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Keywords: renal function
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Clin Sci (Lond) (2018) 132 (18): 2071–2085.
Published: 22 September 2018
... of renal function including reductions in both glomerular filtration rate (GFR) and tubular handling of water and solutes. Although obstruction can be released by surgical operation, the child will suffer from diuresis for sometime. It has been reported that erythropoietin (EPO) could prevent the down...
Includes: Supplementary data
Clin Sci (Lond) (2012) 122 (9): 429–437.
Published: 16 January 2012
... in cardiac contractility and output. Although AM5 activated PRA, plasma aldosterone levels were suppressed and natriuretic peptide concentrations were maintained despite the decline in LAP. AM5 also enhanced renal function, producing significant increases in urine volume, sodium excretion and creatinine...
Clin Sci (Lond) (2012) 122 (3): 105–111.
Published: 27 September 2011
...±0.24 μmol/l; P <0.001). SDMA levels were significantly correlated with markers of renal function. Kaplan–Meier survival analysis demonstrated that cumulative survival decreased significantly with ascending tertiles of SDMA ( P <0.001). Our study provides the first data indicating that SDMA...
Clin Sci (Lond) (2010) 119 (9): 373–387.
Published: 23 July 2010
... jhc36@cam.ac.uk ). 27 4 2010 4 6 2010 8 6 2010 8 6 2010 © The Authors Journal compilation © 2010 Biochemical Society 2010 developmental programming lifespan maternal diet renal function senescence stress response Aging is a biological process...
Includes: Supplementary data
Clin Sci (Lond) (2010) 119 (8): 323–333.
Published: 06 July 2010
... model, and confirmed that short-term treatment was able to delay the progression of kidney cysts and protect renal function, which may relate to down-regulating the abnormally activated β-catenin signalling pathway and its anti-inflammatory and anti-fibrosis effects. Long-term administration...
Clin Sci (Lond) (2009) 116 (3): 257–263.
Published: 08 January 2009
... predictive of plasma copeptin. The present study suggests that gender and renal function specific partition values should be used to interpret copeptin values in future studies of this biomarker in HF or ischaemic heart disease. Correspondence: Dr Sanjay S. Bhandari (email sanjay1bhandari@hotmail.com...
Clin Sci (Lond) (2008) 114 (10): 635–642.
Published: 14 April 2008
... in haemodynamics, hormonal profile and renal function than achieved by captopril alone. These results indicate that dual treatment with these two agents is beneficial. Correspondence: Dr Miriam T. Rademaker (email miriam.rademaker@chmeds.ac.nz ). 15 10 2007 26 11 2007 5 12 2007 5 12...
Clin Sci (Lond) (2007) 113 (7): 297–311.
Published: 03 September 2007
..., gastrointestinal responses, reproductive processes, renal effects etc. This review highlights recent insights into the role of each prostanoid in regulating various aspects of renal function, including haemodynamics, renin secretion, growth responses, tubular transport processes and cell fate. A thorough review...
Clin Sci (Lond) (2004) 106 (1): 27–34.
Published: 01 January 2004
...Pietro PANTALEO; Fabio MARRA; Francesco VIZZUTTI; Saura SPADONI; Giovanni CIABATTONI; Claudio GALLI; Giorgio LA VILLA; Paolo GENTILINI; Giacomo LAFFI Advanced cirrhosis is associated with reduced platelet function and altered renal function and sodium handling. Arachidonic acid (AA) metabolites...
Clin Sci (Lond) (2000) 98 (4): 439–444.
Published: 17 March 2000
... this was not a normal population, but one with a wide range of renal function, GFR/vECF showed a strong inverse association with age, whereas for GFR/BSA the association was weak. In conclusion, these data provide further evidence that vECF is more valid physiologically for indexing GFR than is BSA, especially...
Clin Sci (Lond) (1999) 97 (6): 681–687.
