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Articles

Polycystic kidneys: interaction of notch and renin

Emily A. Daniel, Nicole A. Sommer, Madhulika Sharma

Clin Sci (Lond) (2023) 137 (15): 1145–1150.

https://doi.org/10.1042/CS20230023

Published: 09 August 2023

... 05 07 2023 07 07 2023 © 2023 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2023 notch signalling pathway Polycystic kidney disease renin-angiotensin system Autosomal-dominant polycystic kidney disease (ADPKD) is a form of PKD, which...

View article titled, Polycystic kidneys: interaction of notch and renin

Articles

Overexpression of notch signaling in renin cells leads to a polycystic kidney phenotype

Brian C. Belyea, Fang Xu, Margaret Wiltsie, Hayes Fountain, Jennifer Charlton, Agnes B. Fogo, Maria Luisa Soledad Sequeira-Lopez, Roberto Ariel Gomez

Clin Sci (Lond) (2023) 137 (1): 35–45.

https://doi.org/10.1042/CS20220496

Published: 05 January 2023

.... Correspondence: Brian C. Belyea ( bcb9e@virginia.edu ) 27 07 2022 06 12 2022 08 12 2022 12 12 2022 © 2023 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2023 notch signalling pathway renal physiology renin-angiotensin system...

View article titled, Overexpression of notch signaling in renin cells leads to a polycystic kidney phenotype

Includes: Supplementary data

Articles

Interactions between the intrarenal dopaminergic and the renin–angiotensin systems in the control of systemic arterial pressure

Pedro Alves Soares Vaz de Castro, Pedro A. Jose, Ana Cristina Simões e Silva

Clin Sci (Lond) (2022) 136 (16): 1205–1227.

https://doi.org/10.1042/CS20220338

Published: 18 August 2022

... understood, some systems appear to play major roles in its development. This review aims to update the current knowledge on the interaction of the intrarenal renin–angiotensin system (RAS) and dopaminergic system in the development of hypertension, focusing on recent scientific hallmarks in the field...

View article titled, Interactions between the intrarenal dopaminergic and the renin–angiotensin systems in the control of systemic arterial pressure

Articles

Angiotensin Receptors - Affinity and Beyond

Colin Sumners, Igor Maciel Souza Silva, U. Muscha Steckelings

Clin Sci (Lond) (2022) 136 (10): 799–802.

https://doi.org/10.1042/CS20220024

Published: 27 May 2022

... the main findings of the study, followed by a discussion of the findings and their relevance for various aspects of the biology of receptors of the renin-angiotensin system in the context of the current state of knowledge. Correspondence: U. Muscha Steckelings ( usteckelings@health.sdu.dk ) 25...

View article titled, Angiotensin Receptors - Affinity and Beyond

Articles

Countering the classical renin–angiotensin system

Natalia M. Noto, Yazmin M. Restrepo, Robert C. Speth

Clin Sci (Lond) (2021) 135 (23): 2619–2623.

https://doi.org/10.1042/CS20211043

Published: 08 December 2021

... Limited on behalf of the Biochemical Society 2021 Angiotensin-(1-7) Cardiovascular System Renin-Angiotensin System Sympathetic Nervous System Transgenic Rat Vasopressin The renin–angiotensin system (RAS) regulates hydromineral balance, cardiovascular, renal, neuronal, and other organ...

View article titled, Countering the classical renin–angiotensin system

Articles

High-volume endurance exercise training stimulates hematopoiesis by increasing ACE NH 2 -terminal activity

Flávio de Castro Magalhães, Tiago Fernandes, Vinícius Bassaneze, Katt Coelho Mattos, Isolmar Schettert, Fabio Luiz Navarro Marques, José Eduardo Krieger, Roberto Nava, Valério Garrone Barauna, Oliveira Edilamar Menezes

Clin Sci (Lond) (2021) 135 (20): 2377–2391.

https://doi.org/10.1042/CS20210739

Published: 19 October 2021

... ) 19 07 2021 30 09 2021 05 10 2021 05 10 2021 © 2021 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2021 ACE activity erythropoiesis Exercise training renin-angiotensin system Endurance exercise training (ET) induces...

View article titled, High-volume endurance exercise training stimulates hematopoiesis by increasing ACE NH 2 -terminal activity

Includes: Supplementary data

Articles

Blocking of interleukin-1 suppresses angiotensin II-induced renal injury

Koji Akita, Kikuo Isoda, Fumie Ohtomo, Sarasa Isobe, Tomiharu Niida, Yayoi Sato-Okabayashi, Motoaki Sano, Kazunori Shimada, Yoichiro Iwakura, Tohru Minamino

Clin Sci (Lond) (2021) 135 (17): 2035–2048.

https://doi.org/10.1042/CS20201406

Published: 31 August 2021

... 17 08 2021 17 08 2021 © 2021 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2021 chronic kidney disease inflammation interleukin-1 renin-angiotensin system Hypertension (HT) is one of the most important cause of deaths worldwide...

