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Keywords: protein kinase CClose
Clin Sci (Lond) (2016) 130 (17): 1499–1510.
Published: 18 July 2016
... range of cellular responses, including cell proliferation, differentiation and survival. The protein kinase C (PKC) family of serine/threonine kinases sits at nodal points in many signal transduction pathways; PKC enzymes have been the focus of considerable attention since they contribute to both normal...
Clin Sci (Lond) (2015) 129 (6): 477–487.
Published: 22 June 2015
... ]. PKC (protein kinase C) family isoforms play important roles in regulating cellular functions. Several pro-atherosclerotic factors, such as apolipoprotein CIII, up-regulate the expression level of PKCβ in human endothelial cells [ 9 ]. In addition, oxLDL activates the LOX-1 expression level and PKCβ...
Clin Sci (Lond) (2009) 117 (8): 305–312.
Published: 24 August 2009
... have been reported. In the present study we investigated the effects of dexamethasone on EFS (electrical field stimulation)-induced NO release in MAs from WKY (Wistar–Kyoto) rats and SHRs (spontaneously hypertensive rats) and the role of PKC (protein kinase C) in this response. In endothelium-denuded...
Clin Sci (Lond) (2002) 103 (s2002): 276S–279S.
Published: 01 September 2002
... with elevated ET-1 concentrations. The aim of this study was to find out the influence of ET-1 and ET receptor antagonists on myocardial protein kinase C (PKC) regulation in uraemic cardiomyopathy. Male rats were subtotally nephrectomized and treated with an ET A -receptor antagonist (30mg·kg -1 ·day -1...
Clin Sci (Lond) (2002) 103 (3): 311–321.
Published: 15 August 2002
...Mary A. COTTER; Alison M. JACK; Norman E. CAMERON Elevated protein kinase C activity has been linked to the vascular and neural complications of diabetes. The aim of the present study was to examine the involvement of the β-isoform of protein kinase C in abnormalities of neuronal function, neural...
Clin Sci (Lond) (2000) 99 (4): 277–283.
Published: 01 September 2000
...Jesús MARÍN; Mercedes FERRER; Gloria BALFAGÓN This study examines the influence of hypertension on neuronal nitric oxide (NO) release and its modulation by protein kinase C (PKC). For this purpose, mesenteric segments without endothelium were obtained from Wistar–Kyoto (WKY) rats and spontaneously...
Clin Sci (Lond) (1999) 97 (3): 385–390.
Published: 24 August 1999
.... The short-chain fatty acids, acetate, propionate, butyrate and valerate, the activator of protein kinase C (phorbol-12-myristate-13-acetate) and tumour necrosis factor-α (TNF-α) all stimulated the secretion of IL-8. However, only the motogenic effect of TNF-α was dependent upon IL-8. In conclusion, IL-8...
Clin Sci (Lond) (1999) 97 (3): 355–361.
Published: 06 August 1999
...Xianqin QU; J. Paul SEALE; Richard DONNELLY The mechanisms responsible for the age-related decline in insulin sensitivity have not been clearly identified, but activation of the diacylglycerol/protein kinase C (PKC) signalling pathway (often confined to individual isoforms of PKC) has recently been...
Clin Sci (Lond) (1995) 88 (3): 277–283.
Published: 01 March 1995
... and assesses the role of protein kinase C in the interactions between endothelin-1 and thrombin. Aggregation was measured turbidometrically and the intracellular free calcium concentration was determined with the fluorescent indicator fura 2-acetoxymethyl ester. 2. Endothelin-1 at concentrations from 10 −11...
Clin Sci (Lond) (1993) 85 (3): 265–268.
Published: 01 September 1993
...) that can be phosphory-lated and thereby inactivated by protein kinase C. 2. Stimulation of protein kinase C by 12- O -tetradecanoyl-phorbol-13-acetate attenuated the inhibitory effect of the adenosine agonist. 3. Omental fat cells are less sensitive to adenosine than subcutaneous cells, although...
Clin Sci (Lond) (1993) 85 (1): 57–61.
Published: 01 July 1993
...-triggered hydrolysis of phosphoinositides by phospholipase C was evaluated by measuring [ 3 H]inositol phosphate formation. The role of protein kinase C and protein tyrosine kinases in arginine-vasopressin mitogenicity was assessed by stimulating the cells with arginine-vasopressin in the presence of 12- O...
Clin Sci (Lond) (1990) 78 (5): 509–514.
Published: 01 May 1990
...Rudolf Locher; Agapios Sachinidis; Albert Steiner; Wilhelm Vetter 1. The capacity of low-density lipoprotein-cholesterol (40 μg/ml) to stimulate both the phosphoinositide cycle and the dislocation of the phospholipid- and calcium-dependent protein kinase C activity from the cytosolic...