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Keywords: pulmonary hypertension
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Articles

Repetitive schistosoma exposure causes perivascular lung fibrosis and persistent pulmonary hypertension

Rahul Kumar, Michael H. Lee, Biruk Kassa, Dara C. Fonseca Balladares, Claudia Mickael, Linda Sanders, Adam Andruska, Maya Kumar, Edda Spiekerkoetter, Angela Bandeira, Kurt R. Stenmark, Rubin M. Tuder, Brian B Graham
Journal: Clinical Science
Clin Sci (Lond) (2023) 137 (8): 617–631.
https://doi.org/10.1042/CS20220642
Published: 21 April 2023
...Rahul Kumar; Michael H. Lee; Biruk Kassa; Dara C. Fonseca Balladares; Claudia Mickael; Linda Sanders; Adam Andruska; Maya Kumar; Edda Spiekerkoetter; Angela Bandeira; Kurt R. Stenmark; Rubin M. Tuder; Brian B Graham Background: Pulmonary hypertension (PH) can occur as a complication...
View article titled, Repetitive schistosoma exposure causes perivascular lung fibrosis and persistent <span class="search-highlight">pulmonary</span> <span class="search-highlight">hypertension</span>
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Includes: Supplementary data
Articles

Alpha7 nicotinic acetylcholine receptor mediates chronic nicotine inhalation-induced cardiopulmonary dysfunction

Anna K. Whitehead, Nicholas D. Fried, Zhen Li, Kandasamy Neelamegam, Charlotte S. Pearson, Kyle B. LaPenna, Thomas E. Sharp, David J. Lefer, Eric Lazartigues, Jason D. Gardner, Xinping Yue
Journal: Clinical Science
Clin Sci (Lond) (2022) 136 (12): 973–987.
https://doi.org/10.1042/CS20220083
Published: 22 June 2022
..., the effects of nicotine alone on cardiopulmonary function remain largely unknown. Previously, we have shown that chronic nicotine vapor inhalation in mice leads to the development of pulmonary hypertension (PH) with right ventricular (RV) remodeling. The present study aims to further examine...
View article titled, Alpha7 nicotinic acetylcholine receptor mediates chronic nicotine inhalation-induced cardiopulmonary dysfunction
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Includes: Supplementary data
Articles

Commentary on: Xbp1s-Ddit3, DNA damage and pulmonary hypertension

Sarah-Eve Lemay, Sebastien Bonnet, François Potus
Journal: Clinical Science
Clin Sci (Lond) (2022) 136 (1): 163–166.
https://doi.org/10.1042/CS20211095
Published: 10 January 2022
...Sarah-Eve Lemay; Sebastien Bonnet; François Potus In this commentary, we discuss new observations stating that spliced X-box-binding protein 1 (Xbp1s)-DNA damage-inducible transcript 3 (Ddit3) promotes monocrotaline (MCT)-induced pulmonary hypertension (Jiang et al., Clinical Science (2021) 135 (21...
View article titled, Commentary on: Xbp1s-Ddit3, DNA damage and <span class="search-highlight">pulmonary</span> <span class="search-highlight">hypertension</span>
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Articles

Xbp1s-Ddit3 promotes MCT-induced pulmonary hypertension

Hongxia Jiang, Dandan Ding, Yuanzhou He, Xiaochen Li, Yongjian Xu, Xiansheng Liu
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (21): 2467–2481.
https://doi.org/10.1042/CS20210612
Published: 01 November 2021
...Hongxia Jiang; Dandan Ding; Yuanzhou He; Xiaochen Li; Yongjian Xu; Xiansheng Liu Pulmonary hypertension (PH) is a life-threatening disease characterized by vascular remodeling. Exploring new therapy target is urgent. The purpose of the present study is to investigate whether and how spliced x-box...
View article titled, Xbp1s-Ddit3 promotes MCT-induced <span class="search-highlight">pulmonary</span> <span class="search-highlight">hypertension</span>
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Articles

Interaction between the apelinergic system and ACE2 in the cardiovascular system: therapeutic implications

