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Keywords: nitric oxide
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Clin Sci (Lond) (2021) 135 (20): 2341–2356.
Published: 18 October 2021
... adrenergic receptor density, G protein-coupled receptor kinase 2 (GRK2) and the putative role of nitric oxide (NO). Sepsis was induced in female mice by cecal ligation and puncture (CLP). Wildtype mice were treated with prazosin 12 h after CLP or nitric oxide synthase 2 (NOS-2) inhibitor, 30 min before and 6...
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Clin Sci (Lond) (2019) 133 (23): 2401–2413.
Published: 04 December 2019
...) expression was abolished in the NTS of adult spontaneously hypertensive rats (SHRs). Endomorphin-2 was overexpressed in NTS of adult SHRs compared with that in 6-week-old Wistar-Kyoto rats (WKY). Administration of μOR agonist into the NTS of WKY increased blood pressure (BP), decreased nitric oxide...
Includes: Supplementary data
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Clin Sci (Lond) (2016) 130 (7): 539–549.
Published: 17 February 2016
... after 20 weeks of gestation. However, the mechanisms leading to altered vascular reactivity remain unclear. We hypothesized that circulating factors lead to endothelial dysfunction by increasing oxidative stress and reducing nitric oxide (NO) and prostaglandin (PG) bioavailability. Pregnant rat uterine...
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Clin Sci (Lond) (2014) 127 (7): 499–505.
Published: 17 June 2014
... acid (FA) improves nitric oxide synthase (NOS) function and reduces progression of diabetic nephropathy in animal models. We tested whether high-dose FA treatment improves renal endothelial function and albuminuria in human subjects with incipient diabetic nephropathy. Following a double-blind...
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Clin Sci (Lond) (2014) 127 (4): 265–275.
Published: 29 April 2014
... The pathophysiological changes observed in the mesenteric beds of ovariectomized rats were ameliorated by metformin. If this translates to humans, metformin could have additional benefits for post-menopausal women treated with this drug for glycaemic control. mesenteric bed metformin nitric oxide ovariectomy...
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Clin Sci (Lond) (2014) 126 (6): 401–415.
Published: 15 November 2013
... administered lipophilic statins, data concerning hydrophilic statins are limited. blood pressure nitric oxide oxidative stress sympathetic nervous system statin Statins or HMG-CoA (3-hydroxy-3-methylglutaryl-CoA) reductase inhibitors act competitively on the mevalonate pathway to reduce...
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Clin Sci (Lond) (2013) 124 (12): 719–728.
Published: 26 February 2013
... nitric oxide sex hormone transglutaminase (TG) vascular remodelling vascular structure • Increasing evidence shows that sex hormones exert a protective effect on the vasculature, although the effect of these hormones on vascular remodelling is currently unclear. • In the present study...
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Clin Sci (Lond) (2012) 123 (8): 499–507.
Published: 27 June 2012
... relaxation of PCAs (porcine coronary arteries). Inhibition of SIRT1 (sirtuin 1) by sirtinol partially reversed the effect of RWE on t BHP-induced senescence, whereas both the NOS (nitric oxide synthase) inhibitor L -NMMA ( N G -monomethyl- L -arginine) and the COX (cyclo-oxygenase) inhibitor indomethacin...
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Clin Sci (Lond) (2012) 122 (6): 289–299.
Published: 22 November 2011
... nitric oxide oxidative stress Impaired oxidative phosphorylation is the hallmark of MDs (mitochondrial diseases), a heterogeneous group of prevalently genetic disorders, characterized by the uncoupling of electron transport and decreased ATP generation through the tricarboxylic acid cycle [ 1...
Includes: Supplementary data
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Clin Sci (Lond) (2011) 121 (6): 253–255.
Published: 27 May 2011
... 2011 10 5 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 ischaemia/reperfusion ischaemic preconditioning liver nitric oxide reperfusion injury warm ischaemia Hepatic I/R (ischaemia/reperfusion) injury is an important clinical problem complicating liver...
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Clin Sci (Lond) (2011) 120 (12): 525–536.
Published: 09 March 2011
... (end-stage renal disease) patients starting peritoneal dialysis and 30 matched controls were studied using isolated small artery bioassays. Flow-mediated dilatation was attenuated in ESRD patients compared with controls. NO (nitric oxide) contribution to flow was lacking in ESRD patients, but present...
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Clin Sci (Lond) (2011) 120 (9): 357–375.
Published: 18 January 2011
...-dependent dilation) in response to chemical [typically ACh (acetylcholine)] or mechanical (intravascular shear) stimuli. Reduced bioavailability of the endothelium-synthesized dilating molecule NO (nitric oxide) as a result of oxidative stress is the key mechanism mediating reduced EDD with aging. Vascular...
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Clin Sci (Lond) (2010) 118 (10): 633–640.
Published: 23 February 2010
... of endothelial denudation as a consequence of sheath placement. Radial artery flow-mediated and endothelium-derived NO (nitric oxide)-dependent function (FMD) was assessed within the region of sheath placement (sheath site) and also above the sheath (catheter site). GTN (glyceryl trinitrate) endothelium...
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Clin Sci (Lond) (2009) 117 (1): 23–30.
Published: 02 June 2009
... Biochemical Society 2009 arginine citrulline isotope nitric oxide septic shock Arginine is a dispensable amino acid in normal health, but may be conditionally essential in stressed states such as sepsis [ 1 ]. In addition to acting as a substrate for protein synthesis, arginine serves...
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Clin Sci (Lond) (2009) 116 (9): 731–739.
Published: 02 April 2009
... 2 9 2008 6 11 2008 6 11 2008 © The Authors Journal compilation © 2009 Biochemical Society 2009 cardiac fibrosis glucocorticoid inflammation mineralocorticoid nitric oxide oxidative stress The action of mineralocorticoids has long been considered to be primarily...
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Clin Sci (Lond) (2009) 116 (3): 219–230.
Published: 08 January 2009
... circulation microvascular circulation nitric oxide reactive oxygen species (ROS) tumour necrosis factor-α (TNF-α) IHD (ischaemic heart disease) accounts for over 500000 deaths annually in the United States. AMI (acute myocardial infarction), also known as a heart attack [ 1 ], is a common...
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Clin Sci (Lond) (2007) 112 (10): 527–532.
Published: 12 April 2007
... with an attenuated acute-phase response. This indicates that altered arginine metabolism may be an important characteristic of the metabolic changes in cancer. amino acid arginine cancer metabolism nitric oxide stable isotope surgery We have described recently [ 1 ] that patients with malignant...
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Clin Sci (Lond) (2007) 112 (2): 113–121.
Published: 11 December 2006
... relative to the total number of cells. In each experiment, the mean values of 40 cells were taken. apoptosis cytochrome c release hypoxia/re-oxygenation mitochondrial cGMP mitochondrial permeability transition (MPT) nitric oxide adult rat cardiomyocyte Reperfusion therapy for acute...
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Clin Sci (Lond) (2006) 111 (2): 145–151.
Published: 13 July 2006
... and time course of inhibition, and (v) the effect on nitric oxide production. Aortic rings were incubated (1 h) with NEFA–albumin complexes derived from lauric (C 12:0 ), myristic (C 14:0 ), palmitic (C 16:0 ), stearic (C 18:0 ) and linolenic (C 18:3 ) acids. EDR induced by acetylcholine (0.1–10 μmol/l...