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Dynamics of GRK2 in the kidney: a putative mechanism for sepsis-associated kidney injury

Thiele Osvaldt Rosales, Verônica Vargas Horewicz, Marcella Amorim Ferreira, Geisson Marcos Nardi, Jamil Assreuy

Clin Sci (Lond) (2021) 135 (20): 2341–2356.

https://doi.org/10.1042/CS20210462

Published: 18 October 2021

... adrenergic receptor density, G protein-coupled receptor kinase 2 (GRK2) and the putative role of nitric oxide (NO). Sepsis was induced in female mice by cecal ligation and puncture (CLP). Wildtype mice were treated with prazosin 12 h after CLP or nitric oxide synthase 2 (NOS-2) inhibitor, 30 min before and 6...

View article titled, Dynamics of GRK2 in the kidney: a putative mechanism for sepsis-associated kidney injury

Articles

C21 preserves endothelial function in the thoracic aorta from DIO mice: role for AT 2 , Mas and B 2 receptors

Raquel González-Blázquez, Martín Alcalá, María S. Fernández-Alfonso, Ulrike Muscha Steckelings, M. Paz Lorenzo, Marta Viana, William A. Boisvert, Thomas Unger, Marta Gil-Ortega, Beatriz Somoza

Clin Sci (Lond) (2021) 135 (9): 1145–1163.

https://doi.org/10.1042/CS20210049

Published: 11 May 2021

... and prevents the development of obesity-induced endothelial dysfunction by stimulating NO release through PKA/p-eNOS and AKT/p-eNOS signaling pathways. Angiotensin II type 2 receptor Bradykinin type 2 receptor Compound 21 Diet-induced obesity Mas receptor Nitric oxide Obesity has reached...

View article titled, C21 preserves endothelial function in the thoracic aorta from DIO mice: role for AT 2 , Mas and B 2 receptors

Includes: Supplementary data

Articles

Endothelial-specific overexpression of cationic amino acid transporter-1 prevents loss of kidney function in heart failure

Beverly Giam, Haru Nomura, Sanjaya Kuruppu, Po-Yin Chu, Sumia Essid, Helen Kiriazis, Xiao-Jun Du, David M. Kaye, Niwanthi W. Rajapakse

Clin Sci (Lond) (2020) 134 (20): 2755–2769.

https://doi.org/10.1042/CS20200087

Published: 30 October 2020

... 2020 cardiorenal syndrome chronic kidney disease heart failure nitric oxide Patients with heart failure (HF) frequently develop secondary kidney impairment leading to a vicious cycle injurious to both the heart and the kidney. The presence of concomitant kidney impairment in the setting...

View article titled, Endothelial-specific overexpression of cationic amino acid transporter-1 prevents loss of kidney function in heart failure

Articles

Local endothelial DNA repair deficiency causes aging-resembling endothelial-specific dysfunction

Clin Sci (Lond) (2020) 134 (7): 727–746.

https://doi.org/10.1042/CS20190124

Published: 07 April 2020

... responses measured in organ baths were decreased in aorta, iliac and coronary artery EC-KO compared with WT, of which coronary artery was the earliest to be affected. Nitric oxide-mediated endothelium-dependent vasodilation was abolished in aorta and coronary artery, whereas endothelium-derived...

View article titled, Local endothelial DNA repair deficiency causes aging-resembling endothelial-specific dysfunction

Includes: Supplementary data

Articles

Angiotensin II inhibits DDAH1–nNOS signaling via AT1R and μOR dimerization to modulate blood pressure control in the central nervous system

Gwo-Ching Sun, Tzyy-Yue Wong, Hsin-Hung Chen, Chiu-Yi Ho, Tung-Chen Yeh, Wen-Yu Ho, Ching-Jiunn Tseng, Pei-Wen Cheng

Clin Sci (Lond) (2019) 133 (23): 2401–2413.

https://doi.org/10.1042/CS20191005

Published: 04 December 2019

...) expression was abolished in the NTS of adult spontaneously hypertensive rats (SHRs). Endomorphin-2 was overexpressed in NTS of adult SHRs compared with that in 6-week-old Wistar-Kyoto rats (WKY). Administration of μOR agonist into the NTS of WKY increased blood pressure (BP), decreased nitric oxide...

View article titled, Angiotensin II inhibits DDAH1–nNOS signaling via AT1R and μOR dimerization to modulate blood pressure control in the central nervous system

Includes: Supplementary data

Articles

Impaired l-arginine-nitric oxide pathway contributes to the pathogenesis of resistant hypertension

Niwanthi W. Rajapakse, Beverly Giam, Sanjaya Kuruppu, Geoffrey A. Head, David M. Kaye

Clin Sci (Lond) (2019) 133 (20): 2061–2067.

https://doi.org/10.1042/CS20190851

Published: 18 October 2019

...Niwanthi W. Rajapakse; Beverly Giam; Sanjaya Kuruppu; Geoffrey A. Head; David M. Kaye The precise mechanisms underlying resistant hypertension remain elusive. Reduced nitric oxide (NO) bioavailability is frequently documented in chronic kidney disease, obesity, diabetes and advanced age, all...

