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Keywords: plasma renin activity
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Articles
Journal:
Clinical Science
Clin Sci (Lond) (2005) 109 (3): 311–317.
Published: 24 August 2005
... study was to investigate the responsiveness of circulating Ang II on PRA (plasma renin activity) in normotensive subjects with a PFH or NFH (positive or negative family history of hypertension respectively). PRA, renal haemodynamics and urinary sodium excretion were measured during infusion of Ang II...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1996) 90 (4): 287–293.
Published: 01 April 1996
... in the gain of their cardiac baroreflex (Group I, −6.4 ± 0.4 beats min −1 mmHg −1 ; Group II, −3.2 ± 0.15 beats min −1 mmHg −1 ). 3. In Group I sham-denervated rabbits, mean arterial pressure remained unchanged, and plasma renin activity and heart rate fell significantly in response to the high salt. In Group...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1996) 90 (3): 189–195.
Published: 01 March 1996
... orthostatic stress induced by lower body negative pressure at –15 mmHg. 3. Variations in glycaemia markedly influenced plasma renin activity, which was increased at baseline during hyperglycaemia (3.82 ± 0.66 pmol of angiotensin I h −1 ml −1 compared with 2.13 ± 033 pmol of angiotensin I h −1 ml −1 during...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1994) 86 (4): 383–390.
Published: 01 April 1994
... + countertransport, urinary and plasma levels of digoxin-like factor, plasma renin activity, angiotensin II, aldosterone, noradrenaline, adrenaline and atrial natriuretic factor. The intravenous saline infusion caused a similar natriuresis in diabetic patients and normal subjects; the renin—angiotension-aldosterone...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1992) 82 (3): 247–254.
Published: 01 March 1992
... weight, mean ± sem ) increased by 1 ml min −1 kg −1 . 5. Plasma renin activity [control 0.85 ± 0.15 (RAP-f) and 1.08 ± 0.23 (RAP-sc) pmol of angiotensin I h −1 ml −1 ] decreased similarly in both protocols. 6. Renal sodium excretion, fractional sodium excretion and urine volume increased more in the RAP...
Articles
Ross C. Cuneo, Franco Salomon, Peter Wilmshurst, Chris Byrne, C. Mark Wiles, Richard Hesp, Peter H. Sönksen
Journal:
Clinical Science
Clin Sci (Lond) (1991) 81 (5): 587–592.
Published: 01 November 1991
... ventricular myocardial mass increased in the group given recombinant human growth hormone. 3. The supine plasma renin activity was increased and remained elevated over the 6 months, whereas the plasma aldosterone concentration was unchanged, after treatment with recombinant human growth hormone. Clinical...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1991) 81 (3): 387–392.
Published: 01 September 1991
...Yutaka Kitami; Kunio Hiwada; Eiki Murakami; Takeru Iwata; Shinjiro Muneta; Tatsuo Kokubu 1. The effects of renin inhibitor ES-8891 on renin synthesis and its secretion by the kidney were investigated in normotensive sodium-depleted marmosets. We measured plasma renin activity, plasma immunoreactive...
Articles
D. G. Shirley, D. R. J. Singer, G. A. Sagnella, M. G. Buckley, M. A. Miller, N. D. Markandu, G. A. MacGregor
Journal:
Clinical Science
Clin Sci (Lond) (1991) 81 (1): 59–63.
Published: 01 July 1991
... excretion increased by approximately 19 mmol ( P < 0.01). These effects were confined to the first two 8 h periods and thus occurred before and during the usual lithium clearance period. 5. Plasma renin activity, measured in 10 subjects, increased after the 600 mg dose of lithium carbonate ( P < 0.005...
Articles
D. R. J. Singer, D. G. Shirley, N. D. Markandu, M. A. Miller, M. G. Buckley, A. L. Sugden, G. A. Sagnella, G. A. MacGregor
Journal:
Clinical Science
Clin Sci (Lond) (1991) 80 (4): 293–299.
Published: 01 April 1991
.... During aldosterone infusion, plasma aldosterone was maintained at around 400 pmol/l. 3. Urinary sodium excretion, lithium clearance and plasma atrial natriuretic peptide increased and plasma renin activity decreased after saline infusion, whether or not aldosterone was infused. However, from 60 to 240...
