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Keywords: renal physiology
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Clin Sci (Lond) (2023) 137 (10): 843–846.
Published: 31 May 2023
... ) acute kidney injury circular RNA renal physiology Acute kidney injury (AKI) is a significant clinical problem characterized by a rapid decrease in glomerular filtration rate (GFR) and an increase in serum creatinine [ 1 , 2 ]. AKI affects approximately 15% of all hospitalized patients...
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Clin Sci (Lond) (2023) 137 (9): 769–772.
Published: 18 May 2023
... with Individual. renal physiology skin sodium homeostasis sweat Although a relatively small part of the body of his work, Arthur Guyton is frequently known for his widely accepted theory that the kidney regulates long-term blood pressure by its ability to increase or decrease extracellular fluid...
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Clin Sci (Lond) (2023) 137 (8): 597–601.
Published: 19 April 2023
... hypertension lymphangiogenesis renal physiology Open access for the present article was enabled by the participation of University of Arizona in an all-inclusive Read & Publish agreement with Portland Press and the Biochemical Society under a transformative agreement with Individual. © 2023...
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Clin Sci (Lond) (2023) 137 (1): 35–45.
Published: 05 January 2023
.... Correspondence: Brian C. Belyea ( bcb9e@virginia.edu ) 27 07 2022 06 12 2022 08 12 2022 12 12 2022 © 2023 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2023 notch signalling pathway renal physiology renin-angiotensin system...
Includes: Supplementary data
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Clin Sci (Lond) (2022) 136 (1): 29–44.
Published: 05 January 2022
... 7 days. fibroblasts inflammation renal fibrosis renal physiology Secondly, we induced type 1 diabetic nephropathy (DN) in C57BL/6 mice aged 7–8 weeks (20–25 g, n =8/group) using streptozotocin (STZ). Each mouse was administered with five daily intraperitoneal injections of STZ (55 mg...
Includes: Supplementary data
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Clin Sci (Lond) (2021) 135 (21): 2521–2540.
Published: 09 November 2021
... purinergic signaling Renal Physiology Polycystic kidney disease (PKD) is a group of inherited nephropathies characterized by the formation of fluid-filled sacs along the nephron. There are two main forms of PKD—autosomal dominant ( AD PKD) and autosomal recessive ( AR PKD). ADPKD is a multifactorial...
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Clin Sci (Lond) (2020) 134 (23): 3213–3228.
Published: 11 December 2020
... an adverse pregnancy outcome such as preeclampsia in these animals. Pregnancy produces marked changes in renal physiology, including significant vasodilation, and increased glomerular filtration rate and renal blood flow [ 11 , 34 ]. The osmotic threshold for vasopressin stimulation is lowered, leading...
Includes: Supplementary data
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Clin Sci (Lond) (2020) 134 (21): 2893–2895.
Published: 13 November 2020
... to bedside, but every small step is welcome. microRNA renal physiology therapeutics The renal tubular epithelial cell (rTEC) has been well-characterised with respect to its ability to release and take up extracellular RNA (exRNA) and EVs [ 1 , 2 ]. We also know quite a lot about how these signals...
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Clin Sci (Lond) (2020) 134 (8): 941–953.
Published: 21 April 2020
... 2020 The Author(s). 2020 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY-NC-ND) . congenital sodium diarrhea gastrointestinal physiology homeostasis renal...
Includes: Supplementary data
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Clin Sci (Lond) (2019) 133 (1): 75–82.
Published: 08 January 2019
... of the Biochemical Society 2019 aldosterone intercalated cells renin-angiotensin system renal physiology The RAAS has been known for over a century, since the first discovery of renin by Tigerstedt and Bergman (1898) [ 2 ]. A critical role for the RAAS in the regulation of arterial blood pressure...
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Clin Sci (Lond) (2018) 132 (17): 1995–1997.
Published: 14 September 2018
... ( jakob.voelkl@charite.de ) 02 08 2018 14 08 2018 16 08 2018 © 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2018 acid-base balance adenylyl cyclases renal physiology Systemic acid-base balance results from the complex interplay...
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Clin Sci (Lond) (2018) 132 (16): 1779–1796.
Published: 30 August 2018
... 25 06 2018 © 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2018 adenylyl cyclase acid-base bicarbonate cAMP proton renal physiology Maintaining acid–base homeostasis is critical for normal physiology and various segments...
Includes: Supplementary data
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Clin Sci (Lond) (2018) 132 (13): 1383–1401.
Published: 09 July 2018
... hypertension intratubular angiotensins proximal tubular cell renin-angiotensin system renal physiology Since the seminal discovery of the rate-limiting enzyme renin by Tigerstedt and Bergman (in 1898) [ 1 ] and the landmark study of Goldblatt et al. [ 2 ] on the role of renin in the development...
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Clin Sci (Lond) (2018) 132 (12): 1329–1339.
Published: 28 June 2018
... enhances the incidence or severity of acute kidney injury (AKI). diabetic nephropathy glucose transport renal physiology Type 2 diabetes mellitus (T2DM) is a major public health concern [ 1 ]. The main feature of T2DM is chronic or periodic hyperglycemia which in turn can lead to progression...
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Clin Sci (Lond) (2018) 132 (7): 739–758.
Published: 06 April 2018
... renal physiology Figure 2 Processes involved in de novo albuminuria development Mechanisms involved in the pathogenesis of renal damage and functional implications of observed protein and metabolic alterations related to immune response, inflammation, oxidative stress, vascular remodeling...
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