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Keywords: obesity
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Articles
Clin Sci (Lond) (2023) 137 (19): 1547–1562.
Published: 03 October 2023
...Carolyn J. Wang; Jeremy T. Smith; David Lu; Peter B. Noble; Kimberley C.W. Wang Airway-associated adipose tissue increases with body mass index and is a local source of pro-inflammatory adipokines that may contribute to airway pathology in asthma co-existing with obesity. Genetic susceptibility...
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Clin Sci (Lond) (2023) 137 (15): 1095–1114.
Published: 02 August 2023
...Vanda Marques; Fabiola Arella; Marta B. Afonso; André A. Santos; Cecília M.P. Rodrigues The increasing prevalence of obesity brings forward its importance as a risk factor for cancer development, particularly in the gastrointestinal tract. Obesity may trigger cancer development through several...
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Clin Sci (Lond) (2022) 136 (18): 1347–1366.
Published: 23 September 2022
...Olufunto O. Badmus; Sarah A. Hillhouse; Christopher D. Anderson; Terry D. Hinds, Jr; David E. Stec The metabolic-associated fatty liver disease (MAFLD) is a condition of fat accumulation in the liver in combination with metabolic dysfunction in the form of overweight or obesity and insulin...
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Clin Sci (Lond) (2021) 135 (24): 2729–2748.
Published: 17 December 2021
...Nikita Lad; Alice M. Murphy; Cristina Parenti; Carl P. Nelson; Neil C. Williams; Graham R. Sharpe; Philip G. McTernan Low-grade inflammation is often an underlying cause of several chronic diseases such as asthma, obesity, cardiovascular disease, and type 2 diabetes mellitus (T2DM). Defining...
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Clin Sci (Lond) (2021) 135 (24): 2691–2708.
Published: 15 December 2021
...Simon T. Bond; Anna C. Calkin; Brian G. Drew The escalating prevalence of individuals becoming overweight and obese is a rapidly rising global health problem, placing an enormous burden on health and economic systems worldwide. Whilst obesity has well described lifestyle drivers, there is also...
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Clin Sci (Lond) (2021) 135 (14): 1773–1789.
Published: 30 July 2021
...Osvaldo Rivera-Gonzalez; Natalie A. Wilson; Laura E. Coats; Erin B. Taylor; Joshua S. Speed Endothelin-1 (ET-1) is elevated in patients with obesity; however, its contribution to the pathophysiology related to obesity is not fully understood. We hypothesized that high ET-1 levels cause dyslipidemia...
Includes: Supplementary data
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Clin Sci (Lond) (2021) 135 (13): 1563–1590.
Published: 07 July 2021
...Timothy M. Palmer; Ian P. Salt Despite obesity and diabetes markedly increasing the risk of developing cardiovascular diseases, the molecular and cellular mechanisms that underlie this association remain poorly characterised. In the last 20 years it has become apparent that chronic, low-grade...
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Clin Sci (Lond) (2021) 135 (12): 1523–1544.
Published: 23 June 2021
...Jessica L. Faulkner The pathogenesis of obesity-associated cardiovascular diseases begins long prior to the presentation of a cardiovascular event. In both men and women, cardiovascular events, and their associated hospitalizations and mortality, are often clinically predisposed by the presentation...
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Clin Sci (Lond) (2021) 135 (6): 731–752.
Published: 17 March 2021
...Erin B. Taylor The global obesity epidemic is a major contributor to chronic disease and disability in the world today. Since the discovery of leptin in 1994, a multitude of studies have characterized the pathological changes that occur within adipose tissue in the obese state. One significant...
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Clin Sci (Lond) (2020) 134 (18): 2447–2451.
Published: 25 September 2020
...Anissa Viveiros; Gavin Y. Oudit The global prevalence of obesity has been rising at an alarming rate, accompanied by an increase in both childhood and maternal obesity. The concept of metabolic programming is highly topical, and in this context, describes a predisposition of offspring of obese...
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Clin Sci (Lond) (2020) 134 (13): 1659–1673.
Published: 01 July 2020
... The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2020 adipose dysfunction Cigarette smoking glucose tolerance insulin signalling muscle obesity Today, the number of people that smoke is 1.1 billion worldwide [ 1 ]. Cigarette smoking (CS) has widely...
Includes: Supplementary data
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Clin Sci (Lond) (2020) 134 (12): 1403–1432.
Published: 18 June 2020
... tissue inflammation atherosclerosis cardiovascular disease flavonoids obesity Substantial body of clinical evidence points toward the cardio-vasculoprotective roles of flavonoids [ 48–53 ]. These bountiful health effects of flavonoids may partly explain the interest in herbal medicine of CVD...
