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Richard P. Hulse, Nicholas Beazley-Long, Nikita Ved, Samuel M. Bestall, Hamza Riaz, Priya Singhal, Kurt Ballmer Hofer, Steve J. Harper, David O. Bates, Lucy F. Donaldson
Clin Sci (Lond) (2015) 129 (8): 741–756.
Published: 22 July 2015
... a is both pro-angiogenic and neuroprotective, but pro-nociceptive and increases vascular permeability in animal models. Streptozotocin (STZ)-induced diabetic rats develop both hyperglycaemia and many of the resulting diabetic complications seen in patients, including peripheral neuropathy. In the present...
Junhua He, Yunfei Bian, Fen Gao, Maolian Li, Ling Qiu, Weidong Wu, Hua Zhou, Gaizhen Liu, Chuanshi Xiao
Clin Sci (Lond) (2009) 116 (3): 249–255.
Published: 08 January 2009
...Junhua He; Yunfei Bian; Fen Gao; Maolian Li; Ling Qiu; Weidong Wu; Hua Zhou; Gaizhen Liu; Chuanshi Xiao The purpose of the present study was to investigate the effects on blood pressure and myocardial hypertrophy in SHRs (spontaneously hypertensive rats) of RNAi (RNA interference) targeting ACE...
Clin Sci (Lond) (2005) 108 (4): 349–355.
Published: 22 March 2005
... (spontaneously hypertensive rats). Fifteen SHRs were treated for 40 days with simvastatin, pravastatin or placebo (water) via orogastric administration. Left ventricle and renal cortex were examined by light microscopy and stereology. LV (left ventricular) cardiomyocyte nuclei (N[cmn]) and glomeruli (N[gl...
Brigitte E. P. A. VAN DER HEIJDEN, Alfons B. A. KROESE, Paul M. N. WERKER, Moshe KON, Miriam C. J. DE WITH, Dop P. R. BÄR
Clin Sci (Lond) (2003) 105 (1): 29–37.
Published: 01 July 2003
... The Biochemical Society 2003 cold storage muscle function perfusion pre-storage preservation solution rat Clinical Science (2003) 105, 29 37 (Printed in Great Britain) 29 Preservation of rat skeletal muscle function during storage for 16h at 4 C is not improved by pre-storage perfusion E. P...
Clin Sci (Lond) (2002) 103 (s2002): 31S–34S.
Published: 01 September 2002
... were administered intravenously to anaesthetized rats. In a second series of experiments, animals were pretreated with the ET A receptor antagonists BQ-610 or ETR-P1/fl peptide, or with the ET B receptor antagonist IRL-1038. Intestinal perfusion changes were recorded, and the proportion of degranulated...
Aránzazu URUÑUELA, Manuel A. MANSO, Ana Ma DE LA MANO, Sara SEVILLANO, Alberto ORFAO, Isabel DE DIOS
Clin Sci (Lond) (2002) 102 (6): 615–622.
Published: 30 April 2002
...Aránzazu URUÑUELA; Manuel A. MANSO; Ana Ma DE LA MANO; Sara SEVILLANO; Alberto ORFAO; Isabel DE DIOS Current evidence suggests that alterations within acinar cells are responsible for the development of acute pancreatitis. After inducing acute pancreatitis in rats by pancreatic duct obstruction, we...
Clin Sci (Lond) (2002) 102 (5): 541–546.
Published: 18 April 2002
...-Dawley rats, either intrajejunally or orally, and indices of mitochondrial function were determined. The parameters chosen for this purpose were oxygen uptake by, lactate levels in and the energy charge of jejunal tissue. Oxygen uptake by and energy charge in jejunal tissue were unaffected at 1 and 3h...
Clin Sci (Lond) (2001) 101 (6): 551–558.
Published: 26 October 2001
...Daniel LARBAUD; Michèle BALAGE; Daniel TAILLANDIER; Lydie COMBARET; Jean GRIZARD; Didier ATTAIX In order to characterize the poorly defined mechanisms that account for the anti-proteolytic effects of insulin in skeletal muscle, we investigated in rats the effects of a 3h systemic euglycaemic...
Clin Sci (Lond) (2000) 98 (3): 269–275.
