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Keywords: oxidative stress
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Articles
Clin Sci (Lond) (2022) 136 (13): 1019–1023.
Published: 01 July 2022
...Philip C. Calder Non-alcoholic fatty liver disease (NAFLD) is the most prevalent liver disease globally. The first stage of NAFLD is steatosis, the accumulation of triacylglycerols within hepatocytes. Inflammation and oxidative stress both contribute to progression to more severe disease. In 2004...
Articles
Clin Sci (Lond) (2022) 136 (6): 405–423.
Published: 23 March 2022
... and COPD involve significant local (i.e. lung, vasculature) and systemic inflammation and oxidative stress, of which current pharmacological treatments have limited efficacy, hence the urgency for the development of novel life-saving therapeutics. Currently these diseases must be treated individually...
Articles
Clin Sci (Lond) (2022) 136 (2): 167–180.
Published: 20 January 2022
... oxidative stress as well as increased mesangial expansion and glomerulosclerosis when compared with vehicle-treated diabetic animals. Inhibition of the inflammasome by MCC950 in diabetic mice led to renal up-regulation of markers of inflammation ( Il1 β, Il18 and Mcp1 ), fibrosis ( Col1, Col4 , Fn1, α-SMA...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2021) 135 (24): 2665.
Published: 15 December 2021
... © 2021 The Author(s). 2021 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . Alamandine Angiotensin II Hepatic fibrosis NADPH oxidase Oxidative stress...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2021) 135 (23): 2625–2641.
Published: 08 December 2021
... pathways developed. Vascular reactivity of TA and VC from HF post-MI and sham operated (SO) rats was assessed with a wire myograph, 4 weeks after coronary artery occlusion surgery. Nitric oxide (NO), H 2 O 2 production and oxidative stress were evaluated in situ with fluorescent probes, while protein...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2021) 135 (22): 2589–2605.
Published: 26 November 2021
... ) * These authors contributed equally to this work. 14 09 2021 03 11 2021 05 11 2021 © 2021 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2021 Muscle atrophy oxidative stress Preterm birth Skeletal muscle Improved neonatal care over...
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Articles
Clin Sci (Lond) (2021) 135 (20): 2429–2444.
Published: 28 October 2021
... post-hoc test. Figure 3 Role of Nox1 in OPG-induced oxidative stress and vascular dysfunction in WKY rats ROS generation ( n =13) ( A ), H 2 O 2 levels ( n =9) ( B ) and ONOO − levels ( n =8) ( C ) measured in VSMCs stimulated with OPG (50 ng/ml) in the presence/absence of the Nox1...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2021) 135 (20): 2409–2422.
Published: 22 October 2021
...DongZhu Xu; Nobuyuki Murakoshi; Kazuko Tajiri; Feng Duo; Yuta Okabe; Yoshiko Murakata; Zixun Yuan; Siqi Li; Kazuhiro Aonuma; Zonghu Song; Yuzuno Shimoda; Haruka Mori; Akira Sato; Akihiko Nogami; Kazutaka Aonuma; Masaki Ieda Oxidative stress could be a possible mechanism and a therapeutic target...
Articles
Clin Sci (Lond) (2021) 135 (17): 2103–2119.
Published: 06 September 2021
... in 3-nitrotyrosine (18-fold). Combination of HFD and CS precipitated hepatosteatosis to NASH reflected by exacerbated makers of liver inflammation and fibrosis which were associated with much severe liver oxidative stress (90-fold increase in 3-nitrotyrisine along with 6-fold increase in carbonylated...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2021) 135 (15): 1845–1858.
Published: 04 August 2021
... are not completely understood. The present study tested the hypothesis that lysophosphatidylcholine (LPC), a proatherogenic component of oxLDL, induces endothelial calcium influx, which drives NOX5-dependent reactive oxygen species (ROS) production, oxidative stress, and endothelial cell dysfunction. Approach: Human...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2021) 135 (14): 1767–1772.
Published: 27 July 2021
... S.M. ( 2018 ) Implication of oxidative stress in fetal programming of cardiovascular disease . Front. Physiol. 9 , 602 29875698 10.3389/fphys.2018.00602 12. Savasta M. , Dubois A. and Scatton B. ( 1986 ) Autoradiographic localization of D1 dopamine receptors...
Articles
Clin Sci (Lond) (2021) 135 (10): 1251–1272.
Published: 26 May 2021
... style diseases oxidative stress Human life expectancy has achieved an unprecedented rise, at a rate of 5 years per decade, since the beginning of the millennium. The population aged 65 years or over is projected to reaching 1.5 billion in 2050 [ 1 ]. Despite the improvement of lifespan, health...
Articles
Clin Sci (Lond) (2021) 135 (6): 753–773.