Published: 15 November 1999
... hypertension hypertension genetics hypertension pathogenesis insulin resistance lithium clearance renal function reninangiotensin system 681Clinical Science (1999) 97, 681 687 (Printed in Great Britain) Renal effects of hyperinsulinaemia in subjects with two hypertensive parents Ulrik B. ANDERSEN...
Clin Sci (Lond) (1998) 95 (1): 73–81.
Published: 01 July 1998
... interleukin-2 lithium clearance prostaglandins renal function sodium clearance 73Clinical Science (1998) 95, 73 81 (Printed in Great Britain) Renal haemodynamics, sodium and water reabsorption during continuous intravenous infusion of recombinant interleukin-2 Poul F. GEERTSEN*, Hans VON DER MAASE...
Clin Sci (Lond) (1997) 92 (6): 579–585.
Published: 01 June 1997
... role in acute renal failure. In the present study we therefore investigated renal function and the renal ET system in rats on day 4 after bile-duct ligation (BDL) or sham-operation (SO), without ( n = 7 in each group) and with treatment with bosentan, a combined ET A /ET B receptor blocker, ( n = 5...
Clin Sci (Lond) (1994) 87 (4): 427–434.
Published: 01 October 1994
... vacuolation of the proximal tubule [14]. The role of endothelin in the renal responses to diatrizoate (high-osmolar Key words contmt media, endothelin. endothelin antagonist, phosphoramidon. renal function. Abbreviations Cl,, clearance d [ Clinulin; ECE, endothelin-converting enzyme; ET-I, endothelin-I; FR...
Clin Sci (Lond) (1994) 87 (3): 329–335.
Published: 01 September 1994
... in cirrhosis, and reduced systemic vascular resistance has been suggested as a trigger to renal sodium retention in this disease. We investigated the effect of aprotinin, a protease inhibitor which binds to plasma kallikrein, on systemic haemodynamics and renal function in patients with hepatic cirrhosis...
Clin Sci (Lond) (1994) 86 (5): 599–610.
Published: 01 May 1994
... to renal function in an ovine model of progressive hyperdynamic sepsis. 2. Nine chronically instrumented unanaesthetized sheep were given a continuous intravenous infusion of Escherichia coli endotoxin (20 ng min −1 kg −1 ) for 3 days. 3. Within the first 12 h of infusion, endotoxin induced a major...
Clin Sci (Lond) (1993) 85 (5): 643–649.
Published: 01 November 1993
... to compare the first hour and following hourly values. The Mann-Whitney U-test was used in order to compare control and expansion experiments. A P value of < 0.05 was considered statistically significant. RESULTS Renal function (Fig. I) Vdid not change in control experiments. It was increased in expansion...
Clin Sci (Lond) (1993) 85 (2): 123–127.
Published: 01 August 1993
...C. F. Chen 1. Chronic hypoxic rats are always polycythaemic. It is possible that an increase in packed cell volume may enhance erythrocyte trapping with a consequent increase in renal damage after renal ischaemia. These experiments were designed to assess renal functional changes after renal...
Clin Sci (Lond) (1993) 85 (1): 19–26.
Published: 01 July 1993
... in clearing angiotensin II from the circulation. 8 3 1993 15 3 1993 © 1993 The Biochemical Society and the Medical Research Society 1993 aldosterone angiotensin II atrial natriuretic peptide neutral endopeptidase renal function renin sodium balance Clinical Science (1993) 85...
Clin Sci (Lond) (1993) 84 (5): 531–535.
Published: 01 May 1993
... heart failure. cardiac hypertrophy cardiac output laser-Doppler flowmetry renal function thermodilution Clinical Science (1993) 84, 531-535 (Printed in Great Britain) Haemodynamic and neurohumoral changes in spontaneously hypertensive rats with aortocaval fistulae Tamiko OKA, Hikaru NISHIMURA...
Clin Sci (Lond) (1993) 84 (2): 237–242.