In Collection
ACE2, a multifunctional protein – from cardiovascular regulation to COVID-19
Paulami Chatterjee, Mahmoud Gheblawi, Kaiming Wang, Jeannie Vu, Palsa Kondaiah, Gavin Y. Oudit
Journal: Clinical Science
Clin Sci (Lond) (2020) 134 (17): 2319–2336.
https://doi.org/10.1042/CS20200479
Published: 09 September 2020
... diseases (CVDs). Belonging to WHO classified Group I of pulmonary hypertension, PAH refers to a complex set of pulmonary vascular anomalies representing increased pulmonary vascular resistance [ 120 ]. Endothelial injury, VSMC hyperplasia and fibrosis, and development of plexiform lesions...
View article titled, Interaction between the apelinergic system and ACE2 in the cardiovascular system: therapeutic implications
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Articles

NSD2 silencing alleviates pulmonary arterial hypertension by inhibiting trehalose metabolism and autophagy

Xue-liang Zhou, Zhi-bo Liu, Rong-rong Zhu, Huang Huang, Qi-rong Xu, Hua Xu, Liang Zeng, Yun-yun Li, Cha-hua Huang, Qi-cai Wu, Ji-chun Liu
Journal: Clinical Science
Clin Sci (Lond) (2019) 133 (9): 1085–1096.
https://doi.org/10.1042/CS20190142
Published: 09 May 2019
... pulmonary resistance methylation metabolism pulmonary hypertension Trehalose References 1. D’Alessandro A. , El Kasmi K.C. , Plecita-Hlavata L. , Jezek P. , Li M. , Zhang H. et al . ( 2018 ) Hallmarks of pulmonary hypertension: mesenchymal...
View article titled, NSD2 silencing alleviates pulmonary arterial hypertension by inhibiting trehalose metabolism and autophagy
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Articles

Mitochondrial Sirtuins in cardiometabolic diseases

Xiaoqiang Tang, Xiao-Feng Chen, Hou-Zao Chen, De-Pei Liu
Journal: Clinical Science
Clin Sci (Lond) (2017) 131 (16): 2063–2078.
https://doi.org/10.1042/CS20160685
Published: 24 July 2017
... cardiovascular physiology heart failure mitochondria pulmonary hypertension sirtuins Cardiometabolic disease (CMD) or cardiometabolic syndrome, remains one of the leading causes of morbidity and mortality worldwide. CMD is a disease entity of maladaptive cardiovascular, renal, metabolic...
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Articles

Endothelial Nox1 oxidase assembly in human pulmonary arterial hypertension; driver of Gremlin1-mediated proliferation

Imad Al Ghouleh, Sanghamitra Sahoo, Daniel N. Meijles, Jefferson H. Amaral, Daniel S. de Jesus, John Sembrat, Mauricio Rojas, Dmitry A. Goncharov, Elena A. Goncharova, Patrick J. Pagano
Journal: Clinical Science
Clin Sci (Lond) (2017) 131 (15): 2019–2035.
https://doi.org/10.1042/CS20160812
Published: 17 July 2017
... endothelial cells gremlin1 hedgehog NADPH oxidase pulmonary hypertension reactive oxygen species Despite the availability of a number of FDA-approved drugs, pulmonary arterial hypertension (PAH) remains a deadly disease with a median survival of 2.8 years from diagnosis [ 1 , 2 ]. Current...
View article titled, Endothelial Nox1 oxidase assembly in human pulmonary arterial hypertension; driver of Gremlin1-mediated proliferation
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Articles

Identification of genetic defects in pulmonary arterial hypertension by a new gene panel diagnostic tool

Jie Song, Christina A. Eichstaedt, Rebecca Rodríguez Viales, Nicola Benjamin, Satenik Harutyunova, Christine Fischer, Ekkehard Grünig, Katrin Hinderhofer
Journal: Clinical Science
Clin Sci (Lond) (2016) 130 (22): 2043–2052.
https://doi.org/10.1042/CS20160531
Published: 11 October 2016
... hypertension based on a customized kit and new sequencing technologies. In this manner we identified mutations in routinely assessed genes and one additional gene in PAH patients. genetics mutation analysis panel diagnostic pulmonary hypertension • In this study we present a new PAH...
View article titled, Identification of genetic defects in pulmonary arterial hypertension by a new gene panel diagnostic tool
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Articles

Lung capillary injury and repair in left heart disease: a new target for therapy?