Published: 17 March 2021
... normalised by fasudil and 4-PBA. Cerebral vessels in CADASIL patients exhibited significant oxidative damage. In conclusion, peripheral vascular dysfunction in CADASIL is associated with altered Ca 2+ homoeostasis, oxidative stress and blunted eNOS/sGC/cGMP signaling, processes involving Rho kinase and ER...
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Articles
Clin Sci (Lond) (2021) 135 (4): 613–627.
Published: 18 February 2021
... extracellular matrix (ECM) synthesis and significantly inhibited HG-induced HaCaT cell damage. Further analysis indicated that BBR activated TrxR1, suppressed its downstream JNK signaling, thereby inhibiting oxidative stress and apoptosis, promoted cell proliferation, down-regulated matrix metalloproteinase...
Articles
Clin Sci (Lond) (2020) 134 (21): 2835–2850.
Published: 04 November 2020
... quality of life. Loss in muscle mass cannot alone account for the muscle weakness induced by RA, but instead intramuscular dysfunction appears as a critical factor underlying the decreased force generating capacity for patients afflicted by arthritis. Oxidative stress and associated oxidative post...
Articles
Clin Sci (Lond) (2020) 134 (16): 2161–2175.
Published: 24 August 2020
... oxidative stress and neuronal apoptosis, as well as decreased accumulation of Aβ and Tau in the hippocampus. Taken together, the data demonstrated that transplantation of Mito-Plt attenuated cognitive impairment and mitochondrial dysfunction in db/db mice. This method may be a potential therapeutic...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2020) 134 (15): 2055–2073.
Published: 10 August 2020
... treatment with the Foresaid X receptor (FXR) agonist obeticholic acid (OCA), which inhibits oxidative stress-related pathogenesis, in ascitic cirrhotic rats with hepatorenal syndrome (HRS) developed 6 weeks after bile duct ligation (BDL). Methods: Systemic, splanchnic, and renal hemodynamics and pathogenic...
Articles
Clin Sci (Lond) (2020) 134 (13): 1675.
Published: 06 July 2020
... Oxidative stress The Editorial Office has been made aware of potential issues surrounding the scientific validity of this paper, hence has issued an expression of concern to notify readers whilst the Editorial Office investigates. ...
Articles
Clin Sci (Lond) (2020) 134 (13): 1613–1629.
Published: 30 June 2020
... and oxygen-induced retinopathy (OIR) models. The retina function was monitored by electroretinography (ERG) and retinal thickness was measured by optical coherence tomography (OCT). TUNEL and cell death ELISA were performed to measure the apoptosis. Oxidative stress was detected by the measurement...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2020) 134 (12): 1491–1519.
Published: 25 June 2020
... and stiffening of the large elastic arteries (i.e., the aorta and carotid arteries), contribute importantly to the age-related increase in CVD risk. Vascular aging is driven in large part by oxidative stress, which reduces bioavailability of nitric oxide and promotes alterations in the extracellular matrix...
Articles
Clin Sci (Lond) (2020) 134 (7): 853–869.
Published: 09 April 2020
...Yun Huang; Yang Li; Anni Lou; Guo zhen Wang; Ye Hu; Yijie Zhang; Weichang Huang; Jun Wang; Yue Li; Xintao Zhu; Tingting Chen; Jiayi Lin; Ying Meng; Xu Li Angiotensin II (Ang II) has been reported to aggravate hepatic fibrosis by inducing NADPH oxidase (NOX)-dependent oxidative stress. Alamandine...
Articles
Clin Sci (Lond) (2020) 134 (4): 403–417.
Published: 25 February 2020
... to diabetic kidney disease. Furthermore, it discusses in detail the underlying mechanisms of adipose inflammation, including pro-inflammatory cytokines, oxidative stress, and AMPK/mTOR signaling pathway and critically describes their role in diabetic kidney disease. This in-depth understanding of adipose...
Articles
Clin Sci (Lond) (2020) 134 (1): 73–74.
Published: 14 January 2020
... in cardiac cells [ 7 ] and superoxide production in monocytes [ 8 ]. Finally, Gal-3 decreases the protective fumarate hydratase promoting oxidative stress in human cardiac fibroblasts [ 9 ]. Considering all these findings, it is interesting to speculate that Gal-3-induced oxidative stress could be involved...
Articles
Clin Sci (Lond) (2019) 133 (15): 1705–1720.
Published: 02 August 2019
... function involving the inhibition of oxidative stress-induced injury via sGC-cGMP-PKG pathway and may be a promising therapeutic option for DCM. Correspondence: Liming Chen ( xfx22081@vip.163.com ) or Bei Sun ( sun_peipei220@hotmail.com ) 03 06 2019 19 07 2019 23 07 2019 23 07...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2019) 133 (14): 1609–1627.
