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Keywords: protein synthesis
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Clin Sci (Lond) (2022) 136 (19): 1425–1431.
Published: 14 October 2022
...Philip C. Calder; Nicolaas E.P. Deutz In 1982 and 2011, Clinical Science published papers that used infusion of stable isotope-labeled amino acids to assess skeletal muscle protein synthesis in the fasted and fed state and before and after a period of increased intake of omega-3 fatty acids...
Clin Sci (Lond) (2018) 132 (1): 17–31.
Published: 02 January 2018
... (crossover design). Whole body protein synthesis (PS), breakdown (PB), net PS (PS − PB) protein efficiency (netPSPE), net protein balance (phenylalanine (PHE) intake – PHE hydroxylation) protein efficiency (netBalPE), and splanchnic PHE extraction (SPE PHE ) were assessed using stable isotope tracer...
Includes: Supplementary data
Clin Sci (Lond) (2017) 131 (21): 2643–2653.
Published: 27 October 2017
...W. Kyle Mitchell; Bethan E. Phillips; Ian Hill; Paul Greenhaff; Jonathan N. Lund; John P. Williams; Debbie Rankin; Daniel J. Wilkinson; Kenneth Smith; Philip J. Atherton Leucine modulates muscle protein synthesis (MPS), with potential to facilitate accrual/maintenance of muscle mass. Animal models...
Clin Sci (Lond) (2017) 131 (8): 775–790.
Published: 06 April 2017
... diet (by addition of nonessential amino acid) ( Ctrl ) and trained (running on treadmill 5 days·week −1 ) ( ex ) or not. Maximal endurance activity and body composition were assessed, and muscle protein metabolism (protein synthesis, proteomic approach) and energy metabolism [energy expenditure...
Includes: Supplementary data
Clin Sci (Lond) (2008) 114 (9): 603–610.
Published: 02 April 2008
..., the methodology used in the present study appears to be more sensitive in reflecting directional changes in human muscle protein synthesis compared with traditional methods, particularly based on measurements of amino acid flux. Correspondence: Professor Kent Lundholm ( kent.lundholm@surgery.gu.se...
Includes: Supplementary data
Clin Sci (Lond) (2005) 108 (2): 179–184.
Published: 21 January 2005
.... The aim of the present study was to investigate if the immunological activation of the human palatine tonsil is reflected by a high metabolic activity, as determined by in vivo measurement of protein synthesis. The protein synthesis rate of the tonsil was also compared with that of the circulating T...
Clin Sci (Lond) (2004) 107 (6): 601–607.
Published: 24 November 2004
...Inga TJÄDER; Pia ESSEN; Peter J. GARLICK; Margaret A. McMNURLAN; Olav ROOYACKERS; Jan WERNERMAN Muscle protein catabolism is a considerable clinical problem following surgery. However, the impact of surgical trauma on muscle protein synthesis is not well characterized. In this pilot study, we...
Clin Sci (Lond) (2004) 107 (4): 371–379.
Published: 24 September 2004
... investigated the arginine requirements of tumour cells for optimal protein synthesis and growth, and the metabolic pathway responsible for the arginine-dependent growth. The results showed that MCF-7 cells are highly dependent on arginine for growth and that the requirement for arginine is much higher than...
Clin Sci (Lond) (2003) 105 (6): 691–698.
Published: 01 December 2003
... for 18 h and then received intravenous infusions of saline or parenteral nutrition (PN) with or without glutamine for 6 h. In animals receiving PN, parenteral injections of growth hormone (GH) or saline vehicle were also administered. Fractional rate of liver total protein synthesis was elevated...
Clin Sci (Lond) (2003) 104 (3): 287–294.
Published: 18 February 2003
...Michael KOLL; Julie A. BEESO; Frank J. KELLY; Ulrich A. SIMANOWSKI; Helmut K. SEITZ; Timothy J. PETERS; Victor R. PREEDY Chronic alcohol muscle disease is characterized by reduced skeletal muscle mass precipitated by acute reduction in protein synthesis. The pathogenic mechanisms remain obscure...
Clin Sci (Lond) (2001) 101 (3): 295–304.
Published: 15 August 2001
...Michael J. O'LEARY; Colin N. FERGUSON; Michael J. RENNIE; Charles J. HINDS; John H. COAKLEY; Victor R. PREEDY We have investigated sequential changes in skeletal muscle and hepatic protein synthesis following sepsis, and their relationship to changes in circulating and tissue glutamine...