View article titled, Blocking of interleukin-1 suppresses angiotensin II-induced renal injury

Articles

CRIP1 expression in monocytes related to hypertension

Olga Schweigert, Julia Adler, Natalie Längst, Dylan Aïssi, Jorge Duque Escobar, Teng Tong, Christian Müller, David-Alexandre Trégouët, Robert Lukowski, Tanja Zeller

Clin Sci (Lond) (2021) 135 (7): 911–924.

https://doi.org/10.1042/CS20201372

Published: 12 April 2021

...-angiotensin system For histology of the spleen, the organ was dissected, rinsed in ice-cold PBS, and fixed for 4 h in 2% PFA/PBS. Cryoprotection was accomplished by a sucrose gradient with increasing concentrations (5%, 10% and 20% sucrose in PBS). Neg-50 (Thermo Fisher Scientific)-embedded organs...

View article titled, CRIP1 expression in monocytes related to hypertension

Includes: Supplementary data

Articles

ACE2 and energy metabolism: the connection between COVID-19 and chronic metabolic disorders

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ACE2, a multifunctional protein – from cardiovascular regulation to COVID-19 , Coronavirus

Xi Cao, Li-Ni Song, Jin-Kui Yang

Clin Sci (Lond) (2021) 135 (3): 535–554.

https://doi.org/10.1042/CS20200752

Published: 03 February 2021

...Xi Cao; Li-Ni Song; Jin-Kui Yang The renin–angiotensin system (RAS) has currently attracted increasing attention due to its potential function in regulating energy homeostasis, other than the actions on cellular growth, blood pressure, fluid, and electrolyte balance. The existence of RAS is well...

View article titled, ACE2 and energy metabolism: the connection between COVID-19 and chronic metabolic disorders

Articles

Insulin-regulated aminopeptidase deficiency impairs cardiovascular adaptations and placental development during pregnancy

Sarah L. Walton, Katrina M. Mirabito Colafella, Aneesa Ansari, Siew Yeen Chai, Kate M. Denton

Clin Sci (Lond) (2020) 134 (23): 3213–3228.

https://doi.org/10.1042/CS20201233

Published: 11 December 2020

... – 2063 10.1046/j.1523-1755.1998.00217.x 2. Lumbers E.R. , Delforce S.J. , Arthurs A.L. and Pringle K.G. ( 2019 ) Causes and consequences of the dysregulated maternal renin-angiotensin system in preeclampsia . Front Endocrinol 10 , 563 10.3389/fendo.2019.00563 3...

View article titled, Insulin-regulated aminopeptidase deficiency impairs cardiovascular adaptations and placental development during pregnancy

Includes: Supplementary data

Articles

Renin–angiotensin system overactivation in perivascular adipose tissue contributes to vascular dysfunction in heart failure

Milene Tavares Fontes, Suliana Mesquita Paula, Caroline Antunes Lino, Nathalia Senger, Gisele Kruger Couto, Maria Luiza de Morais Barreto-Chaves, José Geraldo Mill, Luciana Venturini Rossoni

Clin Sci (Lond) (2020) 134 (23): 3195–3211.

https://doi.org/10.1042/CS20201099

Published: 09 December 2020

... diseases. Although heart failure (HF)-induced endothelial dysfunction is associated with renin–angiotensin system (RAS) activation, no data have correlated this syndrome with PVAT dysfunction. Thus, the aim of the present study was to investigate whether the hyperactivation of the RAS in PVAT participates...

View article titled, Renin–angiotensin system overactivation in perivascular adipose tissue contributes to vascular dysfunction in heart failure

Includes: Supplementary data

Articles

ACE2: from protection of liver disease to propagation of COVID-19

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ACE2, a multifunctional protein – from cardiovascular regulation to COVID-19

Fiona J. Warner, Harinda Rajapaksha, Nicholas Shackel, Chandana B. Herath

Clin Sci (Lond) (2020) 134 (23): 3137–3158.

https://doi.org/10.1042/CS20201268

Published: 07 December 2020

...Fiona J. Warner; Harinda Rajapaksha; Nicholas Shackel; Chandana B. Herath Twenty years ago, the discovery of angiotensin-converting enzyme 2 (ACE2) was an important breakthrough dramatically enhancing our understanding of the renin–angiotensin system (RAS). The classical RAS is driven by its key...

View article titled, ACE2: from protection of liver disease to propagation of COVID-19

Articles

ACE2 in the renin–angiotensin system

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ACE2, a multifunctional protein – from cardiovascular regulation to COVID-19

Thiago Verano-Braga, Ana Luiza Valle Martins, Daisy Motta-Santos, Maria José Campagnole-Santos, Robson Augusto Souza Santos

Clin Sci (Lond) (2020) 134 (23): 3063–3078.

https://doi.org/10.1042/CS20200478

Published: 02 December 2020

... associated with the manuscript. The renin–angiotensin system (RAS) is composed by a number of different enzymes and effector peptides that are involved in the dynamic control of many body functions. Many components of the RAS have opposing actions to allow a rapid and coordinated response to different...

View article titled, ACE2 in the renin–angiotensin system

Articles

ACE2, the kidney and the emergence of COVID-19 two decades after ACE2 discovery

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ACE2, a multifunctional protein – from cardiovascular regulation to COVID-19

Enrique Lores, Jan Wysocki, Daniel Batlle

Clin Sci (Lond) (2020) 134 (21): 2791–2805.

https://doi.org/10.1042/CS20200484

Published: 02 November 2020

... in several other organs such as intestine, liver, central nervous system and placental tissue [ 7–10 ]. Since its recognition and characterization, studies on ACE2 have revealed a previously hidden face of the renin–angiotensin system (RAS), the so called ACE2–Ang-(1–7) axis, with many physiologic...