View article titled, Impaired l-arginine-nitric oxide pathway contributes to the pathogenesis of resistant hypertension

Articles

Nitroxyl (HNO) reduces endothelial and monocyte activation and promotes M2 macrophage polarization

Karen L. Andrews, Amanda K. Sampson, Jennifer C. Irvine, Waled A. Shihata, Danielle L. Michell, Natalie G. Lumsden, Chloe Lim, Olivier Huet, Grant R. Drummond, Barbara K. Kemp-Harper, Jaye P. F. Chin-Dusting

Clin Sci (Lond) (2016) 130 (18): 1629–1640.

https://doi.org/10.1042/CS20160097

Published: 08 August 2016

... inflammation and monocyte activation and as such may be an effective treatment for coronary artery disease. inflammation leucocyte adhesion nitrate tolerance nitric oxide nitroxyl To examine the anti-inflammatory potential of the nitroxyl donors AS or isopropylamine NONOate (IPA...

View article titled, Nitroxyl (HNO) reduces endothelial and monocyte activation and promotes M2 macrophage polarization

Articles

Mechanism of vascular dysfunction due to circulating factors in women with pre-eclampsia

Cindy K. Kao, Jude S. Morton, Anita L. Quon, Laura M. Reyes, Patricio Lopez-Jaramillo, Sandra T. Davidge

Clin Sci (Lond) (2016) 130 (7): 539–549.

https://doi.org/10.1042/CS20150678

Published: 17 February 2016

... after 20 weeks of gestation. However, the mechanisms leading to altered vascular reactivity remain unclear. We hypothesized that circulating factors lead to endothelial dysfunction by increasing oxidative stress and reducing nitric oxide (NO) and prostaglandin (PG) bioavailability. Pregnant rat uterine...

View article titled, Mechanism of vascular dysfunction due to circulating factors in women with pre-eclampsia

Articles

Interaction in endothelium of non-muscular myosin light-chain kinase and the NF-κB pathway is critical to lipopolysaccharide-induced vascular hyporeactivity

Sylvain Recoquillon, Nunzia Carusio, Anne-Hélène Lagrue-Lakhal, Simon Tual-Chalot, Amelia Filippelli, Ramaroson Andriantsitohaina, M. Carmen Martinez

Clin Sci (Lond) (2015) 129 (8): 687–698.

https://doi.org/10.1042/CS20140625

Published: 22 July 2015

... and increases nitric oxide (NO) release via induction of inducible NO synthase (iNOS) within the vascular wall. Also, removal of endothelium prevented both NF-κB and iNOS expression in aortic rings. Among the proinflammatory factors released by LPS-treated endothelial cells, interleukin-6 accounts...

View article titled, Interaction in endothelium of non-muscular myosin light-chain kinase and the NF-κB pathway is critical to lipopolysaccharide-induced vascular hyporeactivity

Includes: Supplementary data

Articles

Effects of folic acid on renal endothelial function in patients with diabetic nephropathy: results from a randomized trial

Markus P. Schneider, Andreas Schneider, Agnes Jumar, Iris Kistner, Christian Ott, Roland E. Schmieder

Clin Sci (Lond) (2014) 127 (7): 499–505.

https://doi.org/10.1042/CS20140111

Published: 17 June 2014

... acid (FA) improves nitric oxide synthase (NOS) function and reduces progression of diabetic nephropathy in animal models. We tested whether high-dose FA treatment improves renal endothelial function and albuminuria in human subjects with incipient diabetic nephropathy. Following a double-blind...

View article titled, Effects of folic acid on renal endothelial function in patients with diabetic nephropathy: results from a randomized trial

Articles

Metformin ameliorates ovariectomy-induced vascular dysfunction in non-diabetic Wistar rats

Phablo Wendell C. Oliveira, Glauciene J. de Sousa, Izabela F. Caliman, Aline Z. Lamas, Ana Raquel Santos de Medeiros, Tadeu U. de Andrade, Glaucia R. de Abreu, Suely G. de Figueiredo, Nazaré S. Bissoli

Clin Sci (Lond) (2014) 127 (4): 265–275.

https://doi.org/10.1042/CS20130553

Published: 29 April 2014

... The pathophysiological changes observed in the mesenteric beds of ovariectomized rats were ameliorated by metformin. If this translates to humans, metformin could have additional benefits for post-menopausal women treated with this drug for glycaemic control. mesenteric bed metformin nitric oxide ovariectomy...

View article titled, Metformin ameliorates ovariectomy-induced vascular dysfunction in non-diabetic Wistar rats

Articles

Involvement of proteinase activated receptor-2in the vascular response to sphingosine 1-phosphate

Fiorentina Roviezzo, Antonella De Angelis, Luana De Gruttola, Antonio Bertolino, Nikol Sullo, Vincenzo Brancaleone, Mariarosaria Bucci, Raffaele De Palma, Konrad Urbanek, Bruno D’Agostino, Angela Ianaro, Raffaella Sorrentino, Giuseppe Cirino

Clin Sci (Lond) (2014) 126 (8): 545–556.

https://doi.org/10.1042/CS20130272

Published: 20 December 2013

... have critical effects on morphogenesis and embryonic development of the vasculature as well as of the heart [ 2 ]. S1P has direct vasoactive effect both on isolated vessel and in vivo [ 7 , 9 ]. eNOS (endothelial nitric oxide synthase) activation is a common feature of the S1P response in vascular...

