... exposed by-products are toxic to endothelial cells and parenchymal tissue. Unbalanced NET formation and neutrophil activation may therefore play a significant role in the pathogenesis of numerous non-autoimmune pathologies, such as thrombosis, cystic fibrosis, sepsis, transfusion-related acute lung injury...

.... The pathogenesis of DKD is twofold, so is the principle of treatments. As the underlying disease, diabetes per se is the root cause of DKD and thus a primary focus of therapy. Meanwhile, aberrant molecular signaling in kidney parenchymal cells and inflammatory cells may directly contribute to DKD. Evidence...

... (e.g. polymorphisms in angiotensin-converting enzyme [ACE] and in matrix metalloproteinases [MMPs]) may act as modifier genes in the pathogenesis of BAV aortopathy, further contributing to the variability of its clinical phenotype [ 73 , 74 ]. With reference to hemodynamic factors, there is extensive...

... by which genetic variants contribute to COPD and have led to novel insights in COPD pathogenesis. Through functional investigations of causal variants in COPD, from the proteinase–antiproteinase theory to emerging roles of developmental pathways (such as Hedgehog and Wnt pathways) in COPD, we have greatly...

...Richard J. Russell; Christopher Brightling The pathogenesis of asthma is complex and multi-faceted. Asthma patients have a diverse range of underlying dominant disease processes and pathways despite apparent similarities in clinical expression. Here, we present the current understanding of asthma...

... majority of people with T2DM. Correspondence : Professor Roy Taylor (email roy.taylor@ncl.ac.uk ). 8 9 2014 7 10 2014 24 10 2014 © The Authors Journal Compilation © 2015 Biochemical Society 2015 aetiology obesity pathogenesis Type 2 diabetes weight loss Type 2...

..., leading to OH • formation, and OH • in turn damages DNA, proteins and lipids, resulting in cell death. antibiotic resistance bacterium hydrogenase hydrogen gas hydroxyl radical (OH • ) pathogenesis Since Alexander Fleming discovered the antibacterial property of penicillin...

... ‘membranous webs’ or ‘membrane-associated foci’, whereas viral assembly probably occurs on lipid droplets and endoplasmic reticulum. Liver inflammation plays a central role in the liver damage seen in hepatitis C, but many HCV proteins also directly contribute to HCV pathogenesis. In the present review...

... risk factors for the development and progression of atherosclerosis, which can be identified and modified, may be important therapeutic targets. Infectious agents, such as Chlamydia pneumoniae , have been proposed as contributory factors in the pathogenesis of atherosclerosis. In the present review, we...

...% p67 phox NCF2 1q25 4% Rac2 RAC2 22q13.1 Unknown The Biochemical Society 2006 cellular homoeostasis host defence NADPH oxidase pathogenesis phagocyte reactive oxygen species (ROS) superoxide anion In phagocytes, p22 phox and NOX2 are essential subunits...

.... The discovery of animal models of T1DM in the late 1970s and early 1980s, particularly the NOD (non-obese diabetic) mouse and the BB (BioBreeding) diabetes-prone rat, had a fundamental impact on our ability to understand the genetics, aetiology and pathogenesis of this disease. NOD and BB diabetes-prone rats...

... neurological syndromes. Correspondence: Dr I. Sutton, Department of Neurology, Room 475, Blackburn Building (D06), University of Sydney, NSW 2006, Australia (e-mail iansutton@hotmail.com ). The Biochemical Society and the Medical Research Society © 2002 2002 paraneoplastic pathogenesis...

... pathogenesis stress vascular reactivity Clinical Science (1982) 63,371s-374s 371s Different haemodynamic reaction patterns during noise exposure in normotensive subjects with and without heredity for essential hypertension L. A N D R B N , S. P I R O S , L. H A N S S O N , H . H E R L I T Z A N D 0. J O N...

...K. Abe; M. Yasujima; N. Irokawa; M. Seino; S. Chiba; Y. Sakurai; M. Sato; Y. Imai; K. Saito; T. Ito; T. Haruyama; Y. Otsuka; K. Yoshinaga To investigate the role of renal vasoactive substances in the pathogenesis of essential hypertension, urinary prostaglandin E excretion, urinary kallikrein...