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Clin Sci (Lond) (2022) 136 (8): 599–620.
Published: 22 April 2022
...Theodore W. Kurtz; Michal Pravenec; Stephen E. DiCarlo High-salt diets are a major cause of hypertension and cardiovascular (CV) disease. Many governments are interested in using food salt reduction programs to reduce the risk for salt-induced increases in blood pressure and CV events...
Sheon Mary, Philipp Boder, Giacomo Rossitto, Lesley Graham, Kayley Scott, Arun Flynn, David Kipgen, Delyth Graham, Christian Delles
Clin Sci (Lond) (2021) 135 (24): 2749–2761.
Published: 17 December 2021
... demonstrated an association between UMOD risk variants and hypertension. We aimed to dissect the role of dietary salt in renal UMOD excretion in normotension and chronic hypertension. Normotensive Wistar–Kyoto rats (WKY) and stroke-prone spontaneously hypertensive rats (SHRSP) ( n =8/sex/strain) were...
Includes: Supplementary data
Wei Cao, Meng Shi, Liling Wu, Jiaxin Li, Zhichen Yang, Youhua Liu, Christopher S. Wilcox, Fan Fan Hou
Clin Sci (Lond) (2019) 133 (17): 1883–1899.
Published: 10 September 2019
... resistance (IR), remains unknown. We tested the hypothesis that high-fat (HF) feeding increases afferent impulses from white adipose tissue that reflexively elevate efferent nerve activity to skeletal muscle (SM) and adipose tissue to impair their local glucose uptake. We also investigated how salt-intake...
Includes: Supplementary data
Clin Sci (Lond) (2019) 133 (6): 761.
Published: 19 March 2019
... 2019 09 02 2019 28 02 2019 © 2019 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2019 oedema sodium salt We would like to thank Dr Bhave for the provocative discussion and for providing further details on his theoretical framework...
In CollectionClinical and translational research highlights
Emma L. Bailey, Martin W. McBride, John D. McClure, Wendy Beattie, Delyth Graham, Anna F. Dominiczak, Colin Smith, Joanna M. Wardlaw
Clin Sci (Lond) (2018) 132 (12): 1315–1328.
Published: 26 June 2018
...Emma L. Bailey; Martin W. McBride; John D. McClure; Wendy Beattie; Delyth Graham; Anna F. Dominiczak; Colin Smith; Joanna M. Wardlaw Background: The effect of salt on cerebral small vessel disease (SVD) is poorly understood. We assessed the effect of dietary salt on cerebral tissue of the stroke...
Includes: Supplementary data
Alison H.M. Taylor, Alastair J. Rankin, Emily P. McQuarrie, E. Marie Freel, Natalie Z.M. Homer, Ruth Andrew, Alan G. Jardine, Patrick B. Mark
Clin Sci (Lond) (2018) 132 (2): 285–294.
Published: 25 January 2018
...Alison H.M. Taylor; Alastair J. Rankin; Emily P. McQuarrie; E. Marie Freel; Natalie Z.M. Homer; Ruth Andrew; Alan G. Jardine; Patrick B. Mark Background: Hypertension is prevalent in chronic kidney disease (CKD). Studies suggest that reduction in dietary salt intake reduces blood pressure (BP). We...
Includes: Supplementary data
Angela X. Chen, George Jerums, Sara Baqar, Elisabeth Lambert, Goji Somarajah, Georgina Thomas, Christopher O’Callaghan, Richard J. MacIsaac, Elif I. Ekinci
Clin Sci (Lond) (2015) 129 (5): 415–422.
Published: 11 June 2015
...Angela X. Chen; George Jerums; Sara Baqar; Elisabeth Lambert; Goji Somarajah; Georgina Thomas; Christopher O’Callaghan; Richard J. MacIsaac; Elif I. Ekinci Current guidelines recommend low dietary salt intake (LDS) in patients with diabetes to reduce blood pressure (BP). However, low salt intake...
Clin Sci (Lond) (2010) 118 (11): 669–680.