Published: 25 July 2019
... ischemic reperfusion, nephrotoxic drugs and sepsis. It is characterized by a sudden decline in renal function, in addition to excessive inflammation, oxidative stress and programmed cell death of renal tubular epithelial cells. RIPK1-mediated necroptosis plays an important role in AKI. In the present study...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2019) 133 (14): 1537–1548.
Published: 17 July 2019
...: Soluble ST2 (interleukin 1 receptor-like 1) (sST2) is involved in inflammatory diseases and increased in heart failure (HF). We herein investigated sST2 effects on oxidative stress and inflammation in human cardiac fibroblasts and its pathological role in human aortic stenosis (AS). Methods and results...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2019) 133 (7): 885–904.
Published: 12 April 2019
... and poor diet but the underlying mechanisms have not been fully established. However, there is emerging and compelling experimental and clinical evidence to show that increased oxidative stress causes pulmonary inflammation and that the spill over of pro-inflammatory mediators from the lungs...
Articles
Clin Sci (Lond) (2019) 133 (1): 117–134.
Published: 11 January 2019
... of unconjugated bilirubin (BR) prevent oxidative stress (OS)-induced hepatocanalicular dysfunction and cholestasis. Here, we aimed to ascertain, in the whole rat, whether a similar cholestatic OS injury can be counteracted by heme oxygenase-1 (HO-1) induction that consequently elevates endogenous BR levels...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2018) 132 (20): 2175–2188.
Published: 19 October 2018
... was significantly decreased at the levels of the mRNA and protein in the penis of diabetic rats compared with normal controls. To test the hypothesis that decreased the penile levels of PEDF are associated with oxidative stress and inflammation in DMED, an adenovirus expressing PEDF (Ad-PEDF) or the same titer...
Articles
Clin Sci (Lond) (2018) 132 (16): 1811–1836.
Published: 30 August 2018
...Jay C. Jha; Florence Ho; Christopher Dan; Karin Jandeleit-Dahm Chronic renal and vascular oxidative stress in association with an enhanced inflammatory burden are determinant processes in the development and progression of diabetic complications including cardiovascular disease (CVD...
Articles
Clin Sci (Lond) (2018) 132 (12): 1257–1280.
Published: 29 June 2018
... that a single measurement provides global assessment of plasma oxidative stress. Rather, assessment of individual thiol pools and thiol-proteins specific to any given condition has more solid and logical perspective to yield novel relevant information on disease risk and prognosis. Correspondence...
Articles
Clin Sci (Lond) (2018) 132 (12): 1297–1314.
Published: 26 June 2018
... oxidative stress are both critical for ensuing diabetic tubular cell injury and apoptosis; whether these two processes are interlinked remains unclear. In the present study, we observed changes in mitochondrial morphology and expression of associated proteins in tubules of patients with DN. We demonstrated...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2018) 132 (8): 869–881.
Published: 30 April 2018
..., intracellular insulin and leptin mediators, and oxidative stress (OS) markers were also measured in islets isolated from each experimental group. HS rats had increased plasma triglyceride, insulin, leptin, and lipid peroxidation (OS marker) levels associated with an insulin-resistant state. Their islets...
Articles
Clin Sci (Lond) (2018) 132 (6): 719–738.
Published: 30 March 2018
...@rgcb.res.in ) 14 11 2017 15 12 2017 20 12 2017 30 01 2018 © 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2018 AMPK atherosclerosis Cyclophilin A metformin Macrovascular complications oxidative stress Cyclophilin...
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Articles
Clin Sci (Lond) (2018) 132 (6): 615–626.
Published: 20 March 2018
... Dyslipidemia Kidney stone metabolic syndromes oxidative stress Kidney stones and CVDs are complex multifactorial results from interactions between environmental and genetic factors [ 1–3 ]. According to National Health and Nutrition Examination Survey (NHANES), the prevalence of history of kidney...
Articles
Clin Sci (Lond) (2017) 131 (24): 2865–2883.
Published: 04 December 2017
...Lawson Ung; Ushasree Pattamatta; Nicole Carnt; Jennifer L. Wilkinson-Berka; Gerald Liew; Andrew J.R. White For many years, oxidative stress arising from the ubiquitous production of reactive oxygen species (ROS) has been implicated in the pathogenesis of various eye diseases. While emerging...
Articles
Clin Sci (Lond) (2017) 131 (23): 2807–2812.
Published: 28 November 2017
... ( damian.bailey@southwales.ac.uk ) 02 10 2017 20 10 2017 20 10 2017 20 10 2017 © 2017 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2017 Aging Cerebrovascular Function High-Fat Meal Hyperlipidaemia oxidative stress Oxidative...
Articles
Clin Sci (Lond) (2017) 131 (21): 2573–2599.