View article titled, ACE2, the kidney and the emergence of COVID-19 two decades after ACE2 discovery

Articles

ACE2 as therapeutic agent

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ACE2, a multifunctional protein – from cardiovascular regulation to COVID-19

Qiuhong Li, Maria B. Grant, Elaine M. Richards, Mohan K. Raizada

Clin Sci (Lond) (2020) 134 (19): 2581–2595.

https://doi.org/10.1042/CS20200570

Published: 14 October 2020

...Qiuhong Li; Maria B. Grant; Elaine M. Richards; Mohan K. Raizada The angiotensin-converting enzyme 2 (ACE2) has emerged as a critical regulator of the renin–angiotensin system (RAS), which plays important roles in cardiovascular homeostasis by regulating vascular tone, fluid and electrolyte balance...

View article titled, ACE2 as therapeutic agent

Articles

Brain angiotensin converting enzyme-2 in central cardiovascular regulation

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ACE2, a multifunctional protein – from cardiovascular regulation to COVID-19

Mazher Mohammed, Clara Berdasco, Eric Lazartigues

Clin Sci (Lond) (2020) 134 (19): 2535–2547.

https://doi.org/10.1042/CS20200483

Published: 05 October 2020

...Mazher Mohammed; Clara Berdasco; Eric Lazartigues The brain renin–angiotensin system (RAS) plays an important role in the regulation of autonomic and neuroendocrine functions, and maintains cardiovascular homeostasis. Ang-II is the major effector molecule of RAS and exerts most of its physiological...

View article titled, Brain angiotensin converting enzyme-2 in central cardiovascular regulation

Articles

Discovery and characterization of ACE2 – a 20-year journey of surprises from vasopeptidase to COVID-19

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ACE2, a multifunctional protein – from cardiovascular regulation to COVID-19

Nigel M. Hooper, Daniel W. Lambert, Anthony J. Turner

Clin Sci (Lond) (2020) 134 (18): 2489–2501.

https://doi.org/10.1042/CS20200476

Published: 29 September 2020

...-7) thereby counterbalancing the action of ACE on the renin–angiotensin system (RAS) and providing a cardioprotective role. Unlike ACE, ACE2 does not metabolise bradykinin nor is it inhibited by classical ACE inhibitors. However, it does convert a number of other regulatory peptides in vitro...

View article titled, Discovery and characterization of ACE2 – a 20-year journey of surprises from vasopeptidase to COVID-19

Articles

Interaction between the apelinergic system and ACE2 in the cardiovascular system: therapeutic implications

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ACE2, a multifunctional protein – from cardiovascular regulation to COVID-19

Paulami Chatterjee, Mahmoud Gheblawi, Kaiming Wang, Jeannie Vu, Palsa Kondaiah, Gavin Y. Oudit

Clin Sci (Lond) (2020) 134 (17): 2319–2336.

https://doi.org/10.1042/CS20200479

Published: 09 September 2020

... (CV) system. The apelin pathway’s dominant physiological role has delineated therapeutic implications for coronary artery disease, heart failure (HF), aortic aneurysm, pulmonary arterial hypertension (PAH), and transplant vasculopathy. Apelin peptides interact with the renin–angiotensin system (RAS...

View article titled, Interaction between the apelinergic system and ACE2 in the cardiovascular system: therapeutic implications

Articles

Antiepileptic effects of long-term intracerebroventricular infusion of angiotensin-(1-7) in an animal model of temporal lobe epilepsy

Karina Pereira Gomes, Pedro Paulo Pereira Braga, Claudio Quintino de Lima, Jr, Poliana Peres Ghazale, Gustavo Rodrigues Pedrino, Elizabeth Pereira Mendes, Aline Priscila Pansani, Carlos Henrique Xavier, Carlos Henrique Castro, Diego Basile Colugnati

Clin Sci (Lond) (2020) 134 (17): 2263–2277.

https://doi.org/10.1042/CS20200514

Published: 03 September 2020

... type of epilepsy and is often refractory to pharmacological treatment. In this scenario, extensive research has identified components of the renin–angiotensin system (RAS) as potential therapeutic targets. Therefore, the aim of the present study was to evaluate the effects of long-term treatment...

View article titled, Antiepileptic effects of long-term intracerebroventricular infusion of angiotensin-(1-7) in an animal model of temporal lobe epilepsy

Articles

Ctcf is required for renin expression and maintenance of the structural integrity of the kidney

Maria Florencia Martinez, Alexandre G. Martini, Maria Luisa S. Sequeira-Lopez, R. Ariel Gomez

Clin Sci (Lond) (2020) 134 (13): 1763–1774.

https://doi.org/10.1042/CS20200184

Published: 10 July 2020

... muscle actin Ctcf homeostasis hypertension nephrology renin-angiotensin system vasculature References 1. Gomez R.A. and Sequeira-Lopez M.L.S. ( 2018 ) Renin cells in homeostasis, regeneration and immune defence mechanisms . Nat. Rev. Nephrol. 14 , 231...