Articles
D. R. J. Singer, N. D. Markandu, M. G. Buckley, M. A. Miller, A. L. Sugden, G. A. Sagnella, G. A. MacGregor
Journal:
Clinical Science
Clin Sci (Lond) (1989) 77 (3): 253–258.
Published: 01 September 1989
..., during the 4 h after infusion, urinary sodium excretion was below placebo values. During ANP infusion, packed cell volume increased significantly on both diets but returned to control values by 4 h after the end of infusion. 4. There were no significant changes in plasma renin activity compared...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1989) 76 (3): 249–254.
Published: 01 March 1989
... atrial natriuretic factor hypercapnia hypoxia plasma renin activity Clinical Science ( 1989) 76,249-254 249 Effects of hypoxia and hypercapnia on atrial natriuretic factor and plasma renin activity in conscious dogs JEAN-PAUL CLOZEL', CLAUDE SAUNIER', DENISE HARTEMANN', MUSTAPHA ALLAM...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1988) 74 (1): 63–69.
Published: 01 January 1988
... SHR and normotensive Wistar–Kyoto rats (WKY), at 4, 11 and 16 weeks of age by determining the renal clearances of 51 Cr-ethylenediaminetetra-acetate and 125 I-hippuran respectively. Plasma renin activity was measured at 11 and 16 weeks of age. 2. Mean arterial pressure, glomerular filtration rate...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1987) 72 (5): 525–530.
Published: 01 May 1987
...K. Ogawa; L. F. Arnolda; E. A. Woodcock; M. Hiwatari; C. I. Johnston 1. This study was designed to investigate the effects of intracerebroventricular or intravenous atrial natriuretic peptide (ANP) on plasma arginine-vasopressin (AVP) levels, plasma renin activity (PRA), blood pressure (BP...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1987) 72 (5): 605–609.
Published: 01 May 1987
... ) and sodium excretion ( U Na+ V ), but increased plasma renin activity (PRA) and plasma aldosterone concentration (PAC). 3. Sodium repletion, on the other hand, increased urinary PGE 2 and TXB 2 in proportion to the rise in V , but reduced PRA and PAC. 4. During both sodium diets PGE 2 and TXB 2 correlated...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1986) 70 (5): 477–484.
Published: 01 May 1986
... renal function in these patients is associated with the ability to synthesize prostacyclin and PGE 2 . aldosterone ascites cirrhosis plasma renin activity prostaglandins Clinical Science( 1986) 10, 477-484 477 Renal prostaglandins in cirrhosis of the liver C. GUARNER, I. COLINA*, F. GUARNER, J...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1986) 70 (3): 233–241.
Published: 01 March 1986
... and innervation in mediat- ing renin and aldosterone secretion. Key words: aldosterone, arginine vasopressin, cardiac transplantation, cardiac autonomic dys- function, plasma renin activity. Abbreviations: ADH, antidiuretic hormone; ALD, aldosterone; AVP, arginine vasopressin; ECG, electrocardiogram; PRA, plasma...
Articles
Axel Overlack, Evita Bäcker-Kreutz, Christa Ressel, Hans-Michael Müller, Rainer Kolloch, Klaus-O. Stumpe
Journal:
Clinical Science
Clin Sci (Lond) (1986) 70 (1): 13–17.
Published: 01 January 1986
...-induced potassium loss was enhanced. 3. Kallikrein inhibition decreased urinary prostaglandin (PG) E 2 and prevented the DOCA-induced rise in PGE 2 . Plasma renin activity was stimulated after 10 days of aprotinin administration. 4. The kallikrein-kinin system is not an important mediator of the escape...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1985) 69 (2): 207–214.
Published: 01 August 1985
... rose at both doses, but mean glomerular filtration rate increased only at the lower dose. 4. There was a fall in mean plasma renin activity after the infusion of both 12.5 and 100 μg min −1 kg −1 . 5. Mean urine free dopamine excretion increased by 280- and 2500-fold at infusion rates of 12.5 and 100...