Published: 01 February 1993
...Niels Vidiendal Olsen; Michael Hecht Olsen; Niels Fogh-Andersen; Bo Feldt-Rasmussen; Annelise Kamper; Inger Plum; Svend Strandgaard; Paul Peter Leyssac 1. The effect of a single dose of lithium on renal function before and during intravenous infusion of dopamine (3 μg min −1 kg −1...
Clin Sci (Lond) (1992) 83 (6): 711–715.
Published: 01 December 1992
...F. Zaladek Gil; V. L. Costa Silva; M. F. Cavanal; G. Malnic 1. The influence of thyroparathyroidectomy on renal function and specifically on acid excretion was studied in rats with or without oral supplementation of calcium. 2. Thyroparathyroidectomy caused a significant decrease in glomerular...
Clin Sci (Lond) (1992) 82 (5): 551–557.
Published: 01 May 1992
... significantly in the hypertensive group (0.22 ± 0.01 versus 0.26 ± 0.02, P < 0.05). A similar sustained antidiuresis was also observed after tryptophan administration in both groups. In addition, the above-described renal functional changes were not accompanied by any significant changes in systemic blood...
Clin Sci (Lond) (1992) 82 (2): 185–190.
Published: 01 February 1992
... kidney, Milan hypertensive strain rats, ouabain, renal function. Abbreviations: FRN fractional Na+ reabsorption; GFR, glomerular filtration rate; MHS, Milan hypertensive strain; MNS, Milan normotensive strain; Qol, O2 consump- tion; RPF, renal plasma flow; RVR, renal vascular resistance; UV, urine flow...
Clin Sci (Lond) (1991) 81 (s25): 465–470.
Published: 01 October 1991
...F. Zaladek Gil; V. L. Costa Silva; M. F. Cavanal 1. The influence of thyroparathyroidectomy and/or acidosis on renal function and specifically on acid excretion was studied in rats treated with a cumulative dose of 2 mg of aluminium. 2. Aluminium-treated and non-treated thyroparathyroidectomized...
Clin Sci (Lond) (1991) 80 (5): 427–433.
Published: 01 May 1991
...Allan D. Cumming; Adam Linton 1. The effect of the plasma protein concentration on renal function remains controversial. Most, but not all, experimental studies suggest that a reduced plasma protein concentration perfusing the kidney may reduce tubular sodium reabsorption. Hypoproteinaemic disease...
Clin Sci (Lond) (1991) 80 (2): 143–147.
Published: 01 February 1991
... Society and the Medical Research Society 1991 angiotensin II cirrhosis glomerular contraction glomeruli receptors renal function Clinical Science (1991) 80,143-147 ',143 Glomerular binding and contractile response to angiotensin I1 in rats with chronic experimental cirrhosis of the liver...
Clin Sci (Lond) (1990) 78 (6): 565–572.
Published: 01 June 1990
... intake dietary sodium intake renal function Clinical Science (1990) 78,565-572 565 Atrial natriuretic peptide and chronic renal effects of changes in dietary protein and sodium intake in man C . J. DOORENBOS, J. A. IESTRA, S . E. PAPAPOULOS", J. ODINKt AND P. VAN BRUMMELEN Department of Nephrology...
Clin Sci (Lond) (1990) 78 (2): 165–168.
Published: 01 February 1990
...Paolo Madeddu; Nicola Glorioso; Aldo Soro; Paolo Manunta; Chiara Troffa; Giancarlo Tonolo; Maria Grazia Melis; Antonio Pazzola 1. To evaluate whether sodium intake can modulate the action of endogenous kinins on renal function and haemodynamics, a receptor antagonist of bradykinin was infused...
Clin Sci (Lond) (1989) 77 (6): 643–650.
Published: 01 December 1989
... disease proteinuria renal function vascular permeability Clinical Science ( 1 989) 77,643-650 643 Effect of a-human atrial natriuretic peptide on proteinuria in patients with primary glomerular diseases MASAO ISHII, YASUNOBU HIRATA, TOKUICHIRO SUGIMOTO, HIROAKI MATSUOKA, KENJIRO KIMURA, TOSHIHIKO...
