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Keywords: reactive oxygen speciesClose
Clin Sci (Lond) (2021) 135 (10): 1311–1332.
Published: 28 May 2021
... result in cardiomyopathy and heart failure. Cardiomyocyte toxicity occurs via multiple molecular mechanisms, including topoisomerase II-mediated DNA double-strand breaks and reactive oxygen species (ROS) formation via effects on the mitochondrial electron transport chain, NADPH oxidases (NOXs...
Includes: Supplementary data
Hyun Jin Min, Joon Soon Park, Kyung Soo Kim, Seung Yong Park, Honghwan Choi, Ju Hee Seo, Miran Kang, Joo-Heon Yoon, Chang-Hoon Kim, Sehoon Kim, Hyung-Ju Cho
Clin Sci (Lond) (2021) 135 (3): 483–494.
Published: 01 February 2021
... Press Limited on behalf of the Biochemical Society 2021 allergic rhinitis high mobility group box 1 nasal epithelium reactive oxygen species Th2 cytokines High mobility group box 1 (HMGB1) is a nuclear protein ubiquitous in a variety of cells, such as monocytes, macrophages...
Includes: Supplementary data
Clin Sci (Lond) (2020) 134 (21): 2835–2850.
Published: 04 November 2020
... MCP1 monocyte chemoattractant protein 1 NOS nitric oxide synthases NOX NADPH oxidase OSM oncostatin M PLA phospholipase RA rheumatoid arthritis RF rheumatoid factor ROS reactive oxygen species RNS reactive nitrogen species TNF-α tumor necrosis...
Clin Sci (Lond) (2020) 134 (12): 1491–1519.
Published: 25 June 2020
.... A key upstream driver of vascular oxidative stress is age-associated mitochondrial dysfunction. This review will focus on vascular mitochondria, mitochondrial dysregulation and mitochondrial reactive oxygen species (ROS) production and discuss current evidence for prevention and treatment of vascular...
Lawson Ung, Ushasree Pattamatta, Nicole Carnt, Jennifer L. Wilkinson-Berka, Gerald Liew, Andrew J.R. White
Clin Sci (Lond) (2017) 131 (24): 2865–2883.
Published: 04 December 2017
...Lawson Ung; Ushasree Pattamatta; Nicole Carnt; Jennifer L. Wilkinson-Berka; Gerald Liew; Andrew J.R. White For many years, oxidative stress arising from the ubiquitous production of reactive oxygen species (ROS) has been implicated in the pathogenesis of various eye diseases. While emerging...
Imad Al Ghouleh, Sanghamitra Sahoo, Daniel N. Meijles, Jefferson H. Amaral, Daniel S. de Jesus, John Sembrat, Mauricio Rojas, Dmitry A. Goncharov, Elena A. Goncharova, Patrick J. Pagano
Clin Sci (Lond) (2017) 131 (15): 2019–2035.
Published: 17 July 2017
... responsible for endothelial proliferation, a root cause of PAH-associated vascular remodeling. Lung tissue specimens from PAH and non-PAH patients and hypoxia-exposed human pulmonary artery endothelial cells (ECs) (HPAEC) were assessed for mRNA and protein expression. Reactive oxygen species (ROS) were...
Darnel Prakoso, Miles J. De Blasio, Chengxue Qin, Sarah Rosli, Helen Kiriazis, Hongwei Qian, Xiao-Jun Du, Kate L. Weeks, Paul Gregorevic, Julie R. McMullen, Rebecca H. Ritchie
Clin Sci (Lond) (2017) 131 (12): 1345–1360.
Published: 07 June 2017
... 01 2017 21 04 2017 08 05 2017 09 05 2017 © 2017 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2017 diabetic cardiomyopathy gene therapy myocardial remodeling phosphoinositide 3-kinase reactive oxygen species superoxides...
Includes: Supplementary data
Aline Silva Miranda, Thiago Macedo Cordeiro, Thomas Mucida dos Santos Lacerda Soares, Rodrigo Novaes Ferreira, Ana Cristina Simões e Silva
Clin Sci (Lond) (2017) 131 (11): 1093–1105.
