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Clin Sci (Lond) (2020) 134 (6): 641–656.
Published: 27 March 2020
... of type 2 diabetes, ischemic heart disease and hypertension. Several adverse factors converge and suppress the fetal renin–angiotensin–aldosterone system (RAAS). The aim of this review is to summarize data on the significance of RAAS for kidney development and adult hypertension. Genetic inactivation...
Clin Sci (Lond) (2018) 132 (23): 2469–2481.
Published: 05 December 2018
...Scott Hoffmann; Linda Mullins; Charlotte Buckley; Sebastien Rider; John Mullins The renin–angiotensin system (RAS) is highly conserved, and components of the RAS are present in all vertebrates to some degree. Although the RAS has been studied since the discovery of renin, its biological role...
Clin Sci (Lond) (2018) 132 (12): 1345–1363.
Published: 28 June 2018
... indole-3-carbinol (I3C) for 4 weeks. Plasma prorenin concentration was increased and mean arterial pressure (MAP) increased from 80 ± 18 to 138 ± 17 (mmHg), whereas renal prorenin/renin protein expression was unchanged, in transgenic rats fed with I3C diet. The intact prorenin, not renin, in plasma...
Includes: Supplementary data
Clin Sci (Lond) (2014) 126 (8): 537–544.
Published: 17 December 2013
...Koen Verdonk; Willy Visser; Anton H. Van Den Meiracker; A. H. Jan Danser Pregnancy demands major changes of the cardiovascular system, and this involves, among others, activation of the RAAS (renin–angiotensin–aldosterone system), allowing an aldosterone-dependent increase in volume. Remarkably...
Carlos Maria Ferrario, Sarfaraz Ahmad, Sayaka Nagata, Stephen W. Simington, Jasmina Varagic, Neal Kon, Louis Joseph Dell’Italia
Clin Sci (Lond) (2014) 126 (7): 461–469.
Published: 06 December 2013
... of AngII (angiotensin II) created an underpinning for a more comprehensive exploration of the multiple pathways by which the RAS (renin–angiotensin system) of blood and tissues regulates homoeostasis and its altered state in disease processes. The present review summarizes the progress that has been made...
Clin Sci (Lond) (2014) 126 (3): 195–205.
Published: 01 October 2013
...Robert W. Regenhardt; Douglas M. Bennion; Colin Sumners The goal of the present review is to examine the evidence for beneficial actions of manipulation of the RAS (renin–angiotensin system) in stroke, with particular focus on Ang-(1–7) [angiotensin-(1–7)] and its receptor Mas. The RAS appears...
Clin Sci (Lond) (2012) 123 (3): 121–133.
Published: 05 April 2012
...Wendy W. Batenburg; A. H. Jan Danser Tissue angiotensin generation depends on the uptake of circulating (kidney-derived) renin and/or its precursor prorenin [together denoted as (pro)renin]. Since tissue renin levels are usually somewhat higher than expected based upon the amount of (renin...
Luis E. Okamoto, Satish R. Raj, Amanda Peltier, Alfredo Gamboa, Cyndya Shibao, André Diedrich, Bonnie K. Black, David Robertson, Italo Biaggioni
Clin Sci (Lond) (2012) 122 (4): 183–192.
Published: 24 October 2011
... compared with 1.0±0.3 ng/ml per·h; P =0.033) and upright (5.4±0.6 compared with 3.5±0.8 ng/ml per h; P =0.032) PRA (plasma renin activity). In conclusion, fatigue and CFS-defining symptoms are common in POTS patients. The majority of them met criteria for CFS. CFS–POTS patients have higher markers...
Clin Sci (Lond) (2012) 122 (2): 63–73.
Published: 20 September 2011
... expansion markedly decreased the plasma levels of renin, AngII (angiotensin II) and aldosterone (all P <0.001), while MABP (oscillometry), heart rate, cardiac output (impedance cardiography), RPF (by p -aminohippurate), GFR [glomerular filtration rate; by using 51 Cr-labelled EDTA] and plasma [Na...
Clin Sci (Lond) (2009) 116 (4): 301–314.
Published: 15 January 2009
...Cheng Qian; Regien G. Schoemaker; Wiek H. van Gilst; Anton J. M. Roks Intervention in the RAAS (renin–angiotensin–aldosterone system) is one of the leading pharmacotherapeutic strategies, among others, used for the treatment of cardiovascular disease to improve the prognosis after myocardial...