Sayena Azarbar, Jocelyn Dupuis
Journal: Clinical Science
Clin Sci (Lond) (2014) 127 (2): 65–76.
https://doi.org/10.1042/CS20130296
Published: 17 March 2014
... exchange. This pathological process may also contribute to PH (pulmonary hypertension) due to LHD. Few clinical trials have specifically evaluated lung structural remodelling and the effect of related therapies in LHD. Currently approved treatment for chronic HF (heart failure) may have direct beneficial...
View article titled, Lung capillary injury and repair in left heart disease: a new target for therapy?
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Articles

Effects of pravastatin on functional capacity in patients with chronic obstructive pulmonary disease and pulmonary hypertension

Tsung-Ming Lee, Chien-Chang Chen, Hsiu-Nien Shen, Nen-Chung Chang
Journal: Clinical Science
Clin Sci (Lond) (2009) 116 (6): 497–505.
https://doi.org/10.1042/CS20080241
Published: 12 February 2009
...Tsung-Ming Lee; Chien-Chang Chen; Hsiu-Nien Shen; Nen-Chung Chang PH (pulmonary hypertension) often complicates the disease course of patients with COPD (chronic obstructive pulmonary disease) and is an indication of a worse prognosis. In the present study, we assessed whether pravastatin...
View article titled, Effects of pravastatin on functional capacity in patients with chronic obstructive pulmonary disease and <span class="search-highlight">pulmonary</span> <span class="search-highlight">hypertension</span>
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Articles

Role of pravastatin in pulmonary hypertension in chronic obstructive pulmonary disease

Tamera J. Corte, Stephen J. Wort
Journal: Clinical Science
Clin Sci (Lond) (2009) 116 (6): 493–495.
https://doi.org/10.1042/CS20080590
Published: 12 February 2009
...Tamera J. Corte; Stephen J. Wort COPD (chronic obstructive pulmonary disease) is a significant health concern as the fourth leading cause of morbidity and mortality in the U.S.A. Although the prevalence of PH (pulmonary hypertension) in COPD is unknown, its presence is a risk factor for mortality...
View article titled, Role of pravastatin in <span class="search-highlight">pulmonary</span> <span class="search-highlight">hypertension</span> in chronic obstructive pulmonary disease
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Articles

Impairment of respiratory muscle function in pulmonary hypertension

Hans-Joachim Kabitz, Anja Schwoerer, Hinrich-Cordt Bremer, Florian Sonntag, Stephan Walterspacher, David Walker, Vanessa Schaefer, Nicola Ehlken, Gerd Staehler, Michael Halank, Hans Klose, Hossein A. Ghofrani, Marius M. Hoeper, Ekkehard Gruenig, Wolfram Windisch
Journal: Clinical Science
Clin Sci (Lond) (2008) 114 (2): 165–171.
https://doi.org/10.1042/CS20070238
Published: 11 December 2007
... respiratory muscle function occurs in patients with PH (pulmonary hypertension); however, comprehensive investigations of respiratory muscle function, including the application of non-volitional tests, needed to verify impairment of respiratory muscle strength in patients with PH have not yet been performed...
View article titled, Impairment of respiratory muscle function in <span class="search-highlight">pulmonary</span> <span class="search-highlight">hypertension</span>
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Articles

Activation of the right ventricular endothelin (ET) system in the monocrotaline model of pulmonary hypertension: response to chronic ETA receptor blockade

Jean-François JASMIN, Peter CERNACEK, Jocelyn DUPUIS
Journal: Clinical Science
Clin Sci (Lond) (2003) 105 (6): 647–653.
https://doi.org/10.1042/CS20030139
Published: 01 December 2003
...Jean-François JASMIN; Peter CERNACEK; Jocelyn DUPUIS Although activation of the endothelin (ET) system contributes to pulmonary hypertension, modifications of the cardiopulmonary ET system and its responses to chronic ET receptor blockade are not well known. To investigate this, rats were injected...
View article titled, Activation of the right ventricular endothelin (ET) system in the monocrotaline model of <span class="search-highlight">pulmonary</span> <span class="search-highlight">hypertension</span>: response to chronic ETA receptor blockade
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Articles

Plasma serotonin, pulmonary hypertension and bronchial asthma

Fuad LECHIN, Bertha VAN DER DIJS, Alex E. LECHIN
Journal: Clinical Science
Clin Sci (Lond) (2002) 103 (4): 345.
https://doi.org/10.1042/cs1030345u
Published: 23 August 2002
...Fuad LECHIN; Bertha VAN DER DIJS; Alex E. LECHIN bronchial asthma plasma serotonin pulmonary hypertension therapeutics. Correspondence : Dr F. Lechin (e-mail flechin@telcel.net.ve ). 20 5 2002 The Biochemical Society and the Medical Research Society © 2002 2002...
View article titled, Plasma serotonin, <span class="search-highlight">pulmonary</span> <span class="search-highlight">hypertension</span> and bronchial asthma
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Articles

