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Articles

Eicosanoid receptors as therapeutic targets for asthma

William S. Powell

Clin Sci (Lond) (2021) 135 (16): 1945–1980.

DOI: https://doi.org/10.1042/CS20190657

Published: 17 August 2021

... (LTs) and 5-oxo-6,8,11,14-eicosatetraenoic acid (5-oxo-ETE), and cyclooxygenase (COX), leading to prostaglandins (PGs) and thromboxane (TX). A third group (specialized pro-resolving mediators; SPMs), including lipoxin A 4 (LXA 4 ) and resolvins (Rvs), are formed by the combined actions of different...

View article titled, Eicosanoid receptors as therapeutic targets for asthma

Articles

Conjugated linoleic acid induces lipid peroxidation in men with abdominal obesity

S. BASU, U. RISÉRUS, A. TURPEINEN, B. VESSBY

Clin Sci (Lond) (2000) 99 (6): 511–516.

DOI: https://doi.org/10.1042/cs0990511

Published: 07 November 2000

... to the anti-tumorigenic effects of this agent. The present study investigates the urinary levels of 8-iso-prostaglandin F 2α (8-iso-PGF 2α ), a major isoprostane, and of 15-oxo-dihydro-PGF 2α , a major metabolite of PGF 2α , as indicators of non-enzymic and enzymic arachidonic acid oxidation respectively...

View article titled, Conjugated linoleic acid induces lipid peroxidation in men with abdominal obesity

Articles

Vasodilator prostanoids, but not nitric oxide, may account for skeletal muscle hyperaemia in Type I diabetes mellitus

R. Andrew P. SKYRME-JONES, Richard C. O'BRIEN, Ian T. MEREDITH

Clin Sci (Lond) (2000) 99 (5): 383–392.

DOI: https://doi.org/10.1042/cs0990383

Published: 03 October 2000

... (e-mail ian.meredith@med.monash.edu.au ). 17 12 1999 27 3 2000 28 6 2000 The Biochemical Society and the Medical Research Society © 2000 2000 artery blood flow diabetes mellitus nitric oxide prostaglandins 383Clinical Science (2000) 99, 383 392 (Printed in Great...

View article titled, Vasodilator prostanoids, but not nitric oxide, may account for skeletal muscle hyperaemia in Type I diabetes mellitus

Articles

Non-steroidal anti-inflammatory drugs and renal response to exercise: a comparison of indomethacin and nabumetone

Niels Vidiendal OLSEN, Niels Georg JENSEN, Jesper Melchior HANSEN, Niels Juel CHRISTENSEN, Niels FOGH-ANDERSEN, Inge-Lis KANSTRUP

Clin Sci (Lond) (1999) 97 (4): 457–465.

DOI: https://doi.org/10.1042/cs0970457

Published: 24 August 1999

..., arterial blood pressure, cardiac output and plasma catecholamines at rest and during exercise were not altered by indomethacin or nabumetone. Indomethacin decreased urinary rates of excretion of 6-oxo-prostaglandin F 1α (6-oxo-PGF 1α ) and thromboxane B 2 in all study periods. Nabumetone decreased 6-oxo...

View article titled, Non-steroidal anti-inflammatory drugs and renal response to exercise: a comparison of indomethacin and nabumetone

Articles

Renal targeting of a non-steroidal anti-inflammatory drug: effects on renal prostaglandin synthesis in the rat

Marijke HAAS, Frits MOOLENAAR, Dirk K. F. MEIJER, Paul E. DE JONG, Dick DE ZEEUW

Clin Sci (Lond) (1998) 95 (5): 603–609.

DOI: https://doi.org/10.1042/cs0950603

Published: 01 November 1998

... in a 70-fold increase of naproxen accumulation in the kidney with a subsequent renal release of the active metabolite naproxen–lysine. 2. In the present study we questioned whether naproxen–lysozyme is active in the rat kidney, inhibiting the urinary excretion of prostaglandin E 2 and renal sodium...

View article titled, Renal targeting of a non-steroidal anti-inflammatory drug: effects on renal prostaglandin synthesis in the rat

Articles

Renal haemodynamics, sodium and water reabsorption during continuous intravenous infusion of recombinant interleukin-2

Poul F. GEERTSEN, Hans VON DER MAASE, Niels Vidiendal OLSEN, Niels FOGH-ANDERSEN, Steen Levin NIELSEN, Paul P. LEYSSAC

Clin Sci (Lond) (1998) 95 (1): 73–81.

DOI: https://doi.org/10.1042/cs0950073

Published: 01 July 1998

...) ml/min to 17 (10/21) ml/min ( P = 0.008). Calculated absolute proximal reabsorption rate of water increased from 63 (40/69) ml/min to 71 (47/82) ml/min ( P = 0.04). The urinary excretion rate of thromboxane B 2 and the ratio between excretion rates of thromboxane B 2 and 6-keto-prostaglandin-F 1α...

