin Sci (Lond) (2018) 132 (13): 1433–1438.
Published: 18 July 2018
...Amel Komic; Patricia Martinez-Quinones; Cameron G. McCarthy; R. Clinton Webb; Camilla F. Wenceslau Sepsis is a profoundly morbid and life-threatening condition, and an increasingly alarming burden on modern healthcare economies. Patients with septic shock exhibit persistent hypotension despite...
Clin Sci (Lond) (2017) 131 (8): 747–758.
Published: 06 April 2017
...Jerome Morel; Iain Hargreaves; David Brealey; Viruna Neergheen; Janne T. Backman; Sandro Lindig; Marcus Bläss; Michael Bauer; Daniel F. McAuley; Mervyn Singer Statins may offer protective effects in sepsis through anti-inflammatory, mitochondrial protection and other actions. We thus evaluated...
Includes: Supplementary data
Clin Sci (Lond) (2016) 130 (4): 259–271.
Published: 14 January 2016
...Veronica I. Landoni; Daiana Martire-Greco; Nahuel Rodriguez-Rodrigues; Paula Chiarella; Pablo Schierloh; Martin A. Isturiz; Gabriela C. Fernández Secondary infections due to post-sepsis immunosuppression are a major cause of death in patients with sepsis. Repetitive inoculation of increasing doses...
Includes: Supplementary data
Clin Sci (Lond) (2015) 129 (5): 423–437.
Published: 11 June 2015
.... This hypometabolic phenotype triggered by glucocorticoid-induced mitochondrial dysfunction activating the NLRP1 inflammasome prevents normal lymphocyte functionality and increases apoptosis. apoptosis inflammasome lymphocyte metabolism mitochondria sepsis • The mechanism underlying a potential...
Includes: Supplementary data
Clin Sci (Lond) (2015) 129 (1): 49–61.
Published: 01 April 2015
...Ting He; Jiongyu Hu; Guangning Yan; Lingfei Li; Dongxia Zhang; Qiong Zhang; Bing Chen; Yuesheng Huang The integrity of the vascular barrier, which is essential to blood vessel homoeostasis, can be disrupted by a variety of soluble permeability factors during sepsis. Pigment epithelium-derived...
Includes: Supplementary data
Clin Sci (Lond) (2015) 128 (1): 57–67.
Published: 29 August 2014
...Yvette C. Luiking; Martijn Poeze; Nicolaas E. Deutz Arginine deficiency in sepsis may impair nitric oxide (NO) production for local perfusion and add to the catabolic state. In contrast, excessive NO production has been related to global haemodynamic instability. Therefore, the aim of the present...
Includes: Supplementary data
Clin Sci (Lond) (2014) 126 (12): 857–867.
Published: 05 March 2014
... with sepsis. The target genes were predicted by bioinformatics analysis; the levels of the respective proteins in the sera of patients with sepsis were detected by ELISA. ACVR2A (activin A receptor, type IIA), FOXO1 (forkhead box O1), IHH (Indian hedgehog), STK4 (serine/threonine kinase 4) and DUSP3 (dual...
Clin Sci (Lond) (2014) 126 (5): 355–365.
Published: 01 November 2013
...Daiana Martire-Greco; Veronica I. Landoni; Paula Chiarella; Nahuel Rodriguez-Rodrigues; Pablo Schierloh; Barbara Rearte; Martin A. Isturiz; Gabriela C. Fernandez Secondary infections due to post-sepsis immunosuppression are a major cause of death in patients with sepsis. Strategies aimed...
Clin Sci (Lond) (2013) 125 (3): 131–141.
Published: 12 April 2013
...: Dr Chin-Wei Chiao (email chinwei.chiao@msa.hinet.net ). 5 9 2012 16 1 2013 7 3 2013 7 3 2013 © The Authors Journal compilation © 2013 Biochemical Society 2013 cyclo-oxygenase interleukin-1β lipopolysaccharide nitric oxide synthase P2X 7 receptor sepsis tumour...
Clin Sci (Lond) (2013) 125 (2): 77–85.
