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Keywords: pressure overload
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Articles

Nicotinamide riboside kinase-2 inhibits JNK pathway and limits dilated cardiomyopathy in mice with chronic pressure overload

Syeda Kiran Shahzadi, Hezlin Marzook, Rizwan Qaisar, Firdos Ahmad
Journal: Clinical Science
Clin Sci (Lond) (2022) 136 (2): 181–196.
DOI: https://doi.org/10.1042/CS20210964
Published: 28 January 2022
... activation and mitochondrial depolarization. Thus, our results demonstrate that NRK-2 plays protective roles in pressure overload (PO)-induced dilatative cardiac remodeling and, genetic ablation exacerbates dilated cardiomyopathy (DCM), interstitial collagen deposition, and cardiac dysfunction post-TAC due...
View article titled, Nicotinamide riboside kinase-2 inhibits JNK pathway and limits dilated cardiomyopathy in mice with chronic <span class="search-highlight">pressure</span> <span class="search-highlight">overload</span>
Click here to open pdf in another window PDF for Nicotinamide riboside kinase-2 inhibits JNK pathway and limits dilated cardiomyopathy in mice with chronic <span class="search-highlight">pressure</span> <span class="search-highlight">overload</span>
Includes: Supplementary data
Articles

A role for galectin-3 in the development of early molecular alterations in short-term aortic stenosis

Vanessa Arrieta, Ernesto Martinez-Martinez, Jaime Ibarrola, Virginia Alvarez, Rafael Sádaba, Amaia Garcia-Peña, Amaya Fernández-Celis, Victoria Cachofeiro, Patrick Rossignol, Natalia López-Andrés
Journal: Clinical Science
Clin Sci (Lond) (2017) 131 (10): 935–949.
DOI: https://doi.org/10.1042/CS20170145
Published: 04 May 2017
...Vanessa Arrieta; Ernesto Martinez-Martinez; Jaime Ibarrola; Virginia Alvarez; Rafael Sádaba; Amaia Garcia-Peña; Amaya Fernández-Celis; Victoria Cachofeiro; Patrick Rossignol; Natalia López-Andrés Aortic stenosis (AS) is characterized by pressure overload and causes left ventricular (LV) fibrosis...
View article titled, A role for galectin-3 in the development of early molecular alterations in short-term aortic stenosis
Click here to open pdf in another window PDF for A role for galectin-3 in the development of early molecular alterations in short-term aortic stenosis
Includes: Supplementary data
Articles

OX40 regulates pressure overload-induced cardiac hypertrophy and remodelling via CD4 + T-cells

Qing-Qing Wu, Yuan Yuan, Xiao-Han Jiang, Yang Xiao, Zheng Yang, Zhen-Guo Ma, Hai-Han Liao, Yuan Liu, Wei Chang, Zhou-Yan Bian, Qi-Zhu Tang
Journal: Clinical Science
Clin Sci (Lond) (2016) 130 (22): 2061–2071.
DOI: https://doi.org/10.1042/CS20160074
Published: 14 October 2016
... overload-induced cardiac remodelling. OX40 KO mice with reconstituted CD4 + T-lymphocytes presented deteriorated cardiac remodelling. OX40 alters the pathology of cardiac remodelling via the modulation of CD4 + T-cell function. Ang II cardiac remodelling CD4 + T-lymphocytes OX40 pressure...
View article titled, OX40 regulates <span class="search-highlight">pressure</span> <span class="search-highlight">overload</span>-induced cardiac hypertrophy and remodelling via CD4 + T-cells
Click here to open pdf in another window PDF for OX40 regulates <span class="search-highlight">pressure</span> <span class="search-highlight">overload</span>-induced cardiac hypertrophy and remodelling via CD4 + T-cells
Articles

Overexpression of ankyrin repeat domain 1 enhances cardiomyocyte apoptosis by promoting p53 activation and mitochondrial dysfunction in rodents