Clin Sci (Lond) (1989) 77 (1): 55–60.
Published: 01 July 1989
... natriuretic peptide hippuran extraction renal blood flow renal function renal sodium handling Clinical Science (1989) 77,55-60 55 Atrial natriuretic peptide-induced decreases in renal blood flow in man: implications for the natriuretic mechanism WILBERT M. T. JANSSEN, DICK DE ZEEUW, GJALT K. VAN DER...
Clin Sci (Lond) (1989) 76 (3): 289–296.
Published: 01 March 1989
... clearance was unchanged. This observation may explain the failure of some previous studies to relate hypertension to impairment of renal function. 4. Plasma renin activity, plasma aldosterone and whole-body exchangeable sodium did not differ between normotensive and hypertensive patients with primary...
Clin Sci (Lond) (1989) 76 (1): 31–37.
Published: 01 January 1989
... positive airway pressure (CPAP) treatment. 2. To investigate the mechanisms of these changes in renal function, nocturnal urinary excretion of catecholamines and guanosine 3′:5′-cyclic monophosphate (cyclic GMP), which reflects atrial natriuretic factor (ANF) release, and next-morning plasma active renin...
Clin Sci (Lond) (1988) 74 (2): 137–143.
Published: 01 February 1988
... enhance renal sodium retention. aldosterone cirrhosis dopamine metoclopramide prolactin renal function renin 13 5 1987 30 7 1987 © 1970 The Biochemical Society and the Medical Research Society 1970 Clinical Science ( 1988) 74. 137- 143 137 Unaltered dopaminergic modulation...
Clin Sci (Lond) (1987) 73 (6): 593–599.
Published: 01 December 1987
... pressure cardiac function chronic bile duct ligation eicosanoids mitochondrial function Na + K + -adenosine triphosphatase renal function ...
Clin Sci (Lond) (1987) 73 (2): 171–176.
Published: 01 August 1987
... endoperoxides into formation of vasodilator/natriuretic prostaglandins. These effects might be exaggerated and/or modified in conditions where arachidonic acid metabolism is stimulated. 9 10 1986 16 2 1986 © 1970 The Biochemical Society and the Medical Research Society 1970 renal function...
Clin Sci (Lond) (1987) 73 (2): 135–141.
Published: 01 August 1987
... I showed a greater increase in plasma noradrenaline and adrenaline ( P < 0.05). On multivariate analysis, those with lower systolic blood pressure, better renal function and more reactive sympathetic nervous system were discriminated as group I. 5. These data suggest that group I patients have...
Clin Sci (Lond) (1987) 73 (1): 87–92.
Published: 01 July 1987
... a physiological role in increasing sodium excretion to maintain osmolality after dehydration. 22 12 1986 2 2 1987 © 1970 The Biochemical Society and the Medical Research Society 1970 antidiuretic hormone dehydration osmolality osmolarity renal function sodium sodium potassium...
Clin Sci (Lond) (1986) 71 (5): 533–538.
Published: 01 November 1986
... excretion. 13 6 1986 16 6 1986 © 1986 The Biochemical Society and the Medical Research Society 1986 blood captopril pressure prostaglandin I 2 renal function renin ClinicalScience(1986) 71, 533-538 533 The contribution of PGI, to the effects of captopril in conscious dogs...
Clin Sci (Lond) (1986) 71 (5): 527–532.
Published: 01 November 1986
...,. 5. The calculated basal rate of entry of prosta- glandin I, into the systematic circulation in con- scious dogs is 4 ng min- kg- body weight, which is substantially higher than that previously reported in man. Key words: blood pressure, 6-keto-prostaglandin F prostaglandin I,, renal function...
Clin Sci (Lond) (1985) 69 (3): 293–298.