Published: 17 May 2017
... impairment, and dementia. This risk is generally explained by the high prevalence of both symptomatic and subclinical ischemic cerebrovascular lesions. However, other potential mechanisms, including cytokine/chemokine release, production of reactive oxygen species (ROS), circulating and local formation...
Clin Sci (Lond) (2017) 131 (2): 139–140.
Published: 23 December 2016
...Michael J. Ryan Correspondence: Professor Michael J. Ryan (email email@example.com ) 6 11 2016 19 11 2016 22 11 2016 © 2016 The Author(s). published by Portland Press Limited on behalf of the Biochemical Society 2016 oxidative stress reactive oxygen species...
Clin Sci (Lond) (2016) 130 (16): 1407–1416.
Published: 07 July 2016
...-activated receptor γ co-activator 1-α (PGC-1α) reactive oxygen species Extremely heavy or exhaustive exercise fosters mitochondrial disturbances that could permanently damage its function in health and disease. Exercise-induced mitochondrial dysfunction might be a key proxy for heart abnormalities...
Clin Sci (Lond) (2016) 130 (3): 151–165.
Published: 17 December 2015
..., and promote cell migration and proliferation. Enhanced expression and activity of Nox1 under pathologic conditions results in excessive production of reactive oxygen species and dysregulated cellular function. Indeed, studies using genetic models of Nox1 deficiency or overexpression have revealed roles...
Elyse Di Marco, Jay C. Jha, Arpeeta Sharma, Jennifer L. Wilkinson-Berka, Karin A. Jandeleit-Dahm, Judy B. de Haan
Clin Sci (Lond) (2015) 129 (2): 199–216.
Published: 30 April 2015
... Society 2015 antioxidant therapy cardiovascular disease diabetes complications; reactive nitrogen species reactive oxygen species The pre-clinical evidence in support of a role for reactive oxygen and nitrogen species (ROS/RNS) in diabetic complications such as atherosclerosis remains...
Krishnendu Roy, Yongzhong Wu, Jennifer L. Meitzler, Agnes Juhasz, Han Liu, Guojian Jiang, Jiamo Lu, Smitha Antony, James H. Doroshow
Clin Sci (Lond) (2015) 128 (12): 863–875.
Published: 27 March 2015
...Krishnendu Roy; Yongzhong Wu; Jennifer L. Meitzler; Agnes Juhasz; Han Liu; Guojian Jiang; Jiamo Lu; Smitha Antony; James H. Doroshow The mechanism by which reactive oxygen species (ROS) are produced by tumour cells remained incompletely understood until the discovery over the last 15 years...
Clin Sci (Lond) (2015) 128 (9): 527–535.
Published: 27 January 2015
... and podocytes within the glomerulus. Activation of MRs in these cells appears to lead to glomerular sclerosis. Mechanistically, aldosterone induces excess production of reactive oxygen species (ROS) and oxidative stress in glomerular cells through activation of NADPH oxidase. In mesangial cells, aldosterone...
Clin Sci (Lond) (2015) 128 (8): 465–481.
Published: 23 December 2014
...Chet E. Holterman; Naomi C. Read; Chris R. J. Kennedy Since the first demonstration of Nox enzyme expression in the kidney in the early 1990s and the subsequent identification of Nox4, or RENOX, a decade later, it has become apparent that the Nox family of reactive oxygen species (ROS) generating...
Sebastiano Sciarretta, Derek Yee, Paul Ammann, Narayani Nagarajan, Massimo Volpe, Giacomo Frati, Junichi Sadoshima
Clin Sci (Lond) (2015) 128 (7): 387–403.
Published: 09 December 2014
...Sebastiano Sciarretta; Derek Yee; Paul Ammann; Narayani Nagarajan; Massimo Volpe; Giacomo Frati; Junichi Sadoshima In the past several years, it has been demonstrated that the reactive oxygen species (ROS) may act as intracellular signalling molecules to activate or inhibit specific signalling...
Clin Sci (Lond) (2014) 126 (2): 111–121.
Published: 13 September 2013
... diseases, including hypertension. In addition, it is well known that production of ROS (reactive oxygen species) plays an important role in the impaired contractile and vasodilator responses, vascular remodelling and altered vascular mechanics of hypertension. Of particular interest is the cross-talk...
