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Keywords: obesity
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Articles
Clin Sci (Lond) (2022) 136 (18): 1347–1366.
Published: 23 September 2022
...Olufunto O. Badmus; Sarah A. Hillhouse; Christopher D. Anderson; Terry D. Hinds, Jr; David E. Stec The metabolic-associated fatty liver disease (MAFLD) is a condition of fat accumulation in the liver in combination with metabolic dysfunction in the form of overweight or obesity and insulin...
Articles
Clin Sci (Lond) (2022) 136 (11): 819–824.
Published: 30 May 2022
... inducer methylglyoxal obesity unfolded protein response Increased formation and accumulation of the glucose-derived reactive metabolite, methylglyoxal (MG), and its metabolism by the glyoxalase pathway is currently viewed as an important contributor to metabolic dysfunction-linking hyperglycemia...
Articles
Clin Sci (Lond) (2021) 135 (24): 2763–2780.
Published: 17 December 2021
... AT 2 R agonist, on the prevention of endothelial dysfunction, extracellular matrix (ECM) remodeling and arterial stiffness associated with diet-induced obesity (DIO). Five-week-old male C57BL/6J mice were fed a standard (Chow) or high-fat diet (HF) for 6 weeks. Half of the animals of each group were...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2021) 135 (24): 2729–2748.
Published: 17 December 2021
...Nikita Lad; Alice M. Murphy; Cristina Parenti; Carl P. Nelson; Neil C. Williams; Graham R. Sharpe; Philip G. McTernan Low-grade inflammation is often an underlying cause of several chronic diseases such as asthma, obesity, cardiovascular disease, and type 2 diabetes mellitus (T2DM). Defining...
Articles
Clin Sci (Lond) (2021) 135 (24): 2691–2708.
Published: 15 December 2021
...Simon T. Bond; Anna C. Calkin; Brian G. Drew The escalating prevalence of individuals becoming overweight and obese is a rapidly rising global health problem, placing an enormous burden on health and economic systems worldwide. Whilst obesity has well described lifestyle drivers, there is also...
Articles
Clin Sci (Lond) (2021) 135 (14): 1773–1789.
Published: 30 July 2021
...Osvaldo Rivera-Gonzalez; Natalie A. Wilson; Laura E. Coats; Erin B. Taylor; Joshua S. Speed Endothelin-1 (ET-1) is elevated in patients with obesity; however, its contribution to the pathophysiology related to obesity is not fully understood. We hypothesized that high ET-1 levels cause dyslipidemia...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2021) 135 (13): 1563–1590.
Published: 07 July 2021
...Timothy M. Palmer; Ian P. Salt Despite obesity and diabetes markedly increasing the risk of developing cardiovascular diseases, the molecular and cellular mechanisms that underlie this association remain poorly characterised. In the last 20 years it has become apparent that chronic, low-grade...
Articles
Clin Sci (Lond) (2021) 135 (12): 1523–1544.
Published: 23 June 2021
...Jessica L. Faulkner The pathogenesis of obesity-associated cardiovascular diseases begins long prior to the presentation of a cardiovascular event. In both men and women, cardiovascular events, and their associated hospitalizations and mortality, are often clinically predisposed by the presentation...
Articles
Clin Sci (Lond) (2021) 135 (6): 731–752.
Published: 17 March 2021
...Erin B. Taylor The global obesity epidemic is a major contributor to chronic disease and disability in the world today. Since the discovery of leptin in 1994, a multitude of studies have characterized the pathological changes that occur within adipose tissue in the obese state. One significant...
Articles
Clin Sci (Lond) (2021) 135 (1): 185–200.
Published: 08 January 2021
...Helena L. Fisk; Caroline E. Childs; Elizabeth A. Miles; Robert Ayres; Paul S. Noakes; Carolina Paras-Chavez; Ondrej Kuda; Jan Kopecký; Elie Antoun; Karen A. Lillycrop; Philip C. Calder Obesity is believed to be associated with a dysregulated endocannabinoid system which may reflect enhanced...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2020) 134 (21): 2789.
Published: 02 November 2020
... © 2020 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2020 Green tea polyphenols insulin receptor substrate-1 insulin resistance obesity protein kinase C-θ Zucker fatty rats The Editorial Office has been made aware of potential issues...
Articles
Clin Sci (Lond) (2020) 134 (18): 2447–2451.
Published: 25 September 2020
...Anissa Viveiros; Gavin Y. Oudit The global prevalence of obesity has been rising at an alarming rate, accompanied by an increase in both childhood and maternal obesity. The concept of metabolic programming is highly topical, and in this context, describes a predisposition of offspring of obese...
Articles
Clin Sci (Lond) (2020) 134 (13): 1659–1673.