Published: 26 March 2013
...Hadj Ahmed Mostefai; Jean-Michel Bourget; Ferhat Meziani; Maria Carmen Martinez; Daniela Leonetti; Alain Mercat; Pierre Asfar; Lucie Germain; Ramaroson Andriantsitohaina During sepsis, inflammation can be orchestrated by the interaction between circulating and vascular cells that, under activation...
Clin Sci (Lond) (2013) 124 (6): 389–390.
Published: 27 November 2012
... cycling in cardiac tissue of rats with early sepsis could discriminate survivors from non-survivors. These findings underscore the great potential of systems biology in translational medicine. However, further investigations should be done to make the benchside results more feasible for routine clinical...
Clin Sci (Lond) (2013) 124 (6): 391–401.
Published: 27 November 2012
...Alain Rudiger; Alex Dyson; Karen Felsmann; Jane E. Carré; Valerie Taylor; Sian Hughes; Innes Clatworthy; Alessandro Protti; Denis Pellerin; Jana Lemm; Ralf A. Claus; Michael Bauer; Mervyn Singer Myocardial function is depressed in sepsis and is an important prognosticator in the human condition...
Includes: Supplementary data
Clin Sci (Lond) (2012) 123 (3): 173–192.
Published: 12 April 2012
... of antioxidant processes that reside in every cell. In the present review, we provide an overview of the mitochondrial generation of ROS and discuss the role of ROS in the regulation of endothelial and adipocyte function. Moreover, we also discuss recent findings on the role of ROS in sepsis, cerebral ataxia...
Clin Sci (Lond) (2012) 122 (3): 133–142.
Published: 11 October 2011
..., we investigated whether muscle protein degradation is increased in critically ill patients with sepsis and which proteolytic enzyme systems are involved in this degradation. Eight patients and seven healthy volunteers were studied. In vivo muscle protein kinetics was measured using arteriovenous...
Clin Sci (Lond) (2010) 118 (6): 421–427.
Published: 14 December 2009
...Rokhsareh F. Vesali; Norbert Cibicek; Towe Jakobsson; Maria Klaude; Jan Wernerman; Olav Rooyackers The human endotoxin model has been used to study the early phase of sepsis. The aim of the present study was to assess leg muscle protein kinetics after an endotoxin challenge given to healthy human...
Clin Sci (Lond) (2009) 117 (9): 313–319.
Published: 01 September 2009
... of glutathione status and glutathione kinetics in healthy volunteers during the initial phase of sepsis using a human endotoxin model. The present study was a descriptive pilot study in healthy male volunteers ( n =8) before and after an endotoxin challenge. The glutathione status was determined in plasma...
Clin Sci (Lond) (2009) 116 (9): 721–730.
Published: 02 April 2009
...Visith Thongboonkerd; Wararat Chiangjong; Jan Mares; Jiri Moravec; Zdenek Tuma; Thomas Karvunidis; Supachok Sinchaikul; Shui-Tein Chen; Karel Opatrný, Jr; Martin Matejovic Sepsis is a systemic response to infection commonly found in critically ill patients and is associated with multi-organ failure...
Includes: Supplementary data
Clin Sci (Lond) (2008) 115 (11): 343–351.
Published: 03 November 2008
... studies have demonstrated the immunomodulatory effects of quorum-sensing signal molecules. In the present study, we have examined the impact of these molecules on normal human immune function in vitro and compared this with immune changes in patients with sepsis where quorum-sensing signal molecules were...
Clin Sci (Lond) (2008) 114 (2): 123–130.
Published: 11 December 2007
... compilation © 2008 Biochemical Society 2008 albumin capillary leak fluorophore poly(ethylene glycol) redistribution phase sepsis vascular permeability Attaching PEG [poly(ethylene glycol)] to proteins (PEGylation) increases their intravascular retention time [ t ½ (half-life...
Clin Sci (Lond) (2007) 112 (9): 499–506.
Published: 02 April 2007
...Maria Klaude; Katarina Fredriksson; Inga Tjäder; Folke Hammarqvist; Bo Ahlman; Olav Rooyackers; Jan Wernerman Patients with sepsis in the ICU (intensive care unit) are characterized by skeletal muscle wasting. This leads to muscle dysfunction that also influences the respiratory capacity, resulting...
Clin Sci (Lond) (2002) 102 (6): 645–650.