Recent insights into the pathogenesis and therapeutics of pulmonary hypertension

Julian W. STRANGE, John WHARTON, Peter G. PHILLIPS, Martin R. WILKINS
Journal: Clinical Science
Clin Sci (Lond) (2002) 102 (3): 253–268.
https://doi.org/10.1042/cs1020253
Published: 11 February 2002
... vasoactive factors. Perturbations of these systems may contribute to the pathogenesis of pulmonary hypertension. Recently, mutations in BMPR2 and ALK-1 , genes that encode members of the transforming growth factor-β (TGF-β) receptor superfamily, have been found in patients with primary pulmonary hypertension...
View article titled, Recent insights into the pathogenesis and therapeutics of <span class="search-highlight">pulmonary</span> <span class="search-highlight">hypertension</span>
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Articles

The active molecular form of plasma adrenomedullin is extracted in the pulmonary circulation in patients with mitral stenosis: possible role of adrenomedullin in pulmonary hypertension

Toshio NISHIKIMI, Seiki NAGATA, Tatsuya SASAKI, Fumiki YOSHIHARA, Noritoshi NAGAYA, Takeshi HORIO, Hisayuki MATSUO, Hiroaki MATSUOKA, Kenji KANGAWA
Journal: Clinical Science
Clin Sci (Lond) (2001) 100 (1): 61–66.
https://doi.org/10.1042/cs1000061
Published: 13 December 2000
... hypertension due to mitral stenosis. adrenomedullin mitral stenosis pulmonary circulation pulmonary hypertension The Biochemical Society and the Medical Research Society © 2001 2001 4 5 2000 13 7 2000 26 9 2000 Correspondence : Dr Toshio Nishikimi, Division of Hypertension...
View article titled, The active molecular form of plasma adrenomedullin is extracted in the pulmonary circulation in patients with mitral stenosis: possible role of adrenomedullin in <span class="search-highlight">pulmonary</span> <span class="search-highlight">hypertension</span>
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Articles

Effect of nebulized epoprostenol (prostacyclin) on exhaled nitric oxide in patients with pulmonary hypertension due to congenital heart disease and in normal controls

Ian A. FORREST, Therese SMALL, Paul A. CORRIS
Journal: Clinical Science
Clin Sci (Lond) (1999) 97 (1): 99–102.
https://doi.org/10.1042/cs0970099
Published: 01 June 1999
...Ian A. FORREST; Therese SMALL; Paul A. CORRIS Inhaled epoprostenol (prostacyclin) may be used in the treatment of severe pulmonary hypertension, improving oxygenation and reducing pulmonary artery pressures. We have observed symptomatic benefits of epoprostenol in patients with congenital heart...
View article titled, Effect of nebulized epoprostenol (prostacyclin) on exhaled nitric oxide in patients with <span class="search-highlight">pulmonary</span> <span class="search-highlight">hypertension</span> due to congenital heart disease and in normal controls
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Articles

Increased plasma levels of adrenomedullin in patients with pulmonary hypertension

Mikio KAKISHITA, Toshio NISHIKIMI, Yoshiaki OKANO, Toru SATOH, Shingo KYOTANI, Noritoshi NAGAYA, Kengo FUKUSHIMA, Norifumi NAKANISHI, Shuichi TAKISHITA, Atsuro MIYATA, Kenji KANGAWA, Hisayuki MATSUO, Takeyoshi KUNIEDA
Journal: Clinical Science
Clin Sci (Lond) (1998) 96 (1): 33–39.
https://doi.org/10.1042/cs0960033
Published: 01 January 1999
... patients with severe pulmonary hypertension (12 cases of primary pulmonary hypertension, 21 with chronic thromboembolic pulmonary hypertension; age 49±16 years, mean pulmonary arterial pressure 50±15 mmHg). In addition, plasma levels of adrenomedullin were measured before and after acute nitric oxide...
View article titled, Increased plasma levels of adrenomedullin in patients with <span class="search-highlight">pulmonary</span> <span class="search-highlight">hypertension</span>
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Articles