View article titled, Involvement of proteinase activated receptor-2in the vascular response to sphingosine 1-phosphate

Articles

Statins and the autonomic nervous system

Philip J. Millar, John S. Floras

Clin Sci (Lond) (2014) 126 (6): 401–415.

https://doi.org/10.1042/CS20130332

Published: 15 November 2013

... administered lipophilic statins, data concerning hydrophilic statins are limited. blood pressure nitric oxide oxidative stress sympathetic nervous system statin Statins or HMG-CoA (3-hydroxy-3-methylglutaryl-CoA) reductase inhibitors act competitively on the mevalonate pathway to reduce...

View article titled, Statins and the autonomic nervous system

Articles

Glycine restores glutathione and protects against oxidative stress in vascular tissue from sucrose-fed rats

Angélica Ruiz-Ramírez, Ely Ortiz-Balderas, Guillermo Cardozo-Saldaña, Eulises Diaz-Diaz, Mohammed El-Hafidi

Clin Sci (Lond) (2014) 126 (1): 19–29.

https://doi.org/10.1042/CS20130164

Published: 15 August 2013

...) in the SF rats. 25 3 2013 28 5 2013 6 6 2013 6 6 2013 © The Authors Journal compilation © 2014 Biochemical Society 2014 endothelial dysfunction glutathione nitric oxide obesity oxidative stress vascular complication • Attenuating oxidative stress could...

View article titled, Glycine restores glutathione and protects against oxidative stress in vascular tissue from sucrose-fed rats

Articles

The direct renin inhibitor aliskiren improves vascular remodelling in transgenic rats harbouring human renin and angiotensinogen genes

Carmine Savoia, Emanuele Arrabito, Rosa Parente, Lidia Sada, Luca Madaro, Carmine Nicoletti, Luigi Zezza, Alessandro Alonzo, Speranza Rubattu, Serena Michelini, Dominik N. Muller, Massimo Volpe

Clin Sci (Lond) (2013) 125 (4): 183–189.

https://doi.org/10.1042/CS20120395

Published: 01 May 2013

..., as described previously [ 15 ]. Correspondence: Professor Carmine Savoia (email savoiac@yahoo.it ). 30 7 2012 22 2 2013 26 2 2013 26 2 2013 © The Authors Journal compilation © 2013 Biochemical Society 2013 nitric oxide renin inhibition reactive oxygen species...

View article titled, The direct renin inhibitor aliskiren improves vascular remodelling in transgenic rats harbouring human renin and angiotensinogen genes

Articles

Interleukin-10 controls the protective effects of circulating microparticles from patients with septic shock on tissue-engineered vascular media

Hadj Ahmed Mostefai, Jean-Michel Bourget, Ferhat Meziani, Maria Carmen Martinez, Daniela Leonetti, Alain Mercat, Pierre Asfar, Lucie Germain, Ramaroson Andriantsitohaina

Clin Sci (Lond) (2013) 125 (2): 77–85.

https://doi.org/10.1042/CS20120441

Published: 26 March 2013

... Abdominal 5 Urinary tract 2 Soft and skin tissues 2 Unknown 1 Type of infection ( n ) Gram-positive 5 Gram-negative 5 Unknown 6 inflammation microparticle nitric oxide oxidative stress sepsis shock • Septic MPs may be protective in counteracting...

View article titled, Interleukin-10 controls the protective effects of circulating microparticles from patients with septic shock on tissue-engineered vascular media

Articles

Testosterone and β-oestradiol prevent inward remodelling of rat small mesenteric arteries: role of NO and transglutaminase

Lara del Campo, Bilge Guvenc Tuna, Mercedes Ferrer, Ed van Bavel, Erik N.T.P. Bakker

Clin Sci (Lond) (2013) 124 (12): 719–728.

https://doi.org/10.1042/CS20120700

Published: 26 February 2013

... nitric oxide sex hormone transglutaminase (TG) vascular remodelling vascular structure • Increasing evidence shows that sex hormones exert a protective effect on the vasculature, although the effect of these hormones on vascular remodelling is currently unclear. • In the present study...

View article titled, Testosterone and β-oestradiol prevent inward remodelling of rat small mesenteric arteries: role of NO and transglutaminase

Articles

Angiotensin-converting enzyme inhibition curbs tyrosine nitration of mitochondrial proteins in the renal cortex during the early stage of diabetes mellitus in rats

Naohito Ishii, Pamela K. Carmines, Masanori Yokoba, Hiroyuki Imaizumi, Tsuyoshi Ichikawa, Hideki Ikenagasa, Yoshio Kodera, Masamichi Oh-Ishi, Yoshikazu Aoki, Tadakazu Maeda, Tsuneo Takenaka, Masato Katagiri

Clin Sci (Lond) (2013) 124 (8): 543–552.

https://doi.org/10.1042/CS20120251

Published: 08 January 2013

... ]. Our previous studies performed during the early stage of DM in the rat revealed that accelerated renal cortical O 2 − (superoxide anion) production promotes NO (nitric oxide) degradation via formation of the powerful toxic oxidant, ONOO − (O 2 − +NO→ONOO − ) and subsequent nitration of protein...

