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Keywords: nitric oxideClose
Thiele Osvaldt Rosales, Verônica Vargas Horewicz, Marcella Amorim Ferreira, Geisson Marcos Nardi, Jamil Assreuy
Clin Sci (Lond) (2021) 135 (20): 2341–2356.
Published: 18 October 2021
... adrenergic receptor density, G protein-coupled receptor kinase 2 (GRK2) and the putative role of nitric oxide (NO). Sepsis was induced in female mice by cecal ligation and puncture (CLP). Wildtype mice were treated with prazosin 12 h after CLP or nitric oxide synthase 2 (NOS-2) inhibitor, 30 min before and 6...
Raquel González-Blázquez, Martín Alcalá, María S. Fernández-Alfonso, Ulrike Muscha Steckelings, M. Paz Lorenzo, Marta Viana, William A. Boisvert, Thomas Unger, Marta Gil-Ortega, Beatriz Somoza
Clin Sci (Lond) (2021) 135 (9): 1145–1163.
Published: 11 May 2021
... and prevents the development of obesity-induced endothelial dysfunction by stimulating NO release through PKA/p-eNOS and AKT/p-eNOS signaling pathways. Angiotensin II type 2 receptor Bradykinin type 2 receptor Compound 21 Diet-induced obesity Mas receptor Nitric oxide Obesity has reached...
Includes: Supplementary data
Beverly Giam, Haru Nomura, Sanjaya Kuruppu, Po-Yin Chu, Sumia Essid, Helen Kiriazis, Xiao-Jun Du, David M. Kaye, Niwanthi W. Rajapakse
Clin Sci (Lond) (2020) 134 (20): 2755–2769.
Published: 30 October 2020
... 2020 cardiorenal syndrome chronic kidney disease heart failure nitric oxide Patients with heart failure (HF) frequently develop secondary kidney impairment leading to a vicious cycle injurious to both the heart and the kidney. The presence of concomitant kidney impairment in the setting...
Paula K. Bautista-Niño, Eliana Portilla-Fernandez, Eloisa Rubio-Beltrán, Janette J. van der Linden, René de Vries, Richard van Veghel, Martine de Boer, Matej Durik, Yanto Ridwan, Renata Brandt, Jeroen Essers, Robert I. Menzies, Rachel Thomas, Alain de Bruin, Dirk J. Duncker, Heleen M.M. van Beusekom, Mohsen Ghanbari, Jan H.J. Hoeijmakers, Radislav Sedlacek, Rhian M. Touyz, Augusto C. Montezano, Ingrid van der Pluijm, A.H. Jan Danser, Kristian A. Haanes, Anton J.M. Roks
Clin Sci (Lond) (2020) 134 (7): 727–746.
Published: 07 April 2020
... responses measured in organ baths were decreased in aorta, iliac and coronary artery EC-KO compared with WT, of which coronary artery was the earliest to be affected. Nitric oxide-mediated endothelium-dependent vasodilation was abolished in aorta and coronary artery, whereas endothelium-derived...
Includes: Supplementary data
Gwo-Ching Sun, Tzyy-Yue Wong, Hsin-Hung Chen, Chiu-Yi Ho, Tung-Chen Yeh, Wen-Yu Ho, Ching-Jiunn Tseng, Pei-Wen Cheng
Clin Sci (Lond) (2019) 133 (23): 2401–2413.
Published: 04 December 2019
...) expression was abolished in the NTS of adult spontaneously hypertensive rats (SHRs). Endomorphin-2 was overexpressed in NTS of adult SHRs compared with that in 6-week-old Wistar-Kyoto rats (WKY). Administration of μOR agonist into the NTS of WKY increased blood pressure (BP), decreased nitric oxide...
Includes: Supplementary data
Clin Sci (Lond) (2019) 133 (20): 2061–2067.
