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Mikael Adner, Brendan J. Canning, Herman Meurs, William Ford, Patricia Ramos Ramírez, Mariska P.M. van den Berg, Mark A. Birrell, Eva Stoffels, Lennart K.A. Lundblad, Gunnar P. Nilsson, Henric K. Olsson, Maria G. Belvisi, Sven-Erik Dahlén
Clin Sci (Lond) (2020) 134 (11): 1219–1242.
Published: 05 June 2020
... patients, both in a qualitative and in a quantitative sense [ 18 , 26 ]. Although inflammation and structural remodeling contribute to asthma pathogenesis, majority of studies focus on the inflammatory reactions [ 33 ]. Targeting of inflammation alone has not provided disease modification and thus...
Includes: Supplementary data
Macarena Orejudo, Ana B. García-Redondo, Raúl R. Rodrigues-Diez, Raquel Rodrigues-Díez, Laura Santos-Sanchez, Antonio Tejera-Muñoz, Jesús Egido, Rafael Selgas, Mercedes Salaices, Ana M. Briones, Marta Ruiz-Ortega
Clin Sci (Lond) (2020) 134 (5): 513–527.
Published: 09 March 2020
... suggests that IL-17A could play a role in regulating blood pressure and end-organ damage. Here, our preclinical studies in a murine model of systemic IL-17A administration showed that increased levels of circulating IL-17A raised blood pressure induced inward remodeling of small mesenteric arteries (SMAs...
Kimberley C.W. Wang, Timothy D. Le Cras, Alexander N. Larcombe, Graeme R. Zosky, John G. Elliot, Alan L. James, Peter B. Noble
Clin Sci (Lond) (2018) 132 (3): 327–338.
Published: 02 February 2018
...Kimberley C.W. Wang; Timothy D. Le Cras; Alexander N. Larcombe; Graeme R. Zosky; John G. Elliot; Alan L. James; Peter B. Noble Airway remodelling and allergic inflammation are key features of airway hyperresponsiveness (AHR) in asthma; however, their interrelationships are unclear. The present...
Clin Sci (Lond) (2017) 131 (14): 1723–1735.
Published: 30 June 2017
... pathogenesis. We discuss airway inflammation (both T2 HIGH and T2 LOW ), airway hyperresponsiveness (AHR) and airways remodelling as four key factors in asthma pathogenesis, and also outline other contributory factors such as genetics and co-morbidities. Response to current asthma therapies also varies greatly...
Helena Pulido-Olmo, Concha F. García-Prieto, Gloria Álvarez-Llamas, María G. Barderas, Fernando Vivanco, Isabel Aranguez, Beatriz Somoza, Julián Segura, Reinhold Kreutz, María S. Fernández-Alfonso, Luis M. Ruilope, Gema Ruiz-Hurtado
Clin Sci (Lond) (2016) 130 (7): 525–538.
Published: 17 February 2016
... 2016 Resistant albuminuria developed under chronic RAS blockade is strongly associated with increased circulating MMP-9 activity mediated by oxidative stress. albuminuria metalloproteinase oxidative stress remodelling renin–angiotensin system • Albuminuria is a strong...
Includes: Supplementary data
Clin Sci (Lond) (2014) 126 (12): 815–827.
Published: 26 February 2014
... established that AngII (angiotensin II), the main effector of the RAS, engages the AT 1 R (angiotensin type 1 receptor) and promotes cell growth, proliferation, migration and oxidative stress, all processes which contribute to remodelling of the heart and vasculature, ultimately leading to the development...
Clin Sci (Lond) (2013) 124 (6): 371–387.
Published: 27 November 2012
... inflammation remodelling COPD (chronic obstructive pulmonary disease) is an important cause of morbidity and mortality, and is predicted to become the third leading cause of mortality worldwide by 2030 [ 1 ]. In the U.K., it is responsible for approximately 30000 deaths per year and for >£800...
Clin Sci (Lond) (2012) 123 (7): 399–416.
Published: 07 June 2012
... remodelling, which contributes to the development of CV disease. Arterial calcification is a major event in the arterial remodelling process and is strongly linked to mineral metabolism abnormalities associated with CKD. Arterial remodelling is not limited to arterial calcification and modifications...
Clin Sci (Lond) (2011) 121 (1): 1–10.