View article titled, Renal haemodynamics, sodium and water reabsorption during continuous intravenous infusion of recombinant interleukin-2

Articles

Comparison of the Effects on Urinary Sodium Excretion of Indomethacin and of Carbidopa in normal Volunteers given an Intravenous Saline Infusion

G. S. Stokes, J. C. Monaghan, D. N. Pillai

Clin Sci (Lond) (1997) 92 (4): 409–414.

DOI: https://doi.org/10.1042/cs0920409

Published: 01 April 1997

...G. S. Stokes; J. C. Monaghan; D. N. Pillai 1. Dopamine and prostaglandins are putative endogenous natriuretic hormones. The role of each in facilitating natriuresis induced by intravenous saline infusion was examined in normal volunteers in relation to administration of carbidopa...

View article titled, Comparison of the Effects on Urinary Sodium Excretion of Indomethacin and of Carbidopa in normal Volunteers given an Intravenous Saline Infusion

Articles

Production of Eicosanoids and Cytokines by Kupffer Cells from Young and Old Rats Stimulated by Endotoxin

A. Brouwer, S. G. Parker, H. F. J. Hendriks, L. Gibbons, M. A. Horan

Clin Sci (Lond) (1995) 88 (2): 211–217.

DOI: https://doi.org/10.1042/cs0880211

Published: 01 February 1995

... as described for other types of macrophages, although the pattern was specific for Kupffer cells. 4. Eicosanoids, predominantly prostaglandin D 2 and prostaglandin F 2α , were produced mainly during the first hour after exposure to lipopolysaccharide. Endotoxin stimulated synthesis of mRNAs of interleukin 1...

View article titled, Production of Eicosanoids and Cytokines by Kupffer Cells from Young and Old Rats Stimulated by Endotoxin

Articles

Intraluminal Colonic Release of Immunoreactive Tumour Necrosis Factor in Chronic Ulcerative Colitis

F. Casellas, M. Papo, F. Guarner, M. Antolín, J. R. Armengol, J.-R. Malagelada

Clin Sci (Lond) (1994) 87 (4): 453–458.

DOI: https://doi.org/10.1042/cs0870453

Published: 01 October 1994

... ml/min, and was recovered 30 cm distally by siphonage. Effluents were assayed for tumour necrosis factor by a specific e.l.i.s.a. and for prostaglandin E 2 and leukotriene B 4 by specific r.i.a.s. 3. The intracolonic release of tumour necrosis factor was undetectable in patients with irritable bowel...

View article titled, Intraluminal Colonic Release of Immunoreactive Tumour Necrosis Factor in Chronic Ulcerative Colitis

Articles

Hormonal and other Mechanisms Involved in the Pathogenesis of Cyclosporin-Induced Nephrotoxicity and Hypertension in Man

Nigel D.C. Sturrock, A.D. Struthers

Clin Sci (Lond) (1994) 86 (1): 1–9.

DOI: https://doi.org/10.1042/cs0860001

Published: 01 January 1994

...Nigel D.C. Sturrock; A.D. Struthers © 1994 The Biochemical Society and the Medical Research Society 1994 calcium cyclosporin hypertension nephrotoxicity prostaglandins renin-angiotensin system sodium Clinical Science (1994) 86, 1-9 (Printed in Great Britain) I Editorial Review...

View article titled, Hormonal and other Mechanisms Involved in the Pathogenesis of Cyclosporin-Induced Nephrotoxicity and Hypertension in Man

Articles

Indomethacin Stimulates Basal Glucose Production in Humans without Changes in Concentrations of Glucoregulatory Hormones

E. P. M. Corssmit, J. A. Romijn, E. Endert, H. P. Sauerwein

Clin Sci (Lond) (1993) 85 (6): 679–685.

DOI: https://doi.org/10.1042/cs0850679

Published: 01 December 1993

... and the Medical Research Society 1993 cytokines glucose metabolism prostaglandins Clinical Science (1993) 85, 679-685 (Printed in Great Britain) lndomethacin stimulates basal glucose production in humans without changes in concentrations of glucoregulatory hormones E. P. M. CORSSMIT', J. A. ROMIJN's* E...

View article titled, Indomethacin Stimulates Basal Glucose Production in Humans without Changes in Concentrations of Glucoregulatory Hormones

Articles

Induction of Enhanced Responsiveness of Human Articular Chondrocytes to Extracellular ATP by Tumour Necrosis Factor-α

Weng S. Leong, R. Graham, G. Russell, Alison M. Caswell

Clin Sci (Lond) (1993) 85 (5): 569–575.

DOI: https://doi.org/10.1042/cs0850569

Published: 01 November 1993

...Weng S. Leong; R. Graham; G. Russell; Alison M. Caswell 1. We have observed previously that extracellular ATP acting at P 2 -purinoceptors promotes the production of prostaglandin E 2 by human articular chondrocytes, and that this response is enhanced synergistically by interleukin-1β. Since other...

