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Keywords: regeneration
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Clin Sci (Lond) (2022) 136 (16): 1179–1203.
Published: 18 August 2022
... fostering effective cardiac regeneration are the holy grail of cardiovascular research to stop the heart failure epidemic. The main goal of most myocardial regeneration protocols is the generation of new functional CMs through the differentiation of endogenous or exogenous cardiomyogenic cells...
Clin Sci (Lond) (2022) 136 (12): 911–934.
Published: 20 June 2022
..., the proliferative capacity of CM observed in vertebrate model organisms suggests that the adult mammalian heart could potentially regenerate itself when exposed to appropriate stimuli. For example, centrosomes are functionally essential components of mitotic spindle poles. Thus, they play an important part...
Clin Sci (Lond) (2022) 136 (10): 787–798.
Published: 27 May 2022
... cardiac regeneration to replenish lost or damaged myocardial tissue. Long-term high-resolution intravital imaging of the behaviors and interactions of different cardiac cell types in their native environment could yield unprecedented insights into heart regeneration and repair. However, this task remains...
Clin Sci (Lond) (2017) 131 (24): 2919–2932.
Published: 08 December 2017
...Dezhong Yang; Wenbin Fu; Liangpeng Li; Xuewei Xia; Qiao Liao; Rongchuan Yue; Hongmei Chen; Xiongwen Chen; Songzhu An; Chunyu Zeng; Wei Eric Wang After myocardial infarction (MI), the heart is difficult to repair because of great loss of cardiomyoctyes and lack of cardiac regeneration. Novel drug...
Includes: Supplementary data
Clin Sci (Lond) (2017) 131 (15): 1923–1940.
Published: 13 July 2017
..., a tightly regulated network of molecular signals control development and regeneration, whether due to programmed cell termination or injury. MicroRNAs (miRs) are a relatively recent discovery; they are a class of small non-coding RNAs which possess a multitude of biological functions due to their ability...
Clin Sci (Lond) (2015) 129 (12): 1173–1193.
Published: 11 November 2015
... and autoimmune diseases. The HGF/Met axis also plays an important role in regulating self-renewal and myocardial regeneration through the enhancement of cardiac progenitor cells. HGF/Met has beneficial effects against myocardial infarction and endothelial dysfunction: the cellular and molecular mechanisms...
Clin Sci (Lond) (2015) 128 (2): 81–93.
Published: 05 September 2014
..., and elucidating their molecular and cellular differences may inform novel treatments for disorders in which tissue regeneration is either impaired or excessive. Moreover, these discoveries offer novel cellular targets for therapeutic approaches to many diseases. This review discusses recent studies that support...
Clin Sci (Lond) (2013) 125 (7): 319–327.
Published: 07 June 2013
... endogenous activation induced pluripotent stem cell heart failure regeneration transplantation Ischaemic heart disease and resultant heart failure are the leading causes of death worldwide [ 1 ]. The ongoing loss of cardiomyocytes during and after ischaemic injury and replacement fibrosis...
Clin Sci (Lond) (2010) 118 (12): 691–705.
Published: 30 March 2010
... κB (NF-κB) regeneration NF-κB (nuclear factor κB) was first described in 1986 as a nuclear transcription factor required for immunoglobulin kappa light chain transcription in B-cells [ 1 ]. Since then it has been demonstrated that NF-κB is constitutively expressed in all cell types and holds...
Clin Sci (Lond) (2005) 108 (4): 309–321.
Published: 22 March 2005
... of transdifferentiation, describe the theoretical and practical issues involved in transdifferentiation research and comment on the long-term therapeutic possibilities. The ability to regenerate cells and tissues is possessed by all organisms. However, regenerative capacity varies considerably between species...
Clin Sci (Lond) (1995) 89 (4): 447–452.
Published: 01 October 1995
... contraction mdx myofibre type necrosis regeneration © 1995 The Biochemical Society and the Medical Research Society 1995 15 4 1995 1 6 1995 Clinical Science (1995) 89, 447-452 (printed in Great Britain) Effects of treadmill exercise and high-fat feeding on muscle degeneration in mdx...
Clin Sci (Lond) (1990) 78 (5): 445–450.
Published: 01 May 1990
..., at least in part, to accelerated tubular cell proliferation. creatinine epidermal growth factor epidermal growth factor receptor necrosis regeneration © 1990 The Biochemical Society and the Medical Research Society 1990 5 12 1989 20 12 1989 Clinical Science (1990) 78,445-450...