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Keywords: renin-angiotensin system
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Articles
Clin Sci (Lond) (2022) 136 (16): 1205–1227.
Published: 18 August 2022
... understood, some systems appear to play major roles in its development. This review aims to update the current knowledge on the interaction of the intrarenal reninangiotensin system (RAS) and dopaminergic system in the development of hypertension, focusing on recent scientific hallmarks in the field...
Articles
Clin Sci (Lond) (2022) 136 (10): 799–802.
Published: 27 May 2022
... the main findings of the study, followed by a discussion of the findings and their relevance for various aspects of the biology of receptors of the renin-angiotensin system in the context of the current state of knowledge. The authors declare that there are no competing interests associated...
Articles
Clin Sci (Lond) (2021) 135 (23): 2619–2623.
Published: 08 December 2021
... 2021 Angiotensin-(1-7) Cardiovascular System Renin-Angiotensin System Sympathetic Nervous System Transgenic Rat Vasopressin Correspondence: Robert C. Speth ( rs1251@nova.edu ) The reninangiotensin system (RAS) regulates hydromineral balance, cardiovascular, renal, neuronal...
Articles
Clin Sci (Lond) (2021) 135 (20): 2377–2391.
Published: 19 October 2021
... ) 19 07 2021 30 09 2021 05 10 2021 05 10 2021 © 2021 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2021 ACE activity erythropoiesis Exercise training renin-angiotensin system Endurance exercise training (ET) induces...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2021) 135 (17): 2035–2048.
Published: 31 August 2021
.... Correspondence: Kikuo Isoda ( kisoda@juntendo.ac.jp ) * These authors contributed equally to this work. chronic kidney disease inflammation interleukin-1 renin-angiotensin system Hypertension (HT) is one of the most important cause of deaths worldwide. Improved treatment strategies for HT...
Articles
Clin Sci (Lond) (2021) 135 (7): 911–924.
Published: 12 April 2021
...-angiotensin system Cardiovascular diseases represent a worldwide cause of death. Uncontrolled hypertension or high blood pressure (BP) increases the risk of cardiac dysfunction, stroke and renal diseases [ 1 , 2 ]. The development and progression of hypertension is very complex and involves...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2021) 135 (3): 535–554.
Published: 03 February 2021
...Xi Cao; Li-Ni Song; Jin-Kui Yang The reninangiotensin system (RAS) has currently attracted increasing attention due to its potential function in regulating energy homeostasis, other than the actions on cellular growth, blood pressure, fluid, and electrolyte balance. The existence of RAS is well...
Articles
Clin Sci (Lond) (2020) 134 (23): 3213–3228.
Published: 11 December 2020
... physiology renin-angiotensin system Pregnancy initiates a cascade of profound cardiovascular and renal adaptations, ultimately leading to a rise in cardiac output to ensure adequate oxygen and nutrient supply to the developing fetus [ 1 , 2 ]. Many of these adaptations are mediated by the renin...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2020) 134 (23): 3195–3211.
Published: 09 December 2020
... diseases. Although heart failure (HF)-induced endothelial dysfunction is associated with reninangiotensin system (RAS) activation, no data have correlated this syndrome with PVAT dysfunction. Thus, the aim of the present study was to investigate whether the hyperactivation of the RAS in PVAT participates...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2020) 134 (23): 3137–3158.
Published: 07 December 2020
...Fiona J. Warner; Harinda Rajapaksha; Nicholas Shackel; Chandana B. Herath Twenty years ago, the discovery of angiotensin-converting enzyme 2 (ACE2) was an important breakthrough dramatically enhancing our understanding of the reninangiotensin system (RAS). The classical RAS is driven by its key...
Articles
Clin Sci (Lond) (2020) 134 (23): 3063–3078.
Published: 02 December 2020
... angiotensin converting enzyme 2 angiotensin-(1-7) Covid-19 Renin-angiotensin system The reninangiotensin system (RAS) is composed by a number of different enzymes and effector peptides that are involved in the dynamic control of many body functions. Many components of the RAS have opposing actions...
Articles
Clin Sci (Lond) (2020) 134 (21): 2791–2805.
Published: 02 November 2020
... ) 04 09 2020 14 10 2020 16 10 2020 © 2020 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2020 angiotensin converting enzyme 2 COVID-19 renin-angiotensin system SARS-CoV-2 Angiotensin‐converting enzyme II (ACE2...
Articles
Clin Sci (Lond) (2020) 134 (19): 2581–2595.
Published: 14 October 2020
...Qiuhong Li; Maria B. Grant; Elaine M. Richards; Mohan K. Raizada The angiotensin-converting enzyme 2 (ACE2) has emerged as a critical regulator of the reninangiotensin system (RAS), which plays important roles in cardiovascular homeostasis by regulating vascular tone, fluid and electrolyte balance...