Published: 18 March 2011
... are expressed in other tissues such as those of the cardiovascular system. In the present review, the role of TLRs in septic cardiomyopathy, viral myocarditis, atherosclerosis, ischaemia/reperfusion injury and cardiac remodelling after myocardial infarction are outlined, with attention paid to genetically...
Clin Sci (Lond) (2010) 119 (11): 453–463.
Published: 17 August 2010
... ). The ability of ET-1 to induce vasoconstriction was the first property described [ 2 ] but, since then, ET-1, via its two receptors ET A and ET B , has been shown to induce tissue remodelling. These structural changes can be attributed to the strong binding of ET-1 to its receptors, and its ability to trigger...
Stephen T. Holgate, Hasan S. Arshad, Graham C. Roberts, Peter H. Howarth, Philipp Thurner, Donna E. Davies
Clin Sci (Lond) (2010) 118 (7): 439–450.
Published: 23 December 2009
... in barrier function and an impaired innate immune response to viral infection may provide the substrate upon which allergic sensitization takes place. Once sensitized, the repeated allergen exposure will lead to disease persistence. These mechanisms could also be used to explain airway wall remodelling...
Clin Sci (Lond) (2010) 118 (4): 231–240.
Published: 09 November 2009
..., diuretic and natriuretic properties. In addition, natriuretic peptides may play a role in the modulation of the molecular mechanisms involved in metabolic regulation and cardiovascular remodelling. The metabolic syndrome is characterized by visceral obesity, hyperlipidaemia, vascular inflammation...
Amalia Forte, Mauro Finicelli, Pasquale de Luca, Ina Nordström, Francesco Onorati, Cesare Quarto, Pasquale Santè, Attilio Renzulli, Umberto Galderisi, Liberato Berrino, Marisa de Feo, Per Hellstrand, Francesco Rossi, Maurizio Cotrufo, Antonino Cascino, Marilena Cipollaro
Clin Sci (Lond) (2009) 116 (2): 125–136.
Published: 15 December 2008
...://www.clinsci.org/cs/116/cs1160125add.htm ). blood flow inflammation microarray remodelling renin–angiotensin system vascular injury Surgical procedures to correct atherosclerotic arterial narrowing are always associated with some degree of injury to the vessel wall, which carries the risk of re...
Includes: Supplementary data
Clin Sci (Lond) (2008) 115 (7): 203–218.
Published: 03 September 2008
..., but the role of individual signalling proteins in the pathogenesis of various cardiovascular diseases is still being elucidated. In the present review, the role of the MAPKs ERK (extracellular signal-regulated kinase), JNK (c-Jun N-terminal kinase) and p38 MAPK in cardiac hypertrophy, cardiac remodelling after...
Clin Sci (Lond) (2008) 115 (3): 99–106.
Published: 02 July 2008
... strains is due to the difference in collagen content following MI. In the present study, we compared the difference in matrix remodelling post-MI between β 2 -TG and NTG mice and between mice and rats. MI was induced by ligation of the left main coronary artery. Following MI, tensile strength, insoluble...
Clin Sci (Lond) (2008) 114 (4): 257–264.
Published: 15 January 2008
... in the case of balloon angioplasty. Post-angioplasty restenosis results from two major processes: neointimal formation and constrictive remodelling. Neointimal formation is initiated by arterial injury with a resultant loss of contractile phenotype in tunica media, leading to VSMC [vascular SM (smooth muscle...
Justin L. Grobe, Shant Der Sarkissian, Jillian M. Stewart, J. Gary Meszaros, Mohan K. Raizada, Michael J. Katovich
Clin Sci (Lond) (2007) 113 (8): 357–364.
Published: 12 September 2007
...Justin L. Grobe; Shant Der Sarkissian; Jillian M. Stewart; J. Gary Meszaros; Mohan K. Raizada; Michael J. Katovich Cardiac remodelling is a key risk factor for the development of heart failure in the chronic phase following myocardial infarction. Our previous studies have shown an anti-remodelling...
Clin Sci (Lond) (2007) 113 (3): 119–127.
Published: 02 July 2007
.... Martin (email firstname.lastname@example.org ). 16 1 2007 6 3 2007 15 3 2007 © The Authors Journal compilation © 2007 Biochemical Society 2007 clinical trial heart failure 3-hydroxy-3-methylglutaryl-CoA reductase (HMG-CoA reductase) infarction mortality remodelling...