Concepción MARTÍNEZ-PRIETO, M. Clara ORTÍZ, Lourdes A. FORTEPIANI, Jose Antonio RUIZ-MACIÁ, Noemí M. ATUCHA, Joaquín GARCÍA-ESTAÑ
Clin Sci (Lond) (2000) 98 (5): 611–617.
Published: 26 April 2000
... the controls. Sodium retention increased progressively, and at day 20 BDL rats had retained 0.7 mmol/100 g more than the control animals (accumulated retention: BDL, 2.2±0.2 mmol/100 g; sham-operated, 1.5±0.2 mmol/100 g). Plasma renin activity and aldosterone concentration were not elevated in the BDL animals...
Scott G. RAMSAY, Christopher J. KENYON, Niall WHYTE, Ian C. MCKAY, Neil C. THOMSON, George B. M. LINDOP
Clin Sci (Lond) (2000) 98 (1): 1–7.
Published: 19 November 1999
...Scott G. RAMSAY; Christopher J. KENYON; Niall WHYTE; Ian C. MCKAY; Neil C. THOMSON; George B. M. LINDOP Airway remodelling occurs in chronic asthma. Angiotensin II promotes growth in cardiovascular remodelling. Since the renin–angiotensin system is activated in acute severe asthma, we hypothesized...
Niels Vidiendal OLSEN, Niels Georg JENSEN, Jesper Melchior HANSEN, Niels Juel CHRISTENSEN, Niels FOGH-ANDERSEN, Inge-Lis KANSTRUP
Clin Sci (Lond) (1999) 97 (4): 457–465.
Published: 24 August 1999
.... This study tested whether nabumetone has effects different from those of indomethacin on exercise-induced changes in renal function and the renin–aldosterone system. In a randomized fashion, ten subjects were studied after indomethacin (100 mg), nabumetone (1 g) or no medication (control) administered orally...
Clin Sci (Lond) (1998) 96 (1): 5–15.
Published: 01 January 1999
... angiotensin II arginine vasopressin atrial natriuretic peptide brain natriuretic peptide cyclic GMP glomerular filtration rate heart failure lithium renal plasma flow renin sodium 5Clinical Science (1999) 96, 5 15 (Printed in Great Britain) Renal effects of brain natriuretic peptide in patients...
Gian Paolo Rossi, Edoardo Pavan, Matteo Chiesura-Corona, Michael Bader, Giovanni Paganini, Maurizio Cesari, Renzo De Toni, Gian Pietro Feltrin, Detlev Ganten, Achille C. Pessina
Clin Sci (Lond) (1997) 93 (5): 435–443.
Published: 01 November 1997
...Gian Paolo Rossi; Edoardo Pavan; Matteo Chiesura-Corona; Michael Bader; Giovanni Paganini; Maurizio Cesari; Renzo De Toni; Gian Pietro Feltrin; Detlev Ganten; Achille C. Pessina 1. Low-to-normal renin renovascular hypertension (RVH) and the accuracy of renal vein renin ratios were investigated...
John G. Lainchbury, Garth J. S. Cooper, David H. Coy, Ning-Yi Jiang, Lynley K. Lewis, Timothy G. Yandle, A. Mark Richards, M. Gary Nicholls
Clin Sci (Lond) (1997) 92 (5): 467–472.
Published: 01 May 1997
... of compensatory responses in sympathetic activity or renin release. Urine volume and electrolyte excretion were unaffected. 4. The threshold for biological activity of adrenomedullin in man is lower for arterial pressure than for renal or hormonal responses, and is evident at plasma concentrations seen...
Clin Sci (Lond) (1997) 92 (3): 255–260.
Published: 01 March 1997
... of 0.25 pmol min −1 kg −1 (mean increment above control 3.9 pmol/l, P < 0.001), and tripled ( P < 0.001) with 0.5 pmol min −1 kg −1 . Plasma renin activity was inhibited by both doses (14.8%, P < 0.01, and 20%, P < 0.001, respectively). A significant natriuresis (56% increase in urine sodium...
Clin Sci (Lond) (1996) 91 (2): 169–175.
Published: 01 August 1996
... active renin and kidney morphometry. 2. Serial ultrasound measurements of various morphometric and renal indices were performed in a cohort of 87 singleton fetuses from 22 to 38 weeks gestation. Blood was collected from the umbilical vein at delivery and active renin was measured from the plasma based...
