...Raquel Hernanz; Ana M. Briones; Mercedes Salaices; María J. Alonso Elevated production of prostanoids from the constitutive (COX-1) or inducible (COX-2) cyclo-oxygenases has been involved in the alterations in vascular function, structure and mechanical properties observed in cardiovascular...

...), a selective agonist for α 1 receptors, was also evaluated in endothelium-intact and -denuded rings. 6 7 2009 12 11 2009 3 12 2009 3 12 2009 © The Authors Journal compilation © 2010 Biochemical Society 2010 aorta calcium hydrogen peroxide prostanoid reactive oxygen...

...Rania Nasrallah; Jordan Clark; Richard L. Hébert There are five major PGs (prostaglandins/prostanoids) produced from arachidonic acid via the COX (cyclo-oxygenase) pathway: PGE 2 , PGI 2 (prostacyclin), PGD 2 , PGF 2α and TXA 2 (thromboxane A 2 ). They exert many biological effects through specific...

... Janice M. Marshall (email j.m.marshall@bham.ac.uk ). 2 9 2004 25 2 2005 15 3 2005 15 3 2005 The Biochemical Society 2005 acetylcholine endothelium cyclo-oxygenase prostanoid Raynaud's disease vasodilatation Raynaud's phenomenon was first described...

..., MN 55905, U.S.A. © 2002 The Biochemical Society and the Medical Research Society 2002 aorta carotid artery endothelium high-fat diet prostanoid risk factors thromboxane vascular vasoconstriction 13SClinical Science (2002) 103 (Suppl. 48), 13S 15S (Printed in Great Britain...

... substances such as endothelin A receptor (ET A ) antagonists and prostanoids have been used to improve haemodynamics and clinical outcome. We compared the hemodynamic response to BQ-123 (an ET A receptor antagonist) and prostacyclin or its analogue iloprost in ten patients (four men) with a mean age of 35.9...