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Clin Sci (Lond) (2020) 134 (7): 827–851.
Published: 09 April 2020
...Rim Rafeh; Anissa Viveiros; Gavin Y. Oudit; Ahmed F. El-Yazbi Major shifts in human lifestyle and dietary habits toward sedentary behavior and refined food intake triggered steep increase in the incidence of metabolic disorders including obesity and Type 2 diabetes. Patients with metabolic disease...
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Clin Sci (Lond) (2020) 134 (4): 403–417.
Published: 25 February 2020
... molecules act in autocrine, paracrine or endocrine manner to maintain several physiological functions among which glucose and energy metabolism, angiogenesis and immunity [ 37–40 ]. In obesity-related diabetes, the production of these molecules is dysregulated and more pro-inflammatory cytokines are being...
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Clin Sci (Lond) (2020) 134 (4): 389–401.
Published: 17 February 2020
...Carla El-Mallah; Omar Obeid Obesity and increased body adiposity have been alarmingly increasing over the past decades and have been linked to a rise in food intake. Many dietary restrictive approaches aiming at reducing weight have resulted in contradictory results. Additionally, some policies...
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Clin Sci (Lond) (2019) 133 (22): 2329–2344.
Published: 28 November 2019
... ] Coronary ischemia/reperfusion Adiponectin Leptin Visfatin Omentin Reduced infarct size [ 47 ] Reduced infarct size [ 66 ]Reduced infarct size [ 98 ] Reduced infarct size [ 101 ] Diet-induced obesity Autotaxin Secretion in obesity increased hypertrophy and fibrosis [ 95 ] Isoproterenol infusion...
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Clin Sci (Lond) (2019) 133 (20): 2107–2119.
Published: 25 October 2019
... of their origin or have similar capacity to re-differentiate into different cell types? Answers to these questions may offer new insights into adipocyte biology and open new avenues to treat obesity, cancer and other diseases. We thank Menchus Quan (Purdue University) for critical reading and editing...
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Clin Sci (Lond) (2019) 133 (19): 2029–2044.
Published: 14 October 2019
... potential for the development of a therapeutic approach for the prevention and treatment of T2DM and obesity-related diseases. The authors are thankful to Dr. Aimin Xu for the provision of FGF21 KO mice in the present study. CVX343 (PF-05231023) was a gift from Pfizer (#WI210005) and INS-1E cell line...
Includes: Supplementary data
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Clin Sci (Lond) (2019) 133 (17): 1871–1881.
Published: 10 September 2019
... with several consequence of heart diseases in clinical studies, and overexpression of miR-122 impaired cardiomyocyte function. However, it was unknown whether miR-122 could regulate cardiac biology in obesity. Therefore, present study was to disclose the role of miR-122 in cardiac metabolic disorders...
Includes: Supplementary data
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Clin Sci (Lond) (2018) 132 (15): 1685–1698.
Published: 14 August 2018
...Kenneth Verboven; Rudi Stinkens; Dominique Hansen; Inez Wens; Ines Frederix; Bert O. Eijnde; Johan W.E. Jocken; Gijs H. Goossens; Ellen E. Blaak Obesity-related adipose tissue (AT) dysfunction, in particular subcutaneous AT (SCAT) lipolysis, is characterized by catecholamine resistance and impaired...
Includes: Supplementary data
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Clin Sci (Lond) (2018) 132 (10): 1039–1054.
Published: 25 May 2018
... The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2018 brown adipose tissue beige adipose tissue insulin resistance obesity type 2 diabetes Since the re-discovery and definitive identification of functional brown adipose tissue (BAT) in adult humans...
Includes: Supplementary data
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Clin Sci (Lond) (2018) 132 (2): 295–312.
Published: 25 January 2018
...Redin A. Spann; William J. Lawson; Gene L. Bidwell, III; C. Austin Zamarripa; Rodrigo O. Maranon; Sibali Bandyopadhyay; Erin R. Taylor; Jane F. Reckelhoff; Michael R. Garrett; Bernadette E. Grayson Bariatric surgery is increasingly employed to improve fertility and reduce obesity-related co...
Includes: Supplementary data
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Clin Sci (Lond) (2017) 131 (14): 1689–1700.
Published: 30 June 2017
...John J. Reho; Kamal Rahmouni Obesity is associated with increased cardiovascular morbidity and mortality in part due to vascular abnormalities such as endothelial dysfunction and arterial stiffening. The hypertension and other health complications that arise from these vascular defects increase...
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Clin Sci (Lond) (2017) 131 (5): 343–353.