Articles
J. N. Barnes, P. J. T. Drew, S. S. Furniss, J. M. P. Holly, A. R. Knight, J. D. Skehan, F. J. Goodwin
Journal:
Clinical Science
Clin Sci (Lond) (1985) 68 (6): 625–630.
Published: 01 June 1985
... converting enzyme enalapril hypertension plasma renin activity potassium homoeostasis 16 11 1984 27 12 1984 © 1985 The Biochemical Society and the Medical Research Society 1985 Clinical Science (1985) 68, 625-630 625 Effect of angiotensin converting-enzyme inhibition on potassium...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1985) 68 (5): 545–552.
Published: 01 May 1985
... autonomic dysfunction diabetes plasma renin activity Clinical Science (1985) 68, 545-552 545 Antidiuretic hormone response to volume depletion in diabetic patients with cardiac autonomic dysfunction A N D R ~ G R I M A L D I , WOJCIECH PRUSZCZYNSKI, FRANCIS THERVET A N D R A Y M O N D A R D A I L L O U...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1984) 67 (3): 329–335.
Published: 01 September 1984
... actions of aldosterone when administered acutely than were control adrenalectomized rats. 3. The long term effects of infusions of physiological doses of aldosterone and corticosterone were assessed in adrenalectomized rats maintained in metabolic cages. Aldosterone lowered plasma renin activity...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1984) 67 (3): 353–358.
Published: 01 September 1984
... with an increase in renal sodium excretion which continued during the 24 h after the infusion had been discontinuted. 3. During the infusion plasma renin activity (PRA), plasma aldosterone and noradrenaline, and packed cell volume (PCV) fell; glomerular filtration rate, assessed by endogenous creatinine clearance...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1983) 64 (5): 463–470.
Published: 01 May 1983
...Y. Takata; A. E. Doyle; M. Veroni; S. G. Duffy 1. Blood pressure, the hypotensive effect of captopril, plasma renin activity, renal renin content and kidney weight were measured in the two-kidney—one-clip model, the one-kidney—one-clip model and the two-kidney—one-clip model with the ureter...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1983) 64 (2): 141–152.
Published: 01 February 1983
...J. Brod; J. Bahlmann; M. Cachovan; P. Pretschner 1. Central and peripheral haemodynamics, circulating blood volume and plasma renin activity (PRA) were investigated under resting conditions in 97 patients with chronic nonuraemic renal parenchymatous disease and without anaemia. For comparison...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1982) 63 (4): 349–354.
Published: 01 October 1982
... of that of the controls at both 8 and 90 days after aortic ligature. 5. The plasma renin activity in hypertensive rats was approximately seven times that in control animals 8 days after aortic ligature and did not differ from the control value after 90 days. Renin activity in the kidneys showed the same pattern...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1982) 63 (s8): 109s–112s.
Published: 01 October 1982
...P. Lijnen; R. Fagard; J. Staessen; A. Amery 1. Plasma prostaglandins (PGE and PGF α ) and catecholamine concentrations, and plasma renin activity were measured during an uninterrupted graded exercise test on the bicycle ergometer in 11 hypertensive patients. Blood was withdrawn from the brachial...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1982) 63 (s8): 399s–402s.
Published: 01 October 1982
... correlation with the fall in blood pressure on the low sodium diet and the rise in plasma renin activity from the normal to low sodium diet ( r = −0.36; P < 0.001). 5. Nineteen patients with mild to moderate essential hypertension were studied in a double-blind randomized crossover study of moderate...
Articles
Gloria Valdés, M. Eugenia Soto, Hector R. Croxatto, Teresa Bellolio, Ramón Corbalán, Pablo Casanegra
Journal:
Clinical Science
Clin Sci (Lond) (1982) 63 (s8): 447s–450s.
Published: 01 October 1982
.... Normal sodium intake enhanced the hypotensive action of the drug compared with that during the low and high sodium regimens. Blood pressure remained significantly lower 3 h after drug ingestion. 2. Increases in heart rate and plasma renin activity under all conditions reflected enhanced adrenergic...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1982) 63 (s8): 211s–213s.