Published: 18 October 2019
...Niwanthi W. Rajapakse; Beverly Giam; Sanjaya Kuruppu; Geoffrey A. Head; David M. Kaye The precise mechanisms underlying resistant hypertension remain elusive. Reduced nitric oxide (NO) bioavailability is frequently documented in chronic kidney disease, obesity, diabetes and advanced age, all...
Karen L. Andrews, Amanda K. Sampson, Jennifer C. Irvine, Waled A. Shihata, Danielle L. Michell, Natalie G. Lumsden, Chloe Lim, Olivier Huet, Grant R. Drummond, Barbara K. Kemp-Harper, Jaye P. F. Chin-Dusting
Clin Sci (Lond) (2016) 130 (18): 1629–1640.
Published: 08 August 2016
... inflammation and monocyte activation and as such may be an effective treatment for coronary artery disease. inflammation leucocyte adhesion nitrate tolerance nitric oxide nitroxyl To examine the anti-inflammatory potential of the nitroxyl donors AS or isopropylamine NONOate (IPA...
Cindy K. Kao, Jude S. Morton, Anita L. Quon, Laura M. Reyes, Patricio Lopez-Jaramillo, Sandra T. Davidge
Clin Sci (Lond) (2016) 130 (7): 539–549.
Published: 17 February 2016
... after 20 weeks of gestation. However, the mechanisms leading to altered vascular reactivity remain unclear. We hypothesized that circulating factors lead to endothelial dysfunction by increasing oxidative stress and reducing nitric oxide (NO) and prostaglandin (PG) bioavailability. Pregnant rat uterine...
Sylvain Recoquillon, Nunzia Carusio, Anne-Hélène Lagrue-Lakhal, Simon Tual-Chalot, Amelia Filippelli, Ramaroson Andriantsitohaina, M. Carmen Martinez
Clin Sci (Lond) (2015) 129 (8): 687–698.
Published: 22 July 2015
... and increases nitric oxide (NO) release via induction of inducible NO synthase (iNOS) within the vascular wall. Also, removal of endothelium prevented both NF-κB and iNOS expression in aortic rings. Among the proinflammatory factors released by LPS-treated endothelial cells, interleukin-6 accounts...
Includes: Supplementary data
Markus P. Schneider, Andreas Schneider, Agnes Jumar, Iris Kistner, Christian Ott, Roland E. Schmieder
Clin Sci (Lond) (2014) 127 (7): 499–505.
Published: 17 June 2014
... acid (FA) improves nitric oxide synthase (NOS) function and reduces progression of diabetic nephropathy in animal models. We tested whether high-dose FA treatment improves renal endothelial function and albuminuria in human subjects with incipient diabetic nephropathy. Following a double-blind...
Phablo Wendell C. Oliveira, Glauciene J. de Sousa, Izabela F. Caliman, Aline Z. Lamas, Ana Raquel Santos de Medeiros, Tadeu U. de Andrade, Glaucia R. de Abreu, Suely G. de Figueiredo, Nazaré S. Bissoli
Clin Sci (Lond) (2014) 127 (4): 265–275.
Published: 29 April 2014
... The pathophysiological changes observed in the mesenteric beds of ovariectomized rats were ameliorated by metformin. If this translates to humans, metformin could have additional benefits for post-menopausal women treated with this drug for glycaemic control. mesenteric bed metformin nitric oxide ovariectomy...
Fiorentina Roviezzo, Antonella De Angelis, Luana De Gruttola, Antonio Bertolino, Nikol Sullo, Vincenzo Brancaleone, Mariarosaria Bucci, Raffaele De Palma, Konrad Urbanek, Bruno D’Agostino, Angela Ianaro, Raffaella Sorrentino, Giuseppe Cirino
Clin Sci (Lond) (2014) 126 (8): 545–556.
Published: 20 December 2013
... have critical effects on morphogenesis and embryonic development of the vasculature as well as of the heart [ 2 ]. S1P has direct vasoactive effect both on isolated vessel and in vivo [ 7 , 9 ]. eNOS (endothelial nitric oxide synthase) activation is a common feature of the S1P response in vascular...