Published: 09 March 2010
... subunit expression was reduced. Urine flow rate and sodium excretion increased in both groups in response to salt loading, but this increase in sodium excretion was delayed by approximately 90 min in the uninephrectomized animals, while total sodium output was 12% in excess of the infused load ( P...
Clin Sci (Lond) (2009) 117 (1): 1–11.
Published: 02 June 2009
...Sailesh Mohan; Norm R. C. Campbell HBP (high blood pressure) is the leading risk of death in the world. Unfortunately around the world, blood pressure levels are predicted to become even higher, especially in developing countries. High dietary salt is an important contributor to increased blood...
Jörg TRENKNER, Friedrich PRIEM, Christian BAUER, Hans-Hellmut NEUMAYER, Manfred RASCHAK, Berthold HOCHER
Clin Sci (Lond) (2002) 103 (s2002): 385S–388S.
Published: 01 September 2002
... blockade on blood pressure and kidney function in spontaneously hypertensive rats (SHRs) on a high-salt diet are unknown. We treated SHRs on a 6% (w/v) NaCl sodium diet (SHR-S) for 48 weeks with the ETA antagonist LU 135252 (whose selectivity for ETA is 150 times greater than for ETB) with 10, 30...
Toshihiko Ishimitsu, Toshio Nishikimi, Hiroaki Matsuoka, Kenji Kangawa, Kazuo Kitamura, Jun-Ichi Minami, Hisayuki Matsuo, Tanenao Eto
Clin Sci (Lond) (1996) 91 (3): 293–298.
Published: 01 September 1996
...Toshihiko Ishimitsu; Toshio Nishikimi; Hiroaki Matsuoka; Kenji Kangawa; Kazuo Kitamura; Jun-Ichi Minami; Hisayuki Matsuo; Tanenao Eto 1. Responses of adrenomedullin to acute and chronic salt loading were examined in normotensive and hypertensive subjects. 2. In the acute salt load study, isotonic...
Clin Sci (Lond) (1994) 87 (6): 635–639.
Published: 01 December 1994
...Carmine Zoccali; Francesca Mallamaci; Daniela Leonardis 1. We have assessed the relationship between salt intake and 24 h ambulatory arterial pressure in middle aged men with essential hypertension. 2. During the run-in phase (1 month) we estimated the habitual sodium intake (the average Na...
Kim Hanh Le Quan Sang, Jaroslav Kunes, Josef Zicha, Bernard Lacour, Drori Ben-Ishay, Marie-Aude Devynck
Clin Sci (Lond) (1994) 86 (3): 263–268.
Published: 01 March 1994
...Kim Hanh Le Quan Sang; Jaroslav Kunes; Josef Zicha; Bernard Lacour; Drori Ben-Ishay; Marie-Aude Devynck 1. To investigate the possibility that arterial hypertension is associated with changes in the physicochemical properties of cell membranes, we have studied the effects of dietary salt loading...
Clin Sci (Lond) (1990) 78 (4): 423–429.
Published: 01 April 1990
...Ehud Grossman; Aaron Hoffman; Peter C. Chang; Harry R. Keiser; David S. Goldstein 1. We measured urinary excretion rates of dopamine (3,4-dihydroxyphenethylamine) and dopa (3,4-dihydroxyphenylalanine) and the spillover rate of dopa into arterial blood during dietary salt loading in conscious Dahl...
Antonio P. Quintanilla, Maria I. Weffer, Haengil Koh, Mohammed Rahman, Agostino Molteni, Francesco Del Greco
Clin Sci (Lond) (1988) 75 (2): 167–170.
Published: 01 August 1988
... + in the erythrocytes of 19 healthy volunteers, before and after supplementation of their normal diet with 6.0–8.9 g of salt (102–137 mmol of NaCl) per day, for 5 days. 2. The subjects had a small but significant gain in weight. Mean plasma renin activity decreased from 1.57 to 0.73 pmol of angiotensin I h −1 ml −1...