Patricia Sansilvestri-Morel, Florence Fioretti, Alain Rupin, Karim Senni, Jean Noël Fabiani, Gaston Godeau, Tony J. Verbeuren
Clin Sci (Lond) (2007) 112 (4): 229–239.
Published: 17 January 2007
...Patricia Sansilvestri-Morel; Florence Fioretti; Alain Rupin; Karim Senni; Jean Noël Fabiani; Gaston Godeau; Tony J. Verbeuren Varicose vein disease is a frequently occurring pathology with multifactorial causes and a genetic component. An intense remodelling of the varicose vein wall has been...
Satoshi Yasuda, Shunichi Miyazaki, Hideyuki Kinoshita, Noritoshi Nagaya, Munetake Kanda, Yoichi Goto, Hiroshi Nonogi
Clin Sci (Lond) (2007) 112 (1): 43–49.
Published: 01 December 2006
...Satoshi Yasuda; Shunichi Miyazaki; Hideyuki Kinoshita; Noritoshi Nagaya; Munetake Kanda; Yoichi Goto; Hiroshi Nonogi Previous experimental studies have demonstrated that MMPs (matrix metalloproteinases) contribute to LV (left ventricular) remodelling. We hypothesized that cardiac MMPs are activated...
Clin Sci (Lond) (2005) 108 (6): 531–538.
Published: 24 May 2005
...Maria E. JOHANSSON; Ulrika HÄGG; Johannes WIKSTRÖM; Anna WICKMAN; Göran BERGSTRÖM; Li-ming GAN Flow-mediated vasodilation is suggested as one of the mechanisms involved in arterial expansive remodelling, which is thought to be a defence mechanism in atherogenesis. In the present study, we tested...
Clin Sci (Lond) (2005) 108 (6): 463–477.
Published: 24 May 2005
... muscle mass in both large and small airways probably occurs via multiple mechanisms, and there are probably changes in the phenotype of smooth muscle cells, some showing enhanced synthetic capacity, others enhanced proliferation or contractility. Fixed airflow limitation is probably due to remodelling...
Clin Sci (Lond) (2005) 108 (4): 349–355.
Published: 22 March 2005
...Daniele G. BEZERRA; Carlos A. MANDARIM-de-LACERDA The aim of the present study was to investigate the possibility of different effects of the hydrophobic statin simvastatin and the hydrophilic statin pravastatin on the remodelling process in the overloaded left ventricle and renal cortex of SHRs...
Clin Sci (Lond) (2003) 105 (6): 683–689.
Published: 01 December 2003
... compared with PS and CS arterioles. Active pressure-dependent myogenic tone was completely absent in DS arterioles. The atrophic structural remodelling in DS arterioles were correlated with the changes in vascular mechanics, but not with the ability of these arterioles to contract in response to chemical...
Alice V. STANTON, Jeremy N. CHAPMAN, Jamil MAYET, Peter S. SEVER, Neil R. POULTER, Alun D. HUGHES, Simon A. McG. THOM
Clin Sci (Lond) (2001) 101 (5): 455–464.
Published: 21 September 2001
...-hypertensive agents atherosclerosis carotid artery hypertension intima-media thickness remodelling ultrasound. 455Clinical Science (2001) 101, 455 464 (Printed in Great Britain) Effects of blood pressure lowering with amlodipine or lisinopril on vascular structure of the common carotid artery Alice V...
Esteban C. GABAZZA, Osamu TAGUCHI, Shigenori TAMAKI, Shuichi MURASHIMA, Hiroyasu KOBAYASHI, Hiroki YASUI, Tetsu KOBAYASHI, Osamu HATAJI, Yukihiko ADACHI
Clin Sci (Lond) (2000) 98 (3): 291–294.
Published: 09 February 2000
...Esteban C. GABAZZA; Osamu TAGUCHI; Shigenori TAMAKI; Shuichi MURASHIMA; Hiroyasu KOBAYASHI; Hiroki YASUI; Tetsu KOBAYASHI; Osamu HATAJI; Yukihiko ADACHI Airway remodelling, which is manifested by thickening of bronchial wall, is an important causative factor of bronchial hyper-responsiveness...
Clin Sci (Lond) (1999) 97 (2): 239–246.
Published: 29 June 1999
...Shuntaro IKEDA; Mareomi HAMADA; Kunio HIWADA Various alterations in molecular and cellular events have been considered as possibly contributing to the cardiac remodelling that occurs during the transition from compensated hypertrophy to heart failure. The aim of the present study is to clarify (1...