Articles
Clin Sci (Lond) (2020) 134 (19): 2535–2547.
Published: 05 October 2020
...Mazher Mohammed; Clara Berdasco; Eric Lazartigues The brain reninangiotensin system (RAS) plays an important role in the regulation of autonomic and neuroendocrine functions, and maintains cardiovascular homeostasis. Ang-II is the major effector molecule of RAS and exerts most of its physiological...
Articles
Clin Sci (Lond) (2020) 134 (18): 2489–2501.
Published: 29 September 2020
...-7) thereby counterbalancing the action of ACE on the reninangiotensin system (RAS) and providing a cardioprotective role. Unlike ACE, ACE2 does not metabolise bradykinin nor is it inhibited by classical ACE inhibitors. However, it does convert a number of other regulatory peptides in vitro...
Articles
Clin Sci (Lond) (2020) 134 (17): 2319–2336.
Published: 09 September 2020
... (CV) system. The apelin pathway’s dominant physiological role has delineated therapeutic implications for coronary artery disease, heart failure (HF), aortic aneurysm, pulmonary arterial hypertension (PAH), and transplant vasculopathy. Apelin peptides interact with the reninangiotensin system (RAS...
Articles
Clin Sci (Lond) (2020) 134 (17): 2263–2277.
Published: 03 September 2020
... type of epilepsy and is often refractory to pharmacological treatment. In this scenario, extensive research has identified components of the reninangiotensin system (RAS) as potential therapeutic targets. Therefore, the aim of the present study was to evaluate the effects of long-term treatment...
Articles
Clin Sci (Lond) (2020) 134 (13): 1763–1774.
Published: 10 July 2020
... homeostasis hypertension nephrology renin-angiotensin system vasculature Renin-expressing cells are fundamental for the maintenance of extracellular fluid volume, and blood pressure homeostasis. Through evolution, these cells have acquired additional roles in kidney vascular development...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2020) 134 (11): 1259–1264.
Published: 08 June 2020
... mechanisms and pathways of SARS-CoV-2 related to the pathogenesis of Coronavirus Disease 2019 (Covid-19). After transmembrane angiotensin-converting enzyme 2 (ACE2) has been found to be SARS-CoV-2 receptor, we hypothesized an immune-hematological mechanism for Covid-19 based on reninangiotensin system (RAS...
Articles
Clin Sci (Lond) (2020) 134 (4): 379–388.
Published: 17 February 2020
... 2020 05 02 2020 © 2020 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2020 chronic kidney disease renal glomerulus renin-angiotensin system Clinical trials have recently been published regarding the use of sodium–glucose co-transporter...
Articles
Clin Sci (Lond) (2019) 133 (17): 1883–1899.
Published: 10 September 2019
... transporter 4 (Glut4) trafficking. Dietary salt in HF fed rats also increased the activity of the adipose-cerebral-muscle reninangiotensin system (RAS) axes, SNS, and reactive oxygen species (ROS). Insulin sensitivity was reduced by 32% in HF rats during high-salt intake, but was improved by over 62...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2019) 133 (5): 629–643.
Published: 01 March 2019
...; Silvia Guatimosim; Robson Augusto Souza Santos; Rafaela Fernandes da Silva Aims: The reninangiotensin system (RAS) plays an important role in the pathophysiology of vascular diseases, especially as a mediator of inflammation and tissue remodelling. Alamandine (Ala 1 -angiotensin-(1-7)) is a new...
Articles
Clin Sci (Lond) (2019) 133 (1): 75–82.
Published: 08 January 2019
...). Published by Portland Press Limited on behalf of the Biochemical Society 2019 aldosterone intercalated cells renin-angiotensin system renal physiology Fluid volume regulation by the kidney plays a predominant role in the long-term control of blood pressure. Because of its importance...
Articles
Clin Sci (Lond) (2018) 132 (20): 2207–2220.
Published: 23 October 2018
... disease endothelial dysfunction microparticles renin-angiotensin system sodium intake type 2 diabetes Cardiovascular-related disease is the leading cause of morbidity and mortality in people with diabetes [ 1 ]. Reduction in blood pressure lowers cardiovascular risk [ 2 ]. As high dietary...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2018) 132 (14): 1513–1527.
Published: 23 July 2018
... © 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2018 ADAM17 ACE2 Biased agonist hypertension renin-angiotensin system Arterial hypertension is an important health problem worldwide of difficult treatment due to the complexity of its...
Articles
Clin Sci (Lond) (2018) 132 (14): 1487–1507.