View article titled, Angiotensin-converting enzyme inhibition curbs tyrosine nitration of mitochondrial proteins in the renal cortex during the early stage of diabetes mellitus in rats

Articles

Inhibition of XO or NOX attenuates diethylstilbestrol-induced endothelial nitric oxide deficiency without affecting its effects on LNCaP cell invasion and apoptosis

Ji-Youn Youn, Andrew Nguyen, Hua Cai

Clin Sci (Lond) (2012) 123 (8): 509–518.

https://doi.org/10.1042/CS20110407

Published: 29 June 2012

...@mednet.ucla.edu ). 12 8 2011 8 5 2012 8 5 2012 8 5 2012 © The Authors Journal compilation © 2012 Biochemical Society 2012 combinatorial therapy diethylstilbestrol (DES) LNCaP cell NADPH oxidase (NOX) nitric oxide reactive oxygen species superoxide anion xanthine oxidase...

View article titled, Inhibition of XO or NOX attenuates diethylstilbestrol-induced endothelial nitric oxide deficiency without affecting its effects on LNCaP cell invasion and apoptosis

Articles

Red wine extract protects against oxidative-stress-induced endothelial senescence

Ilse P. G. Botden, Hisko Oeseburg, Matej Durik, Frank P. J. Leijten, Leonie C. Van Vark-Van Der Zee, Usha M. Musterd-Bhaggoe, Ingrid M. Garrelds, Ann L. B. Seynhaeve, Janneke G. Langendonk, Eric J. G. Sijbrands, A. H. Jan Danser, Anton J. M. Roks

Clin Sci (Lond) (2012) 123 (8): 499–507.

https://doi.org/10.1042/CS20110679

Published: 27 June 2012

... relaxation of PCAs (porcine coronary arteries). Inhibition of SIRT1 (sirtuin 1) by sirtinol partially reversed the effect of RWE on t BHP-induced senescence, whereas both the NOS (nitric oxide synthase) inhibitor L -NMMA ( N G -monomethyl- L -arginine) and the COX (cyclo-oxygenase) inhibitor indomethacin...

View article titled, Red wine extract protects against oxidative-stress-induced endothelial senescence

Articles

Darbepoetin enhances endothelium-dependent vasomotor function in patients with stable coronary artery disease only after preceding ischaemia/reperfusion

Lindsey Tilling, Joanne Hunt, Ann Donald, Brian Clapp, Phil Chowienczyk

Clin Sci (Lond) (2012) 122 (7): 329–336.

https://doi.org/10.1042/CS20110369

Published: 07 December 2011

... by increasing expression of the erythropoietin receptor and by a mechanism likely to involve Akt/NO rather than circulating EPCs. © The Authors Journal compilation © 2012 Biochemical Society 2012 endothelial function endothelial progenitor cell erythropoietin ischaemia/reperfusion nitric oxide...

View article titled, Darbepoetin enhances endothelium-dependent vasomotor function in patients with stable coronary artery disease only after preceding ischaemia/reperfusion

Articles

Effect of short- and long-term portal hypertension on adrenergic, nitrergic and sensory functioning in rat mesenteric artery

Esther Sastre, Gloria Balfagón, Elena Revuelta-López, Maria-Ángeles Aller, Maria-Paz Nava, Jaime Arias, Javier Blanco-Rivero

Clin Sci (Lond) (2012) 122 (7): 337–348.

https://doi.org/10.1042/CS20110303

Published: 07 December 2011

... portal vein ligation, and the mechanisms involved in these alterations, if any. For this purpose, we analysed the vasoconstrictor response to EFS (electrical field stimulation) and the effect of the α-antagonist phentolamine, the NOS (nitric oxide synthase) inhibitor L -NAME ( N G -nitro- L -arginine...

View article titled, Effect of short- and long-term portal hypertension on adrenergic, nitrergic and sensory functioning in rat mesenteric artery

Articles

Endothelial dysfunction and increased oxidative stress in mitochondrial diseases

Pietro Minuz, Cristiano Fava, Gaetano Vattemi, Guido Arcaro, Matteo Riccadonna, Paola Tonin, Alessandra Meneguzzi, Maurizio Degan, Valeria Guglielmi, Alessandro Lechi, Giuliano Tomelleri

Clin Sci (Lond) (2012) 122 (6): 289–299.

https://doi.org/10.1042/CS20110199

Published: 22 November 2011

... nitric oxide oxidative stress Impaired oxidative phosphorylation is the hallmark of MDs (mitochondrial diseases), a heterogeneous group of prevalently genetic disorders, characterized by the uncoupling of electron transport and decreased ATP generation through the tricarboxylic acid cycle [ 1...

View article titled, Endothelial dysfunction and increased oxidative stress in mitochondrial diseases

Includes: Supplementary data

Articles

Haem oxygenase-1 counteracts the effects of interleukin-1β on inflammatory and senescence markers in cartilage–subchondral bone explants from osteoarthritic patients

Victoria Clérigues, Maria Isabel Guillén, Francisco Gomar, Maria José Alcaraz

Clin Sci (Lond) (2012) 122 (5): 239–251.

https://doi.org/10.1042/CS20100519

Published: 08 November 2011

... nitric oxide synthase), COX-2 (cyclooxygenase-2) and mPGES-1 (microsomal prostaglandin E synthase-1) induced by IL-1β. In contrast, the expression of HMGB1 (high-mobility group box 1) was not significantly modified. In addition, CoPP decreased the expression of iNOS and mPGES-1 in cells isolated from...