Published: 01 October 1982
... to abolish excretion from the contralateral kidney. 2. Plasma renin activity (PRA), renal renin content (RRC) and the response of blood pressure to captopril were examined. 3. The increase of blood pressure produced by the application of a clip to one renal artery was slightly accelerated by the ureteral...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1982) 63 (s8): 261s–263s.
Published: 01 October 1982
.... According to a randomized cross-over design, we compared the short-term (1 week) effect of indomethacin (50 mg twice daily) and of sulindac (200 mg twice daily) on blood pressure, plasma renin activity (PRA), angiotensin converting enzyme (ACE), serum thromboxane (TX) B 2 and urinary 6-keto PGF 1α of five...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1982) 63 (s8): 379s–381s.
Published: 01 October 1982
... with resting supine ( r = 0.89, P < 0.001) as well as upright ( r = 0.60, P < 0.01) plasma noradrenaline, but not with adrenaline, plasma renin activity and mean blood pressure. 4. In sustained hypertension, posterior wall thickness was positively correlated with mean blood pressure ( r = 0.85, P...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1982) 63 (2): 121–125.
Published: 01 August 1982
...S. Swart; R. F. Bing; J. D. Swales; H. Thurston 1. Plasma renin activity, body weight and blood pressure were measured before and after 7 days' treatment with bendrofluazide in ten hypertensive subjects. They were then treated with bendrofluazide alone (5 mg daily) for a minimum of 3 years...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1982) 62 (6): 667–676.
Published: 01 June 1982
.... Both the underlying mechanism for this tubular cell resistance (against a second glycerol challenge) and the role of proximal tubular function in the pathogenesis of acute renal failure remain unclear. bicarbonate reabsorption glucose reabsorption distal tubule acidification plasma renin activity...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1982) 62 (1): 43–49.
Published: 01 January 1982
... fluid volume normal-renin hypertension plasma renin activity plasma volume total body water Clinical Science (1982) 62 .4349 43 Body-fluid composition in normal and hypertensive man J . H . B A U E R A N D C . S . B R O O K S Research and Medical Services, The Harry S. Truman Memorial Veterans...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1981) 61 (s7): 145s–147s.
Published: 01 December 1981
...-pressure neck-chamber. 2. After 45 min 85° head-up tilt, normal subjects showed an increase in plasma arginine-vasopressin and in plasma renin activity, while plasma volume decreased. In hypertensive patients, plasma arginine-vasopressin showed changes after tilt opposite to those of controls, while...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1981) 61 (s7): 393s–394s.
Published: 01 December 1981
...F. H. Messerli; L. B. Glade; G. R. Dreslinski; F. G. Dunn; E. Reisin; A. A. MacPhee; E. D. Frohlich 1. Systemic and renal haemodynamics, intravascular volume, circulating catecholamines and plasma renin activity were measured in 18 patients with established essential hypertension who were older...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1981) 61 (s7): 17s–20s.
Published: 01 December 1981
..., there was a significant correlation between diastolic pressure and the ability of plasma to stimulate G6PD ( r = 0.69 P < 0.001). 2. The ability of plasma to stimulate G6PD was greatest in the hypertensive patients with values of plasma renin activity below the normal range. In the normotensive subjects the ability...
Articles
Osamu Iimura, Toshiaki Kijima, Kenjiro Kikuchi, Akiyoshi Miyama, Toshiaki Ando, Takashi Nakao, Yoshiichi Takigami
Journal:
Clinical Science
Clin Sci (Lond) (1981) 61 (s7): 77s–80s.
Published: 01 December 1981
... noradrenaline (NA), plasma renin activity (PRA) and plasma aldosterone concentration (PAC) in 20 inpatients with mild or moderate essential hypertension on a control diet (Na: 260, K: 75 mmol/day), and after high (K: 175 mmol/day) and low potassium diets (K: 25 mmol/day). 2. After potassium loading, urinary...
Articles
G. Mancia, A. Ferrari, G. Leonetti, Luisa Gregorini, Laura Terzoli, G. Parati, C. Bianchini, A. Zanchetti
Journal:
Clinical Science
Clin Sci (Lond) (1981) 61 (5): 505–509.