View article titled, Ctcf is required for renin expression and maintenance of the structural integrity of the kidney

Includes: Supplementary data

Articles

Covid-19: the renin–angiotensin system imbalance hypothesis

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Coronavirus

Katharina Lanza, Lucas G. Perez, Larissa B. Costa, Thiago M. Cordeiro, Vitria A. Palmeira, Victor T. Ribeiro, Ana Cristina Simões e Silva

Clin Sci (Lond) (2020) 134 (11): 1259–1264.

https://doi.org/10.1042/CS20200492

Published: 08 June 2020

... mechanisms and pathways of SARS-CoV-2 related to the pathogenesis of Coronavirus Disease 2019 (Covid-19). After transmembrane angiotensin-converting enzyme 2 (ACE2) has been found to be SARS-CoV-2 receptor, we hypothesized an immune-hematological mechanism for Covid-19 based on renin–angiotensin system (RAS...

View article titled, Covid-19: the renin–angiotensin system imbalance hypothesis

Articles

SGLT2 inhibitors – a potential treatment for Alport syndrome

Holly Mabillard, John A. Sayer

Clin Sci (Lond) (2020) 134 (4): 379–388.

https://doi.org/10.1042/CS20191276

Published: 17 February 2020

... Type 2 diabetes mellitus chronic kidney disease renal glomerulus renin-angiotensin system References 1. Wanner C. et al . ( 2016 ) Empagliflozin and Progression of Kidney Disease in Type 2 Diabetes . N. Engl. J. Med. 375 , 323 – 334 10.1056/NEJMoa1515920...

View article titled, SGLT2 inhibitors – a potential treatment for Alport syndrome

Articles

Adipocytes initiate an adipose-cerebral-peripheral sympathetic reflex to induce insulin resistance during high-fat feeding

Wei Cao, Meng Shi, Liling Wu, Jiaxin Li, Zhichen Yang, Youhua Liu, Christopher S. Wilcox, Fan Fan Hou

Clin Sci (Lond) (2019) 133 (17): 1883–1899.

https://doi.org/10.1042/CS20190412

Published: 10 September 2019

... transporter 4 (Glut4) trafficking. Dietary salt in HF fed rats also increased the activity of the adipose-cerebral-muscle renin–angiotensin system (RAS) axes, SNS, and reactive oxygen species (ROS). Insulin sensitivity was reduced by 32% in HF rats during high-salt intake, but was improved by over 62...

View article titled, Adipocytes initiate an adipose-cerebral-peripheral sympathetic reflex to induce insulin resistance during high-fat feeding

Includes: Supplementary data

Articles

Alamandine attenuates arterial remodelling induced by transverse aortic constriction in mice

Fernando Pedro de Souza-Neto, Mario de Morais e Silva, Melissa de Carvalho Santuchi, Thaís Cristina de Alcântara-Leonídio, Daisy Motta-Santos, Aline Cristina Oliveira, Marcos Barrouin Melo, Giovanni Naves Canta, Leandro Eziquiel de Souza, Maria Cláudia Costa Irigoyen, Maria José Campagnole-Santos, Silvia Guatimosim, Robson Augusto Souza Santos, Rafaela Fernandes da Silva

Clin Sci (Lond) (2019) 133 (5): 629–643.

https://doi.org/10.1042/CS20180547

Published: 01 March 2019

...; Silvia Guatimosim; Robson Augusto Souza Santos; Rafaela Fernandes da Silva Aims: The renin–angiotensin system (RAS) plays an important role in the pathophysiology of vascular diseases, especially as a mediator of inflammation and tissue remodelling. Alamandine (Ala 1 -angiotensin-(1-7)) is a new...

View article titled, Alamandine attenuates arterial remodelling induced by transverse aortic constriction in mice

Articles

Electrolyte transport in the renal collecting duct and its regulation by the renin–angiotensin–aldosterone system

Osamu Yamazaki, Kenichi Ishizawa, Daigoro Hirohama, Toshiro Fujita, Shigeru Shibata

Clin Sci (Lond) (2019) 133 (1): 75–82.

https://doi.org/10.1042/CS20180194

Published: 08 January 2019

... of the Biochemical Society 2019 aldosterone intercalated cells renin-angiotensin system renal physiology The RAAS has been known for over a century, since the first discovery of renin by Tigerstedt and Bergman (1898) [ 2 ]. A critical role for the RAAS in the regulation of arterial blood pressure...

View article titled, Electrolyte transport in the renal collecting duct and its regulation by the renin–angiotensin–aldosterone system

Articles

The relationship between habitual dietary sodium intake and RAAS blockade on circulating microparticle levels in type two diabetes

Sara Baqar, Dorothy Liu, Lisa F. Lincz, Yee Wen Kong, George Jerums, Elif I. Ekinci

Clin Sci (Lond) (2018) 132 (20): 2207–2220.

https://doi.org/10.1042/CS20180472

Published: 23 October 2018

... disease endothelial dysfunction microparticles renin-angiotensin system sodium intake type 2 diabetes Cardiovascular-related disease is the leading cause of morbidity and mortality in people with diabetes [ 1 ]. Reduction in blood pressure lowers cardiovascular risk [ 2 ]. As high dietary...