View article titled, Haem oxygenase-1 counteracts the effects of interleukin-1β on inflammatory and senescence markers in cartilage–subchondral bone explants from osteoarthritic patients

Includes: Supplementary data

Articles

Symmetric dimethylarginine is a marker of detrimental outcome in the acute phase after ischaemic stroke: role of renal function

Nicole Lüneburg, Rouven-Alexander von Holten, Rudolf F. Töpper, Edzard Schwedhelm, Renke Maas, Rainer H. Böger

Clin Sci (Lond) (2012) 122 (3): 105–111.

https://doi.org/10.1042/CS20110013

Published: 27 September 2011

...Nicole Lüneburg; Rouven-Alexander von Holten; Rudolf F. Töpper; Edzard Schwedhelm; Renke Maas; Rainer H. Böger Methylarginines have been shown to interfere with NO (nitric oxide) formation by inhibiting NOS (NO synthase)–ADMA (asymmetric dimethylarginine) and cellular L -arginine uptake...

View article titled, Symmetric dimethylarginine is a marker of detrimental outcome in the acute phase after ischaemic stroke: role of renal function

Articles

Acute simvastatin increases endothelial nitric oxide synthase phosphorylation via AMP-activated protein kinase and reduces contractility of isolated rat mesenteric resistance arteries

Luciana V. Rossoni, Mark Wareing, Camilla F. Wenceslau, Mahmood Al-Abri, Chris Cobb, Clare Austin

Clin Sci (Lond) (2011) 121 (10): 449–458.

https://doi.org/10.1042/CS20110259

Published: 25 July 2011

...Luciana V. Rossoni; Mark Wareing; Camilla F. Wenceslau; Mahmood Al-Abri; Chris Cobb; Clare Austin Statins can have beneficial cholesterol-independent effects on vascular contractility, which may involve increases in the bioavailability of NO (nitric oxide) as a result of phosphorylation of eNOS...

View article titled, Acute simvastatin increases endothelial nitric oxide synthase phosphorylation via AMP-activated protein kinase and reduces contractility of isolated rat mesenteric resistance arteries

Articles

Chronic HgCl 2 treatment increases vasoconstriction induced by electrical field stimulation: role of adrenergic and nitrergic innervation

Javier Blanco-Rivero, Lorena B. Furieri, Dalton V. Vassallo, Mercedes Salaices, Gloria Balfagón

Clin Sci (Lond) (2011) 121 (8): 331–341.

https://doi.org/10.1042/CS20110072

Published: 24 June 2011

... a spectrofluorimeter (LS50 PerkinElmer instrument with FL WINLAB software) with the excitation wavelength set at 492 nm and the emission wavelength at 515 nm. © The Authors Journal compilation © 2011 Biochemical Society 2011 electrical field stimulation HgCl 2 noradrenaline nitric oxide vascular...

View article titled, Chronic HgCl 2 treatment increases vasoconstriction induced by electrical field stimulation: role of adrenergic and nitrergic innervation

Articles

Remote hindlimb preconditioning and hepatoprotection: NO-table strides against liver ischaemia/reperfusion injury

Narci C. Teoh

Clin Sci (Lond) (2011) 121 (6): 253–255.

https://doi.org/10.1042/CS20110243

Published: 27 May 2011

... 2011 10 5 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 ischaemia/reperfusion ischaemic preconditioning liver nitric oxide reperfusion injury warm ischaemia Hepatic I/R (ischaemia/reperfusion) injury is an important clinical problem complicating liver...

View article titled, Remote hindlimb preconditioning and hepatoprotection: NO-table strides against liver ischaemia/reperfusion injury

Articles

Nitric oxide is an essential mediator of the protective effects of remote ischaemic preconditioning in a mouse model of liver ischaemia/reperfusion injury

Mahmoud Abu-Amara, Shi Yu Yang, Alberto Quaglia, Peter Rowley, Achala De Mel, Niteen Tapuria, Alexander Seifalian, Brian Davidson, Barry Fuller

Clin Sci (Lond) (2011) 121 (6): 257–266.

https://doi.org/10.1042/CS20100598

Published: 27 May 2011

...Mahmoud Abu-Amara; Shi Yu Yang; Alberto Quaglia; Peter Rowley; Achala De Mel; Niteen Tapuria; Alexander Seifalian; Brian Davidson; Barry Fuller NO (nitric oxide) may protect the liver from IR (ischaemia/reperfusion) injury. RIPC (remote ischaemic preconditioning) also protects against liver IR...

View article titled, Nitric oxide is an essential mediator of the protective effects of remote ischaemic preconditioning in a mouse model of liver ischaemia/reperfusion injury

Articles

Impaired resistance artery function in patients with end-stage renal disease

Natallia Luksha, Leanid Luksha, Juan Jesús Carrero, Folke Hammarqvist, Peter Stenvinkel, Karolina Kublickiene

Clin Sci (Lond) (2011) 120 (12): 525–536.

https://doi.org/10.1042/CS20100277

Published: 09 March 2011

... (end-stage renal disease) patients starting peritoneal dialysis and 30 matched controls were studied using isolated small artery bioassays. Flow-mediated dilatation was attenuated in ESRD patients compared with controls. NO (nitric oxide) contribution to flow was lacking in ESRD patients, but present...