Liang Shen, Ci Chen, Xuan Wei, Xixian Li, Guangjin Luo, Jingwen Zhang, Jianping Bin, Xiaobo Huang, Shiping Cao, Guofeng Li, Yulin Liao
Journal: Clinical Science
Clin Sci (Lond) (2015) 128 (10): 665–678.
DOI: https://doi.org/10.1042/CS20140586
Published: 20 February 2015
..., but it remains inconclusive whether this gene promotes or inhibits cell apoptosis. In the present study, we attempted to investigate the role of Ankrd1 on AngII (angiotensin II)- or pressure-overload-induced cardiomyocyte apoptosis. In the failing hearts of mice with pressure overload, the protein expression...
View article titled, Overexpression of ankyrin repeat domain 1 enhances cardiomyocyte apoptosis by promoting p53 activation and mitochondrial dysfunction in rodents
Click here to open pdf in another window PDF for Overexpression of ankyrin repeat domain 1 enhances cardiomyocyte apoptosis by promoting p53 activation and mitochondrial dysfunction in rodents
Includes: Supplementary data
Articles

microRNA-122 down-regulation may play a role in severe myocardial fibrosis in human aortic stenosis through TGF-β 1 up-regulation

Javier Beaumont, Begoña López, Nerea Hermida, Blanche Schroen, Gorka San José, Stephane Heymans, Félix Valencia, Juan José Gómez-Doblas, Eduardo De Teresa, Javier Díez, Arantxa González
Journal: Clinical Science
Clin Sci (Lond) (2014) 126 (7): 497–506.
DOI: https://doi.org/10.1042/CS20130538
Published: 11 December 2013
... of the enzymatic systems involved in extracellular collagen type I synthesis and deposition. cardiac remodelling miR-122 myocardial fibrosis pressure overload procollagen C-terminal proteinase enhancer-1 (PCPE-1) transforming growth factor-β type 1 (TGF-β 1 ) • The present study...
View article titled, microRNA-122 down-regulation may play a role in severe myocardial fibrosis in human aortic stenosis through TGF-β 1 up-regulation
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Articles

Decreased Nox4 levels in the myocardium of patients with aortic valve stenosis

María U. Moreno, Idoia Gallego, Begoña López, Arantxa González, Ana Fortuño, Gorka San José, Félix Valencia, Juan José Gómez-Doblas, Eduardo de Teresa, Ajay M. Shah, Javier Díez, Guillermo Zalba
Journal: Clinical Science
Clin Sci (Lond) (2013) 125 (6): 291–300.
DOI: https://doi.org/10.1042/CS20120612
Published: 22 May 2013
... differentially contribute to cardiac pathophysiology. Animal studies show uncertain results regarding the regulation of cardiac Nox4 by pressure overload and no data are available on human myocardial Nox4. In the present study, we evaluated Nox4 expression and its relationship with myocardial remodelling and LV...
View article titled, Decreased Nox4 levels in the myocardium of patients with aortic valve stenosis
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Articles

The haplotype of the growth-differentiation factor 15 gene is associated with left ventricular hypertrophy in human essential hypertension

Xiaojian Wang, Xu Yang, Kai Sun, Jingzhou Chen, Xiaodong Song, Hu Wang, Zhe Liu, Changxin Wang, Channa Zhang, Rutai Hui
Journal: Clinical Science
Clin Sci (Lond) (2010) 118 (2): 137–145.
DOI: https://doi.org/10.1042/CS20080637
Published: 19 October 2009
...Xiaojian Wang; Xu Yang; Kai Sun; Jingzhou Chen; Xiaodong Song; Hu Wang; Zhe Liu; Changxin Wang; Channa Zhang; Rutai Hui GDF15 (growth-differentiation factor 15) is a novel antihypertrophic factor which is induced in the heart in response to pressure overload and plays an important regulatory role...
View article titled, The haplotype of the growth-differentiation factor 15 gene is associated with left ventricular hypertrophy in human essential hypertension
Click here to open pdf in another window PDF for The haplotype of the growth-differentiation factor 15 gene is associated with left ventricular hypertrophy in human essential hypertension
Includes: Supplementary data