Clin Sci (Lond) (2013) 125 (8): 361–382.
Published: 14 June 2013
...Yves Gorin; Karen Block Oxidative stress has been linked to the pathogenesis of the major complications of diabetes in the kidney, the heart, the eye or the vasculature. NADPH oxidases of the Nox family are a major source of ROS (reactive oxygen species) and are critical mediators of redox...
Clin Sci (Lond) (2012) 123 (8): 509–518.
Published: 29 June 2012
...@mednet.ucla.edu ). 12 8 2011 8 5 2012 8 5 2012 8 5 2012 © The Authors Journal compilation © 2012 Biochemical Society 2012 combinatorial therapy diethylstilbestrol (DES) LNCaP cell NADPH oxidase (NOX) nitric oxide reactive oxygen species superoxide anion xanthine oxidase...
Ilse P. G. Botden, Hisko Oeseburg, Matej Durik, Frank P. J. Leijten, Leonie C. Van Vark-Van Der Zee, Usha M. Musterd-Bhaggoe, Ingrid M. Garrelds, Ann L. B. Seynhaeve, Janneke G. Langendonk, Eric J. G. Sijbrands, A. H. Jan Danser, Anton J. M. Roks
Clin Sci (Lond) (2012) 123 (8): 499–507.
Published: 27 June 2012
... endothelium nitric oxide prostaglandin reactive oxygen species red wine polyphenol Aging is an independent and important risk factor for CVD (cardiovascular disease) [ 1 ]. Senescence of the vascular wall may be on the causal path to age-related endothelial dysfunction and atherogenesis...
Clin Sci (Lond) (2012) 123 (7): 445–457.
Published: 07 June 2012
...@tmu.edu.tw ). 14 2 2012 10 4 2012 17 4 2012 17 4 2012 © The Authors Journal compilation © 2012 Biochemical Society 2012 arrhythmia deoxycorticosterone acetate-salt hypertension reactive oxygen species sympathetic innervation Cardiovascular sympathetic activation...
Clin Sci (Lond) (2011) 120 (5): 179–181.
Published: 19 November 2010
.... Correspondence: Dr Henrik Ortsäter (email firstname.lastname@example.org ). 25 10 2010 2 11 2010 2 11 2010 2 11 2010 © The Authors Journal compilation © 2011 Biochemical Society 2011 arachidonic acid lipotoxicity palmitic acid pancreatic β-cell reactive oxygen species...
Clin Sci (Lond) (2011) 120 (5): 195–206.
Published: 19 November 2010
... and protective β-cell action, which may be beneficial to function and survival in the ‘lipotoxic’ environment commonly associated with Type 2 diabetes mellitus. arachidonic acid lipotoxicity palmitic acid pancreatic β-cell reactive oxygen species Type 2 diabetes mellitus 1 These authors...
Clin Sci (Lond) (2011) 120 (4): 131–141.
Published: 02 November 2010
...Augusto C. Montezano; Dylan Burger; Graziela S. Ceravolo; Hiba Yusuf; Maria Montero; Rhian M. Touyz The Noxes (NADPH oxidases) are a family of ROS (reactive oxygen species)-generating enzymes. Of the seven family members, four have been identified as important sources of ROS in the vasculature...
Alvaro Yogi, Glaucia E. Callera, Ulisses V. Hipólito, Catiane R. Silva, Rhian M. Touyz, Carlos R. Tirapelli
Clin Sci (Lond) (2010) 118 (11): 657–668.
Published: 09 March 2010
...Alvaro Yogi; Glaucia E. Callera; Ulisses V. Hipólito; Catiane R. Silva; Rhian M. Touyz; Carlos R. Tirapelli The present study investigated the role of ROS (reactive oxygen species) and COX (cyclo-oxygenase) in ethanol-induced contraction and elevation of [Ca 2+ ] i (intracellular [Ca 2...
Clin Sci (Lond) (2005) 109 (3): 217–226.
Published: 24 August 2005
...Robin Ray; Ajay M. Shah Intracellular ROS (reactive oxygen species) such as superoxide and H 2 O 2 have been increasingly appreciated to have a role in endothelial pathophysiology. Of the several sources within the vasculature, a family of multi-subunit NADPH oxidases appears to be a predominant...