View article titled, Impaired resistance artery function in patients with end-stage renal disease

Articles

Aging and vascular endothelial function in humans

Douglas R. Seals, Kristen L. Jablonski, Anthony J. Donato

Clin Sci (Lond) (2011) 120 (9): 357–375.

https://doi.org/10.1042/CS20100476

Published: 18 January 2011

...-dependent dilation) in response to chemical [typically ACh (acetylcholine)] or mechanical (intravascular shear) stimuli. Reduced bioavailability of the endothelium-synthesized dilating molecule NO (nitric oxide) as a result of oxidative stress is the key mechanism mediating reduced EDD with aging. Vascular...

View article titled, Aging and vascular endothelial function in humans

Articles

Simultaneous inhibition of TXA 2 and PGI 2 synthesis increases NO release in mesenteric resistance arteries from cirrhotic rats

Fabiano E. Xavier, Javier Blanco-Rivero, Esther Sastre, Lina Badimón, Gloria Balfagón

Clin Sci (Lond) (2010) 119 (7): 283–292.

https://doi.org/10.1042/CS20090536

Published: 25 June 2010

...) nitric oxide prostaglandin I 2 thromboxane A 2 Cirrhosis is associated with a hyperdynamic circulatory syndrome characterized by high cardiac output, and reduced systemic vascular resistance and arterial pressure. Vascular resistance in circulatory districts other than the splanchnic system...

View article titled, Simultaneous inhibition of TXA 2 and PGI 2 synthesis increases NO release in mesenteric resistance arteries from cirrhotic rats

Articles

Administration of a low dose of sildenafil for 1 week decreases intrahepatic resistance in rats with biliary cirrhosis: the role of NO bioavailability

Kuei-Chuan Lee, Ying-Ying Yang, Yi-Tsau Huang, Fa-Yauh Lee, Ming-Chih Hou, Han-Chieh Lin, Shou-Dong Lee

Clin Sci (Lond) (2010) 119 (1): 45–55.

https://doi.org/10.1042/CS20090601

Published: 07 April 2010

... of Laboratory Animals prepared by the National Academy of Science, U.S.A. cirrhosis intrahepatic resistance microcirculation nitric oxide phosphodiesterase inhibitor tetrahydrobiopterin (BH 4 ) Portal hypertension is responsible for major complications of liver cirrhosis and leads...

View article titled, Administration of a low dose of sildenafil for 1 week decreases intrahepatic resistance in rats with biliary cirrhosis: the role of NO bioavailability

Articles

Impact of catheter insertion using the radial approach on vasodilatation in humans

Ellen A. Dawson, Sudhir Rathore, N. Timothy Cable, D. Jay Wright, John L. Morris, Daniel J. Green

Clin Sci (Lond) (2010) 118 (10): 633–640.

https://doi.org/10.1042/CS20090548

Published: 23 February 2010

... of endothelial denudation as a consequence of sheath placement. Radial artery flow-mediated and endothelium-derived NO (nitric oxide)-dependent function (FMD) was assessed within the region of sheath placement (sheath site) and also above the sheath (catheter site). GTN (glyceryl trinitrate) endothelium...

View article titled, Impact of catheter insertion using the radial approach on vasodilatation in humans

Articles

Statins have beneficial effects on platelet free radical activity and intracellular distribution of GTPases in hyperlipidaemia

Paul K. Hamilton, Sinead M.T. Hughes, Richard D. Plumb, Adrian Devine, William Leahey, Kristopher S. Lyons, Dennis Johnston, Gary E. McVeigh

Clin Sci (Lond) (2010) 118 (5): 359–366.

https://doi.org/10.1042/CS20090388

Published: 01 December 2009

... by atorvastatin. GTPase hyperlipidaemia isoprenoid nitric oxide statin platelet superoxide radical Statins [HMG-CoA (3-hydroxy-3-methylglutaryl-CoA) reductase inhibitors] reduce cardiovascular mortality and morbidity [ 1 , 2 ]. The chief mechanism by which they produce benefit is by lowering LDL...

View article titled, Statins have beneficial effects on platelet free radical activity and intracellular distribution of GTPases in hyperlipidaemia

Articles

Exercise and possible molecular mechanisms of protection from vascular disease and diabetes: the central role of ROS and nitric oxide

Philip Newsholme, Paulo I. Homem De Bittencourt, Jr, Ciara O' Hagan, Giuseppe De Vito, Colin Murphy, Mauricio S. Krause

Clin Sci (Lond) (2010) 118 (5): 341–349.

https://doi.org/10.1042/CS20090433

Published: 23 November 2009

... to the development of increased arterial stiffness and is enhanced in insulin-resistant states [ 16 ]. © The Authors Journal compilation © 2010 Biochemical Society 2010 diabetes endothelial vascular cell exercise nitric oxide pancreatic β-cell reactive oxygen species (ROS) The beneficial...

View article titled, Exercise and possible molecular mechanisms of protection from vascular disease and diabetes: the central role of ROS and nitric oxide

Articles

Long-term portal hypertension increases the vasodilator response to acetylcholine in rat aorta: role of prostaglandin I 2

Javier Blanco-Rivero, Ma Angeles Aller, Jaime Arias, Mercedes Ferrer, Gloria Balfagón

Clin Sci (Lond) (2009) 117 (10): 365–374.

https://doi.org/10.1042/CS20080499

Published: 07 September 2009

... to correct the protein expression in each sample. Correspondence: Dr Gloria Balfagón (email gloria.balfagon@uam.es ). 30 9 2008 3 2 2009 30 3 2009 30 3 2009 © The Authors Journal compilation © 2009 Biochemical Society 2009 acetylcholine aging nitric oxide...