View article titled, Induction of Enhanced Responsiveness of Human Articular Chondrocytes to Extracellular ATP by Tumour Necrosis Factor-α

Articles

Dissociation between Pressor Sensitivity in Vivo and Contractile Reactivity in Vitro to Angiotensin II in Rats with Experimental Cirrhosis

David J. Leehey

Clin Sci (Lond) (1993) 84 (5): 525–529.

DOI: https://doi.org/10.1042/cs0840525

Published: 01 May 1993

...-oxygenase inhibitor indomethacin (3 mg/kg intravenously) restored pressor sensitivity to angiotensin II to normal, suggesting that cyclo-oxygenase products, possibily vasodilator prostaglandins, may be involved in mediating pressor resistance to this hormone in vivo. 23 12 1992 25 1 1993 ©...

View article titled, Dissociation between Pressor Sensitivity in Vivo and Contractile Reactivity in Vitro to Angiotensin II in Rats with Experimental Cirrhosis

Articles

Endothelium-Dependent Modulation of Responses to Endothelin-1 in Human Veins

William G. Haynes, David J. Webb

Clin Sci (Lond) (1993) 84 (4): 427–433.

DOI: https://doi.org/10.1042/cs0840427

Published: 01 April 1993

... of endothelin-1 for 60 min alone or, on two separate occasions, co-infused with the donator of nitric oxide, glyceryl trinitrate, or the vasodilator prostaglandin, prostacyclin. In further studies, endothelin-l was co-infused with an inhibitor of nitric oxide production, N G -monomethyl-L-arginine, or after...

View article titled, Endothelium-Dependent Modulation of Responses to Endothelin-1 in Human Veins

Articles

Cellular and intrarenal control of renin secretion

Ole Skøtt, Boye L. Jensen

Clin Sci (Lond) (1993) 84 (1): 1–10.

DOI: https://doi.org/10.1042/cs0840001

Published: 01 January 1993

...Ole Skøtt; Boye L. Jensen © 1993 The Biochemical Society and the Medical Research Society 1993 angiotensin II baroreceptor calcium cyclic nucleotides endothelial factors juxtaglomerular apparatus macula densa osmotic forces prostaglandins renal nerves renin biosynthesis renin...

View article titled, Cellular and intrarenal control of renin secretion

Articles

Technique for the primary culture of human breast cancer cells and measurement of their prostaglandin secretion

John Watson, Siew Yeam Chuah

Clin Sci (Lond) (1992) 83 (3): 347–352.

DOI: https://doi.org/10.1042/cs0830347

Published: 01 September 1992

...John Watson; Siew Yeam Chuah 1. A method is described for the primary culture of human breast tumour cells on feeder layers of the STO mouse embryo fibroblast cell line. 2. The secretion of the prostaglandins E 2 and F 2α from the cells was measured and the results indicate that the secretion...

View article titled, Technique for the primary culture of human breast cancer cells and measurement of their prostaglandin secretion

Articles

Increased urinary excretion of prostaglandin E 2 in patients with idiopathic hypercalciuria is a primary phenomenon

C. Henríquez-la Roche, B. Rodríguez-Iturbe, G. Parra

Clin Sci (Lond) (1992) 83 (1): 75–80.

DOI: https://doi.org/10.1042/cs0830075

Published: 01 July 1992

...C. Henríquez-la Roche; B. Rodríguez-Iturbe; G. Parra 1. Urinary excretion of prostaglandin E 2 is increased in patients with idiopathic hypercalciuria, but in order to conclude that hyperprostaglandinuria is a primary phenomenon, it must be demonstrated that high levels of urinary prostaglandin E 2...

View article titled, Increased urinary excretion of prostaglandin E 2 in patients with idiopathic hypercalciuria is a primary phenomenon

Articles

Tumour Necrosis Factor-α and Endotoxin Induce Less Prostaglandin E 2 Production from Hypothalami of Rats Fed Coconut Oil than from Hypothalami of Rats Fed Maize Oil

David C. Bibby, Robert F. Grimble

Clin Sci (Lond) (1990) 79 (6): 657–662.

DOI: https://doi.org/10.1042/cs0790657

Published: 01 December 1990

...David C. Bibby; Robert F. Grimble 1. The primary aim of the study was to determine whether the stimulatory effect of tumour necrosis factor-α and endotoxin on hypothalamic prostaglandin E 2 production was influenced by dietary fats containing different amounts of linoleic acid. Rats received diets...

View article titled, Tumour Necrosis Factor-α and Endotoxin Induce Less Prostaglandin E 2 Production from Hypothalami of Rats Fed Coconut Oil than from Hypothalami of Rats Fed Maize Oil

Articles

Effects of infusion of prostacyclin on anatomical intrapulmonary right to left shunt: a useful model of human hypoxic vasoconstriction?

A. Bush, C. M. Busst, W. B. Knight, E. A. Shinebourne

Clin Sci (Lond) (1989) 76 (2): 143–149.