Published: 01 July 2020
... The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2020 adipose dysfunction Cigarette smoking glucose tolerance insulin signalling muscle obesity Today, the number of people that smoke is 1.1 billion worldwide [ 1 ]. Cigarette smoking (CS) has widely...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2020) 134 (12): 1403–1432.
Published: 18 June 2020
... on behalf of the Biochemical Society 2020 adipose tissue inflammation atherosclerosis cardiovascular disease flavonoids obesity The leading cause of morbidity and mortality worldwide is cardiovascular disease (CVD) [ 1 ], with atherosclerosis being the major contributor to this mortality...
Articles
Clin Sci (Lond) (2020) 134 (10): 1167–1180.
Published: 27 May 2020
... associated with significantly decreased activation of the inhibitory (muscle-specific) protein kinase (PKC) isoform, PKC-θ. Taken together, the present study has shown that regular ingestion of GTP exerts a number of favourable metabolic and molecular effects in an established animal model of obesity...
Articles
Clin Sci (Lond) (2020) 134 (7): 827–851.
Published: 09 April 2020
...Rim Rafeh; Anissa Viveiros; Gavin Y. Oudit; Ahmed F. El-Yazbi Major shifts in human lifestyle and dietary habits toward sedentary behavior and refined food intake triggered steep increase in the incidence of metabolic disorders including obesity and Type 2 diabetes. Patients with metabolic disease...
Articles
Clin Sci (Lond) (2020) 134 (5): 547–570.
Published: 13 March 2020
... play a role in inflammation. In this review, we try to elucidate the connections between peripheral inflammation at obesity and Type 2 diabetes and the central inflammatory process. Multiple lines of evidence highlight the importance of peripheral inflammation and its link to neuroinflammation, which...
Articles
Clin Sci (Lond) (2020) 134 (4): 403–417.
Published: 25 February 2020
... 02 2020 10 02 2020 © 2020 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2020 Adipose Inflammation Diabetes Diabetic Kidney Disease NADPH oxidase obesity Oxidative Stress Diabetes mellitus (DM) [ 1 ] is one of the major public...
Articles
Clin Sci (Lond) (2020) 134 (4): 389–401.
Published: 17 February 2020
...Carla El-Mallah; Omar Obeid Obesity and increased body adiposity have been alarmingly increasing over the past decades and have been linked to a rise in food intake. Many dietary restrictive approaches aiming at reducing weight have resulted in contradictory results. Additionally, some policies...
Articles
Clin Sci (Lond) (2019) 133 (24): 2431–2447.
Published: 16 December 2019
...Chayodom Maneechote; Siripong Palee; Nattayaporn Apaijai; Sasiwan Kerdphoo; Thidarat Jaiwongkam; Siriporn C. Chattipakorn; Nipon Chattipakorn Obese insulin resistance impairs cardiac mitochondrial dynamics by increasing mitochondrial fission and decreasing mitochondrial fusion, leading...
Articles
Clin Sci (Lond) (2019) 133 (22): 2329–2344.
Published: 28 November 2019
...(s). Published by Portland Press Limited on behalf of the Biochemical Society 2019 adipokines brown adipose tissue cardiac fibrosis cardiac hypertrophy cardiovascular disease obesity Adipose tissue biology is intricately linked to cardiovascular health, and the growing obesity...
Articles
Clin Sci (Lond) (2019) 133 (20): 2107–2119.
Published: 25 October 2019
... The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2019 adipocyte dedifferentiation differentiation metabolism obesity Obesity and overweight driven by abnormal deposition of adipose tissues not only affect nearly 2 billion people worldwide and reduce...
Articles
Clin Sci (Lond) (2019) 133 (19): 2029–2044.
Published: 14 October 2019
... by Portland Press Limited on behalf of the Biochemical Society 2019 Apoptosis CVX343 Insulin Islets Obesity Type 2 diabetes Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by hyperglycemia and hyperlipidemia. Most patients with T2DM are overweight or obese...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2019) 133 (17): 1871–1881.
Published: 10 September 2019
... with several consequence of heart diseases in clinical studies, and overexpression of miR-122 impaired cardiomyocyte function. However, it was unknown whether miR-122 could regulate cardiac biology in obesity. Therefore, present study was to disclose the role of miR-122 in cardiac metabolic disorders...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2019) 133 (13): 1367–1386.
Published: 01 July 2019
... on long-term stroke recovery. However, the effects of obesity-induced T2D are mostly unknown. We aimed to investigate whether obesity-induced T2D worsens long-term stroke recovery through the impairment of brain’s self-repair mechanisms – stroke-induced neurogenesis and parvalbumin (PV)+ interneurons...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2018) 132 (15): 1685–1698.
Published: 14 August 2018
...Kenneth Verboven; Rudi Stinkens; Dominique Hansen; Inez Wens; Ines Frederix; Bert O. Eijnde; Johan W.E. Jocken; Gijs H. Goossens; Ellen E. Blaak Obesity-related adipose tissue (AT) dysfunction, in particular subcutaneous AT (SCAT) lipolysis, is characterized by catecholamine resistance and impaired...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2018) 132 (14): 1545–1563.