Clin Sci (Lond) (2014) 126 (6): 401–415.
Published: 15 November 2013
... administered lipophilic statins, data concerning hydrophilic statins are limited. blood pressure nitric oxide oxidative stress sympathetic nervous system statin Statins or HMG-CoA (3-hydroxy-3-methylglutaryl-CoA) reductase inhibitors act competitively on the mevalonate pathway to reduce...
Angélica Ruiz-Ramírez, Ely Ortiz-Balderas, Guillermo Cardozo-Saldaña, Eulises Diaz-Diaz, Mohammed El-Hafidi
Clin Sci (Lond) (2014) 126 (1): 19–29.
Published: 15 August 2013
...) in the SF rats. 25 3 2013 28 5 2013 6 6 2013 6 6 2013 © The Authors Journal compilation © 2014 Biochemical Society 2014 endothelial dysfunction glutathione nitric oxide obesity oxidative stress vascular complication • Attenuating oxidative stress could...
Carmine Savoia, Emanuele Arrabito, Rosa Parente, Lidia Sada, Luca Madaro, Carmine Nicoletti, Luigi Zezza, Alessandro Alonzo, Speranza Rubattu, Serena Michelini, Dominik N. Muller, Massimo Volpe
Clin Sci (Lond) (2013) 125 (4): 183–189.
Published: 01 May 2013
..., as described previously [ 15 ]. Correspondence: Professor Carmine Savoia (email email@example.com ). 30 7 2012 22 2 2013 26 2 2013 26 2 2013 © The Authors Journal compilation © 2013 Biochemical Society 2013 nitric oxide renin inhibition reactive oxygen species...
Hadj Ahmed Mostefai, Jean-Michel Bourget, Ferhat Meziani, Maria Carmen Martinez, Daniela Leonetti, Alain Mercat, Pierre Asfar, Lucie Germain, Ramaroson Andriantsitohaina
Clin Sci (Lond) (2013) 125 (2): 77–85.
Published: 26 March 2013
... Abdominal 5 Urinary tract 2 Soft and skin tissues 2 Unknown 1 Type of infection ( n ) Gram-positive 5 Gram-negative 5 Unknown 6 inflammation microparticle nitric oxide oxidative stress sepsis shock • Septic MPs may be protective in counteracting...
Clin Sci (Lond) (2013) 124 (12): 719–728.
Published: 26 February 2013
... nitric oxide sex hormone transglutaminase (TG) vascular remodelling vascular structure • Increasing evidence shows that sex hormones exert a protective effect on the vasculature, although the effect of these hormones on vascular remodelling is currently unclear. • In the present study...
Naohito Ishii, Pamela K. Carmines, Masanori Yokoba, Hiroyuki Imaizumi, Tsuyoshi Ichikawa, Hideki Ikenagasa, Yoshio Kodera, Masamichi Oh-Ishi, Yoshikazu Aoki, Tadakazu Maeda, Tsuneo Takenaka, Masato Katagiri
Clin Sci (Lond) (2013) 124 (8): 543–552.
Published: 08 January 2013
... ]. Our previous studies performed during the early stage of DM in the rat revealed that accelerated renal cortical O 2 − (superoxide anion) production promotes NO (nitric oxide) degradation via formation of the powerful toxic oxidant, ONOO − (O 2 − +NO→ONOO − ) and subsequent nitration of protein...
Clin Sci (Lond) (2012) 123 (8): 509–518.
Published: 29 June 2012
...@mednet.ucla.edu ). 12 8 2011 8 5 2012 8 5 2012 8 5 2012 © The Authors Journal compilation © 2012 Biochemical Society 2012 combinatorial therapy diethylstilbestrol (DES) LNCaP cell NADPH oxidase (NOX) nitric oxide reactive oxygen species superoxide anion xanthine oxidase...
