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Keywords: pregnancy
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Clin Sci (Lond) (2022) 136 (22): 1591–1614.
Published: 14 November 2022
... Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . EMT pregnancy Senescence Reactive oxygen species (ROS) generated in response to both endogenous and exogenous stimuli initiate various stress signaling responses that can determine cell fate which...
Includes: Supplementary data
Clin Sci (Lond) (2022) 1117–1137.
Published: 05 August 2022
...Hager M. Kowash; Harry G. Potter; Rebecca M. Woods; Nick Ashton; Reinmar Hager; Joanna C. Neill; Jocelyn D. Glazier Maternal infection during pregnancy increases the offspring risk of developing a variety of neurodevelopmental disorders (NDDs), including schizophrenia. While the mechanisms remain...
Includes: Supplementary data
In Collection
Clin Sci (Lond) (2021) 135 (15): 1805–1824.
Published: 02 August 2021
...Nayara Azinheira Nobrega Cruz; Danielle Stoll; Dulce Elena Casarini; Mariane Bertagnolli In times of coronavirus disease 2019 (COVID-19), the impact of severe acute respiratory syndrome (SARS)-coronavirus (CoV)-2 infection on pregnancy is still unclear. The presence of angiotensin-converting enzyme...
Clin Sci (Lond) (2021) 135 (11): 1445–1466.
Published: 11 June 2021
... Fetus Nutrients Placenta Pregnancy Fasting during the month of Ramadan is one of the five pillars of Islam. During this period, it is a religious requirement that healthy adult Muslims abstain from consuming food and drink from dawn to sunset for the duration of this holy month. From sunset...
Includes: Supplementary data
Clin Sci (Lond) (2021) 135 (9): 1083–1101.
Published: 07 May 2021
...Anna E. Stanhewicz; Virginia R. Nuckols; Gary L. Pierce Preeclampsia is a hypertensive disorder of pregnancy effecting ∼5–8% of pregnancies in the United States, and ∼8 million pregnancies worldwide. Preeclampsia is clinically diagnosed after the 20 th week of gestation and is characterized by new...
Clin Sci (Lond) (2020) 134 (23): 3213–3228.
Published: 11 December 2020
...Sarah L. Walton; Katrina M. Mirabito Colafella; Aneesa Ansari; Siew Yeen Chai; Kate M. Denton Insulin-regulated aminopeptidase (IRAP), an enzyme that cleaves vasoactive peptides including oxytocin and vasopressin, is suggested to play a role in pregnancy and the onset of preeclampsia. Our aim...
Includes: Supplementary data
Clin Sci (Lond) (2020) 134 (23): 3123–3136.
Published: 07 December 2020
... fetal development Fetal programming neurodevelopmental disorders pregnancy serotonin (5-HT) trophoblast It is well established that a suboptimal intrauterine environment results in fetal adaptations with adverse consequences persisting after birth, throughout the lifespan and in future...
Includes: Supplementary data
Clin Sci (Lond) (2020) 134 (8): 1001–1025.
Published: 27 April 2020
...Sonya Frazier; Martin W. McBride; Helen Mulvana; Delyth Graham Placental microRNAs (miRNAs) regulate the placental transcriptome and play a pathological role in preeclampsia (PE), a hypertensive disorder of pregnancy. Three PE rodent model studies explored the role of placental miRNAs, miR-210, miR...
Clin Sci (Lond) (2019) 133 (23): 2379–2400.
Published: 04 December 2019
...-containing protein (Brd) 2 (Brd2), Brd3 and Brd4 regulate inflammation in non-gestational tissues. The roles of Brd2–4 in human pregnancy are unknown. Using human and mouse models, the present study has identified the Brd proteins part of the process by which inflammation induces parturition. Using human...
Includes: Supplementary data
Clin Sci (Lond) (2019) 133 (12): 1341–1352.
Published: 20 June 2019
...Emilie Hitzerd; Rugina I. Neuman; Katrina M. Mirabito Colafella; Irwin K.M. Reiss; Anton H. van den Meiracker; A.H. Jan Danser; Willy Visser; Jorie Versmissen; Langeza Saleh Preeclampsia (PE) is a pregnancy complication, featuring elevated blood pressure and proteinuria, with no appropriate...