DOI: https://doi.org/10.1042/cs0760143

Published: 01 February 1989

... 6 1988 © 1989 The Biochemical Society and the Medical Research Society 1989 prostaglandins pulmonary circulation pulmonary gas exchange vasoconstriction Clinical Science (1989) 76, 143-149 143 Effects of infusion of prostacyclin on anatomical intrapulmonary right to left shunt...

View article titled, Effects of infusion of prostacyclin on anatomical intrapulmonary right to left shunt: a useful model of human hypoxic vasoconstriction?

Articles

Increased urinary excretion of prostaglandin E in patients with idiopathic hypercalciuria

Carlos Henríquez-La Roche, Bernardo Rodríguez-Iturbe, José Herrera, Gustavo Parra

Clin Sci (Lond) (1988) 75 (6): 581–587.

DOI: https://doi.org/10.1042/cs0750581

Published: 01 December 1988

...Carlos Henríquez-La Roche; Bernardo Rodríguez-Iturbe; José Herrera; Gustavo Parra 1. Because urinary prostaglandin excretion could play a role in idiopathic hypercalciuria (IH), we studied the excretion of prostaglandin E (PGE), calcium and sodium at various urine flows in 21 patients (14 males...

View article titled, Increased urinary excretion of prostaglandin E in patients with idiopathic hypercalciuria

Articles

Prostaglandin precursor fatty acids in cirrhosis with ascites: Effect of linoleic acid infusion in functional renal failure

Antoni Rimola, Pere Ginés, Eulàlia Cusó, Jordi Camps, Joan Gaya, Vincente Arroyo, Joan Rodés

Clin Sci (Lond) (1988) 74 (6): 613–619.

DOI: https://doi.org/10.1042/cs0740613

Published: 01 June 1988

...Antoni Rimola; Pere Ginés; Eulàlia Cusó; Jordi Camps; Joan Gaya; Vincente Arroyo; Joan Rodés 1. Functional renal failure (FRF) in cirrhosis with ascites could be related to an inappropriately low renal prostaglandin (PG) production. To investigate whether the impaired renal PG synthesis...

View article titled, Prostaglandin precursor fatty acids in cirrhosis with ascites: Effect of linoleic acid infusion in functional renal failure

Articles

Prostaglandins E 2 and F 2α are not involved in the monocytic-product (interleukin-1)-induced stimulation of hepatic fibrinogen synthesis in rats

J. C. W. M. Holtslag, H. J. Moshage, J. F. van Pelt, J. A. G. M. Kleuskens, F. W. J. Gribnau, S. H. Yap

Clin Sci (Lond) (1988) 74 (5): 477–483.

DOI: https://doi.org/10.1042/cs0740477

Published: 01 May 1988

...J. C. W. M. Holtslag; H. J. Moshage; J. F. van Pelt; J. A. G. M. Kleuskens; F. W. J. Gribnau; S. H. Yap 1. Monocytic products, especially interleukin-1 (IL-1), play an important role in the acute-phase response. Prostaglandins have been shown to act as second messengers in several physiological...

View article titled, Prostaglandins E 2 and F 2α are not involved in the monocytic-product (interleukin-1)-induced stimulation of hepatic fibrinogen synthesis in rats

Articles

Prostanoid synthesis by isolated rat glomeruli: Effect of oestrous cycle and pregnancy

I. Gregoire, J. P. Dupouy, P. Fievet, J. D. Sraer, A. Fournier

Clin Sci (Lond) (1987) 73 (6): 641–644.

DOI: https://doi.org/10.1042/cs0730641

Published: 01 December 1987

...I. Gregoire; J. P. Dupouy; P. Fievet; J. D. Sraer; A. Fournier 1. An increase in glomerular prostaglandin (PG) synthesis has been reported in two experimental models of increased glomerular filtration rate (GFR). 2. Because pregnancy, in women and rats, is also associated with an increased GFR, we...

View article titled, Prostanoid synthesis by isolated rat glomeruli: Effect of oestrous cycle and pregnancy

Articles

Renal response to vasopressin and indomethacin in cisplatin-treated rats

Christopher J. Lote, Ernest S. Harpur, Andrew Thewles, Donna J. Phipps

Clin Sci (Lond) (1987) 73 (4): 377–381.

DOI: https://doi.org/10.1042/cs0730377

Published: 01 October 1987

... The Biochemical Society and the Medical Research Society 1970 cisplatin kidney polyuria prostaglandins vasopressin ...

View article titled, Renal response to vasopressin and indomethacin in cisplatin-treated rats

Articles

Intravenously administered frusemide increases glomerular permeability

I. Ala-Houhala, H. Vapaatalo, A. Pasternack

Clin Sci (Lond) (1987) 73 (4): 365–370.

DOI: https://doi.org/10.1042/cs0730365

Published: 01 October 1987

... prostaglandins proteinuria ...