Published: 15 February 2017
...Emilie Pastel; Laura J. McCulloch; Rebecca Ward; Shivam Joshi; Kim M. Gooding; Angela C. Shore; Katarina Kos Glucagon-like peptide-1 (GLP-1) analogues aid weight loss that improves obesity-associated adipose tissue (AT) dysfunction. GLP-1 treatment may however also directly influence...
Includes: Supplementary data
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Clin Sci (Lond) (2017) 131 (4): 285–296.
Published: 20 January 2017
...Laurence Poekes; Vanessa Legry; Olivier Schakman; Christine Detrembleur; Anne Bol; Yves Horsmans; Geoffrey C. Farrell; Isabelle A. Leclercq Fatty liver diseases are complications of the metabolic syndrome associated with obesity, insulin resistance and low grade inflammation. Our aim was to uncover...
Includes: Supplementary data
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Clin Sci (Lond) (2016) 130 (22): 2087–2100.
Published: 11 October 2016
...Kelvin H.M. Kwok; Kenneth K.Y. Cheng; Ruby L.C. Hoo; Dewei Ye; Aimin Xu; Karen S.L. Lam Both atherosclerosis and obesity, an independent atherosclerotic risk factor, are associated with enhanced systemic inflammation. Obesity is also characterized by increased adipose tissue inflammation. However...
Includes: Supplementary data
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Clin Sci (Lond) (2016) 130 (19): 1697–1709.
Published: 23 August 2016
.... Failure of this physiological response can lead to energy imbalance, ultimately with extreme consequences, such as leanness or obesity. Here, we will review the data that put brain AMPK in the spotlight as a regulator of appetite. Correspondence: Miguel López (email m.lopez@usc.es ). 18 1...
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Clin Sci (Lond) (2016) 130 (18): 1603–1614.
Published: 08 August 2016
...Matthias Blüher The worldwide obesity epidemic has become a major health concern, because it contributes to higher mortality due to an increased risk for noncommunicable diseases including cardiovascular diseases, type 2 diabetes, musculoskeletal disorders and some cancers. Insulin resistance may...
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Clin Sci (Lond) (2016) 130 (18): 1571–1597.
Published: 08 August 2016
...Hudson Reddon; Jean-Louis Guéant; David Meyre The worldwide obesity epidemic has been mainly attributed to lifestyle changes. However, who becomes obese in an obesity-prone environment is largely determined by genetic factors. In the last 20 years, important progress has been made...
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Clin Sci (Lond) (2015) 129 (12): 1025–1036.
Published: 18 September 2015
.... We conclude that microvascular insulin resistance is an early event in diet-induced obesity and insulin resistance and inflammation plays an essential role in this process. Our data suggest microvascular insulin resistance contributes to the development of metabolic insulin resistance in muscle...
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Clin Sci (Lond) (2015) 129 (11): 933–949.
Published: 10 September 2015
... contributes to energy expenditure and glucose homoeostasis. Brown fat activation has thus emerged as an attractive therapeutic target for the treatment of obesity and the metabolic syndrome. In the present review, we integrate the recent advances on the metabolic role of BAT and its relation with other...
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Clin Sci (Lond) (2015) 128 (12): 839–861.
Published: 27 March 2015
... remains to be determined. advanced glycation endproducts ageing glyoxalase methylglyoxal obesity type 2 diabetes mellitus The Maillard reaction is a process in which reducing sugars react spontaneously with amino residues in proteins, lipids and nucleic acids, to form advanced glycation...
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Clin Sci (Lond) (2015) 128 (10): 715–721.
Published: 10 March 2015
... in mice has been reported to lead to obesity and impaired glucose homoeostasis. Genome-wide genomic and proteomic approaches have revealed that NUCKS is a chromatin regulator that affects transcription. The time is now ripe for further understanding of the role of this novel biomarker of cancer...
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Clin Sci (Lond) (2015) 128 (8): 493–506.
Published: 23 January 2015
...-58) is an intracellular lipolytic activator. In the present study, we show that in mouse visceral fat-derived macrophages or human peripheral blood monocytes, CGI-58 negatively and interleukin (IL)-1β positively correlate with obesity. Saturated non-esterified fatty acid (NEFA) suppresses CGI-58...
Includes: Supplementary data
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Clin Sci (Lond) (2015) 128 (7): 405–410.
Published: 09 December 2014
...Roy Taylor; Rury R. Holman Type 2 diabetes (T2DM) is frequently regarded as a disease of obesity and its occurrence in individuals of normal body mass index (BMI) is often regarded as indicating a non-obesity-related subtype. However, the evidence for such a distinct, common subtype is lacking...