Masahiro Kohzuki, Masayuki Kanazawa, Kazunori Yoshida, Eikatsu Tsutsumi, Minoru Yasujima, Keishi Abe, Colin I. Johnston, Tokutaro Sato
Clin Sci (Lond) (1996) 90 (1): 31–36.
Published: 01 January 1996
... alone. 2. Cardiac weight increased in untreated rats with infarction in comparison with sham-operated controls, indicating the presence of chronic left ventricular dysfunction, although exchangeable body sodium, plasma renin activity, plasma vasopressin and plasma osmolality remained unchanged. 3...
Clin Sci (Lond) (1995) 89 (3): 273–276.
Published: 01 September 1995
...Evelyn A. Millar; Robert M. Angus; Jane E. Nally; Robin Clayton; Neil C. Thomson 1. We have reported that the renin-angiotensin system is activated in acute asthma, and also by high-dose nebulized β 2 -agonists. The contribution of other possible stimuli such as hypoxia is unknown. The present...
Clin Sci (Lond) (1994) 87 (5): 567–574.
Published: 01 November 1994
... Society 1994 24 1 1994 3 6 1994 22 6 1994 angiotensin I angiotensin II angiotensin-converting enzyme activity angiotensin-converting enzyme inhibitors bradykinin antisera kallikrein kinin assay renin Clinical Science (1994) 87, 567-574 (Printed in Great Britain) 567...
Clin Sci (Lond) (1994) 87 (3): 329–335.
Published: 01 September 1994
... urinary sodium excretion during aprotinin infusion. 4. Plasma renin activity, plasma angiotensin II and plasma aldosterone fell significantly during aprotinin infusion. Plasma prekallikrein, plasma noradrenaline and plasma atrial natriuretic peptide did not change. Plasma aprotinin concentration was 209...
Clin Sci (Lond) (1994) 87 (2): 143–149.
Published: 01 August 1994
...Anders Edlund; Hans Ohlsén; Alf Sollevi 1. The effects of local intra-arterial infusion of adenosine on renal blood flow, glomerular filtration and renin release in eight healthy awake subjects have been examined. 2. Renal blood flow and glomerular filtration rate were measured as the clearances...
Clin Sci (Lond) (1994) 86 (5): 575–581.
Published: 01 May 1994
...Mark A. Brown; Loretta Reiter; Alison Rodger; Judith A. Whitworth 1. Pre-eclampsia is characterized by reduced plasma active renin concentration and renal prostacyclin production. The aim of this study was to determine whether the plasma active renin concentration could be stimulated in women...
Clin Sci (Lond) (1994) 86 (4): 391–397.
Published: 01 April 1994
... and the Medical Research Society 1994 aldosterone blood pressure catecholamines ouabain renin 4 11 1993 9 11 1993 Clinical Science (1994) 86, 391-397 (Printed i n Great Britain) 39 I Acute effects of intravenous ouabain in healthy volunteers G. B. PIDGEON', A. M. RICHARDS?, M. G...
Clin Sci (Lond) (1993) 85 (5): 607–614.
Published: 01 November 1993
... urine output. These changes occurred without significant alterations in effective renal plasma flow and glomerular filtration rate. 4. Both 5-hydroxy-L-tryptophan and γ-L-glutamyl-5-hydroxy-L-tryptophan significantly increased plasma aldosterone concentration without a concomitant rise in plasma renin...
Clin Sci (Lond) (1993) 85 (1): 19–26.
Published: 01 July 1993
... therapy had not altered basal plasma concentrations of active renin and angiotensin II, levels of angiotensin II during infusion of the octapeptide were higher during the active phase. The diastolic pressor response to angiotensin II was increased during candoxatril treatment, although this is likely...
Clin Sci (Lond) (1992) 83 (5): 549–556.
Published: 01 November 1992
... −1 for 3 h caused a fall in mean blood arterial pressure from baseline (110.9 ± 11.2 to 95.0 ± 12.8 mmHg) and a rise in heart rate (from 84.6 ± 15.1 to 103 ± 15.2 beats/min). Baseline plasma angiotensin II (42.5 ± 11.8 pg/ml) and renin (64.5 ± 92.7 μ-units/ml) concentrations were already elevated...
Clin Sci (Lond) (1991) 81 (3): 393–399.
Published: 01 September 1991
...Masayuki Hosoi; Shokei Kim; Kenjiro Yamamoto 1. In this study, the carbohydrate structure of pure human renin was examined by using various lectins. 2. Pure renin could be separated into three forms by concanavalin A chromatography, a concanavalin A-unbound form, a loosely bound form and a tightly...
