... under the Creative Commons Attribution License 4.0 (CC BY-NC-ND) . cardiac disease hypertension Prorenin renin renal disease Elevated plasma prorenin levels are commonly found in diabetic patients and it has been known for many years that plasma prorenin levels correlate...

... to a wide variety of renal pathologies through their ability to modify lipids and proteins, damage DNA and activate transcriptional programmes. Diverse studies demonstrate key roles for Nox-derived ROS in kidney fibrosis, particularly in settings of chronic renal disease such as diabetic nephropathy...

... biomarker genomics protein expression proteomics renal disease translational research In a blueprint for the genomic era, the US NHGRI (National Human Genome Research Institute) laid out the major challenges ahead in harnessing the potential of the Human Genome Project to improve humanity's...

...Stephen McDONALD; Graeme MAGUIRE; Natalia DUARTE; Xing Li WANG; Wendy HOY Rates of cardiovascular and renal disease in Australian Aboriginal communities are high, but we do not know the contribution of inflammation to these diseases in this setting. In the present study, we sought to examine...

... with a genetic predisposition to hypertension. The present study investigated the kinetic properties of the sodium—lithium countertransporter and membrane microviscosity in patients with hypertension, renal disease and impaired renal function. 2. Sixty patients with renal disease (28 chronic renal failure, 30...

...Carolyn Thornley; Anne Dawnay; W. R. Cattell 1. A recently developed, simple and sensitive radioimmunoassay has been used to examine 24 h excretion and plasma levels of Tamm-Horsfall glycoprotein (THG) in normal subjects, stone formers and patients with stable chronic renal disease. 2. In normal...

... plasma renin activity renal disease ClinicalScience (1983) 64,141-152 14 1 Development of hypertension in renal disease J. B R O D , J . B A H L M A N N , M. C A C H O V A N A N D P. P R E T S C H N E R Second Chair of Medicine and Division of Nephrologv and Institure of Nuclear Medicine, Medical...

...Ph. Glasson; H. Favre; M. B. Vallotton 1. Chronic ambulatory peritoneal dialysis allows good control of blood pressure in patients with hypertensive end-stage renal disease. The role of the renin-angiotensin-aldosterone system has therefore been studied in seven patients during the first 6 months...

... patients with advanced renal disease was investigated. 2. Urinary excretion of PGE and kallikrein was significantly decreased in patients with sustained hypertension. 3. Four times higher values for fractional sodium excretion and four or five times higher values for the urinary excretion of PGE corrected...