Ilse P. G. Botden, Hisko Oeseburg, Matej Durik, Frank P. J. Leijten, Leonie C. Van Vark-Van Der Zee, Usha M. Musterd-Bhaggoe, Ingrid M. Garrelds, Ann L. B. Seynhaeve, Janneke G. Langendonk, Eric J. G. Sijbrands, A. H. Jan Danser, Anton J. M. Roks
Clin Sci (Lond) (2012) 123 (8): 499–507.
Published: 27 June 2012
... relaxation of PCAs (porcine coronary arteries). Inhibition of SIRT1 (sirtuin 1) by sirtinol partially reversed the effect of RWE on t BHP-induced senescence, whereas both the NOS (nitric oxide synthase) inhibitor L -NMMA ( N G -monomethyl- L -arginine) and the COX (cyclo-oxygenase) inhibitor indomethacin...
Clin Sci (Lond) (2012) 122 (7): 329–336.
Published: 07 December 2011
... by increasing expression of the erythropoietin receptor and by a mechanism likely to involve Akt/NO rather than circulating EPCs. © The Authors Journal compilation © 2012 Biochemical Society 2012 endothelial function endothelial progenitor cell erythropoietin ischaemia/reperfusion nitric oxide...
Esther Sastre, Gloria Balfagón, Elena Revuelta-López, Maria-Ángeles Aller, Maria-Paz Nava, Jaime Arias, Javier Blanco-Rivero
Clin Sci (Lond) (2012) 122 (7): 337–348.
Published: 07 December 2011
... portal vein ligation, and the mechanisms involved in these alterations, if any. For this purpose, we analysed the vasoconstrictor response to EFS (electrical field stimulation) and the effect of the α-antagonist phentolamine, the NOS (nitric oxide synthase) inhibitor L -NAME ( N G -nitro- L -arginine...
Pietro Minuz, Cristiano Fava, Gaetano Vattemi, Guido Arcaro, Matteo Riccadonna, Paola Tonin, Alessandra Meneguzzi, Maurizio Degan, Valeria Guglielmi, Alessandro Lechi, Giuliano Tomelleri
Clin Sci (Lond) (2012) 122 (6): 289–299.
Published: 22 November 2011
... nitric oxide oxidative stress Impaired oxidative phosphorylation is the hallmark of MDs (mitochondrial diseases), a heterogeneous group of prevalently genetic disorders, characterized by the uncoupling of electron transport and decreased ATP generation through the tricarboxylic acid cycle [ 1...
Includes: Supplementary data
Clin Sci (Lond) (2012) 122 (5): 239–251.
Published: 08 November 2011
... nitric oxide synthase), COX-2 (cyclooxygenase-2) and mPGES-1 (microsomal prostaglandin E synthase-1) induced by IL-1β. In contrast, the expression of HMGB1 (high-mobility group box 1) was not significantly modified. In addition, CoPP decreased the expression of iNOS and mPGES-1 in cells isolated from...
Includes: Supplementary data
Nicole Lüneburg, Rouven-Alexander von Holten, Rudolf F. Töpper, Edzard Schwedhelm, Renke Maas, Rainer H. Böger
Clin Sci (Lond) (2012) 122 (3): 105–111.
Published: 27 September 2011
...Nicole Lüneburg; Rouven-Alexander von Holten; Rudolf F. Töpper; Edzard Schwedhelm; Renke Maas; Rainer H. Böger Methylarginines have been shown to interfere with NO (nitric oxide) formation by inhibiting NOS (NO synthase)–ADMA (asymmetric dimethylarginine) and cellular L -arginine uptake...
Clin Sci (Lond) (2011) 121 (10): 449–458.
Published: 25 July 2011
...Luciana V. Rossoni; Mark Wareing; Camilla F. Wenceslau; Mahmood Al-Abri; Chris Cobb; Clare Austin Statins can have beneficial cholesterol-independent effects on vascular contractility, which may involve increases in the bioavailability of NO (nitric oxide) as a result of phosphorylation of eNOS...