Clin Sci (Lond) (2001) 101 (1): 65–72.
Published: 29 May 2001
... who had higher protein turnover at 18 weeks' gestation had babies that were longer at birth. After adjustment for the duration of gestation and the baby's sex, 26% of the variation in length at birth was accounted for by maternal protein synthesis at 18 weeks' gestation. Maternal protein intake...
Clin Sci (Lond) (1998) 95 (6): 725–733.
Published: 01 December 1998
...-oxidation), protein synthesis, S , and degradation, D , were calculated from plasma [1- 13 C]α-ketoisocaproic acid enrichment and 13 CO 2 excretion. 3. PPU protein , calculated as change in leucine balance/change in intake (HP-LP), varied from 0.58 to 0.99 (mean = 0.81±0.10), independently of age or sex...
Clin Sci (Lond) (1998) 94 (4): 413–423.
Published: 01 April 1998
...), in a chronic septic phase (day 6) and in a late septic phase (day 10). Protein synthesis rates were measured in vivo after administration of a flooding dose of l[1- 13 C]valine. 2. During the acute phase, muscle protein loss associated with infection resulted from both a decrease in protein synthesis...
Clin Sci (Lond) (1997) 93 (3): 265–271.
Published: 01 September 1997
... turnover of the urea pool. 3. Protein synthesis, derived from the first ammonia plateau, 179 mg h −1 kg −1 , was significantly higher than that derived from the second plateau, 118 mg h −1 kg −1 . Using the plateau in urea towards the end of the 36 h, the estimate of protein synthesis was 153 mg h −1 kg −1...
Clin Sci (Lond) (1996) 91 (1): 99–106.
Published: 01 July 1996
..., it is difficult to interpret these in vitro findings. Therefore, an in vivo technique has been established for determination of the fractional protein synthesis rate, as an index of metabolic activity in human peripheral blood lymphocytes, by using a stable isotope technique. 2. The rate of protein synthesis...
Clin Sci (Lond) (1995) 89 (4): 383–388.
Published: 01 October 1995
...Peter W. Emery; Peter Sanderson 1. The healing of an abdominal muscle wound after surgery is associated with a considerable increase in the rate of protein synthesis. We have investigated whether this increase in protein synthesis is affected by chronic undernutrition, and whether this causes...
Clin Sci (Lond) (1995) 89 (3): 311–319.
Published: 01 September 1995
...Takashi Higashiguchi; Yoshifumi Noguchi; Tory Meyer; Josef E. Fischer; Per-Olof Hasselgren 1. We studied the effect of sepsis and the regulation by glutamine of protein synthesis in enterocytes isolated from the small intestine of rats. 2. Sepsis was induced by caecal ligation and puncture; control...
Clin Sci (Lond) (1995) 88 (1): 59–66.
Published: 01 January 1995
..., in total fat, to avoid essential fatty acid deficiency. 3. Rats subsequently received 800 μg/kg Escherichia coli endotoxin or sterile saline subcutaneously. Twenty-four hours after injection, the rate of tissue protein synthesis was measured in liver, lung, kidney, tibialis muscle and spleen...
Clin Sci (Lond) (1994) 87 (5): 539–546.
Published: 01 November 1994
...D. C. Macallan; G. E. Griffin 1. Sepsis is associated with marked changes in cardiac muscle protein synthesis. Such changes may be the result of altered transcription of specific myofibrillar protein mRNAs. 2. In order to investigate myofibrillar protein gene expression, a rat model of sepsis...
Clin Sci (Lond) (1994) 87 (5): 607–618.
Published: 01 November 1994
... (all diets), and 14 and 21 days (0.5% protein). In bone this induced delayed inhibition of tibial growth with parallel inhibition of protein synthesis, as measured by the phenylalanine flooding dose method. This was mediated by reductions in both ribosomal capacity (RNA/protein ratio) and activity...
Clin Sci (Lond) (1994) 87 (2): 207–211.
Published: 01 August 1994
...Takashi Higashiguchi; Yoshifumi Noguchi; William O'Brien; Kenneth Wagner; Josef E. Fischer; Per-Olof Hasselgren 1. In a previous study we found that the protein synthesis rate was increased by 50–60% in the mucosa of the jejunum and ileum during sepsis in rats. It is not known if sepsis affects...
Clin Sci (Lond) (1994) 86 (6): 671–675.