View article titled, Intravenously administered frusemide increases glomerular permeability

Articles

Influence of cyclo-oxygenase inhibition and of leukotriene receptor blockade on pulmonary vascular pressure/cardiac index relationships in hyperoxic and in hypoxic dogs

Marc Leeman, Robert Naeije, Philippe Lejeune, Christian Melot

Clin Sci (Lond) (1987) 72 (6): 717–724.

DOI: https://doi.org/10.1042/cs0720717

Published: 01 June 1987

... min (i.e. maximum time needed to generate a MPAP/CI plot) alternately at F 1 o 2 0.4 and at F 1 o 2 0.1. 6. These results suggest that pulmonary vascular reactivity to hypoxia is regulated by balanced actions of vasoconstricting leukotrienes and vasodilating prostaglandins in anaesthetized dogs...

View article titled, Influence of cyclo-oxygenase inhibition and of leukotriene receptor blockade on pulmonary vascular pressure/cardiac index relationships in hyperoxic and in hypoxic dogs

Articles

The effect of sodium intake on rabbit renal prostaglandin E 2 and thromboxane A 2 : dissociation from the renin–angiotensin system

Ahmad A. Attallah

Clin Sci (Lond) (1987) 72 (5): 605–609.

DOI: https://doi.org/10.1042/cs0720605

Published: 01 May 1987

...Ahmad A. Attallah 1. The effects of chronic alterations in dietary sodium intake on urinary prostaglandin (PG) E 2 and thromboxane (TX) B 2 was investigated in the rabbit. 2. Sodium restriction, over a 15-day period, reduced daily urinary PGE 2 and TXB 2 in concordance with urinary flow ( V...

View article titled, The effect of sodium intake on rabbit renal prostaglandin E 2 and thromboxane A 2 : dissociation from the renin–angiotensin system

Articles

Interaction between renal prostaglandins and angiotensin II in controlling glomerular filtration in the dog

Margrethe E. Olsen, John E. Hall, Jean-Pierre Montani, John E. Cornell

Clin Sci (Lond) (1987) 72 (4): 429–436.

DOI: https://doi.org/10.1042/cs0720429

Published: 01 April 1987

...Margrethe E. Olsen; John E. Hall; Jean-Pierre Montani; John E. Cornell 9 7 1986 24 10 1986 © 1970 The Biochemical Society and the Medical Research Society 1970 angiotensin II autoregulation glomerular filtration rate prostaglandins renal blood flow tubuloglomerular...

View article titled, Interaction between renal prostaglandins and angiotensin II in controlling glomerular filtration in the dog

Articles

Renal prostaglandins in cirrhosis of the liver

C. Guarner, I. Colina, F. Guarner, J. Corzo, J. Prieto, F. Vilardell

Clin Sci (Lond) (1986) 70 (5): 477–484.

DOI: https://doi.org/10.1042/cs0700477

Published: 01 May 1986

...C. Guarner; I. Colina; F. Guarner; J. Corzo; J. Prieto; F. Vilardell 1. Urinary prostaglandin excretion was studied in 42 patients with liver cirrhosis and in nine control subjects on restricted sodium intake and on bed rest. Creatinine clearance ( C Cr ), sodium excretion ( U Na V ), plasma renin...

View article titled, Renal prostaglandins in cirrhosis of the liver

Articles

Effects of sulindac on renal function and prostaglandin synthesis in patients with moderate chronic renal insufficiency

C. D. Mistry, C. J. Lote, R. Gokal, W. J. C. Currie, M. Vandenburg, N. P. Mallick

Clin Sci (Lond) (1986) 70 (5): 501–505.

DOI: https://doi.org/10.1042/cs0700501

Published: 01 May 1986

... of the 6-ketoprostaglandin F 1α (6-keto-PGF 1α ), a stable breakdown product of prostacyclin (PGI 2 ), was significantly reduced ( P < 0.02) when compared with four healthy controls, whereas prostaglandin E 2 (PGE 2 ) was unchanged. Administration of sulindac did not significantly alter the excretion...

View article titled, Effects of sulindac on renal function and prostaglandin synthesis in patients with moderate chronic renal insufficiency

Articles

Mineralocorticoid escape during kallikrein inhibition

Axel Overlack, Evita Bäcker-Kreutz, Christa Ressel, Hans-Michael Müller, Rainer Kolloch, Klaus-O. Stumpe

Clin Sci (Lond) (1986) 70 (1): 13–17.

DOI: https://doi.org/10.1042/cs0700013

Published: 01 January 1986

...-induced potassium loss was enhanced. 3. Kallikrein inhibition decreased urinary prostaglandin (PG) E 2 and prevented the DOCA-induced rise in PGE 2 . Plasma renin activity was stimulated after 10 days of aprotinin administration. 4. The kallikrein-kinin system is not an important mediator of the escape...

View article titled, Mineralocorticoid escape during kallikrein inhibition

Articles

Effect of indomethacin on urine concentration and dilution in the rat

C. Ray, S. L. Carney, A. H. B. Gillies

Clin Sci (Lond) (1985) 69 (3): 293–298.