Clin Sci (Lond) (1991) 80 (5): 427–433.
Published: 01 May 1991
... in circulatory volume were minimised by infusion of crystalloid to maintain pulmonary artery occlusion pressure, measured using a Swann-Ganz pulmonary artery catheter. 3. After plasmapheresis, there was no significant change in creatinine clearance, sodium excretion, plasma renin activity or urinary kallikrein...
Clin Sci (Lond) (1991) 80 (4): 339–344.
Published: 01 April 1991
...Nilesh J. Samani; William J. Brammar; John D. Swales 1. Using a ribonuclease-protection assay, renin mRNA levels were compared in the kidneys, livers, brains, hearts and adrenal glands of two-kidney, one-clip Goldblatt hypertensive rats with those of age-matched control rats at 4 weeks (‘early...
Clin Sci (Lond) (1991) 80 (3): 219–225.
Published: 01 March 1991
... < 0.028). At a rise in systolic blood pressure of 18 mmHg, the sodium-retaining effect of insulin appeared to be offset. A shift of the pressure-natriuresis relation to the right is suggested. 3. Plasma catecholamines did not change. Plasma renin activity increased from 1.11 ± 0.17 (basal) to 2.13 ± 0.31...
James J. Morton, Elisabeth C. Beattie, Sheila A. Griffin, Fiona MacPherson, Fiona Lyall, Domenico Russo
Clin Sci (Lond) (1990) 79 (5): 523–530.
Published: 01 November 1990
...James J. Morton; Elisabeth C. Beattie; Sheila A. Griffin; Fiona MacPherson; Fiona Lyall; Domenico Russo 1. Cardiovascular reactivity, blood vessel morphology, blood pressure and the activity of the renin—angiotensin system were determined in the 3-week-old spontaneously hypertensive (SHR), Wistar...
Clin Sci (Lond) (1990) 79 (5): 505–511.
Published: 01 November 1990
...Mark A. Brown; Vivienne C. Zammit; Delma Adsett 1. Active plasma renin concentration but not total renin concentration is reduced in women with pregnancy-induced hypertension compared with normotensive pregnant women. This study was conducted to determine whether women with pregnancy-induced...
Clin Sci (Lond) (1990) 79 (4): 371–376.
Published: 01 October 1990
... to reflect and, in turn, influence changes in intravascular volume. 11 4 1990 28 11 1989 5 6 1990 © 1990 The Biochemical Society and the Medical Research Society 1990 atrial natriuretic factor diurnal variation guanosine 3′:5′-cyclic monophosphate posture renin sodium...
D. J. S. Carmichael, M. S. Sutters, R. J. Unwin, D. Gordon, J. Few, V. H. T. James, J. Wadsworth, W. S. Peart
Clin Sci (Lond) (1990) 78 (6): 605–612.
Published: 01 June 1990
... (5–25 mmol/day) sodium intake in 11 and seven male volunteers, respectively. 2. All subjects showed reduced renal sodium excretion within 36 h of dietary restriction, but the times at which increases in renal aldosterone excretion, saliva aldosterone concentration and plasma renin activity became...
Clin Sci (Lond) (1990) 78 (4): 371–375.
Published: 01 April 1990
..., but the natriuresis during infusion of α-human atrial natriuretic peptide was attenuated. 3. Similar decreases in plasma renin activity with infusion of α-human atrial natriuretic peptide occurred on both days. 4. Administration of lithium may be associated with pharmacological effects and further work is required...
Clin Sci (Lond) (1990) 78 (3): 327–334.
Published: 01 March 1990
... factor. Plasma aldosterone and plasma renin activity increased during the sodium-depleted period but only plasma renin activity was significantly correlated with fractional excretion of filtered sodium. 3. The predominant role of atrial natriuretic factor compared with that of aldosterone in the renal...
Clin Sci (Lond) (1989) 77 (3): 273–279.
Published: 01 September 1989
...Karen Pardy; B. C. Williams; A. R. Noble 1. The role of Ca 2+ in the control of renin release was investigated using a collagenase-dispersed rat kidney cortex cell preparation. 2. Superfusion with a series of low [Ca 2+ ] buffers in either ascending or descending order of concentration increased...
Gordon M. Bell, Richard K. Bernstein, John H. Laragh, Steven A. Atlas, Gary D. James, Mark S. Pecker, Jean E. Sealey
Clin Sci (Lond) (1989) 77 (2): 177–182.