Published: 01 June 1994
...Kenneth G. M. Park; Steven D. Heys; Margaret A. McNurlan; Peter J. Garlick; Oleg Eremin 1. The ‘flooding’ dose technique was used to measure rates of lymphocyte protein synthesis after infusion of [1- 13 C]leucine (20 atoms% enrichment, 4 g/70 kg body weight). Lymphocyte protein synthesis...
Clin Sci (Lond) (1993) 85 (3): 337–342.
Published: 01 September 1993
...Peter E. Ballmer; Margaret A. McNurlan; Ian Grant; Peter J. Garlick 1. The influence of an acute-phase reaction on the ability of protein synthesis rates in liver and three different muscles (gastrocnemius, soleus and heart) to respond to a short intravenous infusion of nutrients (glucose plus...
Clin Sci (Lond) (1993) 84 (2): 177–183.
Published: 01 February 1993
... is that the protein synthesis rate is not stimulated by the flooding dose. A new formula for calculation of the fractional synthesis rate is derived with the alternative assumption that the protein synthesis rate is stimulated by an amount proportional to the change in the intracellular concentration of the infused...
Clin Sci (Lond) (1992) 82 (4): 413–417.
Published: 01 April 1992
... have been reproduced in man there have been few studies of its effects on human tumours. In this study the effects of arginine on human breast cancers were determined by measuring tumour protein synthesis and comparing this with immunohistochemical assessments of cell proliferation. 2. Patients...
Clin Sci (Lond) (1991) 81 (s25): 557–564.
Published: 01 October 1991
...M. A. McNurlan; P. Essen; S. D. Heys; V. Buchan; P. J. Garlick; J. Wernerman 1. The rate of protein synthesis in quadriceps muscle of healthy subjects estimated from the incorporation of l -[1- 13 C]leucine given by continuous infusion was 1.1%/day. The estimate of protein synthesis from...
Clin Sci (Lond) (1991) 80 (6): 587–593.
Published: 01 June 1991
...S. D. Heys; K. G. M. Park; M. A. McNurlan; A. G. Calder; V. Buchan; K. Blessing; O. Eremin; P. J. Garlick 1. A method is described for measuring the rates of protein synthesis in vivo in human colorectal and breast tumours by the intravenous injection of l -[1- 13 C]leucine as a ‘flooding dose'. 2...
Clin Sci (Lond) (1990) 79 (5): 537–542.
Published: 01 November 1990
...S. B. Ireland; P. M. Stewart 1. The effect of uraemia on the rates of protein synthesis and protein degradation in liver, heart and vastus lateralis muscle were examined in the rat. Uraemia was induced by a five-sixths nephrectomy and the rates of protein turnover were compared with pair-fed sham...
Clin Sci (Lond) (1989) 77 (6): 611–616.
Published: 01 December 1989
...Jan Wernerman; Danielle Botta; Folke Hammarqvist; Stig Thunell; Alexandra von der Decken; Erik Vinnars 1. The influence of elevated concentrations of stress hormones on the concentration of ribosomes and the relative proportion of polyribosomes, reflecting protein synthesis in vivo , in human...
Clin Sci (Lond) (1989) 77 (6): 651–655.
Published: 01 December 1989
...S. D. Heys; A. C. Norton; C. R. Dundas; O. Eremin; K. Ferguson; P. J. Garlick 1. Rates of protein synthesis were measured, in vivo , in lung, liver, heart and skeletal muscle of young male rats. Groups of rats were exposed for 1 h duration to one of the following anaesthetic regimens: 1.4...
Clin Sci (Lond) (1989) 77 (3): 329–336.
Published: 01 September 1989
...Peter J. Garlick; Jan Wernerman; Margaret A. McNurlan; Pia Essen; Gerald E. Lobley; Eric Milne; Graham A. Calder; Eric Vinnars 1. The ‘flooding dose’ technique for measuring the rate of protein synthesis in tissues in vivo involves the injection of a large amount of unlabelled amino acid together...
Clin Sci (Lond) (1989) 77 (1): 13–20.
Published: 01 July 1989
... time measurements were made of muscle and liver protein content and synthesis in vivo , muscle protein degradation as the difference between protein synthesis and growth rates, muscle glutamine concentration and plasma insulin. 3. Fenbufen treatment alone tended to lower rectal temperature. It also...
Clin Sci (Lond) (1988) 75 (1): 79–83.