View article titled, The relationship between habitual dietary sodium intake and RAAS blockade on circulating microparticle levels in type two diabetes

Includes: Supplementary data

Articles

Central administration of TRV027 improves baroreflex sensitivity and vascular reactivity in spontaneously hypertensive rats

Alynne Carvalho-Galvão, Blessing Ogunlade, Jiaxi Xu, Cristiane R.A. Silva-Alves, Leônidas G. Mendes-Júnior, Drielle D. Guimarães, Josiane C. Cruz, Thyago M. Queiroz, Camille M. Balarini, Valdir A. Braga, Catalin M. Filipeanu, Eric Lazartigues, Maria do Socorro de França-Silva

Clin Sci (Lond) (2018) 132 (14): 1513–1527.

https://doi.org/10.1042/CS20180222

Published: 23 July 2018

... ) or Eric Lazartigues ( elazar@lsuhsc.edu ) 20 03 2018 08 06 2018 13 06 2018 14 06 2018 © 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2018 ADAM17 ACE2 Biased agonist hypertension renin-angiotensin system Arterial...

View article titled, Central administration of TRV027 improves baroreflex sensitivity and vascular reactivity in spontaneously hypertensive rats

Articles

Modulation of the renin–angiotensin system in white adipose tissue and skeletal muscle: focus on exercise training

Eliete Dalla Corte Frantz, Eliza Prodel, Igor Dutra Braz, Isabele Gomes Giori, Thereza Cristina Lonzetti Bargut, D’Angelo Carlo Magliano, Antonio Claudio Lucas Nobrega

Clin Sci (Lond) (2018) 132 (14): 1487–1507.

https://doi.org/10.1042/CS20180276

Published: 23 July 2018

... ( anobrega@id.uff.br ) * These authors contributed equally to this work. 30 03 2018 13 06 2018 27 06 2018 © 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2018 exercise training renin-angiotensin system sarcopenic obesity...

View article titled, Modulation of the renin–angiotensin system in white adipose tissue and skeletal muscle: focus on exercise training

Articles

Intratubular and intracellular renin–angiotensin system in the kidney: a unifying perspective in blood pressure control

Xiao C. Li, Dongmin Zhu, Xiaowen Zheng, Jiangfeng Zhang, Jia L. Zhuo

Clin Sci (Lond) (2018) 132 (13): 1383–1401.

https://doi.org/10.1042/CS20180121

Published: 09 July 2018

...Xiao C. Li; Dongmin Zhu; Xiaowen Zheng; Jiangfeng Zhang; Jia L. Zhuo The renin–angiotensin system (RAS) is widely recognized as one of the most important vasoactive hormonal systems in the physiological regulation of blood pressure and the development of hypertension. This recognition is derived...

View article titled, Intratubular and intracellular renin–angiotensin system in the kidney: a unifying perspective in blood pressure control

Articles

Identification of protein phosphatase involvement in the AT 2 receptor-induced activation of endothelial nitric oxide synthase

A. Augusto Peluso, Jesper Bork Bertelsen, Kenneth Andersen, Tenna Pavia Mortsensen, Pernille B. Hansen, Colin Sumners, Michael Bader, Robson A. Santos, Ulrike Muscha Steckelings

Clin Sci (Lond) (2018) 132 (7): 777–790.

https://doi.org/10.1042/CS20171598

Published: 06 April 2018

... nitric oxide synthase protein phosphatases renin-angiotensin system Figure 1 AT 2 R expression by HAEC ( A ) AT2R DNA concentration in HAEC as estimated by qPCR. RT–, non-RT mRNA negative control, H 2 O, water negative control. ( B ) Immunofluorescence staining of AT 2 R in HAEC in passage...

View article titled, Identification of protein phosphatase involvement in the AT 2 receptor-induced activation of endothelial nitric oxide synthase

Articles

The angiotensin type 2 receptor in the human adrenocortical zona glomerulosa and in aldosterone-producing adenoma: low expression and no functional role

Paul-Emmanuel Vanderriele, Brasilina Caroccia, Teresa Maria Seccia, Maria Piazza, Livia Lenzini, Francesca Torresan, Maurizio Iacobone, Thomas Unger, Gian Paolo Rossi

Clin Sci (Lond) (2018) 132 (6): 627–640.

https://doi.org/10.1042/CS20171593

Published: 20 March 2018

... concentrations on CYP11B2, do not support the contention that the protective arm of renin–angiotensin system (RAS) blunts aldosterone synthase in the normal adrenal cortex and primary aldosteronism. The polyclonal NCI-H295R and clonal HAC15 cell lines, the latter derived from H295R, were used as in vitro...

View article titled, The angiotensin type 2 receptor in the human adrenocortical zona glomerulosa and in aldosterone-producing adenoma: low expression and no functional role

Includes: Supplementary data

Articles

Non-uniform relationship between salt status and aldosterone activity in patients with chronic kidney disease

Alison H.M. Taylor, Alastair J. Rankin, Emily P. McQuarrie, E. Marie Freel, Natalie Z.M. Homer, Ruth Andrew, Alan G. Jardine, Patrick B. Mark

Clin Sci (Lond) (2018) 132 (2): 285–294.

https://doi.org/10.1042/CS20171603

Published: 25 January 2018

... studied relationships between salt intake, BP and renin–angiotensin system regulation in order to establish if it is disordered in CKD. Methods: Mechanistic crossover study of CKD patients versus non-CKD controls. Participants underwent modified saline suppression test prior to randomization to either low...