View article titled, Long-term portal hypertension increases the vasodilator response to acetylcholine in rat aorta: role of prostaglandin I 2

Articles

Haemodialysis acutely reduces the plasma levels of ADMA without reversing impaired NO-dependent vasodilation

Rolf P. Engelberger, Daniel Teta, Hughes Henry, Olivier De Senarclens, Benoît Dischl, Lucas Liaudet, Michel Burnier, Bernard Waeber, François Feihl

Clin Sci (Lond) (2009) 117 (8): 293–303.

https://doi.org/10.1042/CS20080561

Published: 24 August 2009

... ). 29 10 2008 13 2 2009 5 3 2009 5 3 2009 © The Authors Journal compilation © 2009 Biochemical Society 2009 asymmetric ω- N G , N G -dimethylarginine (ADMA) chronic haemodialysis endothelium-dependent vasodilation end-stage renal disease nitric oxide skin blood flow...

View article titled, Haemodialysis acutely reduces the plasma levels of ADMA without reversing impaired NO-dependent vasodilation

Articles

Dexamethasone decreases neuronal nitric oxide release in mesenteric arteries from hypertensive rats through decreased protein kinase C activation

Rosa Aras-López, Fabiano E. Xavier, Mercedes Ferrer, Gloria Balfagón

Clin Sci (Lond) (2009) 117 (8): 305–312.

https://doi.org/10.1042/CS20080178

Published: 24 August 2009

... Biochemical Society 2009 dexamethasone electrical field stimulation hypertension glucocorticoid nitric oxide protein kinase C Glucocorticoid hormones play an important role in the control of vascular smooth muscle tone by acting on both endothelial and vascular smooth muscle cells through...

View article titled, Dexamethasone decreases neuronal nitric oxide release in mesenteric arteries from hypertensive rats through decreased protein kinase C activation

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Arginine, citrulline and nitric oxide metabolism in sepsis

Christina C. Kao, Venkata Bandi, Kalpalatha K. Guntupalli, Manhong Wu, Leticia Castillo, Farook Jahoor

Clin Sci (Lond) (2009) 117 (1): 23–30.

https://doi.org/10.1042/CS20080444

Published: 02 June 2009

... Biochemical Society 2009 arginine citrulline isotope nitric oxide septic shock Arginine is a dispensable amino acid in normal health, but may be conditionally essential in stressed states such as sepsis [ 1 ]. In addition to acting as a substrate for protein synthesis, arginine serves...

View article titled, Arginine, citrulline and nitric oxide metabolism in sepsis

Articles

Mediators of mineralocorticoid receptor-induced profibrotic inflammatory responses in the heart

Peter Wilson, James Morgan, John W. Funder, Peter J. Fuller, Morag J. Young

Clin Sci (Lond) (2009) 116 (9): 731–739.

https://doi.org/10.1042/CS20080247

Published: 02 April 2009

... 2 9 2008 6 11 2008 6 11 2008 © The Authors Journal compilation © 2009 Biochemical Society 2009 cardiac fibrosis glucocorticoid inflammation mineralocorticoid nitric oxide oxidative stress The action of mineralocorticoids has long been considered to be primarily...

View article titled, Mediators of mineralocorticoid receptor-induced profibrotic inflammatory responses in the heart

Articles

Oral antioxidants and cardiovascular health in the exercise-trained and untrained elderly: a radically different outcome

D. Walter Wray, Abhimanyu Uberoi, Lesley Lawrenson, Damian M. Bailey, Russell S. Richardson

Clin Sci (Lond) (2009) 116 (5): 433–441.

https://doi.org/10.1042/CS20080337

Published: 02 February 2009

... A. Physical activity prevents age-related impairment in nitric oxide availability in elderly athletes Circulation 2000 101 2896 2901 8 Green D. J. Maiorana A. O'Driscoll G. Taylor R. Effect of exercise training on endothelium-derived nitric oxide function in humans J. Physiol...

View article titled, Oral antioxidants and cardiovascular health in the exercise-trained and untrained elderly: a radically different outcome

Articles

Role of TNF-α in vascular dysfunction

Hanrui Zhang, Yoonjung Park, Junxi Wu, Xiu ping Chen, Sewon Lee, Jiyeon Yang, Kevin C. Dellsperger, Cuihua Zhang

Clin Sci (Lond) (2009) 116 (3): 219–230.

https://doi.org/10.1042/CS20080196

Published: 08 January 2009

... circulation microvascular circulation nitric oxide reactive oxygen species (ROS) tumour necrosis factor-α (TNF-α) IHD (ischaemic heart disease) accounts for over 500000 deaths annually in the United States. AMI (acute myocardial infarction), also known as a heart attack [ 1 ], is a common...