Published: 31 July 2018
... and obesity is currently acknowledged to be a health topic which causes low-grade systemic inflammation and insulin resistance and may damage the kidney. Organic anion transporter 3 (Oat3) has been shown as a transporter responsible for renal handling of gut microbiota products which are involved...
Articles
Clin Sci (Lond) (2018) 132 (14): 1581–1596.
Published: 31 July 2018
...Pei-Chi Chan; Ting-Ni Wu; Ying-Chuan Chen; Chieh-Hua Lu; Martin Wabitsch; Yu-Feng Tian; Po-Shiuan Hsieh Adipose tissue (AT) inflammation is crucial to the development of obesity-associated insulin resistance. Our aim was to investigate the contribution of cyclooxygenase-2 (COX-2)/macrophage...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2018) 132 (10): 1039–1054.
Published: 25 May 2018
... of this contribution may be relatively small compared with skeletal muscle [ 7–9 ]. Given this inherent capacity to utilize substrates in a futile cycle, the activation of BAT may have important implications in the treatment of metabolic disorders such as obesity, type 2 diabetes, and non-alcoholic fatty liver disease...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2018) 132 (2): 295–312.
Published: 25 January 2018
...Redin A. Spann; William J. Lawson; Gene L. Bidwell, III; C. Austin Zamarripa; Rodrigo O. Maranon; Sibali Bandyopadhyay; Erin R. Taylor; Jane F. Reckelhoff; Michael R. Garrett; Bernadette E. Grayson Bariatric surgery is increasingly employed to improve fertility and reduce obesity-related co...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2017) 131 (24): 2885–2900.
Published: 04 December 2017
...Gabriela Placoná Diniz; Zhan-Peng Huang; Jianming Liu; Jinghai Chen; Jian Ding; Renata Inzinna Fonseca; Maria Luiza Barreto-Chaves; Jose Donato, Jr; Xiaoyun Hu; Da-Zhi Wang Obesity is associated with development of diverse diseases, including cardiovascular diseases and dyslipidemia. MiRNA-22 (miR...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2017) 131 (14): 1689–1700.
Published: 30 June 2017
...John J. Reho; Kamal Rahmouni Obesity is associated with increased cardiovascular morbidity and mortality in part due to vascular abnormalities such as endothelial dysfunction and arterial stiffening. The hypertension and other health complications that arise from these vascular defects increase...
Articles
Clin Sci (Lond) (2017) 131 (5): 343–353.
Published: 15 February 2017
...Emilie Pastel; Laura J. McCulloch; Rebecca Ward; Shivam Joshi; Kim M. Gooding; Angela C. Shore; Katarina Kos Glucagon-like peptide-1 (GLP-1) analogues aid weight loss that improves obesity-associated adipose tissue (AT) dysfunction. GLP-1 treatment may however also directly influence...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2017) 131 (4): 285–296.
Published: 20 January 2017
...Laurence Poekes; Vanessa Legry; Olivier Schakman; Christine Detrembleur; Anne Bol; Yves Horsmans; Geoffrey C. Farrell; Isabelle A. Leclercq Fatty liver diseases are complications of the metabolic syndrome associated with obesity, insulin resistance and low grade inflammation. Our aim was to uncover...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2016) 130 (22): 2073–2082.
Published: 11 October 2016
... factors. The present study aim was to investigate the effects of proximal and distal colonic infusions with the SCFA acetate on fat oxidation and other metabolic parameters in men. In this randomized, double-blind crossover trial, six overweight/obese men [body mass index (BMI) 25–35 kg/m 2 ] underwent...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2016) 130 (22): 2087–2100.
Published: 11 October 2016
...Kelvin H.M. Kwok; Kenneth K.Y. Cheng; Ruby L.C. Hoo; Dewei Ye; Aimin Xu; Karen S.L. Lam Both atherosclerosis and obesity, an independent atherosclerotic risk factor, are associated with enhanced systemic inflammation. Obesity is also characterized by increased adipose tissue inflammation. However...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2016) 130 (19): 1697–1709.
Published: 23 August 2016
.... Failure of this physiological response can lead to energy imbalance, ultimately with extreme consequences, such as leanness or obesity. Here, we will review the data that put brain AMPK in the spotlight as a regulator of appetite. Correspondence: Miguel López (email m.lopez@usc.es ). 18 1...
Articles
Clin Sci (Lond) (2016) 130 (18): 1603–1614.
Published: 08 August 2016
...Matthias Blüher The worldwide obesity epidemic has become a major health concern, because it contributes to higher mortality due to an increased risk for noncommunicable diseases including cardiovascular diseases, type 2 diabetes, musculoskeletal disorders and some cancers. Insulin resistance may...