Clin Sci (Lond) (2011) 121 (8): 331–341.
Published: 24 June 2011
... a spectrofluorimeter (LS50 PerkinElmer instrument with FL WINLAB software) with the excitation wavelength set at 492 nm and the emission wavelength at 515 nm. © The Authors Journal compilation © 2011 Biochemical Society 2011 electrical field stimulation HgCl 2 noradrenaline nitric oxide vascular...
Clin Sci (Lond) (2011) 121 (6): 253–255.
Published: 27 May 2011
... 2011 10 5 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 ischaemia/reperfusion ischaemic preconditioning liver nitric oxide reperfusion injury warm ischaemia Hepatic I/R (ischaemia/reperfusion) injury is an important clinical problem complicating liver...
Mahmoud Abu-Amara, Shi Yu Yang, Alberto Quaglia, Peter Rowley, Achala De Mel, Niteen Tapuria, Alexander Seifalian, Brian Davidson, Barry Fuller
Clin Sci (Lond) (2011) 121 (6): 257–266.
Published: 27 May 2011
...Mahmoud Abu-Amara; Shi Yu Yang; Alberto Quaglia; Peter Rowley; Achala De Mel; Niteen Tapuria; Alexander Seifalian; Brian Davidson; Barry Fuller NO (nitric oxide) may protect the liver from IR (ischaemia/reperfusion) injury. RIPC (remote ischaemic preconditioning) also protects against liver IR...
Natallia Luksha, Leanid Luksha, Juan Jesús Carrero, Folke Hammarqvist, Peter Stenvinkel, Karolina Kublickiene
Clin Sci (Lond) (2011) 120 (12): 525–536.
Published: 09 March 2011
... (end-stage renal disease) patients starting peritoneal dialysis and 30 matched controls were studied using isolated small artery bioassays. Flow-mediated dilatation was attenuated in ESRD patients compared with controls. NO (nitric oxide) contribution to flow was lacking in ESRD patients, but present...
Clin Sci (Lond) (2011) 120 (9): 357–375.
Published: 18 January 2011
...-dependent dilation) in response to chemical [typically ACh (acetylcholine)] or mechanical (intravascular shear) stimuli. Reduced bioavailability of the endothelium-synthesized dilating molecule NO (nitric oxide) as a result of oxidative stress is the key mechanism mediating reduced EDD with aging. Vascular...
Clin Sci (Lond) (2010) 119 (7): 283–292.
Published: 25 June 2010
...) nitric oxide prostaglandin I 2 thromboxane A 2 Cirrhosis is associated with a hyperdynamic circulatory syndrome characterized by high cardiac output, and reduced systemic vascular resistance and arterial pressure. Vascular resistance in circulatory districts other than the splanchnic system...
Kuei-Chuan Lee, Ying-Ying Yang, Yi-Tsau Huang, Fa-Yauh Lee, Ming-Chih Hou, Han-Chieh Lin, Shou-Dong Lee
Clin Sci (Lond) (2010) 119 (1): 45–55.
Published: 07 April 2010
... of Laboratory Animals prepared by the National Academy of Science, U.S.A. cirrhosis intrahepatic resistance microcirculation nitric oxide phosphodiesterase inhibitor tetrahydrobiopterin (BH 4 ) Portal hypertension is responsible for major complications of liver cirrhosis and leads...
Clin Sci (Lond) (2010) 118 (10): 633–640.
Published: 23 February 2010
... of endothelial denudation as a consequence of sheath placement. Radial artery flow-mediated and endothelium-derived NO (nitric oxide)-dependent function (FMD) was assessed within the region of sheath placement (sheath site) and also above the sheath (catheter site). GTN (glyceryl trinitrate) endothelium...
Paul K. Hamilton, Sinead M.T. Hughes, Richard D. Plumb, Adrian Devine, William Leahey, Kristopher S. Lyons, Dennis Johnston, Gary E. McVeigh
Clin Sci (Lond) (2010) 118 (5): 359–366.