DOI: https://doi.org/10.1042/cs0690293

Published: 01 September 1985

...C. Ray; S. L. Carney; A. H. B. Gillies 1. The precise role of prostaglandins in modulating urine concentration and dilution is unclear. Evidence in vitro has recently cast doubt on the accepted theory that renal prostaglandins inhibit the hydro-osmotic effect of vasopressin. 2. Urine clearance...

View article titled, Effect of indomethacin on urine concentration and dilution in the rat

Articles

Lack of effect of indomethacin on systemic and splanchnic haemodynamics in portal hypertensive rats

A. Blanchart, N. Hernando, D. Fernández-Muñoz, L. Hernando, J. M. López-Novoa

Clin Sci (Lond) (1985) 68 (5): 605–607.

DOI: https://doi.org/10.1042/cs0680605

Published: 01 May 1985

.... 25 4 1984 30 11 1984 © 1985 The Biochemical Society and the Medical Research Society 1985 experimental portal hypertension indomethacin microspheres prostaglandins Clinical Science (1985) 68,605-607 SHORT COMMUNICATION 605 Lack of effect of indomethacin on systemic...

View article titled, Lack of effect of indomethacin on systemic and splanchnic haemodynamics in portal hypertensive rats

Articles

Interaction of renal prostaglandins with the renin-angiotensin and renal adrenergic nervous systems in healthy subjects during dietary changes in sodium intake

Herbert J. Kramer, Bruno Stinnesbeck, Georg Klautke, Jochen Kipnowski, Dietrich Klingmueller, Kilian Glaenzer, Rainer Duesing

Clin Sci (Lond) (1985) 68 (4): 387–393.

DOI: https://doi.org/10.1042/cs0680387

Published: 01 April 1985

...Herbert J. Kramer; Bruno Stinnesbeck; Georg Klautke; Jochen Kipnowski; Dietrich Klingmueller; Kilian Glaenzer; Rainer Duesing 1. In six healthy subjects the role of renal prostaglandins (PG) in modulating the actions of the renin-angiotensin and renal adrenergic nervous systems on renal function...

View article titled, Interaction of renal prostaglandins with the renin-angiotensin and renal adrenergic nervous systems in healthy subjects during dietary changes in sodium intake

Articles

Haemodynamic and Endocrine Responses of the Kidney to Frusemide in Mild Essential Hypertension

I. G. Mackay, K. Nath, A. D. Cumming, A. L. Muir, M. L. Watson

Clin Sci (Lond) (1985) 68 (2): 159–164.

DOI: https://doi.org/10.1042/cs0680159

Published: 01 February 1985

...I. G. Mackay; K. Nath; A. D. Cumming; A. L. Muir; M. L. Watson 1. Prostaglandin-dependent, frusemide-induced changes in renal plasma flow, glomerular filtration rate and plasma renin activity were measured in 14 patients with mild essential hypertension. 2. The renal haemodynamic responses...

View article titled, Haemodynamic and Endocrine Responses of the Kidney to Frusemide in Mild Essential Hypertension

Articles

Effect of Acetylsalicylic Acid and of Indomethacin on Diuresis in Man: The Role of Cyclo-Oxygenase Inhibition

H. Vierhapper, J. Jörg, W. Waldhäusl

Clin Sci (Lond) (1984) 67 (6): 579–583.

DOI: https://doi.org/10.1042/cs0670579

Published: 01 December 1984

...H. Vierhapper; J. Jörg; W. Waldhäusl 1. The effect of acetylsalicylic acid (ASA, 3 g/day for 3 days) and of indomethacin (IND, 150 mg/day for 3 days) on diuresis and on the excretion of prostaglandin E 2 (PGE 2 ) was studied in six healthy, male volunteers. After overnight deprivation the subjects...

View article titled, Effect of Acetylsalicylic Acid and of Indomethacin on Diuresis in Man: The Role of Cyclo-Oxygenase Inhibition

Articles

Dependence of Urinary Prostaglandin E 2 Excretion on Urinary Volume Rather than Solute Handling or Segmental Nephron Function in Man

Sming Kaojarern, Polavat Chennavasin, Ann Burdette, William B. Campbell, D. Craig Brater

Clin Sci (Lond) (1984) 67 (4): 413–420.

DOI: https://doi.org/10.1042/cs0670413

Published: 01 October 1984

... pretreatment with indomethacin. 2. After frusemide administration, increases in urinary sodium excretion paralleled increases in urinary volume, and urinary prostaglandin E 2 (PGE 2 ) excretion correlated closely with sodium excretion ( y = 1.03 x −0.28; r = 0.940; P <.0001). 3. In the absence...

View article titled, Dependence of Urinary Prostaglandin E 2 Excretion on Urinary Volume Rather than Solute Handling or Segmental Nephron Function in Man

Articles

Effect of Uninephrectomy on Urinary Prostaglandin E 2 , F 2α , and 6-Ketoprostaglandin F 1α Excretion in Rats

Philip G. Baer, Alberto Nasjletti

Clin Sci (Lond) (1984) 66 (4): 407–413.