Published: 23 July 2018
... training renin-angiotensin system sarcopenic obesity skeletal muscle white adipose tissue The main pathway that activates browning is through the β3-adrenergic receptor, whose downstream effects lead to activation of p38 mitogen-activated protein kinase (MAPK) that, in turn, activates PPARγ co...
Articles
Clin Sci (Lond) (2018) 132 (13): 1383–1401.
Published: 09 July 2018
...Xiao C. Li; Dongmin Zhu; Xiaowen Zheng; Jiangfeng Zhang; Jia L. Zhuo The reninangiotensin system (RAS) is widely recognized as one of the most important vasoactive hormonal systems in the physiological regulation of blood pressure and the development of hypertension. This recognition is derived...
Articles
Clin Sci (Lond) (2018) 132 (7): 777–790.
Published: 06 April 2018
... AT2-receptor endothelial nitric oxide synthase protein phosphatases renin-angiotensin system Angiotensin II (Ang II) exerts its actions through two main receptors, the Ang II type 1 receptor (AT 1 R) and the Ang II type 2 receptor (AT 2 R) [ 1 ]. These two receptors mediate opposing effects...
Articles
Clin Sci (Lond) (2018) 132 (6): 627–640.
Published: 20 March 2018
... concentrations on CYP11B2, do not support the contention that the protective arm of reninangiotensin system (RAS) blunts aldosterone synthase in the normal adrenal cortex and primary aldosteronism. Correspondence: Gian Paolo Rossi ( gianpaolo.rossi@unipd.it ) 07 12 2017 03 02 2018 04 02...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2018) 132 (2): 285–294.
Published: 25 January 2018
... studied relationships between salt intake, BP and reninangiotensin system regulation in order to establish if it is disordered in CKD. Methods: Mechanistic crossover study of CKD patients versus non-CKD controls. Participants underwent modified saline suppression test prior to randomization to either low...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2017) 131 (15): 1941–1953.
Published: 13 July 2017
..., by preserving genomic integrity. In this mouse mutant displaying prominent accelerated, age-dependent endothelial dysfunction we investigated the signaling pathways involved in improved endothelium-mediated vasodilation by DR, and explore the potential role of the renin-angiotensin system (RAS). Ercc1 Δ/− mice...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2017) 131 (11): 1093–1105.
Published: 17 May 2017
... of trophic factors and of reninangiotensin system (RAS) molecules, could also be involved, especially in the absence of obvious cerebrovascular disease. In this review, we discuss experimental and clinical evidence for the role of these mechanisms in kidney–brain cross-talk. In addition, we hypothesize...
Articles
Clin Sci (Lond) (2016) 130 (14): 1209–1220.
Published: 01 June 2016
... 2015 18 4 2016 18 4 2016 19 4 2016 © 2016 The Author(s). published by Portland Press Limited on behalf of the Biochemical Society 2016 AT 1 receptor antagonist diabetes hypertension neprilysin inhibition reninangiotensin system • Dual angiotensin II type 1...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2016) 130 (13): 1075–1088.
Published: 23 May 2016
... (reninangiotensin system) may contribute to this. This study relied on an established angiotensin, AngII (angiotensin II)-elevated dTGR (double-transgenic rat) model and same-background SD (Sprague–Dawley) rat controls. In dTGRs, plasma levels of AngII were increased. We determined the general retinal...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2016) 130 (7): 525–538.
Published: 17 February 2016
... of the reninangiotensin system, is a clinical problem present in a small number of patients with chronic kidney disease (CKD). The mechanism underlying this resistant albuminuria remains unknown. Matrix metalloproteinases (MMPs) are involved in the pathophysiology of cardiovascular and renal diseases...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2016) 130 (4): 221–238.
Published: 14 January 2016
... literature on the role of the renin-angiotensin system in neurovascular disorders including stroke, retinopathy, traumatic brain injury and cognitive impairment. The review presents both experimental and clinical studies conducted in the field, and sheds light on the translational gap and clinical...
Articles
Clin Sci (Lond) (2015) 129 (6): 461–476.
Published: 22 June 2015
... that angiotensin-(1–7) is a novel peptide that prevents the skeletal muscle atrophy observed in a model of sepsis by inhibiting the catabolic response developed in skeletal muscle and improving its performance. angiotensin-(1–7) lipopolysaccharide Mas receptor reninangiotensin system sepsis syndrome...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2015) 128 (11): 735–747.
Published: 17 March 2015
...Esko Kankuri; Elina E. Mervaala; Markus Storvik; Aija M.J. Ahola; Jouko Levijoki; Dominik N. Müller; Piet Finckenberg; Eero M. Mervaala Hypertension and persistent activation of the reninangiotensin system (RAS) are predisposing factors for the development of acute kidney injury (AKI). Although...