Published: 01 December 2009
... by atorvastatin. GTPase hyperlipidaemia isoprenoid nitric oxide statin platelet superoxide radical Statins [HMG-CoA (3-hydroxy-3-methylglutaryl-CoA) reductase inhibitors] reduce cardiovascular mortality and morbidity [ 1 , 2 ]. The chief mechanism by which they produce benefit is by lowering LDL...
Philip Newsholme, Paulo I. Homem De Bittencourt, Jr, Ciara O' Hagan, Giuseppe De Vito, Colin Murphy, Mauricio S. Krause
Clin Sci (Lond) (2010) 118 (5): 341–349.
Published: 23 November 2009
... to the development of increased arterial stiffness and is enhanced in insulin-resistant states [ 16 ]. © The Authors Journal compilation © 2010 Biochemical Society 2010 diabetes endothelial vascular cell exercise nitric oxide pancreatic β-cell reactive oxygen species (ROS) The beneficial...
Clin Sci (Lond) (2009) 117 (10): 365–374.
Published: 07 September 2009
... to correct the protein expression in each sample. Correspondence: Dr Gloria Balfagón (email firstname.lastname@example.org ). 30 9 2008 3 2 2009 30 3 2009 30 3 2009 © The Authors Journal compilation © 2009 Biochemical Society 2009 acetylcholine aging nitric oxide...
Rolf P. Engelberger, Daniel Teta, Hughes Henry, Olivier De Senarclens, Benoît Dischl, Lucas Liaudet, Michel Burnier, Bernard Waeber, François Feihl
Clin Sci (Lond) (2009) 117 (8): 293–303.
Published: 24 August 2009
... ). 29 10 2008 13 2 2009 5 3 2009 5 3 2009 © The Authors Journal compilation © 2009 Biochemical Society 2009 asymmetric ω- N G , N G -dimethylarginine (ADMA) chronic haemodialysis endothelium-dependent vasodilation end-stage renal disease nitric oxide skin blood flow...
Clin Sci (Lond) (2009) 117 (8): 305–312.
Published: 24 August 2009
... Biochemical Society 2009 dexamethasone electrical field stimulation hypertension glucocorticoid nitric oxide protein kinase C Glucocorticoid hormones play an important role in the control of vascular smooth muscle tone by acting on both endothelial and vascular smooth muscle cells through...
Christina C. Kao, Venkata Bandi, Kalpalatha K. Guntupalli, Manhong Wu, Leticia Castillo, Farook Jahoor
Clin Sci (Lond) (2009) 117 (1): 23–30.
Published: 02 June 2009
... Biochemical Society 2009 arginine citrulline isotope nitric oxide septic shock Arginine is a dispensable amino acid in normal health, but may be conditionally essential in stressed states such as sepsis [ 1 ]. In addition to acting as a substrate for protein synthesis, arginine serves...
Clin Sci (Lond) (2009) 116 (9): 731–739.
Published: 02 April 2009
... 2 9 2008 6 11 2008 6 11 2008 © The Authors Journal compilation © 2009 Biochemical Society 2009 cardiac fibrosis glucocorticoid inflammation mineralocorticoid nitric oxide oxidative stress The action of mineralocorticoids has long been considered to be primarily...
Clin Sci (Lond) (2009) 116 (5): 433–441.
Published: 02 February 2009
... A. Physical activity prevents age-related impairment in nitric oxide availability in elderly athletes Circulation 2000 101 2896 2901 8 Green D. J. Maiorana A. O'Driscoll G. Taylor R. Effect of exercise training on endothelium-derived nitric oxide function in humans J. Physiol...
Hanrui Zhang, Yoonjung Park, Junxi Wu, Xiu ping Chen, Sewon Lee, Jiyeon Yang, Kevin C. Dellsperger, Cuihua Zhang
Clin Sci (Lond) (2009) 116 (3): 219–230.