Includes: Supplementary data
Clin Sci (Lond) (2019) 133 (10): 1185–1196.
Published: 30 May 2019
... by Portland Press Limited on behalf of the Biochemical Society 2019 cardiovascular disease Chorioamnionitis inflammation Pediatrics pregnancy Atherosclerosis is a chronic inflammatory process that underlies cardiovascular disease (CVD) [ 1 ]. In adults, both acute and chronic inflammatory...
Includes: Supplementary data
Clin Sci (Lond) (2018) 132 (22): 2451–2467.
Published: 30 November 2018
..., which are enriched in nanovesicles called exosomes, are important regulators of gene expression. When compared with normal pregnancies, pregnancies with gestational diabetes mellitus (GDM) are associated with skeletal muscle insulin resistance as well as increased levels of circulating placental...
Includes: Supplementary data
Clin Sci (Lond) (2018) 132 (21): 2369–2381.
Published: 13 November 2018
...Floor Spaans; Anita Quon; Stewart R. Rowe; Jude S. Morton; Raven Kirschenman; Tatsuya Sawamura; Dionne S. Tannetta; Ian L. Sargent; Sandra T. Davidge Syncytiotrophoblast extracellular vesicles (STBEVs), released into the maternal circulation during pregnancy, have been shown to affect vascular...
Clin Sci (Lond) (2018) 132 (2): 295–312.
Published: 25 January 2018
...-morbidities in obese women. Surgical weight loss not only improves the chance of conception but reduces the risk of pregnancy complications including pre-eclampsia, gestational diabetes, and macrosomia. However, bariatric procedures increase the incidence of intrauterine growth restriction (IUGR), fetal...
Includes: Supplementary data
Clin Sci (Lond) (2017) 131 (24): 2911–2917.
Published: 08 December 2017
...Erin B. Taylor; Jennifer M. Sasser Although pre-eclampsia (PE), a hypertensive disorder of pregnancy, has significant maternal and fetal morbidity and mortality worldwide, the mechanisms contributing to this disease have not been fully elucidated. Studies in patients and experimental models have...
Clin Sci (Lond) (2017) 131 (23): 2795–2805.
Published: 28 November 2017
...Katrina M. Mirabito Colafella; Chrishan S. Samuel; Kate M. Denton Relaxin is increasingly being recognized as a potent vasodilatory and antifibrotic hormone. Given that relaxin is present in the circulation during the luteal phase of the menstrual cycle and during pregnancy, when arterial pressure...
Clin Sci (Lond) (2017) 131 (23): 2753–2762.
Published: 23 November 2017
... 2017 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2017 Hypertension Intrauterine growth restriction Inflammation Natural Killer Cells Pregnancy Preeclampsia Preeclampsia (PE) is a pregnancy specific multisystem hypertensive disorder...
Clin Sci (Lond) (2017) 131 (17): 2223–2240.
Published: 10 August 2017
...Rachel J. Skow; Emily C. King; Craig D. Steinback; Margie H. Davenport During healthy pregnancy, the cardiovascular system undergoes diverse adaptations to support adequate transfer of oxygen and nutrients from mother to fetus. In order to accommodate the large expansion of blood volume...
Clin Sci (Lond) (2017) 131 (13): 1529–1540.
Published: 28 June 2017
...-inflammatory adipokines in PE and healthy pregnancy. Subcutaneous and visceral adipose tissue biopsies were collected from healthy ( n =13) and PE ( n =13) mothers. Basal and lipopolysaccharide (LPS) stimulated adipocyte TNFα, IL-6, CCL-2, and CRP release was measured. Adipose tissue cell densities...
Includes: Supplementary data
Clin Sci (Lond) (2016) 130 (16): 1417–1434.
Published: 07 July 2016
...Omar C. Logue; Eric M. George; Gene L. Bidwell, III Preeclampsia (PE) is a form of gestational hypertension that complicates ∼5% of pregnancies worldwide. Over 70% of the fatal cases of PE are attributed to cerebral oedema, intracranial haemorrhage and eclampsia. The aetiology of PE originates from...