Published: 09 February 2000
...-protein-diet model of rat pregnancy suggest a role for the renin–angiotensin system in the programming mechanism, since fetal undernutrition permanently elevates pulmonary and plasma angiotensin-converting enzyme activity. Long-term beneficial effects of captopril on blood pressure in this model require...
Clin Sci (Lond) (2000) 98 (1): 21–30.
Published: 19 November 1999
... tissue and muscle), in macrosomic offspring of streptozotocin-induced mildly hyperglycaemic rats. Food intake and nutritional efficiency were also evaluated. Mild hyperglycaemia in pregnant rats was induced by intraperitoneal injection of streptozotocin (40 mg/kg body weight) on day 5 of gestation...
Scott G. RAMSAY, Christopher J. KENYON, Niall WHYTE, Ian C. MCKAY, Neil C. THOMSON, George B. M. LINDOP
Clin Sci (Lond) (2000) 98 (1): 1–7.
Published: 19 November 1999
... that angiotensin II has a role in airway remodelling. A total of 14 young male Wistar rats were randomly divided into two groups. All received 2-week infusions of bromodeoxyuridine, and the experimental group also received angiotensin II. Blood pressure rose in the angiotensin II-infused group [mean levels: pre...
Clin Sci (Lond) (1999) 97 (3): 363–368.
Published: 06 August 1999
... and bicarbonate-treated uraemic Wistar rats using the remnant model. Leptin levels in the culture medium were decreased at an acid pH of 7.1 compared with a control pH of 7.5 at 96 h (562±78 and 831±103 pg·48 h -1 ·well -1 respectively; mean±S.E.M.; P = 0.037). Similarly, serum leptin in uraemic rats was found...
Michael Kaiser, Ole Kahr, Yasuyuki Shimada, Pamela Smith, Martin Kelly, Harin Mahadeva, Matthew Adams, David Lodwick, Christian Aalkjaer, Metin Avkiran, Nilesh J. Samani
Clin Sci (Lond) (1998) 94 (4): 359–365.
Published: 01 April 1998
... is similarly stimulated under such conditions. 2. Ventricular adrenomedullin and atrial natriuretic peptide mRNA levels as well as those of a loading control mRNA (glyceraldehyde-3-phosphate dehydrogenase) were quantified by Northern blot analysis in (a) rats with severe post-infarction heart failure induced...
Clin Sci (Lond) (1998) 94 (3): 293–301.
Published: 01 March 1998
...Manuel A. Manso; Alberto Orfao; M. Dolores Tabernero; Secundino Vicente; Isabel De Dios 1. After monitoring the changes associated with necrotizing acute pancreatitis in rats from early stages to 24 h after infusion of 5% sodium taurocholate in the choledocus, we characterized by flow cytometry...
Clin Sci (Lond) (1997) 92 (6): 579–585.
Published: 01 June 1997
... role in acute renal failure. In the present study we therefore investigated renal function and the renal ET system in rats on day 4 after bile-duct ligation (BDL) or sham-operation (SO), without ( n = 7 in each group) and with treatment with bosentan, a combined ET A /ET B receptor blocker, ( n = 5...
Clin Sci (Lond) (1997) 92 (5): 455–465.
Published: 01 May 1997
.... Four groups of rats ( n = 8–12 per group) were studied 30 days after surgery: (A) sham-operated rats with no treatment, (B) rats with post-MI heart failure induced by ligation of the left coronary artery, (C) sham-operated rats treated with the ACE inhibitor perindopril (1.5 mg day −1 kg −1 ), and (D...
Clin Sci (Lond) (1996) 91 (4): 467–474.
Published: 01 October 1996
...Ruth A. Elliott; Robert I. Norman; Stuart G. Parker; R. Paul Whitaker; C. Mark Castleden 1. The effect of calcium antagonists on the contractile response of human and rat isolated detrusor muscle in vitro was investigated. The effect of treatment with nimodipine on rat detrusor muscle in vivo...
Clin Sci (Lond) (1996) 91 (3): 337–345.
Published: 01 September 1996
...Ken D. O'halloran; Aidan K. Curran; Aidan Bradford 1. Ventilation was measured during normoxia, hypoxia and hypercapnia before and after administration of almitrine in conscious, unrestrained, tracheostomized rats with the superior laryngeal nerves intact or cut. In superior laryngeal nerve-intact...
