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Keywords: pre-eclampsia
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Clin Sci (Lond) (2016) 130 (14): 1179–1184.
Published: 01 June 2016
... production of mitochondrial ROS is intrinsically linked to mitochondrial dysfunction. Furthermore, mitochondrial dysfunction is a key facilitator of oxidative stress, inflammation, apoptosis and metabolism. These are key pathogenic intermediaries of pre-eclampsia, hence we hypothesize that mitochondrial...
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Clin Sci (Lond) (2016) 130 (7): 491–497.
Published: 17 February 2016
... possibility that new HDL of improved function is synthesized around the time of the establishment of the feto-placental circulation. In obese pregnancy and, to a greater extent, in pre-eclampsia, plasma HDL levels are significantly decreased and maternal vascular function is reduced. Wire myography studies...
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Clin Sci (Lond) (2016) 130 (7): 513–523.
Published: 17 February 2016
...Piyali Chatterjee; Valorie L. Chiasson; Lena Pinzur; Shani Raveh; Eytan Abraham; Kathleen A. Jones; Kelsey R. Bounds; Racheli Ofir; Liat Flaishon; Ayelet Chajut; Brett M. Mitchell Pre-eclampsia, the development of hypertension and proteinuria or end-organ damage during pregnancy, is a leading cause...
Includes: Supplementary data
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Clin Sci (Lond) (2009) 116 (12): 871.
Published: 14 May 2009
... testing for serum VEGF levels. A small programme could be conducted to verify that increased serum 25(OH)D during pregnancy increases VEGF and reduces the risk of pre-eclampsia. Other benefits, such as reduced risk of maternal infectious disease and a healthier infant at time of delivery, could also...
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Clin Sci (Lond) (2009) 116 (3): 231–232.
Published: 08 January 2009
...Holger Stepan Pre-eclampsia, a pregnancy complication characterized by hypertension and proteinuria, is still a major cause of neonatal and maternal mortality, and acute and long-term morbidities for both mother and neonate. There is mounting evidence that an imbalance between angiogenic factors...
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Clin Sci (Lond) (2006) 111 (1): 81–86.
Published: 14 June 2006
...Brigitte Leeners; Werner Rath; Sabine Kuse; Claudia Irawan; Bruno Imthurn; Peruka Neumaier-Wagner HDP (hypertensive diseases in pregnancy) are one of the leading causes of maternal and fetal mortality and morbidity. BMI (body mass index) is an established risk factor for pre-eclampsia, but its role...
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Clin Sci (Lond) (2006) 110 (4): 443–458.
Published: 15 March 2006
...Sally Chappell; Linda Morgan Pre-eclampsia and its related syndromes are significant causes of maternal and fetal death, but much remains unclear about the underlying disease mechanisms. Epidemiological research has consistently demonstrated a familial predisposition to pre-eclampsia, which has...
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Clin Sci (Lond) (2005) 108 (1): 81–84.
Published: 15 December 2004
...Danqing CHEN; Minyue DONG; Qin FANG; Jing HE; Zhengping WANG; Xiaofu YANG Resistin is expressed in human placenta and has been postulated to play a role in regulating energy metabolism in pregnancy. However, changes in serum resistin levels in normal pregnancy and in the setting of pre-eclampsia...
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Clin Sci (Lond) (2004) 107 (4): 407–413.
Published: 24 September 2004
...) relationship, however, has not been studied in pre-eclampsia, a condition where hypertension is spontaneously reversible. Twelve normotensive pregnant women and 12 patients with pre-eclampsia matched for maternal age and week of gestation were studied in the third trimester and 3 months postpartum. Carotid...
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Clin Sci (Lond) (2004) 106 (5): 449–450.
Published: 01 May 2004
...Annemarie HENNESSY One of the fundamental issues in pre-eclampsia (hypertension in pregnancy) research is to find serum proteins that can act as markers of disease predisposition, remote disease onset, imminent disease onset or disease activity at the height of its destructive powers. We make...
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Clin Sci (Lond) (2004) 106 (5): 535–540.
Published: 01 May 2004
... interaction ( F =5.8, P =0.025) between the source (maternal or fetal) and gestational group (normotensive or pre-eclamptic). Maternal NT-proCNP levels were raised in the pre-eclampsia group, whereas the converse was observed in umbilical cord blood. In conclusion, the greatly elevated ratio of NT-proCNP/CNP...
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Clin Sci (Lond) (2004) 106 (3): 307–313.
Published: 01 March 2004
...Dan DROBIN; Robert G. HAHN Pre-eclampsia (PE) is a disease of pregnancy associated with peripheral oedema and hypovolaemia, but few details are known about how women with PE handle a volume load of crystalloid fluid compared with healthy pregnant women. To study this issue, Ringer's acetate...
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Clin Sci (Lond) (2002) 103 (s2002): 446S–449S.
Published: 01 September 2002
...Torsten SLOWINSKI; Hans-H. NEUMAYER; Thomas STOLZE; Gabriele GOSSING; Horst HALLE; Berthold HOCHER Pre-eclampsia complicates approximately 5–7% of pregnancies and it may be deleterious to both maternal and fetal health. In a prospective study, we investigated plasma endothelin (ET)-1 concentration...
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Clin Sci (Lond) (2002) 103 (1): 53–57.
