1-50 of 197
Keywords: nitric oxide
Close
Follow your search
Access your saved searches in your account

Would you like to receive an alert when new items match your search?
Close Modal
Sort by
Articles
Clin Sci (Lond) (2021) 135 (20): 2341–2356.
Published: 18 October 2021
... adrenergic receptor density, G protein-coupled receptor kinase 2 (GRK2) and the putative role of nitric oxide (NO). Sepsis was induced in female mice by cecal ligation and puncture (CLP). Wildtype mice were treated with prazosin 12 h after CLP or nitric oxide synthase 2 (NOS-2) inhibitor, 30 min before and 6...
Articles
Articles
Articles
Articles
Clin Sci (Lond) (2019) 133 (23): 2401–2413.
Published: 04 December 2019
...) expression was abolished in the NTS of adult spontaneously hypertensive rats (SHRs). Endomorphin-2 was overexpressed in NTS of adult SHRs compared with that in 6-week-old Wistar-Kyoto rats (WKY). Administration of μOR agonist into the NTS of WKY increased blood pressure (BP), decreased nitric oxide...
Includes: Supplementary data
Articles
Articles
Articles
Clin Sci (Lond) (2016) 130 (7): 539–549.
Published: 17 February 2016
... after 20 weeks of gestation. However, the mechanisms leading to altered vascular reactivity remain unclear. We hypothesized that circulating factors lead to endothelial dysfunction by increasing oxidative stress and reducing nitric oxide (NO) and prostaglandin (PG) bioavailability. Pregnant rat uterine...
Articles
Articles
Articles
Articles
Articles
Clin Sci (Lond) (2014) 126 (6): 401–415.
Published: 15 November 2013
... be considered additional mechanisms by which statins lower cardiovascular risk. Correspondence: Dr John S. Floras (email john.floras@utoronto.ca ). 27 6 2013 27 8 2013 10 9 2013 © The Authors Journal compilation © 2014 Biochemical Society 2014 blood pressure nitric oxide...
Articles
Articles
Articles
Articles
Articles
Articles
Articles
Clin Sci (Lond) (2012) 123 (8): 499–507.
Published: 27 June 2012
... relaxation of PCAs (porcine coronary arteries). Inhibition of SIRT1 (sirtuin 1) by sirtinol partially reversed the effect of RWE on t BHP-induced senescence, whereas both the NOS (nitric oxide synthase) inhibitor L -NMMA ( N G -monomethyl- L -arginine) and the COX (cyclo-oxygenase) inhibitor indomethacin...
Articles
Articles
Articles
Clin Sci (Lond) (2012) 122 (6): 289–299.
Published: 22 November 2011
... nitric oxide oxidative stress Impaired oxidative phosphorylation is the hallmark of MDs (mitochondrial diseases), a heterogeneous group of prevalently genetic disorders, characterized by the uncoupling of electron transport and decreased ATP generation through the tricarboxylic acid cycle [ 1...
Includes: Supplementary data
Articles
Articles
Articles
Articles
Articles
Clin Sci (Lond) (2011) 121 (6): 253–255.
Published: 27 May 2011
... 2011 10 5 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 ischaemia/reperfusion ischaemic preconditioning liver nitric oxide reperfusion injury warm ischaemia Hepatic I/R (ischaemia/reperfusion) injury is an important clinical problem complicating liver...
Articles
Articles
Clin Sci (Lond) (2011) 120 (12): 525–536.
Published: 09 March 2011
... (end-stage renal disease) patients starting peritoneal dialysis and 30 matched controls were studied using isolated small artery bioassays. Flow-mediated dilatation was attenuated in ESRD patients compared with controls. NO (nitric oxide) contribution to flow was lacking in ESRD patients, but present...
Articles
Clin Sci (Lond) (2011) 120 (9): 357–375.
Published: 18 January 2011
...-dependent dilation) in response to chemical [typically ACh (acetylcholine)] or mechanical (intravascular shear) stimuli. Reduced bioavailability of the endothelium-synthesized dilating molecule NO (nitric oxide) as a result of oxidative stress is the key mechanism mediating reduced EDD with aging. Vascular...
Articles
Articles
Articles
Clin Sci (Lond) (2010) 118 (10): 633–640.
Published: 23 February 2010
... of endothelial denudation as a consequence of sheath placement. Radial artery flow-mediated and endothelium-derived NO (nitric oxide)-dependent function (FMD) was assessed within the region of sheath placement (sheath site) and also above the sheath (catheter site). GTN (glyceryl trinitrate) endothelium...
Articles
Articles
Articles
Articles
Clin Sci (Lond) (2009) 117 (8): 293–303.
Published: 24 August 2009
... -dimethylarginine (ADMA) chronic haemodialysis endothelium-dependent vasodilation end-stage renal disease nitric oxide skin blood flow Cardiovascular complications are the most important cause of mortality in ESRD (end-stage renal disease) patients [ 1 ]. In this population, one contributing factor...
Articles
Articles
Clin Sci (Lond) (2009) 117 (1): 23–30.
Published: 02 June 2009
... citrulline isotope nitric oxide septic shock Arginine is a dispensable amino acid in normal health, but may be conditionally essential in stressed states such as sepsis [ 1 ]. In addition to acting as a substrate for protein synthesis, arginine serves important physiological roles, including...
Articles
Clin Sci (Lond) (2009) 116 (9): 731–739.
Published: 02 April 2009
...@princehenrys.org ). 23 6 2008 2 9 2008 6 11 2008 6 11 2008 © The Authors Journal compilation © 2009 Biochemical Society 2009 cardiac fibrosis glucocorticoid inflammation mineralocorticoid nitric oxide oxidative stress The action of mineralocorticoids has long been...
Articles
Articles
Clin Sci (Lond) (2009) 116 (3): 219–230.
Published: 08 January 2009
... circulation microvascular circulation nitric oxide reactive oxygen species (ROS) tumour necrosis factor-α (TNF-α) IHD (ischaemic heart disease) accounts for over 500000 deaths annually in the United States. AMI (acute myocardial infarction), also known as a heart attack [ 1 ], is a common...
Articles
Articles
Articles
Articles
Articles
Clin Sci (Lond) (2007) 112 (2): 113–121.
Published: 11 December 2006
... permeability transition (MPT) nitric oxide adult rat cardiomyocyte Reperfusion therapy for acute myocardial infarction is known to reduce the infarct size, improve left ventricular function and reduce mortality. However, these beneficial effects are limited by acceleration of damage by reperfusion...
Articles
Articles
Clin Sci (Lond) (2006) 111 (2): 145–151.
Published: 13 July 2006
... and time course of inhibition, and (v) the effect on nitric oxide production. Aortic rings were incubated (1 h) with NEFA–albumin complexes derived from lauric (C 12:0 ), myristic (C 14:0 ), palmitic (C 16:0 ), stearic (C 18:0 ) and linolenic (C 18:3 ) acids. EDR induced by acetylcholine (0.1–10 μmol/l...