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Keywords: renal fibrosis
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Clin Sci (Lond) (2023) 137 (20): 1593.
Published: 20 October 2023
... by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . epithelial-to-mesenchymal transition mitogen-activated protein kinases renal fibrosis transforming growth factors The authors of the original article...
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Clin Sci (Lond) (2022) 136 (1): 103–120.
Published: 07 January 2022
...Yong Wu; Huan Yang; Sujuan Xu; Ming Cheng; Jie Gu; Weichen Zhang; Shaojun Liu; Minmin Zhang Inflammatory response and renal fibrosis are the hallmarks of chronic kidney disease (CKD). However, the specific mechanism of aldosterone-induced renal injury in the progress of CKD requires elucidation...
Includes: Supplementary data
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Clin Sci (Lond) (2022) 136 (1): 29–44.
Published: 05 January 2022
... ]. The mice were killed after 48 h of WISP1 injection. fibroblasts inflammation renal fibrosis renal physiology The growing prevalence of chronic kidney disease (CKD) is a major health concern and can be caused by a variety of factors including obesity, diabetes and hypertension. Current...
Includes: Supplementary data
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Clin Sci (Lond) (2021) 135 (17): 2127–2142.
Published: 10 September 2021
... of renal fibrosis via regulation of multiple profibrotic pathways. Correspondence: Yufeng Huang ( Yufeng.huang@hsc.utah.edu ) or Patrice N. Mimche ( Patrice.mimche@path.utah.edu ) or Mark Henkemeyer ( mark.henkemeyer@utsouthwestern.edu ) 21 06 2021 24 08 2021 27 08 2021 31 08...
Includes: Supplementary data
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Clin Sci (Lond) (2021) 135 (2): 409–427.
Published: 29 January 2021
...Daqian Gu; Dandong Fang; Mingming Zhang; Jingwen Guo; Hongmei Ren; Xinyue Li; Ziyue Zhang; Donghai Yang; Xue Zou; Yukai Liu; Wei Eric Wang; Gengze Wu; Pedro A. Jose; Yu Han; Chunyu Zeng Hypertensive nephropathy (HN) is a common cause of end-stage renal disease with renal fibrosis; chronic kidney...
Includes: Supplementary data
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Clin Sci (Lond) (2021) 135 (1): 143–159.
Published: 08 January 2021
... with MI. Renal fibrosis is a potent predictor of progression in patients and is often accompanied by inflammation and oxidative stress; however, the mechanisms involved in these alterations are not well established. Endoplasmic reticulum (ER) plays a central role in protein processing and folding...
Includes: Supplementary data
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Clin Sci (Lond) (2020) 134 (21): 2873–2891.
Published: 13 November 2020
... of extracellular matrix (ECM) proteins in the tubulointerstitium and induction of epithelial–mesenchymal transition (EMT) during renal fibrosis. We tested the anti-fibrotic potential of vorapaxar, a clinically approved PAR-1 antagonist for cardiovascular protection, in an experimental kidney fibrosis model...
Includes: Supplementary data
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Clin Sci (Lond) (2020) 134 (17): 2337–2352.
Published: 10 September 2020
... was measured. renal fibrosis TRAIL type 2 diabetes TNF-related apoptosis-inducing ligand (TRAIL) is a type II transmembrane protein that can be cleaved to form a circulating ligand, which belongs to the TNF family of apoptosis-inducing ligands. Both membrane-bound and circulating TRAIL are able...
Includes: Supplementary data
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Clin Sci (Lond) (2020) 134 (15): 2037–2051.
Published: 07 August 2020
... products—symmetric dimethylarginine (SDMA) and asymmetric dimethylarginine (ADMA)—are involved in several renal pathological processes, including renal fibrosis, acute kidney injury (AKI), diabetic nephropathy (DN), hypertension, graft rejection and renal tumors. We aim in this review to elucidate...
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Clin Sci (Lond) (2020) 134 (12): 1433–1448.
Published: 18 June 2020
... by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY-NC-ND) . inflammation renal fibrosis RNA-binding protein Chronic kidney disease (CKD) is characterized by persistent inflammation and progressive fibrosis...
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Clin Sci (Lond) (2019) 133 (14): 1587–1602.
Published: 22 July 2019
... blunted these effects and led to significantly higher plasma erythropoietin (EPO) levels. Adenine-induced renal fibrosis, endoplasmic reticulum (ER) stress and apoptosis were significantly decreased by PBI-4050. In parallel, Gpr40 −/− mice were more susceptible to adenine-induced fibrosis, renal function...
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Clin Sci (Lond) (2019) 133 (12): 1309–1320.
Published: 19 June 2019
...; UUO and folic acid injection induced renal fibrosis mouse models Kidney Inhibits renal fibroblasts activation, ECM overproduction and deposition, inflammatory cells infiltration and TGF-β-induced fibrotic events, may attenuate pre-established renal fibrosis [ 36 ] Dermal fibroblasts from...
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Clin Sci (Lond) (2018) 132 (21): 2339–2355.
Published: 13 November 2018
...Zhenzhen Li; Xianghua Liu; Fengyan Tian; Ji Li; Qingwei Wang; Chaohui Gu Epithelial-to-mesenchymal transition (EMT) is a phenotypic conversion that plays a crucial role in renal fibrosis leading to chronic renal failure. Mitogen-activated protein kinase phosphatase 2 (MKP2) is a member of the dual...
Includes: Supplementary data
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Clin Sci (Lond) (2018) 132 (21): 2299–2322.
Published: 02 November 2018
... of renal fibroblasts and development of renal fibrosis and suggest that inhibition of autophagy may represent a potential therapeutic strategy for HN. Correspondence: Weijie Yuan ( ywj4169@163.com ) or Na Liu ( naliubrown@163.com ) * These authors contributed equally to this work. 28...
Includes: Supplementary data
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Clin Sci (Lond) (2017) 131 (16): 2125–2143.
Published: 24 July 2017
...), and Src family kinase, which has recently been approved by FDA to treat idiopathic pulmonary fibrosis. Whether it affects renal fibrosis remains unknown. Here, we demonstrated that administration of nintedanib immediately or 3 days after unilateral ureteral obstruction (UUO) injury and with folic acid (FA...
Includes: Supplementary data
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Clin Sci (Lond) (2014) 127 (7): 423–433.
Published: 17 June 2014
...Chunling Huang; Carol A. Pollock; Xin-Ming Chen There is an urgent need to identify novel interventions for mitigating the progression of diabetic nephropathy. Diabetic nephropathy is characterized by progressive renal fibrosis, in which tubulointerstitial fibrosis has been shown to be the final...
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Clin Sci (Lond) (2013) 124 (4): 243–254.
Published: 31 October 2012
...-regulated. In the context of renal fibrosis, Smad3 is pathogenic, whereas Smad2 and Smad7 are renoprotective. However, this counter-balancing mechanism is also altered because TGF-β1 induces Smurf2, a ubiquitin E3-ligase, to target Smad7 as well as Smad2 for degradation. Thus overexpression of renal Smad7...