Articles
Clin Sci (Lond) (2015) 128 (11): 749–750.
Published: 17 March 2015
...Anton J.M. Roks Optimization of stem cell therapy after cardiovascular and renal injury depends on many factors, among which is stem cell donor health. The reninangiotensin system (RAS) plays an important role in cardiovascular and renal homoeostasis and pathophysiology. It is becoming...
Articles
Clin Sci (Lond) (2014) 127 (9): 549–557.
Published: 03 July 2014
...Maria Paz Ocaranza; Luis Michea; Mario Chiong; Carlos F. Lagos; Sergio Lavandero; Jorge E. Jalil Chronic RAS (reninangiotensin system) activation by both AngII (angiotensin II) and aldosterone leads to hypertension and perpetuates a cascade of pro-hypertrophic, pro-inflammatory, pro-thrombotic...
Articles
Clin Sci (Lond) (2014) 126 (10): 695–706.
Published: 27 January 2014
... type 2 receptor (AT 2 R) heart failure reninangiotensin system CHF (chronic heart failure) is the end result of various insults to the myocardium, the most common of which is ischaemic heart disease [ 1 ]. Whenever cardiac output falls, more than momentarily, compensatory mechanisms...
Articles
Clin Sci (Lond) (2014) 126 (7): 507–516.
Published: 11 December 2013
... by which levels of ACE2 are regulated by conditions of cell stress such as hypoxia and cytokine treatment. angiotensin-converting enzyme (ACE) angiotensin-converting enzyme 2 (ACE2) AMP-activated protein kinase (AMPK) angiotensin-(1–7) reninangiotensin system SIRT1 • Recent work has...
Articles
Clin Sci (Lond) (2014) 126 (1): 31–39.
Published: 30 August 2013
... in relation to our understanding of the underlying mechanisms involved in septic shock, and highlight the attempts made to improve animal experimental models. We also review recent studies reporting promising results with two vastly different therapeutic approaches influencing the reninangiotensin system...
Articles
Clin Sci (Lond) (2013) 125 (9): 433–438.
Published: 27 June 2013
... both significantly decreased serum insulin levels, and non-additively elevated blood glucose levels. In conclusion, the present study suggests that a local pancreatic RAS (reninangiotensin system), sensitive to acute administration of telmisartan and ramipril, controls pancreatic IBF and insulin...
Articles
Clin Sci (Lond) (2013) 125 (7): 311–318.
Published: 07 June 2013
... Society 2013 androgen endothelin menopause obesity oestrogen reninangiotensin system sympathetic nervous system The roles played by sex and gender in controlling blood pressure have not been completely elucidated, and studies have shown that these mechanisms are not as easily...
Articles
Clin Sci (Lond) (2013) 124 (2): 87–96.
Published: 26 September 2012
... The Authors Journal compilation © 2013 Biochemical Society 2013 angiotensin II type 2 receptor (AT 2 receptor) B 1 kinin receptor B 2 kinin receptor heart failure inflammation myocardial infarction reninangiotensin system • CVD is the leading cause of death in the U.S.A...
Articles
Clin Sci (Lond) (2012) 123 (11): 649–658.
Published: 01 August 2012
...Luke J. Burchill; Elena Velkoska; Rachael G. Dean; Karen Griggs; Sheila K. Patel; Louise M. Burrell The RAS (reninangiotensin system) is activated after MI (myocardial infarction), and RAS blockade with ACEis [ACE (angiotensin-converting enzyme) inhibitors] or ARBs (angiotensin receptor blockers...
Articles
Clin Sci (Lond) (2012) 123 (10): 567–590.
Published: 23 July 2012
... 5 2012 © The Authors Journal compilation © 2012 Biochemical Society 2012 angiotensin II type 1 receptor blocker (ARB) brain inflammation neuronal injury reninangiotensin system ARBs {AT 1 [AngII (angiotensin II) type 1] receptor blockers} have significant potential...
Articles
Clin Sci (Lond) (2012) 123 (9): 531–543.
Published: 13 July 2012
... diseases in humans that appear to have distinct pathologies and mechanisms. Despite this divergence, there are numerous and consistent demonstrations that overactivation of the RAS (reninangiotensin system) promotes both AAAs and TAAs in animal models. For example, in mice, both AAAs and TAAs are formed...
Articles
Clin Sci (Lond) (2012) 123 (8): 519–529.
Published: 03 July 2012
.... In the present study, we examine the effect of ACE2 deficiency on the early cardiac and vascular changes associated with experimental diabetes. Streptozotocin diabetes was induced in male C57BL6 mice and Ace2 -KO (knockout) mice, and markers of RAS (reninangiotensin system) activity, cardiac function and injury...
Includes: Supplementary data