Effects of the Neutral Endopeptidase Inhibitor, SCH 42495, on the Cardiovascular Remodelling Secondary to Chronic Hypoxia in Rats

J. S. Thompson, W. Sheedy, A. H. Morice
Journal: Clinical Science
Clin Sci (Lond) (1994) 87 (1): 109–114.
https://doi.org/10.1042/cs0870109
Published: 01 July 1994
... of atrial natriuretic peptide within the pulmonary vasculature may be responsible for this effect. Modulation of atrial natriuretic peptide may have therapeutic potential in the management of conditions characterized by pulmonary hypertension and pulmonary vascular remodelling. 18 3 1993 8 2 1994...
View article titled, Effects of the Neutral Endopeptidase Inhibitor, SCH 42495, on the Cardiovascular Remodelling Secondary to Chronic Hypoxia in Rats
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Articles

Effect of Ligustrazine on Pulmonary Vascular Changes Induced by Chronic Hypoxia in Rats

Y. N. Cai, G. R. Barer
Journal: Clinical Science
Clin Sci (Lond) (1989) 77 (5): 515–520.
https://doi.org/10.1042/cs0770515
Published: 01 November 1989
... effect was undiminished. 27 4 1989 4 5 1989 © 1989 The Biochemical Society and the Medical Research Society 1989 chronic hypoxia ligustrazine pulmonary hypertension pulmonary vasodilatation Clinical Science ( 1989) 77.5 15-520 515 Effect of ligustrazine on pulmonary vascular...
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Articles

Pulmonary Blood Volume in Chronic Bronchitis

B. Raffestin, H. Valette, J. L. Hebert, P. Duhaze, A. Lockhart
Journal: Clinical Science
Clin Sci Mol Med (1977) 53 (6): 587–593.
https://doi.org/10.1042/cs0530587
Published: 01 December 1977
... between the amount of emphysema and the reduction in pulmonary blood volume. Key words: bronchitis, dyedilution curves, emphysema, oxygen, pulmonary hypertension. Abbreviations: FEVl.o, forced expiratory vol- ume in 1 s; PW, pulmonary wedge pressure; RV, residual volume; TLC, total lung capacity; VC...
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Articles

Effect of α-Methyldopa on the Pulmonary Vascular Changes Induced by Chronic Hypoxia in Rats

A. J. Suggett, J. Herget
Journal: Clinical Science
Clin Sci Mol Med (1977) 53 (4): 397–400.
https://doi.org/10.1042/cs0530397
Published: 01 October 1977
...-dihydroxyphenylalanine methyldopa pulmonary hypertension Clinical Science and Molecular Medicine (1977) 53, 397400. SHORT COMMUNICATION Effect of amethyldopa on the pulmonary vascular changes induced by chronic hypoxia in rats A. J. SUGGETT AND J. HERGET* Section of Experimental Medicine, Academic Division...
View article titled, Effect of α-Methyldopa on the Pulmonary Vascular Changes Induced by Chronic Hypoxia in Rats
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Articles

Vasodilating Drugs: Contrasting Haemodynamic Effects

R. C. Tarazi, H. P. Dustan, E. L. Bravo, A. P. Niarchos
Journal: Clinical Science
Clin Sci Mol Med (1976) 51 (s3): 575s–578s.
https://doi.org/10.1042/cs051575s
Published: 01 December 1976
..., and pulmonary artery pressure. Nitroprusside, although decreasing pressure and vascular resistance, caused no significant change in the other functions except for reducing pulmonary artery pressure. Minoxidil, when given orally, had the potential for causing pulmonary hypertension. This seemed explained...
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Articles

Growth of the Heart and Lungs in Hypoxic Rodents: A Model of Human Hypoxic Disease

Carolin Hunter, Gwenda R. Barer, J. W. Shaw, E. J. Clegg
Journal: Clinical Science
Clin Sci Mol Med (1974) 46 (3): 375–391.
https://doi.org/10.1042/cs0460375
Published: 01 March 1974
..., but the perinuclear sarcoplasm had increased. All layers of the myocardium participated in the hypertrophy. 6 11 1973 © 1974 The Biochemical Society and the Medical Research Society 1974 hypoxia right ventricular hypertrophy pulmonary hypertension pulmonary arterioles Clinical Science...
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