DOI: https://doi.org/10.1042/cs0660407

Published: 01 April 1984

...Philip G. Baer; Alberto Nasjletti 1. Male Wistar rats were used to examine whether renal prostaglandins (PG) contribute to functional compensatory changes in the remaining kidney after uninephrectomy. Total urinary excretion of PGE 2 , PGF 2α and 6-keto-PGF 1α , a metabolite of PGI 2 , was measured...

View article titled, Effect of Uninephrectomy on Urinary Prostaglandin E 2 , F 2α , and 6-Ketoprostaglandin F 1α Excretion in Rats

Articles

Prostaglandins Cause An Increase in Serum Acute-Phase Proteins in Man, Which is Diminished in Systemic Sclerosis

J. T. Whicher, A. M. Bell, M. F. R. Martin, L. A. Marshall, P. A. Dieppe

Clin Sci (Lond) (1984) 66 (2): 165–171.

DOI: https://doi.org/10.1042/cs0660165

Published: 01 February 1984

...J. T. Whicher; A. M. Bell; M. F. R. Martin; L. A. Marshall; P. A. Dieppe 1. The prostaglandin E 1 increases the plasma concentration of acute-phase proteins in man and decreases the concentration of certain carrier proteins. 2. This response is greatly diminished in patients with systemic sclerosis...

View article titled, Prostaglandins Cause An Increase in Serum Acute-Phase Proteins in Man, Which is Diminished in Systemic Sclerosis

Articles

Hypokalaemia Stimulates Prostacyclin Synthesis in the Rat

Hans-Georg GÜLlner, Andrew K. Graf, John R. Gill, Murray D. Mitchell

Clin Sci (Lond) (1983) 65 (1): 43–46.

DOI: https://doi.org/10.1042/cs0650043

Published: 01 July 1983

..., are due to overproduction of prostacyclin, the principal prostaglandin (PG) synthesized by the vascular endothelium, we studied the effect of experimental hypokalaemia on the urinary excretion of immunoreactive 6-keto-prostaglandin F 1α , a stable metabolite of prostacyclin, in the rat. 2. The animals...

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Articles

Dose-Dependent Effects of Meclofenamate on Peripheral Vasculature of Conscious Rabbits

R. A. Banks, L. J. Beilin, J. Soltys

Clin Sci (Lond) (1983) 64 (5): 471–474.

DOI: https://doi.org/10.1042/cs0640471

Published: 01 May 1983

...R. A. Banks; L. J. Beilin; J. Soltys 1. Changes in systemic haemodynamics and organ blood flow were measured in conscious rabbits after various doses of intravenous sodium meclofenamate, an inhibitor of prostaglandin cyclo-oxygenase. 2. Meclofenamate had no effect on arterial pressure or cardiac...

View article titled, Dose-Dependent Effects of Meclofenamate on Peripheral Vasculature of Conscious Rabbits

Articles

Effect of Aspirin on Urinary Excretion of 6-Ketoprostaglandin F 1α

P. B. B. Jones, R. G. G. Russell

Clin Sci (Lond) (1983) 64 (4): 395–398.

DOI: https://doi.org/10.1042/cs0640395

Published: 01 April 1983

... and the Medical Research Society 1983 aspirin endothelium haemostasis prostacyclin prostaglandins Clinical Science (1983) 64,395-398 395 Effect of aspirin on urinary excretion of 6-ketoprostaglandin FI, P. B. B. JONES* AND R. G. G. RUSSELL Department of Human Metabolism and Clinical Biochemistry...

View article titled, Effect of Aspirin on Urinary Excretion of 6-Ketoprostaglandin F 1α

Articles

The Influence of Different Types of ω 3 Polyunsaturated Fatty Acids on Blood Lipids and Platelet Function in Healthy Volunteers

T. A. B. Sanders, Farah Roshanai

Clin Sci (Lond) (1983) 64 (1): 91–99.

DOI: https://doi.org/10.1042/cs0640091

Published: 01 January 1983

... of these supplements on plasma lipid concentrations, the fatty acid composition of platelet phosphoglycerides, template bleeding time and platelet aggregation induced by collagen and the prostaglandin analogue compound U46619 were studied. 3. In the platelet lipids, the proportion of 20:5 ω3 was increased by the 20 ml...

View article titled, The Influence of Different Types of ω 3 Polyunsaturated Fatty Acids on Blood Lipids and Platelet Function in Healthy Volunteers

Articles

Dissociation between Plasma Prostaglandins E and F α , Renin and Catecholamines in Hypertensive Patients

P. Lijnen, R. Fagard, J. Staessen, A. Amery

Clin Sci (Lond) (1982) 63 (s8): 109s–112s.