Clin Sci (Lond) (2016) 130 (9): 651–665.
Published: 18 March 2016
...Michèle Bisson; Isabelle Marc; Patrice Brassard Cerebral blood flow (CBF) regulation is an indicator of cerebrovascular health increasingly recognized as being influenced by physical activity. Although regular exercise is recommended during healthy pregnancy, the effects of exercise on CBF...
Clin Sci (Lond) (2016) 130 (7): 491–497.
Published: 17 February 2016
...Wan N. Wan Sulaiman; Muriel J. Caslake; Christian Delles; Helen Karlsson; Monique T. Mulder; Delyth Graham; Dilys J. Freeman The maternal adaptation to pregnancy includes hyperlipidaemia, oxidative stress and chronic inflammation. In non-pregnant individuals, these processes are usually associated...
Clin Sci (Lond) (2016) 130 (6): 409–419.
Published: 04 February 2016
...Ashlyn C. Harmon; Denise C. Cornelius; Lorena M. Amaral; Jessica L. Faulkner; Mark W. Cunningham, Jr; Kedra Wallace; Babbette LaMarca Preeclampsia (PE) affects 5–7% of all pregnancies in the United States and is the leading cause of maternal and prenatal morbidity. PE is associated...
Clin Sci (Lond) (2015) 129 (12): 1131–1141.
Published: 22 October 2015
... from women with pregnancies complicated by IUGR ( n =25) and gestational age-matched women with appropriately grown control infants ( n =19, birth weights between the twenty-fifth to seventy-fifth percentiles). The activity of mTORC1 and mTORC2 was decreased whereas the protein expression...
Includes: Supplementary data
Clin Sci (Lond) (2014) 126 (5): 347–354.
Published: 01 November 2013
...David Lissauer; Oliver Goodyear; Rahela Khanum; Paul A. H. Moss; Mark D. Kilby The traditional paradigm suggests that during normal pregnancy maternal immunological tolerance of the allogenic fetus is association with a maternal T-lymphocyte shift from a Th1 to a Th2 phenotype, with the opposite...
Clin Sci (Lond) (2013) 124 (1): 27–40.
Published: 07 September 2012
...Pengfei Li; Wei Guo; Leilei Du; Junli Zhao; Yaping Wang; Liu Liu; Yali Hu; Yayi Hou PE (pre-eclampsia), a pregnancy-specific disorder, is characterized by increased trophoblast cell death and deficient trophoblast invasion and reduced trophoblast-mediated remodelling of spiral arteries. The present...
Includes: Supplementary data
Clin Sci (Lond) (2012) 123 (7): 429–435.
Published: 07 June 2012
... and mitochondria. mtDNA may be the trigger of systemic inflammation in pathologies associated with abnormal cell death. PE (pre-eclampsia) is a hypertensive disorder of pregnancy with devastating maternal and fetal consequences. The aetiology of PE is unknown and removal of the placenta is the only effective cure...
Clin Sci (Lond) (2012) 123 (2): 53–72.
Published: 23 March 2012
...Esther F. Davis; Laura Newton; Adam J. Lewandowski; Merzaka Lazdam; Brenda A. Kelly; Theodosios Kyriakou; Paul Leeson Pre-eclampsia is increasingly recognized as more than an isolated disease of pregnancy. Women who have had a pregnancy complicated by pre-eclampsia have a 4-fold increased risk...
Clin Sci (Lond) (2012) 122 (2): 53–61.
Published: 20 September 2011
...Moulinath Banerjee; Simon G. Anderson; Rayaz A. Malik; Clare E. Austin; J. Kennedy Cruickshank GDM (gestational diabetes mellitus) is associated with later adverse cardiovascular risk. The present study examined the relationship between glycaemia during pregnancy and small artery function...
Clin Sci (Lond) (2011) 121 (8): 355–365.