View article titled, Non-uniform relationship between salt status and aldosterone activity in patients with chronic kidney disease

Includes: Supplementary data

Articles

Dietary restriction but not angiotensin II type 1 receptor blockade improves DNA damage-related vasodilator dysfunction in rapidly aging Ercc1 Δ/− mice

Haiyan Wu, Bibi S. van Thiel, Paula K. Bautista-Niño, Erwin Reiling, Matej Durik, Frank P.J. Leijten, Yanto Ridwan, Renata M.C. Brandt, Harry van Steeg, Martijn E.T. Dollé, Wilbert P. Vermeij, Jan H.J. Hoeijmakers, Jeroen Essers, Ingrid van der Pluijm, A.H. Jan Danser, Anton J.M. Roks

Clin Sci (Lond) (2017) 131 (15): 1941–1953.

https://doi.org/10.1042/CS20170026

Published: 13 July 2017

..., by preserving genomic integrity. In this mouse mutant displaying prominent accelerated, age-dependent endothelial dysfunction we investigated the signaling pathways involved in improved endothelium-mediated vasodilation by DR, and explore the potential role of the renin-angiotensin system (RAS). Ercc1 Δ/− mice...

View article titled, Dietary restriction but not angiotensin II type 1 receptor blockade improves DNA damage-related vasodilator dysfunction in rapidly aging Ercc1 Δ/− mice

Includes: Supplementary data

Articles

Kidney–brain axis inflammatory cross-talk: from bench to bedside

Aline Silva Miranda, Thiago Macedo Cordeiro, Thomas Mucida dos Santos Lacerda Soares, Rodrigo Novaes Ferreira, Ana Cristina Simões e Silva

Clin Sci (Lond) (2017) 131 (11): 1093–1105.

https://doi.org/10.1042/CS20160927

Published: 17 May 2017

... of trophic factors and of renin–angiotensin system (RAS) molecules, could also be involved, especially in the absence of obvious cerebrovascular disease. In this review, we discuss experimental and clinical evidence for the role of these mechanisms in kidney–brain cross-talk. In addition, we hypothesize...

View article titled, Kidney–brain axis inflammatory cross-talk: from bench to bedside

Articles

Blood pressure-independent renoprotection in diabetic rats treated with AT 1 receptor–neprilysin inhibition compared with AT 1 receptor blockade alone

Lodi C.W. Roksnoer, Richard van Veghel, Marian C. Clahsen- van Groningen, René de Vries, Ingrid M. Garrelds, Usha M. Bhaggoe, Jeanette M.G. van Gool, Edith C.H. Friesema, Frank P.J. Leijten, Ewout J. Hoorn, A.H. Jan Danser, Wendy W. Batenburg

Clin Sci (Lond) (2016) 130 (14): 1209–1220.

https://doi.org/10.1042/CS20160197

Published: 01 June 2016

... hypoxanthine phosphoribosyltransferase-1, β 2 -microglobulin and β-actin for normalization. AT 1 receptor antagonist diabetes hypertension neprilysin inhibition renin–angiotensin system • Dual angiotensin II type 1 (AT 1 ) receptor–neprilysin inhibition (ARNI) exerts beneficial effects...

View article titled, Blood pressure-independent renoprotection in diabetic rats treated with AT 1 receptor–neprilysin inhibition compared with AT 1 receptor blockade alone

Includes: Supplementary data

Articles

Hypertensive retinopathy in a transgenic angiotensin-based model

Nadine Reichhart, Nadine Haase, Sergio Crespo-Garcia, Sergej Skosyrski, Christina Herrspiegel, Norbert Kociok, Rudolf Fuchshofer, Andrea Dillinger, Marco Poglitsch, Dominik N. Müller, Antonia M. Joussen, Friedrich C. Luft, Ralf Dechend, Olaf Strauß

Clin Sci (Lond) (2016) 130 (13): 1075–1088.

https://doi.org/10.1042/CS20160092

Published: 23 May 2016

... (renin–angiotensin system) may contribute to this. This study relied on an established angiotensin, AngII (angiotensin II)-elevated dTGR (double-transgenic rat) model and same-background SD (Sprague–Dawley) rat controls. In dTGRs, plasma levels of AngII were increased. We determined the general retinal...

View article titled, Hypertensive retinopathy in a transgenic angiotensin-based model

Includes: Supplementary data

Articles

Role of matrix metalloproteinase-9 in chronic kidney disease: a new biomarker of resistant albuminuria

Helena Pulido-Olmo, Concha F. García-Prieto, Gloria Álvarez-Llamas, María G. Barderas, Fernando Vivanco, Isabel Aranguez, Beatriz Somoza, Julián Segura, Reinhold Kreutz, María S. Fernández-Alfonso, Luis M. Ruilope, Gema Ruiz-Hurtado

Clin Sci (Lond) (2016) 130 (7): 525–538.

https://doi.org/10.1042/CS20150517

Published: 17 February 2016

... of the renin–angiotensin system, is a clinical problem present in a small number of patients with chronic kidney disease (CKD). The mechanism underlying this resistant albuminuria remains unknown. Matrix metalloproteinases (MMPs) are involved in the pathophysiology of cardiovascular and renal diseases...