Published: 11 June 2002
...Fortunato SCALERA; Tina FISCHER; Dietmar SCHLEMBACH; Ernst BEINDER This study was conducted to compare the effects of serum from healthy pregnant women and that from pregnant women with pre-eclampsia on oxidative stress in endothelial cells in culture. Human umbilical vein endothelial cells (HUVECs...
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Clin Sci (Lond) (2000) 99 (6): 505–510.
Published: 07 November 2000
...N. ANIM-NYAME; S. R. SOORANNA; M. R. JOHNSON; J. GAMBLE; P. J. STEER Multiple organ dysfunction followed by end organ failure occurs in pre-eclampsia. While one would intuitively reason that one of the factors contributing to the end organ failure is poor nutritional blood flow, this has yet...
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Clin Sci (Lond) (1997) 93 (5): 413–421.
Published: 01 November 1997
...Jenny V. Garmendia; Ylse Gutiérrez; Isaac Blanca; N. E. Bianco; J. B. De Sanctis 1. Serum nitric oxide (NO) levels (determined by its products of oxidation) were assessed in nonpregnant women, normal pregnant women and patients suffering from mild pre-eclampsia (MPE), severe pre-eclampsia (SPE...
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Clin Sci (Lond) (1997) 93 (1): 51–55.
Published: 01 July 1997
...S. P. Brennecke; N. M. Gude; J. L. Di Iulio; R. G. King 1. The role of the potent vasodilator nitric oxide in the pathogenesis of pre-eclampsia is unclear. We have tested the hypothesis that placental activity of the enzyme which synthesizes nitric oxide (nitric oxide synthase) is reduced in pre...
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Clin Sci (Lond) (1997) 92 (1): 37–44.
Published: 01 January 1997
...A. Barden; D. Graham; L. J. Beilin; J. Ritchie; R. Baker; B. N. Walters; C. A. Michael 1. Neutrophil activation was examined in 22 women with pre-eclampsia and 22 age- and gestation-matched control subjects using whole-blood flow cytometry to assess basal and platelet-activating factor stimulated...
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Clin Sci (Lond) (1994) 86 (5): 575–581.
Published: 01 May 1994
...Mark A. Brown; Loretta Reiter; Alison Rodger; Judith A. Whitworth 1. Pre-eclampsia is characterized by reduced plasma active renin concentration and renal prostacyclin production. The aim of this study was to determine whether the plasma active renin concentration could be stimulated in women...
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Clin Sci (Lond) (1994) 86 (3): 251–255.
Published: 01 March 1994
... with hypertension who had 24 h urinary total protein excretion within the normal range. 2. Twenty-four hour urinary creatinine and albumin excretions were determined prospectively in 26 non-pregnant and 115 pregnant women in their third trimester (40 in normal pregnancy, 38 with mild pre-eclampsia, 20 with severe...
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Clin Sci (Lond) (1993) 85 (4): 417–424.
Published: 01 October 1993
...L. P. McMahon; C. W. G. Redman; J. D. Firth 1. Maternal vasoconstriction and fetal growth retardation are part of the syndrome of pre-eclampsia and are thought to be related to placental insufficiency. There is evidence to suggest that the powerfully vasoactive endothelin peptides might be involved...
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Clin Sci (Lond) (1993) 85 (1): 63–70.
Published: 01 July 1993
... mechanisms. 1 2 1993 19 3 1993 © 1993 The Biochemical Society and the Medical Research Society 1993 eicosanoid hypertension leucocyte platelet-activating factor pre-eclampsia pregnancy Clinical Science (1993) 85, 63-70 (Printed in Great Britain) 63 Neutrophil platelet...
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Clin Sci (Lond) (1992) 82 (2): 157–162.
Published: 01 February 1992
.... MATERIALS AND METHODS Subjects Twenty-eight pregnant women in the first or second trimester were recruited from patients admitted to the Key words: angiotensin I1 receptors, pre-eclampsia, vascular reactivity. Abbreviations: ACE, angiotensin-converting enzyme; A N G II, angiotensin II; NA, noradrenaline...
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Clin Sci (Lond) (1991) 80 (6): 549–558.
Published: 01 June 1991
... and pre-eclampsia. Non-pregnant young women were used as controls. 3. Pharmacological agents which increase levels of cyclic AMP were significantly less effective as inhibitors of platelet activation during pregnancy, but there was no difference between the healthy and hypertensive pregnant subjects. 4...
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Clin Sci (Lond) (1980) 59 (s6): 199s–201s.
Published: 01 December 1980
...T. E. Forrester; G. A. O. Alleyne 1. Leucocyte electrolytes were measured in pre-eclampsia and comparison was made with leucocytes from normal primigravidae and from the original pre-eclamptic subjects 6 months after delivery when blood pressure had returned to normal. 2. In pre-eclamptic subjects...
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Clin Sci Mol Med (1976) 51 (s3): 687s–689s.
Published: 01 December 1976
...C. W. G. Redman; L. J. Beilin; J. Bonnar 1. Reversal of the normal diurnal blood pressure pattern has been demonstrated in women with severe hypertension and renal impairment in pregnancy (pre-eclampsia). 2. Maximum arterial pressure occurred at night in these women. The phenomenon was not due...