F. C. Luft, H. Steinberg, U. Ganten, D. Meyer, K. H. Gless, R. E. Lang, N. S. Fineberg, W. Rascher, Th. Unger, D. Ganten
Clin Sci (Lond) (1988) 74 (6): 577–585.
Published: 01 June 1988
... atrial natriuretic peptide chloride mineral water salt sodium Clinical Science (1988) 74,577-585 577 Effect of sodium chloride and sodium bicarbonate on blood pressure in stroke-prone spontaneously hypertensive rats F. C. LUFT, H. STEINBERG, U. GANTEN, D. MEYER, K. H. GLESS, R. E. LANG, N. S...
Clin Sci (Lond) (1987) 72 (1): 81–86.
Published: 01 January 1987
... Research Society 1970 lithium marker substance salt Clinical Science (1987) 7 2 , 8 1-86 81 The potential use of lithium as a marker for the assessment of the sources of dietary salt: cooking studies and physiological experiments in men C. P. SANCHEZ-CASTILLo*, J. SEIDELL AND W. P. T. JAMES MRC...
Clin Sci (Lond) (1982) 63 (s8): 419s–421s.
Published: 01 October 1982
... (1982) 63,4199-421s 419s Kidney size and body size in the context of salt and blood pressure F. 0. S I M P S O N , R . D O E S B U R G , A. G . D E M P S T E R q 2 M. K I H A R A . 3 Y. Y A M O R I A N D J . K O S H I N A G A Wellcome Medical Research Institute and fDepartment of Pathology...
Clin Sci (Lond) (1981) 61 (s7): 53s–55s.
Published: 01 December 1981
...Atsuo Goto; Toshio Ikeda; Louis Tobian; Junichi Iwai; Mary A. Johnson 1. The rise in blood pressure in Dahl salt-sensitive rats that received intracerebroventricular 6-hydroxydopamine was almost half that of the control rats throughout 20 weeks of high (8%) NaCl feeding. 2. The rise in bood...
Clin Sci (Lond) (1981) 61 (1): 115–118.
Published: 01 July 1981
...M. F. Villamil; C. Amorena; J. Ponce; A. Müller; A. C. Taquini 1. Sequential changes in the ionic composition of the aorta and skeletal muscle were followed during 1, 2 and 4–6 weeks in 30 rats given deoxycorticosterone (DOC) and salt supplemented with potassium chloride. Twenty-one rats, drinking...
Clin Sci (Lond) (1980) 59 (s6): 169s–170s.
Published: 01 December 1980
...A. A. MacPhee; H. L. Blakesley; Karen A. Graci; E. D. Frohlich; F. E. Cole 1. Altered adrenergic responsiveness of hearts and blood vessels occurs in both experimental and clinical hypertension. 2. Since salt excess aggravates both types of hypertension, we investigated β-adrenoreceptor properties...
Clin Sci (Lond) (1979) 57 (s5): 251s–253s.
Published: 01 December 1979
... between the two groups in heart rate, body weight, fluid intake, urine volume, U Na V, U K V and right ventricular weight. 4. The results suggest that the combination of high sodium intake and meclofenamate exerts a greater damaging effect on the arterial pressure and renal function of SH rats than salt...
Clin Sci Mol Med (1976) 51 (s3): 129s–132s.
Published: 01 December 1976
... 1976 The Biochemical Society and the Medical Research Society 1976 blood pressure frusemide renal hypertension renin salt Clinical Science and Molecular Medicine (1976) 51, 1299-132s. Salt, frusemide and renin in severe experimental renal hypertension M. FERNANDES, G . ONESTI, R. DYKYJ, R...
Clin Sci Mol Med (1973) 45 (s1): 257s–261s.
Published: 01 August 1973
...E. Eric Muirhead; Byron E. Leach; Frank B. Armstrong 1. Experimental hypertension could be induced in rats by injecting angiotensin I or II subcutaneously. 2. Such hypertension lasted for about 1 h after injection. 3. Angiotensin-induced hypertension was enhanced and sustained by salt loading...