Gregory WHYTE, Keith GEORGE, Robert SHAVE, Ellen DAWSON, Claire STEPHENSON, Ben EDWARDS, David GAZE, David OXBOROUGH, Jan FORSTER, Rickie SIMSPON
Clin Sci (Lond) (2005) 108 (1): 73–80.
Published: 15 December 2004
... to reactive oxygen species. Correspondence: Dr Greg Whyte (email email@example.com ). 29 6 2004 18 8 2004 20 9 2004 20 9 2004 The Biochemical Society 2005 cardiac troponin T echocardiography marathon tissue Doppler imaging reactive oxygen species...
Clin Sci (Lond) (2004) 107 (4): 355–364.
Published: 24 September 2004
... 2 •− (superoxide anion radicals). O 2 •− , through both enzymic and non-enzymic reactions, can cause the generation of other ROS (reactive oxygen species). The ensuing state of oxidative stress results in damage to ETC components and mtDNA (mitochondrial DNA), thus increasing further the production...
Carlene A. HAMILTON, William H. MILLER, Sammy AL-BENNA, M. Julia BROSNAN, Russell D. DRUMMOND, Martin W. McBRIDE, Anna F. DOMINICZAK
Clin Sci (Lond) (2004) 106 (3): 219–234.
Published: 01 March 2004
...Carlene A. HAMILTON; William H. MILLER; Sammy AL-BENNA; M. Julia BROSNAN; Russell D. DRUMMOND; Martin W. McBRIDE; Anna F. DOMINICZAK A multitude of studies in experimental animals, together with clinical data, provide evidence that increased production of ROS (reactive oxygen species) are involved...
M. S. SPENCE, P. G. McGLINCHEY, C. C. PATTERSON, A. R. ALLEN, G. MURPHY, U. BAYRAKTUTAN, D. G. FOGARTY, A. E. EVANS, P. P. McKEOWN
Clin Sci (Lond) (2003) 105 (6): 677–682.
Published: 01 December 2003
...M. S. SPENCE; P. G. McGLINCHEY; C. C. PATTERSON; A. R. ALLEN; G. MURPHY; U. BAYRAKTUTAN; D. G. FOGARTY; A. E. EVANS; P. P. McKEOWN Ischaemic heart disease is a complex phenotype arising from the interaction of genetic and environmental factors. Excessive production of reactive oxygen species...
Clin Sci (Lond) (2001) 100 (2): 169–182.
Published: 02 January 2001
...G. J. QUINLAN; Y. CHEN; T. W. EVANS; J. M. C. GUTTERIDGE Reactive oxygen species produced at toxic levels are damaging species. When produced at sub-toxic levels, however, they are involved as second messengers in numerous signal transduction pathways. In addition to these findings, we can add...
Clin Sci (Lond) (1994) 86 (4): 453–460.
Published: 01 April 1994
... support and fluid resusci- tation [ 11. Although the mechanism($ of these pathological conditions are still not fully under- stood, it has long been known that anaesthesia, haemorrhage, hypovolaemic ischaemia, reperfusion and infection are likely contributory causes [2-51, and that reactive oxygen species...
Clin Sci (Lond) (1993) 85 (6): 747–751.
Published: 01 December 1993
...). 3. These findings suggest that reactive oxygen species may play a major role in determining the mesangial cell proliferation that occurs in certain forms of glomerulonephritis, acting either alone or in combination with other growth factors. 10 3 1993 23 7 1993 © 1993...
M. González-Rubio, C. García-Escribano, M. L. Díez-Marqués, I. Arribas, P. Martínez-Onsurbe, M. Rodríguez-Puyol, D. Rodríguez-Puyol
Clin Sci (Lond) (1993) 85 (5): 615–621.
Published: 01 November 1993
... pathogenic role of reactive oxygen species and to elucidate a possible therapeutic role for somatostatin. 2. Mild pancreatitis was induced by low blockade of the biliary duct and severe pancreatitis was evoked by retrograde infusion of bile salts. Renal function was studied by clearance techniques in rats...