DOI: https://doi.org/10.1042/cs063109s

Published: 01 October 1982

...P. Lijnen; R. Fagard; J. Staessen; A. Amery 1. Plasma prostaglandins (PGE and PGF α ) and catecholamine concentrations, and plasma renin activity were measured during an uninterrupted graded exercise test on the bicycle ergometer in 11 hypertensive patients. Blood was withdrawn from the brachial...

View article titled, Dissociation between Plasma Prostaglandins E and F α , Renin and Catecholamines in Hypertensive Patients

Articles

Decreased Prostaglandin E 2 Renal Synthesis in Women with Phaeochromocytoma

H. Ignatowska-Świtalska, B. Wocial, S. Filipecki, W. Januszewicz

Clin Sci (Lond) (1982) 63 (s8): 247s–248s.

DOI: https://doi.org/10.1042/cs063247s

Published: 01 October 1982

...H. Ignatowska-Świtalska; B. Wocial; S. Filipecki; W. Januszewicz 1. Urinary excretion of prostaglandins E 2 and F 2α were determined in 11 women with phaeochromocytoma and in 23 healthy women. 2. In patients with phaeochromocytoma a significant decrease in urinary excretion of PGE 2...

View article titled, Decreased Prostaglandin E 2 Renal Synthesis in Women with Phaeochromocytoma

Articles

Renal and Vascular Wall Prostaglandins in Spontaneously Hypertensive Rats

Yukio Ozawa, Keika Kan, Konosuke Konishi, Waichi Kitajima, Yasuo Matsumura

Clin Sci (Lond) (1982) 63 (s8): 253s–255s.

DOI: https://doi.org/10.1042/cs063253s

Published: 01 October 1982

... and the release of prostaglandins into the incubation medium was measured. 2. Compared with Wistar-Kyoto control animals, the release of prostaglandin E from renal medullary tissue in spontaneously hypertensive rats was raised at 30 days (pre-hypertensive stage) and 90 days (early hypertensive stage...

View article titled, Renal and Vascular Wall Prostaglandins in Spontaneously Hypertensive Rats

Articles

Involvement of Prostaglandins in the Actions of Captopril

H. Witzgall, B. Scherer, P. C. Weber

Clin Sci (Lond) (1982) 63 (s8): 265s–267s.

DOI: https://doi.org/10.1042/cs063265s

Published: 01 October 1982

... < 0.02). Heart rate did not change. Plasma renin activity (PRA) increased ( P < 0.002), and plasma and urinary aldosterone as well as plasma 18-hydroxycorticosterone (18- OH-B) decreased after captopril ( P < 0.02). Prostaglandin (PG) E 2 , kallikrein, urine volume, sodium and potassium excretion...

View article titled, Involvement of Prostaglandins in the Actions of Captopril

Articles

Acute Haemodynamic and Hormonal Effects of Captopril are Diminished by Indomethacin

H. Witzgall, F. Hirsch, B. Scherer, P. C. Weber

Clin Sci (Lond) (1982) 62 (6): 611–615.

DOI: https://doi.org/10.1042/cs0620611

Published: 01 June 1982

...). Prostaglandin (PG) E 2 , sodium and potassium excretion rates remained constant after captopril. 3. Under indomethacin pretreatment, the fall in mean arterial blood pressure was less than without indomethacin at 30 and 60 min after captopril ( P < 0.05). Heart rate was constantly lower than without...

View article titled, Acute Haemodynamic and Hormonal Effects of Captopril are Diminished by Indomethacin

Articles

Mechanisms of Gastric Mucosal Protection: A Role for the ‘Mucus-Bicarbonate’ Barrier

W. D. W. Rees, L. A. Turnberg

Clin Sci (Lond) (1982) 62 (4): 343–348.

DOI: https://doi.org/10.1042/cs0620343

Published: 01 April 1982

...W. D. W. Rees; L. A. Turnberg © 1982 The Biochemical Society and the Medical Research Society 1982 alkali secretion cytoprotection gastric mucosa prostaglandins Clinical Science (1982) 6% 343-348 343 EDITORIAL REVIEW Mechanisms of gastric mucosal protection: a role for the mucus...

View article titled, Mechanisms of Gastric Mucosal Protection: A Role for the ‘Mucus-Bicarbonate’ Barrier

Articles

Is the Pro-Adhesive Activity of Plasma Von Willebrand Factor Counteracted by a Physiological Inhibitor of Platelet Adhesiveness?

M. Porta, E. Cagliero, E. M. Kohner

Clin Sci (Lond) (1982) 62 (2): 239–242.

DOI: https://doi.org/10.1042/cs0620239

Published: 01 February 1982

...M. Porta; E. Cagliero; E. M. Kohner 1. Abnormal plasma levels of von Willebrand factor are accompanied by abnormal platelet function in some disease states. 2. Platelet retention in glass bead columns, platelet aggregation in vitro , β-thromboglobulin and 6-oxo-prostaglandin F 1α were monitored...

View article titled, Is the Pro-Adhesive Activity of Plasma Von Willebrand Factor Counteracted by a Physiological Inhibitor of Platelet Adhesiveness?

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