Annick Buvry, Monique Garbarg, Violetta Dimitriadou, Agnès Rouleau, George F. J. Newlands, Reza Tavakoli, Virginie Poaty, Alain Lockhart, Jean-Charles Schwartz, Nelly Frossard
Clin Sci (Lond) (1996) 91 (3): 319–327.
Published: 01 September 1996
..., followed by repair processes. This is frequently associated with bronchial hyper-responsiveness. A common feature of tissue repair is an increase in the number of mast cells. Three phenotypically distinct mast cell subsets, with respect to their protease content, have been identified in rat lung...
Clin Sci (Lond) (1996) 90 (5): 369–377.
Published: 01 May 1996
... was to evaluate the effects of l-canavanine, a potentially selective inhibitor of inducible nitric oxide synthase, in an animal model of septic shock. 2. Anaesthetized rats were challenged with 10 mg/kg lipopolysaccharide intravenously. One hour later, they randomly received a 5 h infusion of either l-canavanine...
Clin Sci (Lond) (1995) 89 (2): 177–182.
Published: 01 August 1995
...Naoyoshi Minami; Yutaka Imai; Jun-Ichiro Hashimoto; Keishi Abe 1. The aim of this study was to clarify the extent to which vascular nitric oxide contributes to basal blood pressure in conscious spontaneously hypertensive rats and normotensive Wistar Kyoto rats. 2. The contribution of vascular...
Clin Sci (Lond) (1995) 88 (2): 219–224.
Published: 01 February 1995
...K. J. Lindley; D. P. R. Muller; P. J. Milla 1. Recent initiatives which advocate an increase in dietary polyunsaturated fat intake have led to the study of the effects of this upon gastrointestinal function. 2. Weanling rats were for 21 weeks fed diets containing 10% fat that were either high...
Clin Sci (Lond) (1995) 88 (1): 39–45.
Published: 01 January 1995
...Herbert J. Kramer; Kriemhild Schwarting; Angela Bäcker 1. Patients with obstructive jaundice are especially susceptible to acute renal failure. We have previously observed that in rats with bile duct ligation impaired renal function is associated with increased urinary thromboxane excretion. 2...
Clin Sci (Lond) (1985) 69 (6): 687–689.
Published: 01 December 1985
...D. B. Webb; R. Mackenzie; S. N. Zoob; A. J. Rees 1. The accelerated model of nephrotoxic serum nephritis (NTSN) was produced in 12 Sprague-Dawley rats. Six of these rats were administered superoxide dismutase (EC 22.214.171.124; SOD) subcutaneously (8 mg/kg) 8-hourly for 4 days. The first dose was given...
Clin Sci (Lond) (1984) 67 (2): 237–241.
Published: 01 August 1984
...Ilkka Tikkanen; Frej Fyhrquist; Terje Forslund 1. Based on a specific binding of labelled inhibitor to the enzyme active centre, a new principle of enzyme assay, inhibitor binding assay (IBA), was developed and applied to measurement of rat serum angiotensin converting enzyme (ACE). 2. Serum...
Clin Sci Mol Med (1974) 46 (4): 501–510.
Published: 01 April 1974
...Manjusri Das; A. N. Radhakrishnan 1. A comparative study has been made of glycyl-l-leucine hydrolase activity in the soluble and particulate fractions of intestinal mucosa from monkey, guinea-pig, rabbit and rat. The specific activity of the soluble enzyme is very high in monkey and guinea-pig...
Clin Sci (1972) 43 (6): 731–742.
Published: 01 December 1972
...M. H. Gleeson; J. Cullen; R. H. Dowling 1. To study further the influence of luminal nutrition on small bowel structure and function, segments of rat jejunum and ileum were completely excluded from intestinal continuity by Thiry-Vella by-pass operations. The effect of partial deprivation of luminal...
Clin Sci (1972) 43 (6): 743–757.
Published: 01 December 1972
... than in jejunum. 4. The adaptive changes seen in the by-passed intestine and the intestine in continuity are a result of ‘hypoplasia’ and ‘hyperplasia’ respectively. CIinical Science (1972) 43,743-757. BIOCHEMICAL CHANGES I N INTESTINAL MUCOSA AFTER EXPERIMENTAL SMALL BOWEL BY-PASS I N T H E RAT M. H...