View article titled, Role of matrix metalloproteinase-9 in chronic kidney disease: a new biomarker of resistant albuminuria

Includes: Supplementary data

Articles

Renin–angiotensin system as a potential therapeutic target in stroke and retinopathy: experimental and clinical evidence

Abdelrahman Y. Fouda, Sandeep Artham, Azza B. El-Remessy, Susan C. Fagan

Clin Sci (Lond) (2016) 130 (4): 221–238.

https://doi.org/10.1042/CS20150350

Published: 14 January 2016

... literature on the role of the renin-angiotensin system in neurovascular disorders including stroke, retinopathy, traumatic brain injury and cognitive impairment. The review presents both experimental and clinical studies conducted in the field, and sheds light on the translational gap and clinical...

View article titled, Renin–angiotensin system as a potential therapeutic target in stroke and retinopathy: experimental and clinical evidence

Articles

Endotoxin-induced skeletal muscle wasting is prevented by angiotensin-(1–7) through a p38 MAPK-dependent mechanism

María Gabriela Morales, Hugo Olguín, Gabriella Di Capua, Enrique Brandan, Felipe Simon, Claudio Cabello-Verrugio

Clin Sci (Lond) (2015) 129 (6): 461–476.

https://doi.org/10.1042/CS20140840

Published: 22 June 2015

... was normalized by the body weight. angiotensin-(1–7) lipopolysaccharide Mas receptor renin–angiotensin system sepsis syndrome skeletal muscle atrophy • During sepsis syndrome induced by endotoxaemia, loss of strength and muscle mass occur, resulting in a pathological condition called...

View article titled, Endotoxin-induced skeletal muscle wasting is prevented by angiotensin-(1–7) through a p38 MAPK-dependent mechanism

Includes: Supplementary data

Articles

Angiotensin II, oxidative stress and stem cell therapy: a matter of delicacy

Anton J.M. Roks

Clin Sci (Lond) (2015) 128 (11): 749–750.

https://doi.org/10.1042/CS20150082

Published: 17 March 2015

...Anton J.M. Roks Optimization of stem cell therapy after cardiovascular and renal injury depends on many factors, among which is stem cell donor health. The renin–angiotensin system (RAS) plays an important role in cardiovascular and renal homoeostasis and pathophysiology. It is becoming...

View article titled, Angiotensin II, oxidative stress and stem cell therapy: a matter of delicacy

Articles

Exacerbation of acute kidney injury by bone marrow stromal cells from rats with persistent renin–angiotensin system activation

Esko Kankuri, Elina E. Mervaala, Markus Storvik, Aija M.J. Ahola, Jouko Levijoki, Dominik N. Müller, Piet Finckenberg, Eero M. Mervaala

Clin Sci (Lond) (2015) 128 (11): 735–747.

https://doi.org/10.1042/CS20140445

Published: 17 March 2015

...Esko Kankuri; Elina E. Mervaala; Markus Storvik; Aija M.J. Ahola; Jouko Levijoki; Dominik N. Müller; Piet Finckenberg; Eero M. Mervaala Hypertension and persistent activation of the renin–angiotensin system (RAS) are predisposing factors for the development of acute kidney injury (AKI). Although...

View article titled, Exacerbation of acute kidney injury by bone marrow stromal cells from rats with persistent renin–angiotensin system activation

Articles

Recent insights and therapeutic perspectives of angiotensin-(1–9) in the cardiovascular system

Maria Paz Ocaranza, Luis Michea, Mario Chiong, Carlos F. Lagos, Sergio Lavandero, Jorge E. Jalil

Clin Sci (Lond) (2014) 127 (9): 549–557.

https://doi.org/10.1042/CS20130449

Published: 03 July 2014

...Maria Paz Ocaranza; Luis Michea; Mario Chiong; Carlos F. Lagos; Sergio Lavandero; Jorge E. Jalil Chronic RAS (renin–angiotensin system) activation by both AngII (angiotensin II) and aldosterone leads to hypertension and perpetuates a cascade of pro-hypertrophic, pro-inflammatory, pro-thrombotic...

View article titled, Recent insights and therapeutic perspectives of angiotensin-(1–9) in the cardiovascular system

Articles

The central renin–angiotensin system and sympathetic nerve activity in chronic heart failure

Irving H. Zucker, Liang Xiao, Karla K. V. Haack

Clin Sci (Lond) (2014) 126 (10): 695–706.

https://doi.org/10.1042/CS20130294

Published: 27 January 2014

... type 2 receptor (AT 2 R) heart failure renin–angiotensin system CHF (chronic heart failure) is the end result of various insults to the myocardium, the most common of which is ischaemic heart disease [ 1 ]. Whenever cardiac output falls, more than momentarily, compensatory mechanisms...