Published: 25 October 2017
... homeostasis may make older people more susceptible to many diseases. Chronic oxidative stress and defective protein homeostasis (proteostasis) are two major factors associated with the etiology of age-related disorders. In the present paper, we review the contribution of impaired responses to oxidative stress...
Articles
Clin Sci (Lond) (2017) 131 (19): 2409–2426.
Published: 15 September 2017
... and the liver damage biomarker aspartate aminotransferase (AST), increased in magnitude 1.5 and 2.5 times compared with controls, respectively. THS exposure for 2 months resulted in further damage and at 4 and 6 months, many factors related to oxidative stress were altered and caused molecular damage. We also...
Articles
Clin Sci (Lond) (2017) 131 (18): 2397–2408.
Published: 08 September 2017
... the intracellular and the extracellular miR-200c expression levels. In conclusion, circulating miR-200c is up-regulated in FH, probably due to oxidative stress and inflammation and via a miR-33a/b -ZEB1-dependent mechanism. The present study could provide the first evidence to point to the use of miR-33a/b and miR...
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Articles
Clin Sci (Lond) (2017) 131 (14): 1701–1712.
Published: 30 June 2017
... of the Biochemical Society 2017 bronchopulmonary dysplasia hyperoxic stress HO-1 hyperoxic lung injuries Nrf2 Oxidative stress Preterm newborns – described as birth prior to 37 weeks of gestation – are estimated to be approximately 15 million every year and one of the main features is immature...
Articles
Clin Sci (Lond) (2017) 131 (14): 1689–1700.
Published: 30 June 2017
... provide an effective therapeutic approach to prevent the cardiovascular sequelae associated with excessive adiposity. In this review, we discuss the recent evidence supporting the role of oxidative stress and cytokines and inflammatory signals within the vasculature as well as the impact...
Articles
Clin Sci (Lond) (2017) 131 (13): 1449–1463.
Published: 28 June 2017
... 2017 © 2017 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2017 Calcitriol Inflammation Oxidative stress Paricalcitol Phosphate VSMCs High serum phosphate levels are an independent predictor of mortality in chronic kidney disease (CKD...
Articles
Clin Sci (Lond) (2017) 131 (13): 1419–1428.
Published: 23 June 2017
...D. La Russa; E. Brunelli; D. Pellegrino In both humans and animals, essential hypertension acts as a risk factor for subclinical kidney damage and precedes renal dysfunction. Several lines of evidence indicate that hypertension and oxidative stress are closely related. The increase in vascular...
Articles
Clin Sci (Lond) (2017) 131 (10): 981–990.
Published: 04 May 2017
...Jay C. Jha; Anna M.D. Watson; Geetha Mathew; Lisanne C. de Vos; Karin Jandeleit-Dahm Oxidative stress is a consequence of up-regulation of pro-oxidant enzyme-induced reactive oxygen species (ROS) production and concomitant depletion of antioxidants. Elevated levels of ROS act as an intermediate...
Articles
Clin Sci (Lond) (2017) 131 (9): 803–822.
Published: 19 April 2017
..., and resistance to oxidative stress. In turn, sex hormones regulate mitochondrial function and biogenesis. Mutations in genes encoding mitochondrial proteins are the origin of serious mitochondrial genetic diseases. Mitochondrial dysfunction is also an important parameter for a large panel of pathologies...
Articles
Clin Sci (Lond) (2017) 131 (6): 471–485.
Published: 06 March 2017
... colorectal cancer Escherichia coli microsatellite instability mutL homologue 1 (MLH1) oxidative stress • The study presents the first clinical evidence for an interaction between pathogenic colibactin-producing E. coli and DNA MMR deficiency in CRC. • Moreover, this work revealed...
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Articles
Clin Sci (Lond) (2017) 131 (2): 139–140.
Published: 23 December 2016
...Michael J. Ryan Correspondence: Professor Michael J. Ryan (email mjryan@umc.edu ) 6 11 2016 19 11 2016 22 11 2016 © 2016 The Author(s). published by Portland Press Limited on behalf of the Biochemical Society 2016 oxidative stress reactive oxygen species...
Articles
Clin Sci (Lond) (2016) 130 (15): 1363–1374.
Published: 29 June 2016
...Elyse Di Marco; Stephen P. Gray; Phyllis Chew; Kit Kennedy; Mark E. Cooper; Harald H.H.W. Schmidt; Karin A.M. Jandeleit-Dahm Oxidative stress and inflammation are central mediators of atherosclerosis particularly in the context of diabetes. The potential interactions between the major producers...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2016) 130 (13): 1039–1050.
Published: 23 May 2016
... and smoking, or the association of COPD with traditional stroke risk factors. In addition, we propose that COPD-related systemic inflammation and oxidative stress may play important roles by promoting cerebral vascular dysfunction and platelet hyperactivity. In this review, we briefly discuss the pathogenesis...