Published: 01 August 1989
...Gordon M. Bell; Richard K. Bernstein; John H. Laragh; Steven A. Atlas; Gary D. James; Mark S. Pecker; Jean E. Sealey 1. To investigate atrial natriuretic factor (ANF) and its relationship to the renin system in diabetes, we measured plasma immunoreactive ANF and plasma renin activity (PRA) in 27...
Clin Sci (Lond) (1989) 76 (5): 553–557.
Published: 01 May 1989
... or rectal temperature during exercise were observed between the two salt intakes. 4. Plasma sodium, potassium and osmolality were similar on the two salt intakes both before and during exercise. Plasma renin activity and aldosterone concentration were elevated after 2 weeks on the reduced salt intake...
Clin Sci (Lond) (1989) 76 (5): 529–534.
Published: 01 May 1989
... rises in basal plasma renin and ANG II concentrations and a fall in aldosterone concentration were not statistically significant. 3. The diastolic pressor response to ANG II was blunted during PGI 2 infusion by comparison with controls ( P < 0.025); this diminution in response was greatest...
Akira Ohishi, Hiromichi Suzuki, Hidetomo Nakamoto, Hiroshige Katsumata, Hiroshi Sakaguchi, Takao Saruta
Clin Sci (Lond) (1989) 76 (4): 353–356.
Published: 01 April 1989
...Akira Ohishi; Hiromichi Suzuki; Hidetomo Nakamoto; Hiroshige Katsumata; Hiroshi Sakaguchi; Takao Saruta 1. We have investigated the effects of the non-renin-mediated actions of angiotensin converting enzyme inhibitors on the progression of chronic renal failure accelerated by hypertension...
Clin Sci (Lond) (1989) 76 (4): 439–446.
Published: 01 April 1989
...Arne Høj Nielsen; Arne Johannessen; Knud Poulsen 1. The plasma concentration of inactive renin was two-to three-fold higher in male than in female mice independently of whether mice of strains with low (BALB/c) or high (Theiller) content of active renin in the submandibular salivary glands were...
Clin Sci (Lond) (1988) 75 (6): 669–672.
Published: 01 December 1988
...Jitsuo Higaki; Toshio Ogihara; Yuichi Kumahara 1. The plasma renin concentration (PRC) and active renin concentration determined by radioimmunometric assay (ARC) were measured before and after administration of frusemide or captopril to normal volunteers. 2. Injection of 40 mg of frusemide followed...
Clin Sci (Lond) (1988) 75 (4): 395–402.
Published: 01 October 1988
...D. M. Tillman; P. F. Semple 1. Because disturbances of calcium metabolism have been described in hypertension, measurements of plasma and serum concentrations of ionized calcium, total calcium, magnesium and renin were made in 38 patients with essential hypertension and age- and sex-matched control...
Clin Sci (Lond) (1988) 75 (3): 331–336.
Published: 01 September 1988
...Ingrid Mazanti; Kirstine Lintrup Hermann; Arne Høj Nielsen; Knud Poulsen 1. In order to study the role of the kidney in the elimination of endogenous plasma renin, renin was measured in the plasma and urine of female mice. 2. The renin concentration was two orders of magnitude lower in urine than...
Clin Sci (Lond) (1988) 74 (6): 571–576.
Published: 01 June 1988
... concentrations; both increased markedly during pacing ( P < 0.01). Plasma concentrations of arginine vasopressin and plasma renin activity did not change signficantly. 4. Urine flow and free water clearance increased during the latter 30 min of pacing ( P < 0.05). There was no significant change in sodium...
M. Bernardi, Rossana De Palma, F. Trevisani, R. Malatesta, M. Baraldini, Carmela Cursaro, G. Gasbarrini
Clin Sci (Lond) (1988) 74 (2): 137–143.
Published: 01 February 1988
... with cirrhosis (10 without and 13 with ascites). Plasma renin activity, glomerular filtration rate and renal sodium excretion were also determined. 2. Metoclopramide did not significantly influence plasma renin activity, whereas both plasma aldosterone and plasma prolactin rose significantly. The incremental...
Clin Sci (Lond) (1988) 74 (1): 37–40.
Published: 01 January 1988
... kg −1 . At the same dose, glutyrosine had no effect on the volume or sodium content of the urine. 3. There was a 400-600-fold increase in urine dopamine output after gludopa; there was no conversion of glutyrosine to dopamine. 4. Gludopa significantly inhibited plasma renin activity, whereas...