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Keywords: preeclampsia
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Clin Sci (Lond) (2024) 138 (4): 137–151.
Published: 14 February 2024
... hypercholesterolemia increases the risk of complications, such as preeclampsia. However, the underlying mechanisms are unclear. Toll-like receptor 4 (TLR4) is a membrane receptor modulated by high cholesterol levels, leading to endothelial dysfunction; but whether excessive hypercholesterolemia in pregnancy activates...
Includes: Supplementary data
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Clin Sci (Lond) (2023) 137 (22): 1699–1719.
Published: 21 November 2023
...Yangyang Chen; Gui Wan; Zeyun Li; Xiaoxia Liu; Yin Zhao; Li Zou; Weifang Liu Placental neovascularization plays a crucial role in fetomaternal circulation throughout pregnancy and is dysregulated in several pregnancy-related diseases, including preeclampsia, gestational diabetes mellitus, and fetal...
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Clin Sci (Lond) (2023) 137 (16): 1211–1224.
Published: 22 August 2023
...Helen Casey; Natalie Dennehy; Abigail Fraser; Christoph Lees; Carmel M. McEniery; Kayley Scott; Ian B. Wilkinson; Christian Delles The placental syndromes gestational hypertension, preeclampsia and intrauterine growth restriction are associated with an increased cardiovascular risk to the mother...
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Clin Sci (Lond) (2022) 136 (24): 1793–1807.
Published: 13 December 2022
...Toluwalase Awoyemi; Ana Sofia Cerdeira; Wei Zhang; Shuhan Jiang; Maryam Rahbar; Prassana Logenthiran; Christopher Redman; Manu Vatish Preeclampsia (PE) is a hypertensive complication of pregnancy that affects 2–8% of women worldwide and is one of the leading causes of maternal deaths and premature...
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Clin Sci (Lond) (2022) 136 (4): 257–272.
Published: 14 February 2022
... in preeclampsia, but its origin and contribution to preeclampsia remain unknown. We therefore studied (1) placental chemerin expression and release in human pregnancy, and (2) the consequences of chemerin overexpression via lentivirus-mediated trophoblast-specific gene manipulation in both mice and immortalized...
Includes: Supplementary data
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Clin Sci (Lond) (2021) 135 (19): 2307–2327.
Published: 13 October 2021
...Usman M. Ashraf; Dalton L. Hall; Adam Z. Rawls; Barbara T. Alexander Preeclampsia (PE), the leading cause of maternal and fetal morbidity and mortality, is associated with poor fetal growth, intrauterine growth restriction (IUGR) and low birth weight (LBW). Offspring of women who had PE...
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Clin Sci (Lond) (2021) 135 (12): 1523–1544.
Published: 23 June 2021
... © 2021 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2021 heart failure hypertension leptin Obesity preeclampsia Women's Health Both adolescent and adult obesity prevalence has reached proportions of >30% in the United States...
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Clin Sci (Lond) (2021) 135 (9): 1083–1101.
Published: 07 May 2021
...Anna E. Stanhewicz; Virginia R. Nuckols; Gary L. Pierce Preeclampsia is a hypertensive disorder of pregnancy effecting ∼5–8% of pregnancies in the United States, and ∼8 million pregnancies worldwide. Preeclampsia is clinically diagnosed after the 20 th week of gestation and is characterized by new...
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Clin Sci (Lond) (2019) 133 (12): 1341–1352.
Published: 20 June 2019
...Emilie Hitzerd; Rugina I. Neuman; Katrina M. Mirabito Colafella; Irwin K.M. Reiss; Anton H. van den Meiracker; A.H. Jan Danser; Willy Visser; Jorie Versmissen; Langeza Saleh Preeclampsia (PE) is a pregnancy complication, featuring elevated blood pressure and proteinuria, with no appropriate...
Includes: Supplementary data
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Clin Sci (Lond) (2018) 132 (12): 1215–1242.
Published: 21 June 2018
..., most prominent being marinobufagenin (MBG). A synthetic pathway for MBG has been identified in mammalian placental tissue. Elevated maternal and fetal EDLF, O and MBG have been demonstrated in preeclampsia (PE), and inhibition of red cell membrane sodium, potassium ATPase (Na, K ATPase (NKA)) by EDLF...
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Clin Sci (Lond) (2018) 132 (1): 33–36.
Published: 02 January 2018
... preeclampsia Pre-eclampsia, defined as de novo hypertension after 20 weeks’ gestation and albuminuria, maternal organ dysfunction (renal insufficiency, hemolysis, elevated liver enzymes, low platelet count (HELLP) syndrome, or neurological complications) and/or fetal growth restriction, is associated...
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Clin Sci (Lond) (2017) 131 (24): 2911–2917.
Published: 08 December 2017
... I.L. , Borzychowski A.M. and Redman C.W. ( 2007 ) NK cells and pre-eclampsia . J. Reprod. Immunol. 76 , 40 – 44 10 Fukui A. , Yokota M. , Funamizu A. , Nakamua R. , Fukuhara R. , Yamada K. ( 2012 ) Changes of NK cells in preeclampsia . Am...
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Clin Sci (Lond) (2017) 131 (23): 2753–2762.
Published: 23 November 2017
...Jamil Elfarra; Lorena M. Amaral; Maggie McCalmon; Jeremy D. Scott; Mark W. Cunningham, Jr; Ashley Gnam; Tarek Ibrahim; Babbette LaMarca; Denise C. Cornelius Preeclampsia is associated with hypertension, small-for-gestational-age babies, and increased cytolytic natural killer (NK) cells...
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Clin Sci (Lond) (2016) 130 (4): 239–246.
Published: 14 January 2016
...Nina D. Paauw; Kim Luijken; Arie Franx; Marianne C. Verhaar; A. Titia Lely Preeclampsia (PE) is a hypertensive pregnancy disorder complicating up to 1–5% of pregnancies, and a major cause of maternal and fetal morbidity and mortality. In recent years, observational studies have consistently shown...
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Clin Sci (Lond) (1985) 69 (4): 477–482.
Published: 01 October 1985
...-eclampsia, 10 normotensive pregnant women and eight normotensive nonpregnant women were determined. 2. In vessels from the women with preeclampsia, the ratio of media thickness to lumen diameter was increased, compared with that in vessels from the other two groups. 3. The vessels from the women...