Published: 01 July 1988
...J. N. A. Gibson; M. J. McMaster; C. M. Scrimgeour; P. J. Stoward; M. J. Rennie 1. The rate of paraspinal (multifidus) muscle protein synthesis was measured bilaterally at the top, apex and bottom of the thoracic curve in nine children with an idiopathic scoliosis, using the stable-isotope-labelled...
Clin Sci (Lond) (1988) 74 (5): 461–466.
Published: 01 May 1988
...Victor R. Preedy; Timothy J. Peters 1. The effects of a single dose of ethanol (75 mmol/kg body weight) on rates of muscle protein synthesis were examined in young rats. Fractional rates of protein synthesis were measured in the soleus, plantaris, gastrocnemius, diaphragm and stomach by the large...
Clin Sci (Lond) (1987) 73 (1): 69–75.
Published: 01 July 1987
...M. A. McNurlan; K. C. McHardy; J. Broom; E. Milne; L. M. Fearns; P. J. Reeds; P. J. Garlick 1. Protein synthesis was measured in muscle of fed and fasted rats. Synthesis rates were 29% higher with feeding. Treatment with indomethacin before feeding completely blocked the stimulation of protein...
Clin Sci (Lond) (1987) 72 (4): 503–509.
Published: 01 April 1987
..., with the decrement in muscle mass being due mainly to a substantial (25%) depression of muscle protein synthesis. 17 9 1986 20 11 1986 © 1970 The Biochemical Society and the Medical Research Society 1970 fractured tibia immobilization protein breakdown protein synthesis skeletal muscle...
Clin Sci (Lond) (1985) 68 (3): 271–282.
Published: 01 March 1985
...Edward B. Fern; Peter J. Garlick; John C. Waterlow 1. The rate of protein synthesis in the whole body was measured in one fed subject with seven 15 N-labelled amino acids (intravenous and oral doses) and two 15 N protein mixtures (oral doses only). The rates were determined individually from...
Clin Sci (Lond) (1984) 66 (3): 337–342.
Published: 01 March 1984
...Marc Yudkoff; Itzhak Nissim; Mark Glassman; Stanton Segal 1. Whole body nitrogen turnover and protein synthesis were calculated by the method of D. Picou & T. Taylor-Roberts [ Clinical Science and Molecular Medicine (1969) 36, 283–296] except that plateau plasma enrichment of [ guanidino - 15 N...
Clin Sci (Lond) (1982) 63 (6): 519–523.
Published: 01 December 1982
...M. J. Rennie; R. H. T. Edwards; D. Halliday; D. E. Matthews; S. L. Wolman; D. J. Millward 1. Measurements have been made of whole-body and skeletal muscle protein synthesis in fed and fasted adults with l -[1- 13 C]leucine. 2. The marked increase in whole-body synthesis on feeding largely reflects...
Clin Sci Mol Med (1976) 50 (5): 425–429.
Published: 01 May 1976
... DNA synthesis jejunum protein synthesis radioautography tissue culture Clinical Science and Molecular Medicine (1976) 50, 425-429. Biochemical and morphological studies on human jejunal mucosa maintained in culture C. L HIRONDEL, W. F. DOE AND T. J. PETERS Royal Postgraduate Medical School...
Clin Sci Mol Med (1975) 48 (5): 373–378.
Published: 01 May 1975
... and the Medical Research Society 1975 bound and free ribosomes parathyroid gland protein synthesis Clinical Science and Molecular Medicine (1975) 48, 373-378. Protein synthetic activity of membrane-bound and free ribosomes from parathyroid glands of dogs F. P. ALFORD,(i) P. S. COOK, R. S. SWENSON AND G...
Clin Sci Mol Med (1974) 47 (6): 531–545.
Published: 01 December 1974
.... Cooksley et al. factors other than the synthesis of TCII and the concentration of vitamin B,, or unsaturated transcobalamin in the plasma. Key words : bile secretion, liver perfusion, protein synthesis, transcobalamin 11, vitamin B Protein-binding of vitamin B,, has been shown to play a role in its...
Clin Sci Mol Med (1973) 44 (1): 1–8.
Published: 01 January 1973
... hormone cell culture protein synthesis affinity chromatography Clinical Science (1973) 44, 1-8. SYNTHESIS O F HUMAN PARATHYROID HORMONE BY CULTURED CELLS: EVIDENCE FOR RELEASE OF PROHORMONE BY SOME ADENOMATA T. J. MARTIN, P. B. GREENBERG AND V. MICHELANGELI University of Melbourne Department...