Published: 14 May 2002
...Michael C. READE; Megan F. CLARK; J. Duncan YOUNG; C.A.R. BOYD Increased production of nitric oxide (NO) is thought to be a factor in the pathogenesis of many human diseases - among them the hypotension that often accompanies sepsis. The supply of the cationic amino acid arginine is known...
Clin Sci (Lond) (2001) 101 (3): 295–304.
Published: 15 August 2001
...Michael J. O'LEARY; Colin N. FERGUSON; Michael J. RENNIE; Charles J. HINDS; John H. COAKLEY; Victor R. PREEDY We have investigated sequential changes in skeletal muscle and hepatic protein synthesis following sepsis, and their relationship to changes in circulating and tissue glutamine...
Clin Sci (Lond) (2001) 100 (2): 169–182.
Published: 02 January 2001
... the concept that iron (often viewed as the ‘villain’ in free radical biology) can also be considered as a signalling species. Iron is intimately involved in the regulation of its own storage, compartmentalization and turnover. During adult respiratory distress syndrome (ARDS) and sepsis, such regulation may...
Clin Sci (Lond) (2001) 100 (1): 81–89.
Published: 08 December 2000
...Suveer SINGH; Peter B. ANNING; C. Peter WINLOVE; Timothy W. EVANS Sepsis is characterized by increased microvascular permeability and regional variations in capillary perfusion, which may be modulated by nitric oxide (NO) and reversed by fluid resuscitation (FR). The effects of saline FR...
Clin Sci (Lond) (2000) 99 (6): 489–496.
Published: 07 November 2000
...Quan WANG; Xiaoyan SUN; Timothy A. PRITTS; Hector R. WONG; Per-Olof HASSELGREN Previous studies suggest that production of interleukin-6 (IL-6) is increased in the intestinal mucosa during sepsis and endotoxaemia. We tested the hypothesis that mucosal IL-6 production during endotoxaemia...
Clin Sci (Lond) (2000) 99 (4): 321–328.
Published: 05 September 2000
...Cécile CHAMBRIER; Martine LAVILLE; Khalid RHZIOUAL BERRADA; Michelle ODEON; Paul BOULÉTREAU; Michel BEYLOT In order to quantify the changes in insulin sensitivity, particularly of endogenous glucose production and fat metabolism, in patients with severe sepsis, a prospective study was conducted...
Clin Sci (Lond) (2000) 98 (2): 193–200.
Published: 11 January 2000
... increase in blood pressure as observed in matched sheep of the l -NMMA group (non-septic phase). Treatment was discontinued after 3 h. Sepsis was initiated and maintained by a continuous infusion of live Pseudomonas aeruginosa . After 24 h of sepsis, the sheep were again challenged over a treatment period...
Clin Sci (Lond) (1999) 97 (5): 529–538.
Published: 15 September 1999
... and monocytes, and higher concentrations of IL-6, IL-8 and sIL-2R. C-reactive protein and soluble E-selectin concentrations did not differ between groups. No parameter alone identified all patients that subsequently developed OF. However, a sepsis-related inflammation severity score (SISS), developed...
Clin Sci (Lond) (1998) 95 (4): 467–478.
Published: 01 October 1998
... injury normally found during sepsis in our porcine model. 8. These findings suggest that during sepsis a protective endogenous β 2 adrenergic receptor-mediated anti-inflammatory response is activated via cell membrane transduction to stimulate the trimeric G-protein complex Gs and activate the second...
Clin Sci (Lond) (1997) 92 (5): 519–525.
Published: 01 May 1997
...Tory A. Meyer; Jing Jing Wang; Gregory M. Tiao; Cora K. Ogle; Josef E. Fischer; Per-Olof Hasselgren 1. In previous studies, experimental endotoxaemia was found to stimulate cytokine production in the central nervous system. The effect of sepsis on brain cytokines is not fully known. We compared...
Clin Sci (Lond) (1996) 91 (3): 371–374.
Published: 01 September 1996
.... 30 4 1996 7 5 1996 © 1996 The Biochemical Society and the Medical Research Society 1996 lipid neutrophils sepsis total parenteral nutrition Clinical Science (1996) 91, 371-374 (Printed in Great Britain) 37 I Neutrophil adhesion molecule expression and response to stimulation...