Articles
Clin Sci (Lond) (2016) 130 (18): 1571–1597.
Published: 08 August 2016
...Hudson Reddon; Jean-Louis Guéant; David Meyre The worldwide obesity epidemic has been mainly attributed to lifestyle changes. However, who becomes obese in an obesity-prone environment is largely determined by genetic factors. In the last 20 years, important progress has been made...
Articles
Clin Sci (Lond) (2016) 130 (13): 1105–1114.
Published: 23 May 2016
...Kenneth Verboven; Dominique Hansen; Cedric Moro; Bert O. Eijnde; Nicole Hoebers; Joep Knol; Wim Bouckaert; Anne Dams; Ellen E. Blaak; Johan W.E. Jocken Catecholamines and atrial natriuretic peptide (ANP) are major regulators of adipocyte lipolysis. Although obesity is characterized by catecholamine...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2016) 130 (11): 843–852.
Published: 22 April 2016
...Dennis Dahlmans; Alexandre Houzelle; Patrick Schrauwen; Joris Hoeks The western dietary habits and sedentary lifestyle largely contributes to the growing epidemic of obesity. Mitochondria are at the front line of cellular energy homoeostasis and are implicated in the pathophysiology of obesity...
Articles
Clin Sci (Lond) (2015) 129 (12): 1025–1036.
Published: 18 September 2015
.... We conclude that microvascular insulin resistance is an early event in diet-induced obesity and insulin resistance and inflammation plays an essential role in this process. Our data suggest microvascular insulin resistance contributes to the development of metabolic insulin resistance in muscle...
Articles
Clin Sci (Lond) (2015) 129 (11): 933–949.
Published: 10 September 2015
... contributes to energy expenditure and glucose homoeostasis. Brown fat activation has thus emerged as an attractive therapeutic target for the treatment of obesity and the metabolic syndrome. In the present review, we integrate the recent advances on the metabolic role of BAT and its relation with other...
Articles
Clin Sci (Lond) (2015) 128 (12): 839–861.
Published: 27 March 2015
... 2015 © The Authors Journal compilation © 2015 Biochemical Society 2015 advanced glycation endproducts ageing glyoxalase methylglyoxal obesity type 2 diabetes mellitus The Maillard reaction is a process in which reducing sugars react spontaneously with amino residues in proteins...
Articles
Clin Sci (Lond) (2015) 128 (10): 715–721.
Published: 10 March 2015
... in mice has been reported to lead to obesity and impaired glucose homoeostasis. Genome-wide genomic and proteomic approaches have revealed that NUCKS is a chromatin regulator that affects transcription. The time is now ripe for further understanding of the role of this novel biomarker of cancer...
Articles
Clin Sci (Lond) (2015) 128 (8): 493–506.
Published: 23 January 2015
...-58) is an intracellular lipolytic activator. In the present study, we show that in mouse visceral fat-derived macrophages or human peripheral blood monocytes, CGI-58 negatively and interleukin (IL)-1β positively correlate with obesity. Saturated non-esterified fatty acid (NEFA) suppresses CGI-58...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2015) 128 (7): 405–410.
Published: 09 December 2014
...Roy Taylor; Rury R. Holman Type 2 diabetes (T2DM) is frequently regarded as a disease of obesity and its occurrence in individuals of normal body mass index (BMI) is often regarded as indicating a non-obesity-related subtype. However, the evidence for such a distinct, common subtype is lacking...
Articles
Clin Sci (Lond) (2015) 128 (6): 379–385.
Published: 02 December 2014
...Dick C. Chan; Annette T. Y. Wong; Jing Pang; P. Hugh R. Barrett; Gerald F. Watts Postprandial lipaemia, due to elevated plasma apolipoprotein (apo) B-48 concentrations, contributes to increased cardiovascular (CV) risk in obesity. Proprotein convertase subtilisin/kexin type 9 (PCSK9) and apoC-III...
Articles
Clin Sci (Lond) (2014) 127 (4): 209–216.
Published: 10 April 2014
... and increased age, the strongest risk factor is obesity. The aim of the present review is to focus on three cutting-edge topics with respect to OSA. The section on animal models covers various strategies used to simulate the physiology or the effects of OSA in animals, and how these have helped to understand...
Articles
Clin Sci (Lond) (2014) 127 (1): 33–45.
Published: 10 March 2014
...Marta Toral; Manuel Gómez-Guzmán; Rosario Jiménez; Miguel Romero; Manuel Sánchez; María Pilar Utrilla; Natividad Garrido-Mesa; María Elena Rodríguez-Cabezas; Mónica Olivares; Julio Gálvez; Juan Duarte Obesity is associated with intestine dysbiosis and is characterized by a low-grade inflammatory...
Includes: Supplementary data