... assigned treatments: (i) control (no drug), (ii) low-dose phentolamine, and (iii) high-dose phentolamine. On each day cold intravenous saline (4°C) was given until both vasoconstriction and shivering were triggered or a maximum fluid volume (40 ml/kg) was delivered. Core temperature, peripheral...

... not been performed in humans to determine the role of α-adrenoceptors in the maintenance of core temperature. 2. α-Adrenoceptor blockade was achieved with three doses of phentolamine given by random assignment on three different study days in five male and five female healthy subjects. Core temperature...

...P. T. Larsson; N. H. Wallén; N. Egberg; P. Hjemdahl 1. The effects of phentolamine (500 μg/min) on platelet aggregability in vivo at rest and during adrenaline infusion were assessed by ex vivo filtragometry and measurements of plasma β-thromboglobulin levels in 10 healthy male subjects. Plasma...

... the onset of hypoglycaemia. The splenic image completely disappeared at some time after hypoglycaemia in all subjects. 3. The reduction of splenic radioactivity was abolished during non-selective α-adrenergic blockade with phentolamine, but was unaffected by β-adrenergic blockade with propranolol...

... hypertension. 2. Intra-arterial infusion of ouabain per se decreased forearm blood flow without changes in systemic arterial pressure or contralateral flow. However, the vasoconstrictor effect of the glycoside was abolished after local pre-treatment with either phentolamine, a competitive α-adrenoceptor...

...O. J. Hartling; J. Trap-Jensen 1. The pre- and post-junctional α-adrenoceptor blocking agent, phentolamine, was given by intravenous infusion to eight healthy volunteers during rest, forearm exercise and post-exercise. 2. Phentolamine produced a sustained increase in heart rate. The diastolic blood...

...M. Burnier; J. Biollaz; H. R. Brunner; H. Gavras 1. The effect of α-adrenoceptor blockade by phentolamine on plasma arginine vasopressin, on vasopressin dependency of blood pressure and on responsiveness to exogenous lysine vasopressin was studied in conscious normotensive...

... and the Medical Research Society 1982 arterioles forearm hypertension iproveratril nitroprusside phentolamine smooth muscle Clinical Science (1982) 63,33-42 33 Response of forearm resistance vessels to verapamil and sodium nitroprusside in normotensive and hypertensive men: evidence...

...A. Salvetti; R. Pedrinelli; F. Arzilli; P. Sassano; G. Leonetti; L. Terzoli; C. Bianchini; M. Fruscio 1. A stepwise infusion of phentolamine was administered to 26 patients with mild uncomplicated essential hypertension, whose basal renin was inversely related to age. 2. Phentolamine caused a dose...

...R. A. Banks; L. J. Beilin 1. Systemic and regional vascular changes were measured in conscious rabbits after intravenous sodium meclofenamate, captopril and phentolamine. These drugs were used respectively to inhibit prostaglandin synthesis and angiotensin-converting enzyme, and to block α...

... the systolic and diastolic increases in pressure. Clonidine reduced the systolic but not the diastolic increase. Oxprenolol alone or in combination with phentolamine or phenyoxybenzamine failed to influence the pressor response. 3. The increase in systemic blood pressure associated with sustained contraction...

...W. Kiowski; P. Van Brummelen; F. R. Bühler 1. The relationships between plasma noradrenaline concentration at rest and blood pressure, as well as increase in forearm blood flow in response to a brachial artery infusion of the α-adrenoreceptor-blocking agent phentolamine, were investigated...

...-exercise blood pressures. Small reductions were seen only with sustained phentolamine administration. 4. The combined effect of the two drugs appeared to be additive only at the lower doses of oxprenolol. 5. Labetalol produced significantly greater reductions in supine and standing blood pressure than...

... excitation. An elevated total peripheral vascular resistance at rest and a greater fall in peripheral resistance with α-adrenoreceptor blockade (intravenous phentolamine) suggested the existence of a neurogenic increase in arteriolar resistance. 3. Blood pressure was normalized by ‘total’ autonomic blockade...

... The Biochemical Society and the Medical Research Society 1975 atropine autonomic nervous system borderline hypertension haemodynamics phentolamine propranolol Clinical Science and Molecular Medicine (1975) 48, 2 4 3 ~ 2 5 2 s . Role of the autonomic nervous system in mild human hypertension S. J U L...