Published: 01 September 1985
... in distal nephron water permeability. Correspondence: Dr S. Carney, Department of Medicine, Maddison Building, Royal Newcastle Hospital, Newcastle, New South Wales, 2300, Australia. Key words: counter-current mechanism, indo- methacin, potassium, prostaglandins, renal function, sodium, urine concentration...
Clin Sci (Lond) (1985) 68 (4): 387–393.
Published: 01 April 1985
...Herbert J. Kramer; Bruno Stinnesbeck; Georg Klautke; Jochen Kipnowski; Dietrich Klingmueller; Kilian Glaenzer; Rainer Duesing 1. In six healthy subjects the role of renal prostaglandins (PG) in modulating the actions of the renin-angiotensin and renal adrenergic nervous systems on renal function...
Clin Sci (Lond) (1982) 63 (6): 539–548.
Published: 01 December 1982
...Denise Laouari; Claire Kleinknecht; Giulia Cournot-Witmer; Renée Habib; Françoise Mounier; Michel Broyer 1. Diets deficient in phosphorus have been shown to preserve the renal function of uraemic rats, but the role of concomitant alterations in the intake of other nutrients caused by such diets...
Clin Sci (Lond) (1982) 63 (4): 387–392.
Published: 01 October 1982
... and the Medical Research Society 1982 cirrhosis liver proteinuria renal function Clinical Science (1982) 63, 387-392 387 Proteinuria in patients with cirrhosis: relationship between renal and hepatic fbnction L. M I L A N I , A . G A T T A , C . M E R K E L A N D A. R U O L Universitci degli Studi di...
Clin Sci (Lond) (1981) 61 (1): 61–67.
Published: 01 July 1981
... 1981 The Biochemical Society and the Medical Research Society 1981 arginine vasopressin desaminoarginine vasopressin diabetes insipidus kallikrein plasma renin activity prostaglandins renal function CIinicalScience (1981) 61,61-67 61 Renal prostaglandins and water balance: studies...
Clin Sci (Lond) (1979) 57 (4): 359–365.
Published: 01 October 1979
... cause blood pressure to rise. 20 9 1978 2 5 1979 © 1979 The Biochemical Society and the Medical Research Society 1979 blood pressure hypertension indomethacin renal function prostaglandins prostaglandin synthesis inhibition Clinical Science (1979) 51,359-365 Effect...
Clin Sci (Lond) (1979) 56 (6): 547–553.
Published: 01 June 1979
... and in volume-expanded rats during the expansion phase, but not during stable expansion. 6. The results suggest that the kallikrein-kinin system may contribute to changes in renal function during extracellular volume expansion. This action may not necessarily be associated with changes in renal prostaglandin E...
Clin Sci Mol Med (1978) 55 (s4): 367s–371s.
Published: 01 December 1978
... plasma renin activity plasma and urinary electrolytes plasma volume renal function urinary aldosterone Clinical ScienceandMolecular Medicine (1918) 55,367s-311s Familial hypertension and hormonal profile, renal haemodynamics and body fluids of young normotensive subjects G . B I A N C H I , G. B...
Clin Sci Mol Med (1977) 52 (2): 205–213.
Published: 01 February 1977
... assume a greater role in this regard. However, renal clearance appears to be an important route for the disposition of dipeptides which are poorly hydrolysed by body tissues. Key words: amino acid nutrition, dipeptide hydrolysis, dipeptide transport, renal function. Introduction In the preceding paper...
Clin Sci Mol Med (1976) 51 (s3): 249s–251s.
Published: 01 December 1976
... activity and plasma prostaglandin E 2 , but caused increased mean blood pressure (102 to 121 mmHg, sem 4 and 6 respectively; P < 0·01) and decreased renal function (plasma creatinine 0·9 ± 0·04 to 3·5 ± 1 mg/100 ml, sem 0·04 and 1 respectively; P < 0·01). 6. Aggravation of hypertension...