Published: 24 June 2011
...Tracey L. Weissgerber; Gregory A. L. Davies; Michael E. Tschakovsky Whether brachial artery FMD (flow-mediated dilation) is altered in pregnancy by 28–35 weeks compared with non-pregnant women remains controversial. The controversy may be due to limitations of previous studies that include failing...
Includes: Supplementary data
Clin Sci (Lond) (2010) 119 (3): 123–129.
Published: 28 April 2010
... pregnancy is associated with exaggerated metabolic adaptation, endothelial dysfunction and increased risk of adverse pregnancy outcome. We hypothesize that the preferential storage of fat in central rather than ‘safer’ lower-body depots in obese pregnancy leads to lipotoxicity. The combination of excess...
Clin Sci (Lond) (2010) 118 (5): 351–358.
Published: 23 November 2009
...Henar Ortega-Senovilla; Gioia Alvino; Emanuela Taricco; Irene Cetin; Emilio Herrera IUGR (intrauterine growth restriction) increases the incidence of perinatal complications and, although several placental transport functions have been shown to be altered in pregnancies complicated by IUGR...
Clin Sci (Lond) (2009) 117 (2): 85–93.
Published: 15 June 2009
... investigates the potential underlying mechanisms of these observations. Rats were established as follows: (i) control animals [offspring of control dams fed a 20% (w/v) protein diet], (ii) recuperated animals [offspring of dams fed an isocaloric low-protein (8%, w/v) diet during pregnancy and nursed by control...
Clin Sci (Lond) (2009) 116 (7): 599–606.
Published: 02 March 2009
...Dominica Zentner; Moira du Plessis; Shaun Brennecke; James Wong; Leeanne Grigg; Stephen B. Harrap The aim of the present study was to undertake a longitudinal study of systolic and diastolic cardiac function during normal pregnancy. At a median of 16 weeks of gestation, 100 primiparous women...
Clin Sci (Lond) (2008) 115 (7): 219–224.
Published: 03 September 2008
... alterations in adiponectin and leptin levels predate the development of PE and FGR (fetal growth restriction) in women at increased risk of these complications, as assessed by Doppler examination of the uterine arteries during the second trimester of pregnancy. We also sought to investigate the circulating...
Clin Sci (Lond) (2007) 113 (1): 1–13.
Published: 01 June 2007
... the placenta in order to affect the fetus. Here, we review recent insights into how the placenta responds to changes in the maternal environment and discuss possible mechanisms by which the placenta mediates fetal programming. In IUGR (intrauterine growth restriction) pregnancies, the increased placental...
Clin Sci (Lond) (2007) 112 (1): 51–57.
Published: 01 December 2006
... pregnancy at the time of delivery. VEGF (vascular endothelial growth factor), PlGF (placental growth factor), sFlt-1 (soluble fms-like tyrosine kinase 1), sKDR (soluble kinase domain receptor) and bFGF (basic fibroblast growth factor) were measured by ELISA in serum from a maternal peripheral vein...
Clin Sci (Lond) (2006) 111 (4): 289–294.
Published: 13 September 2006
... pregnancy, a hyperlipidaemic state, remains unknown. We took the opportunity to investigate maternal lipid levels and blood pressure during and after pregnancy, and fetal lipid levels at birth, in a study that aimed primarily to examine the effect of fish oil supplementation during pregnancy on immune...
Clin Sci (Lond) (2006) 110 (5): 605–609.
Published: 11 April 2006
... are limited. To evaluate the role of visfatin in GDM (gestational diabetes mellitus), we determined visfatin levels in women with GDM and in healthy pregnant controls. Furthermore, visfatin concentrations were investigated longitudinally during pregnancy and after delivery in a subgroup of women with GDM...
Clin Sci (Lond) (2006) 110 (4): 459–465.
Published: 15 March 2006
...Gustavo Castaño; Silvia Lucangioli; Silvia Sookoian; Marcelo Mesquida; Abraham Lemberg; Mirta Di Scala; Paula Franchi; Clyde Carducci; Valeria Tripodi ICP (intrahepatic cholestasis of pregnancy) is characterized by pruritus and biochemical cholestasis, including raised SBAs (serum bile acids...