Clin Sci (Lond) (1996) 90 (3): 173–182.
Published: 01 March 1996
...Mark Sair; C. Peter Winlove; Timothy W. Evans © 1996 The Biochemical Society and the Medical Research Society 1996 microcirculationn sepsis tissue nutrition tissue oxygenation tissue perfusion Clinical Science (1996) 90. 173-182 (Printed in Great Britain) Editorial Review I73...
Clin Sci (Lond) (1995) 89 (6): 601–609.
Published: 01 December 1995
...Ceri J. Green; I. T. Campbell; Ellen O'sullivan; S. Underhill; D. P. M. McLaren; L. J. Hipkin; I. A. MacDonald; Jean Russell 1. Patients suffering trauma and sepsis are insulin resistant, but no studies have specifically been made of patients suffering multiple organ failure. 2. We have studied...
Clin Sci (Lond) (1995) 89 (3): 311–319.
Published: 01 September 1995
...Takashi Higashiguchi; Yoshifumi Noguchi; Tory Meyer; Josef E. Fischer; Per-Olof Hasselgren 1. We studied the effect of sepsis and the regulation by glutamine of protein synthesis in enterocytes isolated from the small intestine of rats. 2. Sepsis was induced by caecal ligation and puncture; control...
Clin Sci (Lond) (1995) 88 (5): 587–594.
Published: 01 May 1995
...Bart J. Biemond; Marcel Levi; Hugo Ten Cate; Tom Van Der Poll; Harry R. Büller; C. Erik Hack; Jan W. Ten Cate 1. Disseminated intravascular coagulation frequently accompanies Gram-negative sepsis and may contribute to widespread deposition of microthrombi. Besides the endotoxin-induced activation...
Clin Sci (Lond) (1995) 88 (4): 393–400.
Published: 01 April 1995
...Jon S. Friedland © 1995 The Biochemical Society and the Medical Research Society 1995 65-kDa heat shock protein Interleukin 8 malaria monocyte chemotactic protein 1 sepsis toxoplasmosis tuberculosis Clinical Science (1995) 88, 393-400 (Printed in Great Britain) 393 Glaxo/MRS Young...
Clin Sci (Lond) (1994) 87 (5): 539–546.
Published: 01 November 1994
...D. C. Macallan; G. E. Griffin 1. Sepsis is associated with marked changes in cardiac muscle protein synthesis. Such changes may be the result of altered transcription of specific myofibrillar protein mRNAs. 2. In order to investigate myofibrillar protein gene expression, a rat model of sepsis...
Clin Sci (Lond) (1994) 87 (2): 207–211.
Published: 01 August 1994
...Takashi Higashiguchi; Yoshifumi Noguchi; William O'Brien; Kenneth Wagner; Josef E. Fischer; Per-Olof Hasselgren 1. In a previous study we found that the protein synthesis rate was increased by 50–60% in the mucosa of the jejunum and ileum during sepsis in rats. It is not known if sepsis affects...
Clin Sci (Lond) (1994) 86 (4): 359–374.
Published: 01 April 1994
...Nicholas P. Curzen; Mark J. D. Griffiths; Timothy W. Evans © 1994 The Biochemical Society and the Medical Research Society 1994 endothelin endothelium nitric oxide sepsis vasculature Clinical Science (1994) 86, 359-374 (Printed in Great Britain) Editorial Review 359 Role...
Clin Sci (Lond) (1993) 84 (3): 247–256.
Published: 01 March 1993
...Tom van der Poll; Hans P. Sauerwein © 1993 The Biochemical Society and the Medical Research Society 1993 cytokines endotoxin fat glucose metabolism sepsis stress hormones tumor necrosis factor-α Clinical Science (1993) 84, 247-256 (Printed in Great Britain) Editorial Review...
Clin Sci (Lond) (1992) 83 (4): 495–501.
Published: 01 October 1992
...-esterified fatty acids secondary to hepatic vasoconstriction. © 1992 The Biochemical Society and the Medical Research Society 1992 ketone bodies lipolysis platelet-activating factor sepsis Clinical Science (1992) 83, 495-501 (Printed in Great Britain) PI atele t;Lc t i vat i ng factor causes...