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Keywords: prostaglandin
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Clin Sci (Lond) (2016) 130 (7): 539–549.
Published: 17 February 2016
... after 20 weeks of gestation. However, the mechanisms leading to altered vascular reactivity remain unclear. We hypothesized that circulating factors lead to endothelial dysfunction by increasing oxidative stress and reducing nitric oxide (NO) and prostaglandin (PG) bioavailability. Pregnant rat uterine...
Clin Sci (Lond) (2007) 113 (7): 297–311.
Published: 03 September 2007
...Rania Nasrallah; Jordan Clark; Richard L. Hébert There are five major PGs (prostaglandins/prostanoids) produced from arachidonic acid via the COX (cyclo-oxygenase) pathway: PGE 2 , PGI 2 (prostacyclin), PGD 2 , PGF 2α and TXA 2 (thromboxane A 2 ). They exert many biological effects through specific...
Clin Sci (Lond) (2005) 108 (6): 479–491.
Published: 24 May 2005
... are lipid mediators derived from arachidonic acid, the most studied of which are the prostaglandins and leukotrienes. Although they are primarily known for their roles in asthma, pain, fever and vascular responses, present evidence indicates that eicosanoids exert relevant effects on immune/inflammatory...
Clin Sci (Lond) (2004) 107 (6): 561–570.
Published: 24 November 2004
.... Renal microvascular CYP4A and COX-2 protein levels were increased and CYP2C protein levels decreased in obese Zucker rats. TX (thromboxane) B 2 excretion was 2-fold higher and PG (prostaglandin) E 2 excretion significantly lower in obese Zucker rats. Additional studies investigated the ability...
Clin Sci (Lond) (2004) 106 (1): 27–34.
Published: 01 January 2004
... composition, platelet aggregation and renal prostaglandin (PG) metabolism. At baseline, all patients had reduced platelet aggregation. Patients treated with AA showed a significant increase in the percentage of AA in plasma lipids and membrane phospholipids. These changes were associated with an increased...
Clin Sci (Lond) (1997) 92 (2): 123–131.
Published: 01 February 1997
... not be mediated by either nitric oxide or prostaglandins and that ATP-induced vasodilatation may also not be mediated by nitric oxide. 23 8 1996 26 9 1996 © 1997 The Biochemical Society and the Medical Research Society 1997 acetylcholine l -arginine endothelium N G -monomethyl- l...
Clin Sci (Lond) (1989) 77 (1): 13–20.
Published: 01 July 1989
... treatment increased rectal temperature by 1.6°C, and this was abolished by fenbufen, indicating that the dose of the drug was sufficient to block prostaglandin production in the hypothalamus. 5. LPS treatment induced similar losses in body weight and muscle protein in both control and fenbufen groups...
Clin Sci (Lond) (1985) 69 (6): 691–699.
Published: 01 December 1985
...James P. Codde; Lawrence J. Beilin 1. This study was designed to examine the effect of dexamethasone treatment on tissue and urinary prostanoids, and to determine whether inhibition of prostaglandin biosynthesis by manipulation of dietary fatty acids accelerates the development of glucocorticoid...
Clin Sci (Lond) (1985) 69 (4): 403–411.
Published: 01 October 1985
...Keiichi Ohya; Shoji Yamada; Rolf Felix; Herbert Fleisch 1. Bisphosphonates are potent inhibitors of bone resorption and also inhibit prostaglandin (PG) E 2 synthesis in bone cells. Therefore we have investigated whether a correlation exists between inhibition of bone resorption and inhibition...
Clin Sci (Lond) (1982) 62 (4): 361–366.
Published: 01 April 1982
... or aprotinin. Blood pressure at 24 h was normal and did not differ significantly from that of unclipped rats given a glucose infusion. 5. The fall in blood pressure produced by unclipping therefore did not appear to be mediated via the prostaglandin or kallikrein systems. aprotinin Goldblatt hypertension...
Clin Sci (Lond) (1980) 59 (s6): 141s–144s.
Published: 01 December 1980
...Keishi Abe; Toru Ito; Makito Sato; Toshiaki Haruyama; KO Sato; Ken Omata; Masao Hiwatari; Yutaka Sakurai; Yutaka Imai; Kaoru Yoshinaga 1. The role of endogenous prostaglandins in the antihypertensive mechanism of the angiotensin converting enzyme inhibitor, captopril, was investigated. 2...
Clin Sci (Lond) (1980) 58 (1): 45–51.
Published: 01 January 1980
...]Phenylethylamine was also metabolized in human lung. 4. Prostaglandin E 2 was inactivated and this inactivation inhibited by bromocresol green and frusemide. 5. About 10% of the radioactivity from infused [ 14 C]arachidonic acid emerged from the lung and a small amount of biological activation occurred. 6. Of [ 14...
Clin Sci (Lond) (1979) 56 (3): 235–241.
Published: 01 March 1979
... conductance at 1 min after histamine but not at 5 or 10 min. Bupivacaine and sodium cromoglycate had no protective effect on histamine-induced bronchoconstriction at 1, 5 and 10 min. 6. Ipratropium bromide and bupivacaine were tested on prostaglandin F 2 α-induced bronchoconstriction in normal subjects...
Clin Sci Mol Med (1978) 54 (1): 115–118.
Published: 01 January 1978
...F. Dray 1. The daily urine excretion has been studied of prostaglandins (PG) E 2 and F 2α , as measured by radioimmunoassay, in eight children and seven adults with Bartter's syndrome. 2. Excretion of both PGE 2 and PGF 2α was significantly higher in the patients with Bartter's syndrome than in 17...
Clin Sci Mol Med (1977) 52 (6): 615–620.
Published: 01 June 1977
.... 2. The exudates were examined for smooth muscle-contracting activity by a superfusion cascade bioassay, for prostaglandin F 2α by radioimmunoassay and by Lipidex 5000 gel-partition chromatography for other prostaglandins and related compounds. 3. Tetrahydrofurfuryl nicotinate (Trafuril) was applied...
Clin Sci Mol Med (1976) 50 (1): 87–90.
Published: 01 January 1976
...Y. S. Bakhle; A. J. Block 1. The inactivation of noradrenaline and prostaglandin E 2 was studied in the pulmonary circulation of anaesthetized dogs. 2. Under chloralose anaesthesia and ventilation with air, the inactivation of noradrenaline was 20% and that of prostaglandin E 2 was 91...
Clin Sci Mol Med (1975) 48 (s2): 303s–306s.
Published: 01 January 1975
...D. Pugsley; L. J. Beilin; R. Peto 1. The hypothesis that suppression of prostaglandin E synthesis by indomethacin exacerbates renal-clip hypertension in the rat was investigated in four groups of rats. 2. Indomethacin was shown to exacerbate hypertension in renal-clip animals. 3. Synthesis...
Clin Sci (1972) 43 (3): 401–411.
Published: 01 September 1972
... by an indicator-dilution technique. 2. Increases in renal blood flow during graded intravenous iso-osmotic saline or hyperosmotic mannitol infusions and during renal arterial infusions of acetylcholine or prostaglandin E 1 were consistently associated with reduced E PAH . 3. The cortical fraction of renal blood...