Clin Sci (Lond) (2006) 110 (4): 443–458.
Published: 15 March 2006
... clinically after the 20th week of gestation, in many cases it has its origins much earlier in pregnancy, at the time of trophoblastic invasion into maternal tissues. In normal pregnancy, specialized extravillous trophoblast cells infiltrate the maternal spiral arteries supplying the placental bed, converting...
Includes: Supplementary data
Clin Sci (Lond) (2006) 110 (3): 337–342.
Published: 10 February 2006
... Placentas were collected either at elective Caesarean section without spontaneous onset of labour (not-in-labour) or after normal vaginal deliveries or at Caesarean section with spontaneous onset of labour (in-labour) from women with singleton pregnancies. Placentas were obtained at both pre-term (between...
Clin Sci (Lond) (2005) 109 (3): 287–295.
Published: 24 August 2005
...Nassima A. Soulimane-Mokhtari; Baya Guermouche; Akadiri Yessoufou; Myrieum Saker; Kebirou Moutairou; Aziz Hichami; Hafida Merzouk; Naim A. Khan The time course of changes in lipid metabolism by dietary n −3 PUFAs (polyunsaturated fatty acids) in streptozotocin-induced diabetic rats during pregnancy...
Clin Sci (Lond) (2005) 109 (2): 209–215.
Published: 25 July 2005
... 2005 28 4 2005 The Biochemical Society 2005 arterial pressure endothelin-1 (ET-1) pre-eclampsia pregnancy uterus Pre-eclampsia, a disorder unique to pregnancy, is one of the leading causes of maternal and fetal mortality and morbidity worldwide [ 1 , 2 ]. Hypertension...
Clin Sci (Lond) (2005) 109 (1): 103–107.
Published: 23 June 2005
...Beatrix MERSICH; János RIGÓ, Jr; Csilla BESENYEI; Zsuzsanna LÉNÁRD; Péter STUDINGER; Márk KOLLAI Systemic arterial compliance has been known to increase during healthy pregnancy, whereas, recently, the carotid artery has been reported to stiffen. To clarify this controversy, we simultaneously...
Clin Sci (Lond) (2005) 108 (1): 81–84.
Published: 15 December 2004
...Danqing CHEN; Minyue DONG; Qin FANG; Jing HE; Zhengping WANG; Xiaofu YANG Resistin is expressed in human placenta and has been postulated to play a role in regulating energy metabolism in pregnancy. However, changes in serum resistin levels in normal pregnancy and in the setting of pre-eclampsia...
Clin Sci (Lond) (2004) 107 (4): 407–413.
Published: 24 September 2004
.... Correspondence: Dr Mark Kollai (email kollai@elet2.sote.hu ). 5 5 2004 17 6 2004 23 6 2004 23 6 2004 The Biochemical Society 2004 baroreceptor carotid artery hypertension pre-eclampsia pregnancy Hypertension is associated with impaired arterial baroreflex...
Clin Sci (Lond) (2004) 106 (5): 449–450.
Published: 01 May 2004
...Annemarie HENNESSY One of the fundamental issues in pre-eclampsia (hypertension in pregnancy) research is to find serum proteins that can act as markers of disease predisposition, remote disease onset, imminent disease onset or disease activity at the height of its destructive powers. We make...
Clin Sci (Lond) (2004) 106 (4): 377–382.
Published: 01 April 2004
...M. W. AARDEMA; M. C. S. SARO; M. LANDER; B. T. H. M. DE WOLF; H. OOSTERHOF; J. G. AARNOUDSE The ‘classical’ concept that pregnancy-induced hypertension (PIH) and pre-eclampsia (PE) primarily originate from defective placentation in early pregnancy has been challenged recently. There is growing...
Clin Sci (Lond) (2004) 106 (3): 307–313.
Published: 01 March 2004
...Dan DROBIN; Robert G. HAHN Pre-eclampsia (PE) is a disease of pregnancy associated with peripheral oedema and hypovolaemia, but few details are known about how women with PE handle a volume load of crystalloid fluid compared with healthy pregnant women. To study this issue, Ringer's acetate...