View article titled, The central renin–angiotensin system and sympathetic nerve activity in chronic heart failure

Articles

Epigenetic regulation of angiotensin-converting enzyme 2 (ACE2) by SIRT1 under conditions of cell energy stress

Nicola E. Clarke, Nikolai D. Belyaev, Daniel W. Lambert, Anthony J. Turner

Clin Sci (Lond) (2014) 126 (7): 507–516.

https://doi.org/10.1042/CS20130291

Published: 11 December 2013

... by which levels of ACE2 are regulated by conditions of cell stress such as hypoxia and cytokine treatment. angiotensin-converting enzyme (ACE) angiotensin-converting enzyme 2 (ACE2) AMP-activated protein kinase (AMPK) angiotensin-(1–7) renin–angiotensin system SIRT1 • Recent work has...

View article titled, Epigenetic regulation of angiotensin-converting enzyme 2 (ACE2) by SIRT1 under conditions of cell energy stress

Articles

Septic shock: desperately seeking treatment

Olivier Huet, Jaye P. F. Chin-Dusting

Clin Sci (Lond) (2014) 126 (1): 31–39.

https://doi.org/10.1042/CS20120668

Published: 30 August 2013

... in relation to our understanding of the underlying mechanisms involved in septic shock, and highlight the attempts made to improve animal experimental models. We also review recent studies reporting promising results with two vastly different therapeutic approaches influencing the renin–angiotensin system...

View article titled, Septic shock: desperately seeking treatment

Articles

Acute regulation of pancreatic islet microcirculation and glycaemia by telmisartan and ramipril: discordant effects between normal and Type 2 diabetic rats

Anna Olverling, Zhen Huang, Thomas Nyström, Åke Sjöholm

Clin Sci (Lond) (2013) 125 (9): 433–438.

https://doi.org/10.1042/CS20120635

Published: 27 June 2013

... both significantly decreased serum insulin levels, and non-additively elevated blood glucose levels. In conclusion, the present study suggests that a local pancreatic RAS (renin–angiotensin system), sensitive to acute administration of telmisartan and ramipril, controls pancreatic IBF and insulin...

View article titled, Acute regulation of pancreatic islet microcirculation and glycaemia by telmisartan and ramipril: discordant effects between normal and Type 2 diabetic rats

Articles

Sex and gender differences in control of blood pressure

Rodrigo Maranon, Jane F. Reckelhoff

Clin Sci (Lond) (2013) 125 (7): 311–318.

https://doi.org/10.1042/CS20130140

Published: 07 June 2013

... F. Reckelhoff (email jreckelhoff@umc.edu ) 11 3 2013 22 3 2013 © The Authors Journal compilation © 2013 Biochemical Society 2013 androgen endothelin menopause obesity oestrogen renin–angiotensin system sympathetic nervous system The effect of HRT on blood...

View article titled, Sex and gender differences in control of blood pressure

Articles

Protective role of AT 2 and B 1 receptors in kinin B 2 -receptor-knockout mice with myocardial infarction

Jiang Xu, Oscar A. Carretero, Liping Zhu, Edward G. Shesely, Nour-Eddine Rhaleb, Xiangguo Dai, Luchen Wang, James J. Yang, Xiao-Ping Yang

Clin Sci (Lond) (2013) 124 (2): 87–96.

https://doi.org/10.1042/CS20120341

Published: 26 September 2012

... infarction renin–angiotensin system • CVD is the leading cause of death in the U.S.A. and worldwide. Activation of the RAS plays a crucial role in the pathophysiology of CVD and up until now the standard therapy has been inhibition of the RAS using ACEi and/or ARB. • We and others have...

View article titled, Protective role of AT 2 and B 1 receptors in kinin B 2 -receptor-knockout mice with myocardial infarction

Articles

Combination renin–angiotensin system blockade and angiotensin-converting enzyme 2 in experimental myocardial infarction: implications for future therapeutic directions

Luke J. Burchill, Elena Velkoska, Rachael G. Dean, Karen Griggs, Sheila K. Patel, Louise M. Burrell

Clin Sci (Lond) (2012) 123 (11): 649–658.

https://doi.org/10.1042/CS20120162

Published: 01 August 2012

...Luke J. Burchill; Elena Velkoska; Rachael G. Dean; Karen Griggs; Sheila K. Patel; Louise M. Burrell The RAS (renin–angiotensin system) is activated after MI (myocardial infarction), and RAS blockade with ACEis [ACE (angiotensin-converting enzyme) inhibitors] or ARBs (angiotensin receptor blockers...

View article titled, Combination renin–angiotensin system blockade and angiotensin-converting enzyme 2 in experimental myocardial infarction: implications for future therapeutic directions

Articles

Angiotensin II AT 1 receptor blockers as treatments for inflammatory brain disorders

Juan M. Saavedra

Clin Sci (Lond) (2012) 123 (10): 567–590.

https://doi.org/10.1042/CS20120078

Published: 23 July 2012

... processes of the brain. angiotensin II type 1 receptor blocker (ARB) brain inflammation neuronal injury renin–angiotensin system ARBs {AT 1 [AngII (angiotensin II) type 1] receptor blockers} have significant potential for treating conditions of high prevalence and without adequate...

View article titled, Angiotensin II AT 1 receptor blockers as treatments for inflammatory brain disorders

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