View article titled, Role of TNF-α in vascular dysfunction

Articles

Effects of chronic L-NAME on nitrotyrosine expression and renal vascular reactivity in rats with chronic bile-duct ligation

Antonia Alcaraz, David Hernández, David Iyú, Rubén Mota, Noemí M. Atucha, Antonio J. Ortiz, Joaquín García-Estañ, María C. Ortiz

Clin Sci (Lond) (2008) 115 (2): 57–68.

https://doi.org/10.1042/CS20070312

Published: 12 June 2008

... 2007 19 12 2007 9 1 2008 9 1 2008 © The Authors Journal compilation © 2008 Biochemical Society 2008 biliary cirrhosis kidney nitric oxide nitrotyrosine oxidative stress peroxynitrite Increased NO production contributes to the renal excretory and vascular...

View article titled, Effects of chronic L-NAME on nitrotyrosine expression and renal vascular reactivity in rats with chronic bile-duct ligation

Articles

Hypertension increases middle cerebral artery resting tone in spontaneously hypertensive rats: role of tonic vasoactive factor availability

José M. González, Beatriz Somoza, M. Victoria Conde, Maria S. Fernández-Alfonso, M. Carmen González, Silvia M. Arribas

Clin Sci (Lond) (2008) 114 (10): 651–659.

https://doi.org/10.1042/CS20070361

Published: 14 April 2008

.... Correspondence: Dr Silvia M. Arribas (email silvia.arribas@uam.es ). 12 10 2007 27 11 2007 19 12 2007 19 12 2007 © The Authors Journal compilation © 2008 Biochemical Society 2008 mesenteric resistance artery middle cerebral artery nitric oxide spontaneously hypertensive rat...

View article titled, Hypertension increases middle cerebral artery resting tone in spontaneously hypertensive rats: role of tonic vasoactive factor availability

Articles

Can rodent models of diabetic kidney disease clarify the significance of early hyperfiltration?: recognizing clinical and experimental uncertainties

David Z. Levine

Clin Sci (Lond) (2008) 114 (2): 109–118.

https://doi.org/10.1042/CS20070088

Published: 11 December 2007

... nephropathy glomerular filtration rate hyperfiltration nitric oxide rodent model In T1DM, hyperfiltration appears to be absent early in the disease in approx. 30% of patients [ 13 ], whereas, in T2DM, hyperfiltration is probably absent in approx. 50% of patients [ 14 ]. Does the presence...

View article titled, Can rodent models of diabetic kidney disease clarify the significance of early hyperfiltration?: recognizing clinical and experimental uncertainties

Articles

Presence of tumour inhibits the normal post-operative response in arginine and NO production in non-cachectic mice

Yvonne L. J. Vissers, Maarten F. von Meyenfeldt, Yvette C. Luiking, Cornelis H. C. Dejong, Wim A. Buurman, Nicolaas E. P. Deutz

Clin Sci (Lond) (2007) 112 (10): 527–532.

https://doi.org/10.1042/CS20060340

Published: 12 April 2007

... with an attenuated acute-phase response. This indicates that altered arginine metabolism may be an important characteristic of the metabolic changes in cancer. amino acid arginine cancer metabolism nitric oxide stable isotope surgery We have described recently [ 1 ] that patients with malignant...

View article titled, Presence of tumour inhibits the normal post-operative response in arginine and NO production in non-cachectic mice

Articles

Cardiac mitochondrial cGMP stimulates cytochrome c release

Kazuhiko Seya, Shigeru Motomura, Ken-Ichi Furukawa

Clin Sci (Lond) (2007) 112 (2): 113–121.

https://doi.org/10.1042/CS20060144

Published: 11 December 2006

... relative to the total number of cells. In each experiment, the mean values of 40 cells were taken. apoptosis cytochrome c release hypoxia/re-oxygenation mitochondrial cGMP mitochondrial permeability transition (MPT) nitric oxide adult rat cardiomyocyte Reperfusion therapy for acute...

View article titled, Cardiac mitochondrial cGMP stimulates cytochrome c release

Articles

Inducible nitric oxide synthase activity does not contribute to the maintenance of peripheral vascular tone in patients with heart failure

Anna R. Dover, Stanley Chia, James W. Ferguson, Nicholas L. Cruden, Ian L. Megson, Keith A. A. Fox, David E. Newby

Clin Sci (Lond) (2006) 111 (4): 275–280.

https://doi.org/10.1042/CS20060104

Published: 13 September 2006

...Anna R. Dover; Stanley Chia; James W. Ferguson; Nicholas L. Cruden; Ian L. Megson; Keith A. A. Fox; David E. Newby Enhanced iNOS (inducible nitric oxide synthase) activity may contribute to vascular dysfunction in patients with heart failure. In the present study, we aimed to determine whether iNOS...

View article titled, Inducible nitric oxide synthase activity does not contribute to the maintenance of peripheral vascular tone in patients with heart failure

Articles

Effect of fatty acids on endothelium-dependent relaxation in the rabbit aorta

Indika Edirisinghe, Kellie McCormick Hallam, C. Tissa Kappagoda

Clin Sci (Lond) (2006) 111 (2): 145–151.

https://doi.org/10.1042/CS20060001

Published: 13 July 2006

... and time course of inhibition, and (v) the effect on nitric oxide production. Aortic rings were incubated (1 h) with NEFA–albumin complexes derived from lauric (C 12:0 ), myristic (C 14:0 ), palmitic (C 16:0 ), stearic (C 18:0 ) and linolenic (C 18:3 ) acids. EDR induced by acetylcholine (0.1–10 μmol/l...

View article titled, Effect of fatty acids on endothelium-dependent relaxation in the rabbit aorta

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