Published: 01 November 1981
..., but an inconsistent change in the renal venous—arterial difference in plasma renin activity (PRA). 3. During baroreceptor stimulation there was a modest fall in mean arterial pressure and a marked rise in the renal venous—arterial difference in PRA. This was opposite to the fall which might have been predicted...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1981) 61 (2): 175–180.
Published: 01 August 1981
...Hiromichi Suzuki; Kazuoki Kondo; Michiko Handa; Takao Saruta 1. To examine the possible participation of the brain iso-renin-angiotensin system in the control of blood pressure, as well as in the regulation of plasma renin activity, saralasin and captopril were injected into the cerebral ventricles...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1981) 61 (2): 245–247.
Published: 01 August 1981
...B. M. Frier; R. J. M. Corrall; J. L. Pritchard; P. S. Sever 1. The changes in blood glucose, plasma noradrenaline and plasma renin activity were measured in 11 normal subjects and in six tetraplegic subjects with a transection of the cervical spinal cord (preganglionic sympathectomy), in response...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1981) 61 (1): 61–67.
Published: 01 July 1981
... 1981 The Biochemical Society and the Medical Research Society 1981 arginine vasopressin desaminoarginine vasopressin diabetes insipidus kallikrein plasma renin activity prostaglandins renal function CIinicalScience (1981) 61,61-67 61 Renal prostaglandins and water balance: studies...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1981) 60 (5): 591–593.
Published: 01 May 1981
...S. Rasmussen; M. Damkjaer Nielsen; J. Giese 1. We have measured plasma concentrations of renin, renin substrate and angiotensins I and II as well as plasma renin activity in nine patients with severe or malignant hypertension during treatment with captopril, hydrochlorothiazide and propranolol. 2...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1980) 59 (s6): 149s–151s.
Published: 01 December 1980
... hypertension). 2. The low sodium diet neither prevented the development nor changed the severity of two-kidney, one-clip hypertension, and the latter was not accompanied by an increase in plasma renin activity. 3. After nephrectomy arterial pressure further increased and plasma renin activity decreased...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1980) 59 (s6): 319s–321s.
Published: 01 December 1980
...G. Leonetti; C. Bianchini; G. B. Picotti; A. Cesura; Letizia Caccamo; A. Marini 1. Plasma noradrenaline and adrenaline concentrations and plasma renin activity were measured in 21 mothers at delivery and in their babies at birth (umbilical cord blood) and on days 1 and 5 of extrauterine life. 2...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1980) 59 (1): 49–53.
Published: 01 July 1980
...E. D. M. Gallery; G. S. Stokes; A. Z. Györy; J. Rowe; J. Williams 1. Because hypertension is the central feature of pre-eclampsia, and because plasma renin activity is known to be elevated in normal pregnancy (with conflicting results published for pre-eclampsia), a prospective study of plasma...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1980) 58 (3): 227–233.
Published: 01 March 1980
... the metabolism of aldosterone or cortisol. 4. Spironolactone administration produced: (a) a marked increase in both aldosterone secretion and plasma renin activity, but no change in the plasma aldosterone/plasma renin activity ratio, the cortisol secretion rate or the plasma corticosterone concentration; (b...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1979) 57 (s5): 153s–155s.
Published: 01 December 1979
... range of 120–130 mmHg. 4. Plasma renin activities were not related to the extent of blood pressure reduction by SQ 14 225. Hence other factors in addition to the renin—angiotensin mechanism play a part in maintaining chronic psychosocial hypertension. captopril plasma renin activity psychosocial...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1979) 57 (s5): 115s–117s.
Published: 01 December 1979
.... After chronic treatment, blood pressure remained reduced and heart rate did not rise. 3. Plasma catecholamines and plasma renin activity increased significantly in normotensive subjects after acute administration. 4. After both acute and chronic administration, only plasma noradrenaline...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1979) 57 (s5): 229s–231s.
Published: 01 December 1979
... and of their metabolites as well as plasma renin activity before and after the test were studied. 2. In both groups a significant increase of noradrenaline and adrenaline in blood and noradrenaline in urine was observed. The urinary excretion of dopamine fell significantly in both groups after stress. 3. After mental...