Published: 08 January 2009
... circulation microvascular circulation nitric oxide reactive oxygen species (ROS) tumour necrosis factor-α (TNF-α) IHD (ischaemic heart disease) accounts for over 500000 deaths annually in the United States. AMI (acute myocardial infarction), also known as a heart attack [ 1 ], is a common...
Antonia Alcaraz, David Hernández, David Iyú, Rubén Mota, Noemí M. Atucha, Antonio J. Ortiz, Joaquín García-Estañ, María C. Ortiz
Clin Sci (Lond) (2008) 115 (2): 57–68.
Published: 12 June 2008
... 2007 19 12 2007 9 1 2008 9 1 2008 © The Authors Journal compilation © 2008 Biochemical Society 2008 biliary cirrhosis kidney nitric oxide nitrotyrosine oxidative stress peroxynitrite Increased NO production contributes to the renal excretory and vascular...
José M. González, Beatriz Somoza, M. Victoria Conde, Maria S. Fernández-Alfonso, M. Carmen González, Silvia M. Arribas
Clin Sci (Lond) (2008) 114 (10): 651–659.
Published: 14 April 2008
.... Correspondence: Dr Silvia M. Arribas (email email@example.com ). 12 10 2007 27 11 2007 19 12 2007 19 12 2007 © The Authors Journal compilation © 2008 Biochemical Society 2008 mesenteric resistance artery middle cerebral artery nitric oxide spontaneously hypertensive rat...
Clin Sci (Lond) (2008) 114 (2): 109–118.
Published: 11 December 2007
... nephropathy glomerular filtration rate hyperfiltration nitric oxide rodent model In T1DM, hyperfiltration appears to be absent early in the disease in approx. 30% of patients [ 13 ], whereas, in T2DM, hyperfiltration is probably absent in approx. 50% of patients [ 14 ]. Does the presence...
Yvonne L. J. Vissers, Maarten F. von Meyenfeldt, Yvette C. Luiking, Cornelis H. C. Dejong, Wim A. Buurman, Nicolaas E. P. Deutz
Clin Sci (Lond) (2007) 112 (10): 527–532.
Published: 12 April 2007
... with an attenuated acute-phase response. This indicates that altered arginine metabolism may be an important characteristic of the metabolic changes in cancer. amino acid arginine cancer metabolism nitric oxide stable isotope surgery We have described recently [ 1 ] that patients with malignant...
Clin Sci (Lond) (2007) 112 (2): 113–121.
Published: 11 December 2006
... relative to the total number of cells. In each experiment, the mean values of 40 cells were taken. apoptosis cytochrome c release hypoxia/re-oxygenation mitochondrial cGMP mitochondrial permeability transition (MPT) nitric oxide adult rat cardiomyocyte Reperfusion therapy for acute...
Anna R. Dover, Stanley Chia, James W. Ferguson, Nicholas L. Cruden, Ian L. Megson, Keith A. A. Fox, David E. Newby
Clin Sci (Lond) (2006) 111 (4): 275–280.
Published: 13 September 2006
...Anna R. Dover; Stanley Chia; James W. Ferguson; Nicholas L. Cruden; Ian L. Megson; Keith A. A. Fox; David E. Newby Enhanced iNOS (inducible nitric oxide synthase) activity may contribute to vascular dysfunction in patients with heart failure. In the present study, we aimed to determine whether iNOS...
Clin Sci (Lond) (2006) 111 (2): 145–151.
Published: 13 July 2006
... and time course of inhibition, and (v) the effect on nitric oxide production. Aortic rings were incubated (1 h) with NEFA–albumin complexes derived from lauric (C 12:0 ), myristic (C 14:0 ), palmitic (C 16:0 ), stearic (C 18:0 ) and linolenic (C 18:3 ) acids. EDR induced by acetylcholine (0.1–10 μmol/l...